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The map label for this gene is pepA1 [H]

Identifier: 119773754

GI number: 119773754

Start: 768849

End: 770375

Strand: Direct

Name: pepA1 [H]

Synonym: Sama_0616

Alternate gene names: 119773754

Gene position: 768849-770375 (Clockwise)

Preceding gene: 119773753

Following gene: 119773755

Centisome position: 17.85

GC content: 57.56

Gene sequence:

>1527_bases
ATGCTGAAAACCTCTAAATCCACTCTTGCTGTGCTGTTCGCCTCTTTACTCTCGTTGCCTGCAATGGCCGATAAGGTGAA
CTTTTCCTCCGAGCTGACTGCCAGTGGCGAAACCCTGGTGCTGTTTAAGGTGAAGGATACTGACTTCCCCGGTGCGCGCG
TGCTGAGCGACGGTAGCCTGACGCATCTTGAGCGTGCCATGCAGGTAAATGGTTTCGACGGTGGCGAAGGGGAAATGCTG
GAAGTGCTTGCCCCTGCCGGTAGTCAACTTAACCGGATCCTGGTGATGGGGCTGGGTGATGGCAAGCTGACTGATGGTGA
ACTCAATACTCTGGGGGCCAAGCTCGCCGACAAGATCGCGGCTCACAAAGACACCCGCATTACCTTGATTGCTGAGGGTG
CTCCGGACGCAGCCAATCTGGCAGCAGAAGTTGCCCATGGCTTTGATTTGAAACGTTATCAATTTGGTCGCTATACCAAT
AAGACGCAGGATGAACGTGAACTCAGCTTCGCCCTCTCCGACGCCAAAGCCGCAGCCACCGAATATGCCCGCTTAGCTGC
CGTCGATGCAGGGGTGGTGCTGGCAAGAGATTTGGTGAATACCCCCGCAGGGGATATGACCCCGGAAGACTTTGCCGCCG
AGGCCCGTAAGCTCAAGAGCCTGGGCGTAAAGGTGACAGTGCTGGATGCCAAAGGCATTGAAAAGTTGGGCATGGGCGCC
CTGGCCGGTGTCGGTAAGGGCAGCGAGAGTGGGCCGCGTCTTGTGGTGGCTCACTGGGAAGGTGCCAAAGGGGCTCCCAT
CGCCATGGTCGGCAAGGGCATTACCTTTGACTCGGGCGGTTACAACATCAAGGCTTCGGGGGATTCCATCTCCCACATGA
AATCAGACATGGCCGGCGCTGCTGCCATTTTGGGTACGGTTAAAGCCATGGCCATGCAAAAGGCCAAGGTGAATCTGGTG
GCCGTGTTGCCGCTGGCGGAAAACATGGTTTCCGGTGATGCCCTGCGTCCGGGCGATGTGCTGCGTACCGCGCAGGGCCT
GACGGTGGAAGTGATGAATACCGATGCCGAAGGCAGGCTCATTCTGGCTGATGGCATGTGGTATGCCAGAACCCATTATC
AGCCCAGGGTGCTGATTGATGTGGCAACCCTCACCGGCTCCAAAGTGCGCGCCTTGGGCCGGGAGTATGCGGGTATTTTC
AGTGATGAAGAGTCGCTGGTGTCAGGTTTGACTGCCTCCGGCGCCGCCGTGGGTGAGAAGCTCTGGCGCTTGCCGCTGGA
TAAGGCCTATGGCGATGAACTCAAGTCCAACATCGCGGATATGAAAAATACCGGCGCCGAAGGCAGTGCCGGTGCCTCTT
CTGCCGCCATGTTCCTAAAGCGTTTCGCCGCAGATGTGCCCTGGGCGCACCTGGATATTGCCGGTAATGCGTTATCTTCA
TCGGAAAAACCACTGAGCCCGGCAGGCGCCACCGGTTTTGGGGTGCGTTTACTTAGTCACTGGTTGGCCGGGCAGAGTGC
TGATTGA

Upstream 100 bases:

>100_bases
TGAAAATTGTAAGTCTCTGTTAACCCGGCGTAAGGTCGGGTTACCCCTCGAATACTCCTTTGTTATTCTTGCCAGTCCCA
TAATAACAAGGTGTGTTCTC

Downstream 100 bases:

