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The map label for this gene is moeA [H]

Identifier: 119773262

GI number: 119773262

Start: 133572

End: 135371

Strand: Reverse

Name: moeA [H]

Synonym: Sama_0120

Alternate gene names: 119773262

Gene position: 135371-133572 (Counterclockwise)

Preceding gene: 119773263

Following gene: 119773261

Centisome position: 3.14

GC content: 58.78

Gene sequence:

>1800_bases
ATGACGACAGCCTTTCGCAATCCCCTTCCCGTGCCCGTATTGGGATTTTGTGCCTACAGTGGCACTGGCAAAACCACCCT
TCTGTTGAAACTCATCCCGGAGCTGAACCGCCGTGGATTAAAGCTGGCTGTCGTTAAACATGCCCACCACGACTTTGATG
TGGATATTCCCGGCAAGGACAGCTATGAGCTGCGCAAGGCCGGTGCCCGCCAGATGCTGGTTGCCTCCCACGTGCGTTGG
GCACTGATGACAGAAGACGCCCGCGACTCAGACCCCGAGCTGCCCCATCTGCTGAATCAAATCGAAGCCGACAAGGTGGA
TATTGTGCTGGTAGAGGGCTTTAAGAAGCTTTCGCTGCCGAAGATAGAGCTGCACAGAGCTGCACACGGCAAGCCATTTA
TCCATACCCAGGATCCGGACATTCTCGCCGTCGCATGCTGTGACGACACCCAGTTACCATCCGACCTGCCAAGACTCGAT
ATCAACAATGTGGCCGAAATTGCCGACTTTGTGCAGCAGTATATTGCCAACTGGTGCCCTGCCACGCCGTCATTGCCACT
GGCGCCGGCTTGTGGCTGCGAGGCCGACATGAGCAAGACCCTGTCGGTCCGTCAGGGTATGGACGCCATTCTCGCCAAAG
TCGTCCCAGTCAGCGAAACCGACTTAGCGCCGCTGGACGAACTCGATGGCCGGGTGCTGGCCTGCGACGCCATTTCGCCG
GTGGACGTGCCCCAGCAAACCAACTCGGCCATGGATGGATTTGCCTTCCGCTTTGCCGACCCCATGCCGGACGCGCTGAA
CATTGTTGGTGCCTCATTTGCCGGACACGGGTTTGCCGACACCCTCAAGCCCGGTGAGGCGGTACGTATCATGACGGGCG
CGCCGCTGCCCGCCGGCGCCGACACGGTTCAGCCACGGGAGCTTGCCGATGACAGAGGCGATACTGTGTCGCTGCAGGGC
AAGCTGGAGGTCGGCCAGCATGTGCGTCTGGCCGGAGAAGACATAACCAAAGGCGCAGTGGCACTTGGCGCCGGTGAACG
CATCGATGCCGCCGCCACCGGCCTGCTGGCGTCGCTTGGCTTTGACAAGGTACAGGTAAAGCGCCGCCCACGTGTAGCAG
TGTTTTCCACCGGTGATGAGGTGAGCGCACCGGGAGAGCCCCTCGCACCCAGCTGTATCTACGACTCCAACCGTTTCACT
ATCAAAAACATGGCCAAACGTCTTGGCTGTGAAGTGATTGACCTTGGCATCATCGAAGACTCAGAGGCCAGCCTGATGGC
GGCCCTCGAGCAGGGTGCCAGCTGCGCCGATGTGGTGATAAGTTCGGGGGGCGTGTCAGTGGGCGATGCCGACTACATCA
AAACGGCGCTGGAAAAGCTTGGTCAAATCGGTTTCTGGCGCATCAACATGCGCCCGGGGCGGCCGCTGGCTTTTGGGGAA
ATCAATCGGGCACTGTTTTTTGGCCTGCCCGGTAACCCTGTGGCTGTGATGGTGTCTTTCCTGCAATTTGTGCAACCTGC
CCTGCGCAAACTCGCCGGTGAAAATCAGTACCAGCCCAGGTTTATCCCTGCCATCACCGACGAGGTGCTCAGGAGCCGTA
TCGGTCGCACCGAGTTTTTCCGGGGTATTTACCATCTGGGAGACGATGGTCAGCTCCATGTGAAAACCACAGGGGCGCAG
GGTTCAGGCATGCTGAGCTCAATGGTAAAAGGCAACTGCCTGATTGTGCTGGCAGAGCCGGATGAACAGCTCGCCATCGG
CAGCAGGGTTTATATCCAGCCCTTTGCTGATTTACTCTGA

Upstream 100 bases:

>100_bases
TCCTTTGCCGACCAGCCCAATGCCTTCGTAAACGTCAACACGCCAGAGCAAGTAGAACAACTATCCAAGGCGCTGACACA
GTGATTTTTTTGAGGTGAGC

Downstream 100 bases:

