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The map label for this gene is lepB [H]

Identifier: 119774016

GI number: 119774016

Start: 1068870

End: 1069787

Strand: Direct

Name: lepB [H]

Synonym: Sama_0879

Alternate gene names: 119774016

Gene position: 1068870-1069787 (Clockwise)

Preceding gene: 119774015

Following gene: 119774017

Centisome position: 24.82

GC content: 53.16

Gene sequence:

>918_bases
ATGGCTGCGTATTTTTCACAAATTCTGGTGATAGTCACCCTGGTGTCAGGGTTGATTTGGCTGTTTGATGTGTTGTTTCA
GGCCCCTAAGCGCAAGGCCGCATTGGCTGTGGCTCAGTCCGGCGATGCCAACCTGTCAGAAGACGCTGTCGAAGCCATCA
CCAAGGAACCCTACATAGTCGAAACCGCACACTCTGTGTTCCCGGTCATCGCCTTTGTATTGGTGCTGCGTTCGTTCCTG
TATGAACCTTTTCAAATTCCGTCCGGCTCCATGATGCCAACCCTGTTGGTGGGGGACTTTATTCTGGTGGAAAAATTCAG
CTACGGCATCAAAGAGCCTATGTGGCGCAAAGAGGTTATCGCCACAGGTAAGCCGGAGCGCGGTGATGTGGTGGTCTTCA
AATACCCTGAAGATCCCAGAATTGACTATATTAAGCGTGTGGTAGGCCTGCCGGGAGACCGCGTGTTTTATCAAAACAAA
GAGCTCTACATTCAGCGAGCCTGTGTTGAAGGCGAGATCTGCCAGAGCGTCCCAGCCAAGGTTGACCGTATTGCCCTTGG
CGACAGCGAGTTTGTGCAGGATGGCGTGCGTCTTAAGCATTACAAAGAGCAGCTTGGCGACGTTGAGCACGAAATTTTGA
TTAATCCAGCCCGCCCCGACATGCGCGGCATGTTCTACCGCAAAGGCAGTGTGCCAGCGGGTGAATTTGTGGTGCCGGAA
GGCCAATACTTTGTGATGGGTGATAACCGCGACAACAGTACCGACAGCCGTTTTTGGGGCTTTGTGCCCGAAGAGAACCT
TGTGGGTAAGGCCGTGGCCATTTGGATTAGCTTTGAGTTTGACCGCAAGCCATCTGACACCCTGCCAACCTGGGTGCCCA
CAGGTGTGCGTTTTGAGCGCGTAGGCGGTATCCAGTGA

Upstream 100 bases:

>100_bases
GATCTTTTGGGTGTGCTCACCAAAGCGACTGGCTCTGAGTCAAATTCGTTTGCCGCAGAGTTAAGCCAATCACTTTTAAT
GCCAAGGAGTTAACCCGTTA

Downstream 100 bases:

>100_bases
GCATGATGGAGCCGATTAAAAATCTGCCGCGACTGTGCCGGACTCTGGGCTATGAGTTCAGCGATATCCGTCTGCTTGAG
CAGGCACTGACTCACAGAAG

Product: Signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAAYFSQILVIVTLVSGLIWLFDVLFQAPKRKAALAVAQSGDANLSEDAVEAITKEPYIVETAHSVFPVIAFVLVLRSFL
YEPFQIPSGSMMPTLLVGDFILVEKFSYGIKEPMWRKEVIATGKPERGDVVVFKYPEDPRIDYIKRVVGLPGDRVFYQNK
ELYIQRACVEGEICQSVPAKVDRIALGDSEFVQDGVRLKHYKEQLGDVEHEILINPARPDMRGMFYRKGSVPAGEFVVPE
GQYFVMGDNRDNSTDSRFWGFVPEENLVGKAVAIWISFEFDRKPSDTLPTWVPTGVRFERVGGIQ

Sequences:

>Translated_305_residues
MAAYFSQILVIVTLVSGLIWLFDVLFQAPKRKAALAVAQSGDANLSEDAVEAITKEPYIVETAHSVFPVIAFVLVLRSFL
YEPFQIPSGSMMPTLLVGDFILVEKFSYGIKEPMWRKEVIATGKPERGDVVVFKYPEDPRIDYIKRVVGLPGDRVFYQNK
ELYIQRACVEGEICQSVPAKVDRIALGDSEFVQDGVRLKHYKEQLGDVEHEILINPARPDMRGMFYRKGSVPAGEFVVPE
GQYFVMGDNRDNSTDSRFWGFVPEENLVGKAVAIWISFEFDRKPSDTLPTWVPTGVRFERVGGIQ
>Mature_304_residues
AAYFSQILVIVTLVSGLIWLFDVLFQAPKRKAALAVAQSGDANLSEDAVEAITKEPYIVETAHSVFPVIAFVLVLRSFLY
EPFQIPSGSMMPTLLVGDFILVEKFSYGIKEPMWRKEVIATGKPERGDVVVFKYPEDPRIDYIKRVVGLPGDRVFYQNKE
LYIQRACVEGEICQSVPAKVDRIALGDSEFVQDGVRLKHYKEQLGDVEHEILINPARPDMRGMFYRKGSVPAGEFVVPEG
QYFVMGDNRDNSTDSRFWGFVPEENLVGKAVAIWISFEFDRKPSDTLPTWVPTGVRFERVGGIQ

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=332, Percent_Identity=50.9036144578313, Blast_Score=316, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 34409; Mature: 34278

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYFSQILVIVTLVSGLIWLFDVLFQAPKRKAALAVAQSGDANLSEDAVEAITKEPYIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCHHHHHHHHHCCCEEE
ETAHSVFPVIAFVLVLRSFLYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKEPMWRKEVI
EHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ATGKPERGDVVVFKYPEDPRIDYIKRVVGLPGDRVFYQNKELYIQRACVEGEICQSVPAK
HCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCHHEEEHHHHCCHHHHHCCHH
VDRIALGDSEFVQDGVRLKHYKEQLGDVEHEILINPARPDMRGMFYRKGSVPAGEFVVPE
HHEEECCCHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHEEECCCCCCCCEEECC
GQYFVMGDNRDNSTDSRFWGFVPEENLVGKAVAIWISFEFDRKPSDTLPTWVPTGVRFER
CCEEEEECCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEECC
VGGIQ
CCCCC
>Mature Secondary Structure 
AAYFSQILVIVTLVSGLIWLFDVLFQAPKRKAALAVAQSGDANLSEDAVEAITKEPYIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCHHHHHHHHHCCCEEE
ETAHSVFPVIAFVLVLRSFLYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKEPMWRKEVI
EHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ATGKPERGDVVVFKYPEDPRIDYIKRVVGLPGDRVFYQNKELYIQRACVEGEICQSVPAK
HCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCHHEEEHHHHCCHHHHHCCHH
VDRIALGDSEFVQDGVRLKHYKEQLGDVEHEILINPARPDMRGMFYRKGSVPAGEFVVPE
HHEEECCCHHHHHCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHEEECCCCCCCCEEECC
GQYFVMGDNRDNSTDSRFWGFVPEENLVGKAVAIWISFEFDRKPSDTLPTWVPTGVRFER
CCEEEEECCCCCCCCCCEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEECC
VGGIQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]