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The map label for this gene is rnc

Identifier: 119774017

GI number: 119774017

Start: 1069793

End: 1070473

Strand: Direct

Name: rnc

Synonym: Sama_0880

Alternate gene names: 119774017

Gene position: 1069793-1070473 (Clockwise)

Preceding gene: 119774016

Following gene: 119774018

Centisome position: 24.84

GC content: 55.65

Gene sequence:

>681_bases
ATGGAGCCGATTAAAAATCTGCCGCGACTGTGCCGGACTCTGGGCTATGAGTTCAGCGATATCCGTCTGCTTGAGCAGGC
ACTGACTCACAGAAGTGCCTCAAACCAGCATAACGAACGGCTGGAGTTTTTGGGTGATTCCATTCTCTCCATCGTGATAT
CCGATGCGCTGTTTCATCAGTTCCCCAAGGCCACGGAAGGTGACCTGAGCCGTATGCGCGCCACCCTAGTGCGGGGCGAT
ACCCTGGCGGTGATTGCCAAGGAATTCAAGCTGGGGGATTACCTCAATCTGGGCCCGGGAGAGCTCAAGAGCGGTGGTTT
CCGCCGGGAGTCTATCCTGGCGGATGCGGTGGAAGCCATCATAGGTGCCGTCTATTTGGATGCGGACCTTGAAACCTGCC
GCAGTTTATTGCTGGGCTGGTACGAAACCAGGCTTGCCGACATCAAGCCCGGGGTTGGCCAAAAGGATGCCAAGACCCTG
CTTCAGGAGTATCTGCAGGGAATGAAAAAGCCCCTGCCTGAATATCAGGTGACCCAGGTAGAAGGTGAGGCGCACGATCA
GACCTTTACCGTGGAATGCCGGGTGACCGACCTTGCCGATGCCGTCGTGGGTGTTGGCAGTTCTCGCCGTAAAGCCGAAC
AAATGGCGGCGGCACAAGTTTTGGAATTATTGAATCAATGA

Upstream 100 bases:

>100_bases
GGATTAGCTTTGAGTTTGACCGCAAGCCATCTGACACCCTGCCAACCTGGGTGCCCACAGGTGTGCGTTTTGAGCGCGTA
GGCGGTATCCAGTGAGCATG

Downstream 100 bases:

>100_bases
GCAAGAAACCCGCACCAGGCGTACCGGAAAACGAACCAAGCCTGGAAGATTTGCTGGCACAGATGAACAGCCAGAATCAA
CCCGAAGAGCACTACGATGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MEPIKNLPRLCRTLGYEFSDIRLLEQALTHRSASNQHNERLEFLGDSILSIVISDALFHQFPKATEGDLSRMRATLVRGD
TLAVIAKEFKLGDYLNLGPGELKSGGFRRESILADAVEAIIGAVYLDADLETCRSLLLGWYETRLADIKPGVGQKDAKTL
LQEYLQGMKKPLPEYQVTQVEGEAHDQTFTVECRVTDLADAVVGVGSSRRKAEQMAAAQVLELLNQ

Sequences:

>Translated_226_residues
MEPIKNLPRLCRTLGYEFSDIRLLEQALTHRSASNQHNERLEFLGDSILSIVISDALFHQFPKATEGDLSRMRATLVRGD
TLAVIAKEFKLGDYLNLGPGELKSGGFRRESILADAVEAIIGAVYLDADLETCRSLLLGWYETRLADIKPGVGQKDAKTL
LQEYLQGMKKPLPEYQVTQVEGEAHDQTFTVECRVTDLADAVVGVGSSRRKAEQMAAAQVLELLNQ
>Mature_226_residues
MEPIKNLPRLCRTLGYEFSDIRLLEQALTHRSASNQHNERLEFLGDSILSIVISDALFHQFPKATEGDLSRMRATLVRGD
TLAVIAKEFKLGDYLNLGPGELKSGGFRRESILADAVEAIIGAVYLDADLETCRSLLLGWYETRLADIKPGVGQKDAKTL
LQEYLQGMKKPLPEYQVTQVEGEAHDQTFTVECRVTDLADAVVGVGSSRRKAEQMAAAQVLELLNQ

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=223, Percent_Identity=32.7354260089686, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI155030236, Length=223, Percent_Identity=32.7354260089686, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788920, Length=211, Percent_Identity=67.2985781990521, Blast_Score=293, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI17506883, Length=189, Percent_Identity=34.3915343915344, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193202651, Length=189, Percent_Identity=34.3915343915344, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17137682, Length=234, Percent_Identity=32.0512820512821, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_SHEAM (A1S3Y1)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926757.1
- ProteinModelPortal:   A1S3Y1
- SMR:   A1S3Y1
- STRING:   A1S3Y1
- GeneID:   4603132
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0880
- NMPDR:   fig|326297.7.peg.829
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   A1S3Y1
- ProtClustDB:   PRK00102
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25063; Mature: 25063

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKNLPRLCRTLGYEFSDIRLLEQALTHRSASNQHNERLEFLGDSILSIVISDALFHQ
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FPKATEGDLSRMRATLVRGDTLAVIAKEFKLGDYLNLGPGELKSGGFRRESILADAVEAI
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IGAVYLDADLETCRSLLLGWYETRLADIKPGVGQKDAKTLLQEYLQGMKKPLPEYQVTQV
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
EGEAHDQTFTVECRVTDLADAVVGVGSSRRKAEQMAAAQVLELLNQ
CCCCCCCEEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPIKNLPRLCRTLGYEFSDIRLLEQALTHRSASNQHNERLEFLGDSILSIVISDALFHQ
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FPKATEGDLSRMRATLVRGDTLAVIAKEFKLGDYLNLGPGELKSGGFRRESILADAVEAI
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IGAVYLDADLETCRSLLLGWYETRLADIKPGVGQKDAKTLLQEYLQGMKKPLPEYQVTQV
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
EGEAHDQTFTVECRVTDLADAVVGVGSSRRKAEQMAAAQVLELLNQ
CCCCCCCEEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA