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The map label for this gene is moeA [H]

Identifier: 119773280

GI number: 119773280

Start: 154760

End: 156001

Strand: Reverse

Name: moeA [H]

Synonym: Sama_0138

Alternate gene names: 119773280

Gene position: 156001-154760 (Counterclockwise)

Preceding gene: 119773281

Following gene: 119773279

Centisome position: 3.62

GC content: 58.86

Gene sequence:

>1242_bases
ATGCCCAGCCAAGACCCATGCAGCAAACCCGAACTCATGCATCCGGATGAGGCCATCAAGAAACTGCTCGAGCAGGTGAA
ACCCATTTCAGATACCGAAATGGTTACACTGAACCACGCCCTGGGACGGGTATTGGCCGAAGACTTGAACAGTCAGCTGG
ACTTGCCCCCATTCGATAATTCCGCCATGGACGGATACGCCTTCCGCTTTGCCGATCTCGAGGCATTCAATGGCGTGCTG
ACCCTCAAAGGCCAGTCCTTCGCAGGCCATCCCTTTAAGGGCCAACTGGCCGCCGGGGATTGTGTTCGCATTATGACCGG
GGCGCCGATTCCCGCCGGTCTGGACACTGTGCAGATGCAGGAGGCAACCCGGGCCGAAGGTGAGCACATCCATATCACGG
CCCCCAAGGCCGCCGGTGAGCATGTGCGCCGCCGCGGCGAAGAACTTAAGGCGGGTGATACCGTGCTTTGCACTGGTGTA
CGCATTCGTGCCGCCGAGCTTGGCGTGCTGGCCACCGTTGGCATCAGCCAGATCAGGGTATTTCGTACCCTCAAGGTCGC
CTTTTTCTCAACGGGCGACGAACTCAGGCCCGTCGGCAGTGAGCTGGCACCGGGACAAATCTATGATTCGAACAGATATT
CCATTCGTGGGTTGCTGGAAAAGTCCGGCTTTGAGTGGCTGGATCTCGGTGTGATCCCCGATAGCCCCGACGCCATTCGT
CAGGCATTTCGCGAGGCGGCAAGCCGCGCCGACGTTGTGCTGACCTCTGGTGGCGTGTCTGTGGGGGAGGCCGACTTCAC
CAAACAGATTCTGAGCGAAGAAGGGCAAATCACCTTCTGGAAACTCGCCATCAAACCCGGAAAACCCTTCGCCTGTGGTC
GCATCGGCCAGGCACTGTTTTGCGGTTTGCCCGGCAACCCAGTGTCCTCCATGGTGACCTTCCAGAAACTGGTGTGGCCT
ATGCTGCGCAAGATGCAGGGCATGCCCCAGCGTCCTGCGCTGTTAGTGGAGGCCACACTGGCGAGCGCCATTCGCCGCCA
ACCCGGTCGGGTGGAATATCAGCGTGGCATACTGACACGGGAAGACAAGGGCCTCATGGTGCGCACCACAGGTGGCCAGG
GGTCAGGTATGCTGACCTCCATGAGCCTCGCCAACTGCTTTATCCATCTGCCTCAATTTCAGGGCAGCCTGGAAGCGGGC
GAGACTATTCTGGTTGAACCCTTCGATAGCATTTTGGACTAA

Upstream 100 bases:

>100_bases
CAATTCACAATTTTTGCCTGTCTGGATCATACAGTTACCCCGCTATGCCATGGCATAATGGCGGCCTTACATCCAAGCAA
ACCAATCCCAGGGAGCCTGA

Downstream 100 bases:

>100_bases
GCCCAATGACCGACGACATACTCTCTGACACAGAGCTGCTACGCTACAGTCGCCAGATTTCCATAAAATCCATGGATATA
GAGGGTCAGGAAAAGCTCAA

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MPSQDPCSKPELMHPDEAIKKLLEQVKPISDTEMVTLNHALGRVLAEDLNSQLDLPPFDNSAMDGYAFRFADLEAFNGVL
TLKGQSFAGHPFKGQLAAGDCVRIMTGAPIPAGLDTVQMQEATRAEGEHIHITAPKAAGEHVRRRGEELKAGDTVLCTGV
RIRAAELGVLATVGISQIRVFRTLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIRGLLEKSGFEWLDLGVIPDSPDAIR
QAFREAASRADVVLTSGGVSVGEADFTKQILSEEGQITFWKLAIKPGKPFACGRIGQALFCGLPGNPVSSMVTFQKLVWP
MLRKMQGMPQRPALLVEATLASAIRRQPGRVEYQRGILTREDKGLMVRTTGGQGSGMLTSMSLANCFIHLPQFQGSLEAG
ETILVEPFDSILD

Sequences:

