Click here to switch to the map view.

The map label for this gene is tyrA [H]

Identifier: 119774031

GI number: 119774031

Start: 1081419

End: 1082558

Strand: Direct

Name: tyrA [H]

Synonym: Sama_0894

Alternate gene names: 119774031

Gene position: 1081419-1082558 (Clockwise)

Preceding gene: 119774030

Following gene: 119774032

Centisome position: 25.11

GC content: 54.91

Gene sequence:

>1140_bases
ATGACAGAAAAGACCACCGCTGAGCTGGAAAACCTACGGGGCCTGATTGATGGTGTCGACAGCCAGTTACTGTCGCTGCT
TCGCAAGCGTCTTGATTTGGTGGCACAGGTTGGCACAGTCAAACATGCGGCGGGACTGCCGATTTACGCGCCTGCACGGG
AAGCGGCCATGCTCGGTAAGCGTCGCGCCGAAGCCGAAGCCATGGGAGTAAGTCCACAGCTGATTGAGGATATCTTGAGA
CGCCTGATGCGCGAATCCTACATGAGTGAAAAAGACGTGGGCTTCAAGCAGGTCAATCCTGAGCTGGGCCATATTGTTAT
CATAGGTGGGCAAGGGCAGCTGGGACGCTTATTCGCTCAGATGTTTGCGCTTTCCGGCTATGAAGTGCGTCTCTTGGATA
AAGATGACTGGGACCATGCAGATGAGCTGTTCGATGGTGCAGGTCTGGTATTGGTGACAGTGCCCATTGCGACTACCTGC
TCGCTTATCCGTGAGCGCCTGGATCACCTTCCCGAGCACTGTATCTTGGCGGATCTGACCTCCGTCAAAGGGGCGCCACT
CAAGGCCATGCTGGAAACCCATAAGGGCCCAGTGGTGGGGTTGCACCCCATGTTTGGTCCGGACGTGGGCAGTTTGGCCA
AACAGGTGGTGGTAGTGTGCCATGGCCGTGCGCCGGAAAAGTACCAATGGCTGATGGAGCAGATTGGCATCTGGGGCGCC
AGACTGGTCGAGGCCGATGCGGGTCGCCATGATAAGGCGATGCAGCTGGTGCAGGCTATGCGTCACTTTTCATCGTTTGT
GTATGGCTTGAACCTGTGCCGTGAGCAGGCTGATATAGACACGCTGCTTGAATTCAGCTCGCCTATTTATCGGCTGGAGC
TGGCCATGGTGGGGCGTCTCTTTGCCCAGAGCGGCGAGCTGTACGCCGACATTATTTTTGCCCAGGAAGAAAGCCTGACG
GCGATTTCGGACTTCATCGATAACTACCGCGATGCACTGGAGCTTCTGAAAACAGGCGATAGGGCAGGCTTTATCGCACG
CTTTAATGAAGTTTCAAACTGGTTTGGCAATTACTCCCAACAGTTCCTTACCGAGAGTCGCGCCATGCTGCAATCGGTCA
ATGATATGCGTTCAGTTTAA

Upstream 100 bases:

>100_bases
ACCGAAACCTTGCTGCGTGAAGGTGCCGAGAACCTGGCGTCTGTTATTCCCTCAAGATTTGTTATGCTGAAGGCCGCCAA
TGGCTGACAGGATATTTGAT

Downstream 100 bases:

>100_bases
GATGCTGTTCTTTATACTGAAAAAGCGCCATTAAGGCGCTTTTTTTATTTTAAATCAGCAACTCCTTAAGATGATCTGCT
TCAAGGAACCGAGCTTTGCT

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTEKTTAELENLRGLIDGVDSQLLSLLRKRLDLVAQVGTVKHAAGLPIYAPAREAAMLGKRRAEAEAMGVSPQLIEDILR
RLMRESYMSEKDVGFKQVNPELGHIVIIGGQGQLGRLFAQMFALSGYEVRLLDKDDWDHADELFDGAGLVLVTVPIATTC
SLIRERLDHLPEHCILADLTSVKGAPLKAMLETHKGPVVGLHPMFGPDVGSLAKQVVVVCHGRAPEKYQWLMEQIGIWGA
RLVEADAGRHDKAMQLVQAMRHFSSFVYGLNLCREQADIDTLLEFSSPIYRLELAMVGRLFAQSGELYADIIFAQEESLT
AISDFIDNYRDALELLKTGDRAGFIARFNEVSNWFGNYSQQFLTESRAMLQSVNDMRSV

