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The map label for this gene is folK [H]

Identifier: 119773967

GI number: 119773967

Start: 1013883

End: 1014386

Strand: Direct

Name: folK [H]

Synonym: Sama_0830

Alternate gene names: 119773967

Gene position: 1013883-1014386 (Clockwise)

Preceding gene: 119773966

Following gene: 119773968

Centisome position: 23.55

GC content: 52.38

Gene sequence:

>504_bases
ATGACCCGGATCTATATCAGTGTAGGCAGTAATATTGAGCCGGAAAAATACCTGAGAAACGCCGCAGTTGCCCTGAGAGC
GCATCTGGGTGAGCTGCAACTGTCACCCGTGTATCAATCCGAAGCAGTGGGGTTTGAAGGGGAGCACTTCCTCAACATGG
TGATAGGCGCCGATACCTCTTTGGGCATCAGTGACCTTGTCGCGTTACTGAAACAGATTGAGCTGGACAATGGCCGCAAA
CCCGGCGCCAAAAAATTCAGCGCCAGAACCCTGGATTTGGATTTACTGCTCTTTGGCGATGTTGTTTGCCATGAGCCCAT
CGAACTGCCCAGGGCGGAAATTCGCTATAACGCCTTTGTGCTCTGGCCTCTGGCAGACATAGCCCCGGAATGGGTACATC
CGTTGGCGGGACAAACTTATGCAGAGCTTTGGCAGCAATTCGATAAACAAAGCCAGCGCCTTTGGCCGGTGGCATTTTCC
TGGAACGACGCTTCCCTCATTTAA

Upstream 100 bases:

>100_bases
GGGTGTCCTGGGTTCGGGTCCGGGTAATGAAACCCGGCGCGGTGAAAACGGCCGAGGCCGTGGGCGTTGAAATTGAGCGC
AGTGCCGGGGATTGCTGAGC

Downstream 100 bases:

>100_bases
TAAAGGAATATTATGGATACCTTGCAGGTCATTATCCTTGCCCTTATTCAGGGCCTGACCGAATTTTTGCCCATTTCCAG
CTCGGCCCACCTGATTTTAC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MTRIYISVGSNIEPEKYLRNAAVALRAHLGELQLSPVYQSEAVGFEGEHFLNMVIGADTSLGISDLVALLKQIELDNGRK
PGAKKFSARTLDLDLLLFGDVVCHEPIELPRAEIRYNAFVLWPLADIAPEWVHPLAGQTYAELWQQFDKQSQRLWPVAFS
WNDASLI

Sequences:

>Translated_167_residues
MTRIYISVGSNIEPEKYLRNAAVALRAHLGELQLSPVYQSEAVGFEGEHFLNMVIGADTSLGISDLVALLKQIELDNGRK
PGAKKFSARTLDLDLLLFGDVVCHEPIELPRAEIRYNAFVLWPLADIAPEWVHPLAGQTYAELWQQFDKQSQRLWPVAFS
WNDASLI
>Mature_166_residues
TRIYISVGSNIEPEKYLRNAAVALRAHLGELQLSPVYQSEAVGFEGEHFLNMVIGADTSLGISDLVALLKQIELDNGRKP
GAKKFSARTLDLDLLLFGDVVCHEPIELPRAEIRYNAFVLWPLADIAPEWVHPLAGQTYAELWQQFDKQSQRLWPVAFSW
NDASLI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=35.9712230215827, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18776; Mature: 18644

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIYISVGSNIEPEKYLRNAAVALRAHLGELQLSPVYQSEAVGFEGEHFLNMVIGADTS
CEEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCHHHEEHEECCCCC
LGISDLVALLKQIELDNGRKPGAKKFSARTLDLDLLLFGDVVCHEPIELPRAEIRYNAFV
CCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCEEECEEE
LWPLADIAPEWVHPLAGQTYAELWQQFDKQSQRLWPVAFSWNDASLI
EEEHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
TRIYISVGSNIEPEKYLRNAAVALRAHLGELQLSPVYQSEAVGFEGEHFLNMVIGADTS
EEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCHHHEEHEECCCCC
LGISDLVALLKQIELDNGRKPGAKKFSARTLDLDLLLFGDVVCHEPIELPRAEIRYNAFV
CCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCEEECEEE
LWPLADIAPEWVHPLAGQTYAELWQQFDKQSQRLWPVAFSWNDASLI
EEEHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1325970; 8202364; 9278503; 1657875; 2537812; 10378268; 10452528 [H]