>100_bases
CCCCAATGCGGCCCGGCACTGATTGATGCGTAACGAAAAAGGGAAAACTTGGGCTTTCCCTTTTTTCGATTGGTTCAAAT
AAAAAATCGATTAAGGTGAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase 1; LAP 1; Leucyl aminopeptidase 1 [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MLKTSKSTLAVLFASLLSLPAMADKVNFSSELTASGETLVLFKVKDTDFPGARVLSDGSLTHLERAMQVNGFDGGEGEML
EVLAPAGSQLNRILVMGLGDGKLTDGELNTLGAKLADKIAAHKDTRITLIAEGAPDAANLAAEVAHGFDLKRYQFGRYTN
KTQDERELSFALSDAKAAATEYARLAAVDAGVVLARDLVNTPAGDMTPEDFAAEARKLKSLGVKVTVLDAKGIEKLGMGA
LAGVGKGSESGPRLVVAHWEGAKGAPIAMVGKGITFDSGGYNIKASGDSISHMKSDMAGAAAILGTVKAMAMQKAKVNLV
AVLPLAENMVSGDALRPGDVLRTAQGLTVEVMNTDAEGRLILADGMWYARTHYQPRVLIDVATLTGSKVRALGREYAGIF
SDEESLVSGLTASGAAVGEKLWRLPLDKAYGDELKSNIADMKNTGAEGSAGASSAAMFLKRFAADVPWAHLDIAGNALSS
SEKPLSPAGATGFGVRLLSHWLAGQSAD

Sequences:

>Translated_508_residues
MLKTSKSTLAVLFASLLSLPAMADKVNFSSELTASGETLVLFKVKDTDFPGARVLSDGSLTHLERAMQVNGFDGGEGEML
EVLAPAGSQLNRILVMGLGDGKLTDGELNTLGAKLADKIAAHKDTRITLIAEGAPDAANLAAEVAHGFDLKRYQFGRYTN
KTQDERELSFALSDAKAAATEYARLAAVDAGVVLARDLVNTPAGDMTPEDFAAEARKLKSLGVKVTVLDAKGIEKLGMGA
LAGVGKGSESGPRLVVAHWEGAKGAPIAMVGKGITFDSGGYNIKASGDSISHMKSDMAGAAAILGTVKAMAMQKAKVNLV
AVLPLAENMVSGDALRPGDVLRTAQGLTVEVMNTDAEGRLILADGMWYARTHYQPRVLIDVATLTGSKVRALGREYAGIF
SDEESLVSGLTASGAAVGEKLWRLPLDKAYGDELKSNIADMKNTGAEGSAGASSAAMFLKRFAADVPWAHLDIAGNALSS
SEKPLSPAGATGFGVRLLSHWLAGQSAD
>Mature_508_residues
MLKTSKSTLAVLFASLLSLPAMADKVNFSSELTASGETLVLFKVKDTDFPGARVLSDGSLTHLERAMQVNGFDGGEGEML
EVLAPAGSQLNRILVMGLGDGKLTDGELNTLGAKLADKIAAHKDTRITLIAEGAPDAANLAAEVAHGFDLKRYQFGRYTN
KTQDERELSFALSDAKAAATEYARLAAVDAGVVLARDLVNTPAGDMTPEDFAAEARKLKSLGVKVTVLDAKGIEKLGMGA
LAGVGKGSESGPRLVVAHWEGAKGAPIAMVGKGITFDSGGYNIKASGDSISHMKSDMAGAAAILGTVKAMAMQKAKVNLV
AVLPLAENMVSGDALRPGDVLRTAQGLTVEVMNTDAEGRLILADGMWYARTHYQPRVLIDVATLTGSKVRALGREYAGIF
SDEESLVSGLTASGAAVGEKLWRLPLDKAYGDELKSNIADMKNTGAEGSAGASSAAMFLKRFAADVPWAHLDIAGNALSS
SEKPLSPAGATGFGVRLLSHWLAGQSAD