Sequences:

>Translated_379_residues
MTEKTTAELENLRGLIDGVDSQLLSLLRKRLDLVAQVGTVKHAAGLPIYAPAREAAMLGKRRAEAEAMGVSPQLIEDILR
RLMRESYMSEKDVGFKQVNPELGHIVIIGGQGQLGRLFAQMFALSGYEVRLLDKDDWDHADELFDGAGLVLVTVPIATTC
SLIRERLDHLPEHCILADLTSVKGAPLKAMLETHKGPVVGLHPMFGPDVGSLAKQVVVVCHGRAPEKYQWLMEQIGIWGA
RLVEADAGRHDKAMQLVQAMRHFSSFVYGLNLCREQADIDTLLEFSSPIYRLELAMVGRLFAQSGELYADIIFAQEESLT
AISDFIDNYRDALELLKTGDRAGFIARFNEVSNWFGNYSQQFLTESRAMLQSVNDMRSV
>Mature_378_residues
TEKTTAELENLRGLIDGVDSQLLSLLRKRLDLVAQVGTVKHAAGLPIYAPAREAAMLGKRRAEAEAMGVSPQLIEDILRR
LMRESYMSEKDVGFKQVNPELGHIVIIGGQGQLGRLFAQMFALSGYEVRLLDKDDWDHADELFDGAGLVLVTVPIATTCS
LIRERLDHLPEHCILADLTSVKGAPLKAMLETHKGPVVGLHPMFGPDVGSLAKQVVVVCHGRAPEKYQWLMEQIGIWGAR
LVEADAGRHDKAMQLVQAMRHFSSFVYGLNLCREQADIDTLLEFSSPIYRLELAMVGRLFAQSGELYADIIFAQEESLTA
ISDFIDNYRDALELLKTGDRAGFIARFNEVSNWFGNYSQQFLTESRAMLQSVNDMRSV

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=372, Percent_Identity=58.0645161290323, Blast_Score=441, Evalue=1e-125,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42177; Mature: 42046

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKTTAELENLRGLIDGVDSQLLSLLRKRLDLVAQVGTVKHAAGLPIYAPAREAAMLGK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RRAEAEAMGVSPQLIEDILRRLMRESYMSEKDVGFKQVNPELGHIVIIGGQGQLGRLFAQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHCCCHHHCCCCCCEEEEECCCCHHHHHHHH
MFALSGYEVRLLDKDDWDHADELFDGAGLVLVTVPIATTCSLIRERLDHLPEHCILADLT
HHHCCCCEEEEECCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHH
SVKGAPLKAMLETHKGPVVGLHPMFGPDVGSLAKQVVVVCHGRAPEKYQWLMEQIGIWGA
HCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHH
RLVEADAGRHDKAMQLVQAMRHFSSFVYGLNLCREQADIDTLLEFSSPIYRLELAMVGRL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FAQSGELYADIIFAQEESLTAISDFIDNYRDALELLKTGDRAGFIARFNEVSNWFGNYSQ
HHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
QFLTESRAMLQSVNDMRSV
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEKTTAELENLRGLIDGVDSQLLSLLRKRLDLVAQVGTVKHAAGLPIYAPAREAAMLGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RRAEAEAMGVSPQLIEDILRRLMRESYMSEKDVGFKQVNPELGHIVIIGGQGQLGRLFAQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHCCCHHHCCCCCCEEEEECCCCHHHHHHHH
MFALSGYEVRLLDKDDWDHADELFDGAGLVLVTVPIATTCSLIRERLDHLPEHCILADLT
HHHCCCCEEEEECCCCCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHH
SVKGAPLKAMLETHKGPVVGLHPMFGPDVGSLAKQVVVVCHGRAPEKYQWLMEQIGIWGA
HCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHH
RLVEADAGRHDKAMQLVQAMRHFSSFVYGLNLCREQADIDTLLEFSSPIYRLELAMVGRL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FAQSGELYADIIFAQEESLTAISDFIDNYRDALELLKTGDRAGFIARFNEVSNWFGNYSQ
HHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
QFLTESRAMLQSVNDMRSV
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]