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The map label for this gene is 119773628

Identifier: 119773628

GI number: 119773628

Start: 598963

End: 599883

Strand: Direct

Name: 119773628

Synonym: Sama_0488

Alternate gene names: NA

Gene position: 598963-599883 (Clockwise)

Preceding gene: 119773626

Following gene: 119773633

Centisome position: 13.91

GC content: 54.83

Gene sequence:

>921_bases
GTGAGCTTTATTGCAAAGACCTCGACCCTGATAATGGCACTGGGTTTGGCTACAGTGCCTGTGATTGGCAATGCCAAAAA
CGACAATGCCTTCGACAATGCCAACCCCAATGCATCCTTCCTGCGCTGTGGTACCAAGCAGCCCAGCATCCAGGAAGCCG
AATTACGTGAAAAACATTTTCAAACCTTGAAGGCCGCCAAAGGTAAGCCCGGTGGCGGAGGCGGTGGCAGCACCTACCAG
CCTCGCCCCAATGGCAGTGTAGCGGTTGACGTATATATGCACGTAATCACCGATAACAGTGGCAACGGTAACTTGTCTGC
AGGTGCAATAGATGCCCAAATCAACGTGCTGAACGATGCTTATGCCAATACGCCCTTTACCTTTAAAGTGGCAGGTATCA
CCCGTACCGCCAACAACAGTTGGTACACGGCTACCCATGGTTCGACCGCTGAGAAGGAAATGAAGGCGGCACTGCGTCAG
GGCGATGCTGCCGATTTGAACTTCTACACCAATAACATGGGTGGCGGCCTGCTTGGCTGGGCAACCTTCCCAAGCAGCTA
TTCCTCTGACCCGGTGAATGATGGTGTGGTAGTGCTTTACTCCAGCCTGCCCGGCGGCAGCGCCGCGCCCTATAACGAAG
GCGATACAGGCACCCATGAAGTGGGCCACTGGCTCGGGTTGTATCATACCTTCCAGGGTGGCTGCAGCGGCAATGGTGAC
TATGTGGCCGACACTCCAGCCGAGCGCAGTCCGGCTTATGGTTGTCCGGTGAACCGCGATTCCTGCGCCGGTAACCGTTA
TCCTGGCCTCGACCCCATCACCAACTTCATGGATTACACCGATGACTCCTGCATGTATGAGTTTTCGGAAGGTCAGGCCA
ATCGCGCTGATGAGCTGAGCTTCATCTACCGGAGTCTTTAA

Upstream 100 bases:

>100_bases
TTACATCATGTAGTTTGTGCCGTTTCAGGCTGCGTCGTTGGTGTCTGTGTCGCACGGTGCGCCGTGATTTGACTAACAAG
ATAAAGACAAGGAGCCCATT

Downstream 100 bases:

>100_bases
TCTTTGGAATAGTCAAAAGGCACCTCAGGGTGCCTTTTTTGTTGGAGAGGTTGCCCTACCTGACCACCAATACGGGGCAG
TGGGCCTTGTTCACCACCTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSFIAKTSTLIMALGLATVPVIGNAKNDNAFDNANPNASFLRCGTKQPSIQEAELREKHFQTLKAAKGKPGGGGGGSTYQ
PRPNGSVAVDVYMHVITDNSGNGNLSAGAIDAQINVLNDAYANTPFTFKVAGITRTANNSWYTATHGSTAEKEMKAALRQ
GDAADLNFYTNNMGGGLLGWATFPSSYSSDPVNDGVVVLYSSLPGGSAAPYNEGDTGTHEVGHWLGLYHTFQGGCSGNGD
YVADTPAERSPAYGCPVNRDSCAGNRYPGLDPITNFMDYTDDSCMYEFSEGQANRADELSFIYRSL

Sequences:

>Translated_306_residues
MSFIAKTSTLIMALGLATVPVIGNAKNDNAFDNANPNASFLRCGTKQPSIQEAELREKHFQTLKAAKGKPGGGGGGSTYQ
PRPNGSVAVDVYMHVITDNSGNGNLSAGAIDAQINVLNDAYANTPFTFKVAGITRTANNSWYTATHGSTAEKEMKAALRQ
GDAADLNFYTNNMGGGLLGWATFPSSYSSDPVNDGVVVLYSSLPGGSAAPYNEGDTGTHEVGHWLGLYHTFQGGCSGNGD
YVADTPAERSPAYGCPVNRDSCAGNRYPGLDPITNFMDYTDDSCMYEFSEGQANRADELSFIYRSL
>Mature_305_residues
SFIAKTSTLIMALGLATVPVIGNAKNDNAFDNANPNASFLRCGTKQPSIQEAELREKHFQTLKAAKGKPGGGGGGSTYQP
RPNGSVAVDVYMHVITDNSGNGNLSAGAIDAQINVLNDAYANTPFTFKVAGITRTANNSWYTATHGSTAEKEMKAALRQG
DAADLNFYTNNMGGGLLGWATFPSSYSSDPVNDGVVVLYSSLPGGSAAPYNEGDTGTHEVGHWLGLYHTFQGGCSGNGDY
VADTPAERSPAYGCPVNRDSCAGNRYPGLDPITNFMDYTDDSCMYEFSEGQANRADELSFIYRSL

Specific function: Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M43B family [H]

Homologues:

Organism=Homo sapiens, GI116174738, Length=166, Percent_Identity=36.7469879518072, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008754 [H]

Pfam domain/function: PF05572 Peptidase_M43 [H]

EC number: NA

Molecular weight: Translated: 32412; Mature: 32281

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIAKTSTLIMALGLATVPVIGNAKNDNAFDNANPNASFLRCGTKQPSIQEAELREKHF
CCCHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHH
QTLKAAKGKPGGGGGGSTYQPRPNGSVAVDVYMHVITDNSGNGNLSAGAIDAQINVLNDA
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEECCEEEEEEEEEHHH
YANTPFTFKVAGITRTANNSWYTATHGSTAEKEMKAALRQGDAADLNFYTNNMGGGLLGW
HCCCCEEEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEE
ATFPSSYSSDPVNDGVVVLYSSLPGGSAAPYNEGDTGTHEVGHWLGLYHTFQGGCSGNGD
EECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
YVADTPAERSPAYGCPVNRDSCAGNRYPGLDPITNFMDYTDDSCMYEFSEGQANRADELS
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHH
FIYRSL
HHHHCC
>Mature Secondary Structure 
SFIAKTSTLIMALGLATVPVIGNAKNDNAFDNANPNASFLRCGTKQPSIQEAELREKHF
CCHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHH
QTLKAAKGKPGGGGGGSTYQPRPNGSVAVDVYMHVITDNSGNGNLSAGAIDAQINVLNDA
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEECCEEEEEEEEEHHH
YANTPFTFKVAGITRTANNSWYTATHGSTAEKEMKAALRQGDAADLNFYTNNMGGGLLGW
HCCCCEEEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEE
ATFPSSYSSDPVNDGVVVLYSSLPGGSAAPYNEGDTGTHEVGHWLGLYHTFQGGCSGNGD
EECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
YVADTPAERSPAYGCPVNRDSCAGNRYPGLDPITNFMDYTDDSCMYEFSEGQANRADELS
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHH
FIYRSL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]