>Translated_413_residues
MPSQDPCSKPELMHPDEAIKKLLEQVKPISDTEMVTLNHALGRVLAEDLNSQLDLPPFDNSAMDGYAFRFADLEAFNGVL
TLKGQSFAGHPFKGQLAAGDCVRIMTGAPIPAGLDTVQMQEATRAEGEHIHITAPKAAGEHVRRRGEELKAGDTVLCTGV
RIRAAELGVLATVGISQIRVFRTLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIRGLLEKSGFEWLDLGVIPDSPDAIR
QAFREAASRADVVLTSGGVSVGEADFTKQILSEEGQITFWKLAIKPGKPFACGRIGQALFCGLPGNPVSSMVTFQKLVWP
MLRKMQGMPQRPALLVEATLASAIRRQPGRVEYQRGILTREDKGLMVRTTGGQGSGMLTSMSLANCFIHLPQFQGSLEAG
ETILVEPFDSILD
>Mature_412_residues
PSQDPCSKPELMHPDEAIKKLLEQVKPISDTEMVTLNHALGRVLAEDLNSQLDLPPFDNSAMDGYAFRFADLEAFNGVLT
LKGQSFAGHPFKGQLAAGDCVRIMTGAPIPAGLDTVQMQEATRAEGEHIHITAPKAAGEHVRRRGEELKAGDTVLCTGVR
IRAAELGVLATVGISQIRVFRTLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIRGLLEKSGFEWLDLGVIPDSPDAIRQ
AFREAASRADVVLTSGGVSVGEADFTKQILSEEGQITFWKLAIKPGKPFACGRIGQALFCGLPGNPVSSMVTFQKLVWPM
LRKMQGMPQRPALLVEATLASAIRRQPGRVEYQRGILTREDKGLMVRTTGGQGSGMLTSMSLANCFIHLPQFQGSLEAGE
TILVEPFDSILD

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=392, Percent_Identity=37.7551020408163, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI66932975, Length=392, Percent_Identity=37.7551020408163, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1787049, Length=407, Percent_Identity=49.8771498771499, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI25147659, Length=408, Percent_Identity=30.6372549019608, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=357, Percent_Identity=26.890756302521, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136978, Length=368, Percent_Identity=32.0652173913043, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24638841, Length=368, Percent_Identity=32.0652173913043, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44745; Mature: 44614

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSQDPCSKPELMHPDEAIKKLLEQVKPISDTEMVTLNHALGRVLAEDLNSQLDLPPFDN
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCC
SAMDGYAFRFADLEAFNGVLTLKGQSFAGHPFKGQLAAGDCVRIMTGAPIPAGLDTVQMQ
CCCCCEEEEEECHHHHCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHH
EATRAEGEHIHITAPKAAGEHVRRRGEELKAGDTVLCTGVRIRAAELGVLATVGISQIRV
HHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCCEEEEECCEEEHHHCCCHHHHCHHHHHH
FRTLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIRGLLEKSGFEWLDLGVIPDSPDAIR
HHHHEEEEECCCCCCCCCCCCCCCCEEECCCCEEEEEHHHHCCCCEEEECCCCCCHHHHH
QAFREAASRADVVLTSGGVSVGEADFTKQILSEEGQITFWKLAIKPGKPFACGRIGQALF
HHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHCCCCEE
CGLPGNPVSSMVTFQKLVWPMLRKMQGMPQRPALLVEATLASAIRRQPGRVEYQRGILTR
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHCCEEE
EDKGLMVRTTGGQGSGMLTSMSLANCFIHLPQFQGSLEAGETILVEPFDSILD
CCCCEEEEECCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCEEEECCHHHHCC
>Mature Secondary Structure 
PSQDPCSKPELMHPDEAIKKLLEQVKPISDTEMVTLNHALGRVLAEDLNSQLDLPPFDN
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCC
SAMDGYAFRFADLEAFNGVLTLKGQSFAGHPFKGQLAAGDCVRIMTGAPIPAGLDTVQMQ
CCCCCEEEEEECHHHHCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHH
EATRAEGEHIHITAPKAAGEHVRRRGEELKAGDTVLCTGVRIRAAELGVLATVGISQIRV
HHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCCEEEEECCEEEHHHCCCHHHHCHHHHHH
FRTLKVAFFSTGDELRPVGSELAPGQIYDSNRYSIRGLLEKSGFEWLDLGVIPDSPDAIR
HHHHEEEEECCCCCCCCCCCCCCCCEEECCCCEEEEEHHHHCCCCEEEECCCCCCHHHHH
QAFREAASRADVVLTSGGVSVGEADFTKQILSEEGQITFWKLAIKPGKPFACGRIGQALF
HHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHCCCCEE
CGLPGNPVSSMVTFQKLVWPMLRKMQGMPQRPALLVEATLASAIRRQPGRVEYQRGILTR
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHCCEEE
EDKGLMVRTTGGQGSGMLTSMSLANCFIHLPQFQGSLEAGETILVEPFDSILD
CCCCEEEEECCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]