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=326, Percent_Identity=42.638036809816, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI47155554, Length=382, Percent_Identity=35.0785340314136, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1790710, Length=379, Percent_Identity=38.5224274406332, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082123, Length=330, Percent_Identity=40.9090909090909, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=391, Percent_Identity=33.5038363171356, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=287, Percent_Identity=26.1324041811847, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662227, Length=289, Percent_Identity=33.9100346020761, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI221379063, Length=317, Percent_Identity=37.2239747634069, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI221379062, Length=317, Percent_Identity=37.2239747634069, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI21357381, Length=317, Percent_Identity=37.2239747634069, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24661038, Length=283, Percent_Identity=32.8621908127208, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI161077148, Length=295, Percent_Identity=34.5762711864407, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20130057, Length=295, Percent_Identity=34.5762711864407, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21355725, Length=283, Percent_Identity=33.2155477031802, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21355645, Length=316, Percent_Identity=33.5443037974684, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24662223, Length=316, Percent_Identity=33.5443037974684, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20129969, Length=291, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI20129963, Length=296, Percent_Identity=34.4594594594595, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19922386, Length=289, Percent_Identity=32.5259515570934, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646701, Length=358, Percent_Identity=28.4916201117318, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646703, Length=358, Percent_Identity=28.4916201117318, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358201, Length=358, Percent_Identity=28.4916201117318, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52891; Mature: 52891

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTSKSTLAVLFASLLSLPAMADKVNFSSELTASGETLVLFKVKDTDFPGARVLSDGSL
CCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEECCCCH
THLERAMQVNGFDGGEGEMLEVLAPAGSQLNRILVMGLGDGKLTDGELNTLGAKLADKIA
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AHKDTRITLIAEGAPDAANLAAEVAHGFDLKRYQFGRYTNKTQDERELSFALSDAKAAAT
CCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHH
EYARLAAVDAGVVLARDLVNTPAGDMTPEDFAAEARKLKSLGVKVTVLDAKGIEKLGMGA
HHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHCCHH
LAGVGKGSESGPRLVVAHWEGAKGAPIAMVGKGITFDSGGYNIKASGDSISHMKSDMAGA
HHCCCCCCCCCCEEEEEECCCCCCCCEEEEECCEEECCCCCEEEECCCHHHHHHHHHHHH
AAILGTVKAMAMQKAKVNLVAVLPLAENMVSGDALRPGDVLRTAQGLTVEVMNTDAEGRL
HHHHHHHHHHHHHHCCEEEEEEEEHHHHHCCCCCCCCHHHHHHCCCCEEEEEECCCCCEE
ILADGMWYARTHYQPRVLIDVATLTGSKVRALGREYAGIFSDEESLVSGLTASGAAVGEK
EEECCCEEEECCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHH
LWRLPLDKAYGDELKSNIADMKNTGAEGSAGASSAAMFLKRFAADVPWAHLDIAGNALSS
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCC
SEKPLSPAGATGFGVRLLSHWLAGQSAD
CCCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLKTSKSTLAVLFASLLSLPAMADKVNFSSELTASGETLVLFKVKDTDFPGARVLSDGSL
CCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEECCCCH
THLERAMQVNGFDGGEGEMLEVLAPAGSQLNRILVMGLGDGKLTDGELNTLGAKLADKIA
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AHKDTRITLIAEGAPDAANLAAEVAHGFDLKRYQFGRYTNKTQDERELSFALSDAKAAAT
CCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHH
EYARLAAVDAGVVLARDLVNTPAGDMTPEDFAAEARKLKSLGVKVTVLDAKGIEKLGMGA
HHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHCCHH
LAGVGKGSESGPRLVVAHWEGAKGAPIAMVGKGITFDSGGYNIKASGDSISHMKSDMAGA
HHCCCCCCCCCCEEEEEECCCCCCCCEEEEECCEEECCCCCEEEECCCHHHHHHHHHHHH
AAILGTVKAMAMQKAKVNLVAVLPLAENMVSGDALRPGDVLRTAQGLTVEVMNTDAEGRL
HHHHHHHHHHHHHHCCEEEEEEEEHHHHHCCCCCCCCHHHHHHCCCCEEEEEECCCCCEE
ILADGMWYARTHYQPRVLIDVATLTGSKVRALGREYAGIFSDEESLVSGLTASGAAVGEK
EEECCCEEEECCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHH
LWRLPLDKAYGDELKSNIADMKNTGAEGSAGASSAAMFLKRFAADVPWAHLDIAGNALSS
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCC
SEKPLSPAGATGFGVRLLSHWLAGQSAD
CCCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]