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The map label for this gene is map [H]

Identifier: 119774275

GI number: 119774275

Start: 1388187

End: 1388987

Strand: Reverse

Name: map [H]

Synonym: Sama_1138

Alternate gene names: 119774275

Gene position: 1388987-1388187 (Counterclockwise)

Preceding gene: 119774293

Following gene: 119774274

Centisome position: 32.26

GC content: 51.44

Gene sequence:

>801_bases
ATGAGTATAGTCATCAAGACCGCCGATGAGATAGAAAAAATGCGCGCCGCAGGTAAGCTGGCCGCAGATGTTCTTGAAAT
GATTGCGCCCTTTGTCAAGGCTGGCGTGACCACCAATGAACTCAACGATATTTGCGCCAAATACACCGAAGAACAGGGTG
CCATTTCTGCGCCGCTCAACTACCACGGCTTTCCCAAGTCTATCTGTACTTCGGTCAATGAAGTTATCTGCCACGGCATC
CCCTCAGATCAGCCACTGAAAGACGGCGATATCCTCAATATCGATATTACAGTCATCAAAGACGGTTACCACGGTGATAC
GTCCAAGATGTTTTTCATCGGTGAAGTATCTCCAAAAGACAAGCGCCTGTGCCGAATCGCACAGGAGAGCCTGTACGCAG
CCATTCGCAAGGTTCGTCCCGGCATGAAGCTGGGTGAAATCGGCGCCACCATTGAAAAAGTGGTCAAGGGAGCCAAGACC
GGCCTTGAGAAATACAGCATTGTCCGTGACTACTGCGGCCACGGCATTGGTGCCACTTTCCACGAAGAGCCTCAGGTCGT
GCACTACAAAAACACCGACAACACGGTTCTTCGCCCCGGCATGTGCTTTACCATTGAACCGATGATCAACGCGGGTCGTC
ACCAGACTGTGCTCGACAAAGACGATGGCTGGACTGTGACCACCATCGATGGCAAAAACTCTGCCCAGTACGAACACACT
CTCTTGGTAACCGAGACGGGTGTGGAAGTACTCACCCTGCGCAGCGAAGAAGATTTCCCACGCATAATCAATCACAAATA
A

Upstream 100 bases:

>100_bases
CTTTATACCATAAATCAGCCCGCAACACAAATTTTTGCGGGCTGATTTATGGCACGTCAGCGCCCCAATTCCCTGTGATA
CTAGGTGAGAAAACAACTGC

Downstream 100 bases:

>100_bases
GGCAATCCATGACGACGGCTCAGCAGGCCAAAGCCTCTTTGCAGGCGCTGAATCAGGAACTGGCGCTGGCCTTCGCGGCC
CGTGAAGATGTTGTCGAACT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSIVIKTADEIEKMRAAGKLAADVLEMIAPFVKAGVTTNELNDICAKYTEEQGAISAPLNYHGFPKSICTSVNEVICHGI
PSDQPLKDGDILNIDITVIKDGYHGDTSKMFFIGEVSPKDKRLCRIAQESLYAAIRKVRPGMKLGEIGATIEKVVKGAKT
GLEKYSIVRDYCGHGIGATFHEEPQVVHYKNTDNTVLRPGMCFTIEPMINAGRHQTVLDKDDGWTVTTIDGKNSAQYEHT
LLVTETGVEVLTLRSEEDFPRIINHK

Sequences:

>Translated_266_residues
MSIVIKTADEIEKMRAAGKLAADVLEMIAPFVKAGVTTNELNDICAKYTEEQGAISAPLNYHGFPKSICTSVNEVICHGI
PSDQPLKDGDILNIDITVIKDGYHGDTSKMFFIGEVSPKDKRLCRIAQESLYAAIRKVRPGMKLGEIGATIEKVVKGAKT
GLEKYSIVRDYCGHGIGATFHEEPQVVHYKNTDNTVLRPGMCFTIEPMINAGRHQTVLDKDDGWTVTTIDGKNSAQYEHT
LLVTETGVEVLTLRSEEDFPRIINHK
>Mature_265_residues
SIVIKTADEIEKMRAAGKLAADVLEMIAPFVKAGVTTNELNDICAKYTEEQGAISAPLNYHGFPKSICTSVNEVICHGIP
SDQPLKDGDILNIDITVIKDGYHGDTSKMFFIGEVSPKDKRLCRIAQESLYAAIRKVRPGMKLGEIGATIEKVVKGAKTG
LEKYSIVRDYCGHGIGATFHEEPQVVHYKNTDNTVLRPGMCFTIEPMINAGRHQTVLDKDDGWTVTTIDGKNSAQYEHTL
LVTETGVEVLTLRSEEDFPRIINHK

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=264, Percent_Identity=45.8333333333333, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=40.6374501992032, Blast_Score=204, Evalue=8e-53,
Organism=Escherichia coli, GI1786364, Length=268, Percent_Identity=60.4477611940298, Blast_Score=328, Evalue=2e-91,
Organism=Escherichia coli, GI1788728, Length=256, Percent_Identity=28.125, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1789275, Length=270, Percent_Identity=24.4444444444444, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=254, Percent_Identity=44.4881889763779, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6323273, Length=258, Percent_Identity=47.2868217054264, Blast_Score=233, Evalue=2e-62,
Organism=Drosophila melanogaster, GI21355531, Length=251, Percent_Identity=50.996015936255, Blast_Score=243, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24583427, Length=248, Percent_Identity=41.1290322580645, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29320; Mature: 29189

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVIKTADEIEKMRAAGKLAADVLEMIAPFVKAGVTTNELNDICAKYTEEQGAISAPLN
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCC
YHGFPKSICTSVNEVICHGIPSDQPLKDGDILNIDITVIKDGYHGDTSKMFFIGEVSPKD
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCH
KRLCRIAQESLYAAIRKVRPGMKLGEIGATIEKVVKGAKTGLEKYSIVRDYCGHGIGATF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HEEPQVVHYKNTDNTVLRPGMCFTIEPMINAGRHQTVLDKDDGWTVTTIDGKNSAQYEHT
CCCCCEEEEECCCCCEECCCCEEEECHHHCCCCCCEEEECCCCEEEEEECCCCCCCEEEE
LLVTETGVEVLTLRSEEDFPRIINHK
EEEEECCCEEEEECCCCCCCHHCCCC
>Mature Secondary Structure 
SIVIKTADEIEKMRAAGKLAADVLEMIAPFVKAGVTTNELNDICAKYTEEQGAISAPLN
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCC
YHGFPKSICTSVNEVICHGIPSDQPLKDGDILNIDITVIKDGYHGDTSKMFFIGEVSPKD
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCCCCH
KRLCRIAQESLYAAIRKVRPGMKLGEIGATIEKVVKGAKTGLEKYSIVRDYCGHGIGATF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HEEPQVVHYKNTDNTVLRPGMCFTIEPMINAGRHQTVLDKDDGWTVTTIDGKNSAQYEHT
CCCCCEEEEECCCCCEECCCCEEEECHHHCCCCCCEEEECCCCEEEEEECCCCCCCEEEE
LLVTETGVEVLTLRSEEDFPRIINHK
EEEEECCCEEEEECCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]