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The map label for this gene is mazG [H]

Identifier: 119774171

GI number: 119774171

Start: 1252330

End: 1253157

Strand: Direct

Name: mazG [H]

Synonym: Sama_1034

Alternate gene names: 119774171

Gene position: 1252330-1253157 (Clockwise)

Preceding gene: 119774170

Following gene: 119774172

Centisome position: 29.08

GC content: 55.68

Gene sequence:

>828_bases
ATGAGCACCGAAATCATTGCAAATGAAGAGCCAAATGCCGACATCAATCCGCTACTGGCCATCATGGCCAAATTGCGTGA
CCCAAAACATGGCTGCCCCTGGGACAAGGCCCAGCGCTTCGAGACCATAGTGCCCTTCACCCTGGAAGAGGCCTATGAAG
TGGCCGACACCATTGAGCGCATGGATCTTGATGAGTTGCCGGACGAGCTGGGGGACCTTTTGTTTCAGGTGGTGTTCTAC
TGCCAGCTTGGCAAAGAACAGGGGCTGTTTGATTTCGATGAGGTGGTAAAGCGCATCTGCGCCAAGCTCACTTCCCGCCA
TCCACATGTGTTTGGCGATATTGAAGTGAGTTCCAGTAAAGAAGTGAAAGACAACTGGGAGGCCATCAAGGCCAGTGAGC
GTAAAGCCAAAGACAAACACTCGGTGCTCGATGATGTGCCGGTTGGCCTGCCAGCCCTAAGCCGCGCCGCCAAAATCCAG
AAGCGGGTGGCCCGGGTGGGTTTTGACTGGGGCGAGCTGCCGCCGGTGGTGGCCAAGGTGGAAGAAGAAATTGCCGAAGT
GCTGGCCGAAGTGCAGGTGGACAGTCCCGACCAGGAGCGGGTTGCCAGTGAGATGGGTGACCTGTTGTTTGCAGTGGTGA
ATATGGCGCGCCATCTTGGTGTTGAGCCCGAGCAGGCACTTCGCCGGGCCAATCAAAAGTTTGAACGCCGTTTTCGCGGC
GTGGAAGAACTGGCAACCCTGGGAGGCAGACAATTGACCGATTATTCCCTTGCTGAGCTCGATGGCTTCTGGGATCAGGT
AAAAGAGCAGGAAAAATCTCCCCGTTGA

Upstream 100 bases:

>100_bases
ATGAATACTGAACCTTTCAAATAAGGGCTGCGTTGCAGCCTTTGTTTTTAACGTCTTTTAAGTCATAGCTGCGCTGTTTT
CGCAGCAGAAGGGAATGCAA

Downstream 100 bases:

>100_bases
GGTTTGTCGAAAGCACAGGGCTTTGATATACTGTCGCCCCGTCCTGGTGCTTTCTTACAAGCACATATTTTCACACTCAT
ATTTTCTCAGGTTCAGCATG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSTEIIANEEPNADINPLLAIMAKLRDPKHGCPWDKAQRFETIVPFTLEEAYEVADTIERMDLDELPDELGDLLFQVVFY
CQLGKEQGLFDFDEVVKRICAKLTSRHPHVFGDIEVSSSKEVKDNWEAIKASERKAKDKHSVLDDVPVGLPALSRAAKIQ
KRVARVGFDWGELPPVVAKVEEEIAEVLAEVQVDSPDQERVASEMGDLLFAVVNMARHLGVEPEQALRRANQKFERRFRG
VEELATLGGRQLTDYSLAELDGFWDQVKEQEKSPR

Sequences:

>Translated_275_residues
MSTEIIANEEPNADINPLLAIMAKLRDPKHGCPWDKAQRFETIVPFTLEEAYEVADTIERMDLDELPDELGDLLFQVVFY
CQLGKEQGLFDFDEVVKRICAKLTSRHPHVFGDIEVSSSKEVKDNWEAIKASERKAKDKHSVLDDVPVGLPALSRAAKIQ
KRVARVGFDWGELPPVVAKVEEEIAEVLAEVQVDSPDQERVASEMGDLLFAVVNMARHLGVEPEQALRRANQKFERRFRG
VEELATLGGRQLTDYSLAELDGFWDQVKEQEKSPR
>Mature_274_residues
STEIIANEEPNADINPLLAIMAKLRDPKHGCPWDKAQRFETIVPFTLEEAYEVADTIERMDLDELPDELGDLLFQVVFYC
QLGKEQGLFDFDEVVKRICAKLTSRHPHVFGDIEVSSSKEVKDNWEAIKASERKAKDKHSVLDDVPVGLPALSRAAKIQK
RVARVGFDWGELPPVVAKVEEEIAEVLAEVQVDSPDQERVASEMGDLLFAVVNMARHLGVEPEQALRRANQKFERRFRGV
EELATLGGRQLTDYSLAELDGFWDQVKEQEKSPR

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=257, Percent_Identity=56.8093385214008, Blast_Score=293, Evalue=6e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31127; Mature: 30995

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEIIANEEPNADINPLLAIMAKLRDPKHGCPWDKAQRFETIVPFTLEEAYEVADTIER
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
MDLDELPDELGDLLFQVVFYCQLGKEQGLFDFDEVVKRICAKLTSRHPHVFGDIEVSSSK
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEECEECCCCC
EVKDNWEAIKASERKAKDKHSVLDDVPVGLPALSRAAKIQKRVARVGFDWGELPPVVAKV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EEEIAEVLAEVQVDSPDQERVASEMGDLLFAVVNMARHLGVEPEQALRRANQKFERRFRG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VEELATLGGRQLTDYSLAELDGFWDQVKEQEKSPR
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STEIIANEEPNADINPLLAIMAKLRDPKHGCPWDKAQRFETIVPFTLEEAYEVADTIER
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
MDLDELPDELGDLLFQVVFYCQLGKEQGLFDFDEVVKRICAKLTSRHPHVFGDIEVSSSK
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEECEECCCCC
EVKDNWEAIKASERKAKDKHSVLDDVPVGLPALSRAAKIQKRVARVGFDWGELPPVVAKV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EEEIAEVLAEVQVDSPDQERVASEMGDLLFAVVNMARHLGVEPEQALRRANQKFERRFRG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VEELATLGGRQLTDYSLAELDGFWDQVKEQEKSPR
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]