>100_bases
GGCCGGTTCATGTCTGCCCTGTGCGACAGTTTTGGCCGCAAGGTCGAGTACCTGAGGCTATCGGTCACAGACCGCTGTGA
TTTCCGCTGTGTCTATTGCA

Product: putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTTAFRNPLPVPVLGFCAYSGTGKTTLLLKLIPELNRRGLKLAVVKHAHHDFDVDIPGKDSYELRKAGARQMLVASHVRW
ALMTEDARDSDPELPHLLNQIEADKVDIVLVEGFKKLSLPKIELHRAAHGKPFIHTQDPDILAVACCDDTQLPSDLPRLD
INNVAEIADFVQQYIANWCPATPSLPLAPACGCEADMSKTLSVRQGMDAILAKVVPVSETDLAPLDELDGRVLACDAISP
VDVPQQTNSAMDGFAFRFADPMPDALNIVGASFAGHGFADTLKPGEAVRIMTGAPLPAGADTVQPRELADDRGDTVSLQG
KLEVGQHVRLAGEDITKGAVALGAGERIDAAATGLLASLGFDKVQVKRRPRVAVFSTGDEVSAPGEPLAPSCIYDSNRFT
IKNMAKRLGCEVIDLGIIEDSEASLMAALEQGASCADVVISSGGVSVGDADYIKTALEKLGQIGFWRINMRPGRPLAFGE
INRALFFGLPGNPVAVMVSFLQFVQPALRKLAGENQYQPRFIPAITDEVLRSRIGRTEFFRGIYHLGDDGQLHVKTTGAQ
GSGMLSSMVKGNCLIVLAEPDEQLAIGSRVYIQPFADLL

Sequences:

>Translated_599_residues
MTTAFRNPLPVPVLGFCAYSGTGKTTLLLKLIPELNRRGLKLAVVKHAHHDFDVDIPGKDSYELRKAGARQMLVASHVRW
ALMTEDARDSDPELPHLLNQIEADKVDIVLVEGFKKLSLPKIELHRAAHGKPFIHTQDPDILAVACCDDTQLPSDLPRLD
INNVAEIADFVQQYIANWCPATPSLPLAPACGCEADMSKTLSVRQGMDAILAKVVPVSETDLAPLDELDGRVLACDAISP
VDVPQQTNSAMDGFAFRFADPMPDALNIVGASFAGHGFADTLKPGEAVRIMTGAPLPAGADTVQPRELADDRGDTVSLQG
KLEVGQHVRLAGEDITKGAVALGAGERIDAAATGLLASLGFDKVQVKRRPRVAVFSTGDEVSAPGEPLAPSCIYDSNRFT
IKNMAKRLGCEVIDLGIIEDSEASLMAALEQGASCADVVISSGGVSVGDADYIKTALEKLGQIGFWRINMRPGRPLAFGE
INRALFFGLPGNPVAVMVSFLQFVQPALRKLAGENQYQPRFIPAITDEVLRSRIGRTEFFRGIYHLGDDGQLHVKTTGAQ
GSGMLSSMVKGNCLIVLAEPDEQLAIGSRVYIQPFADLL
>Mature_598_residues
TTAFRNPLPVPVLGFCAYSGTGKTTLLLKLIPELNRRGLKLAVVKHAHHDFDVDIPGKDSYELRKAGARQMLVASHVRWA
LMTEDARDSDPELPHLLNQIEADKVDIVLVEGFKKLSLPKIELHRAAHGKPFIHTQDPDILAVACCDDTQLPSDLPRLDI
NNVAEIADFVQQYIANWCPATPSLPLAPACGCEADMSKTLSVRQGMDAILAKVVPVSETDLAPLDELDGRVLACDAISPV
DVPQQTNSAMDGFAFRFADPMPDALNIVGASFAGHGFADTLKPGEAVRIMTGAPLPAGADTVQPRELADDRGDTVSLQGK
LEVGQHVRLAGEDITKGAVALGAGERIDAAATGLLASLGFDKVQVKRRPRVAVFSTGDEVSAPGEPLAPSCIYDSNRFTI
KNMAKRLGCEVIDLGIIEDSEASLMAALEQGASCADVVISSGGVSVGDADYIKTALEKLGQIGFWRINMRPGRPLAFGEI
NRALFFGLPGNPVAVMVSFLQFVQPALRKLAGENQYQPRFIPAITDEVLRSRIGRTEFFRGIYHLGDDGQLHVKTTGAQG
SGMLSSMVKGNCLIVLAEPDEQLAIGSRVYIQPFADLL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=389, Percent_Identity=38.0462724935733, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI66932975, Length=389, Percent_Identity=38.0462724935733, Blast_Score=205, Evalue=1e-52,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=45.6919060052219, Blast_Score=325, Evalue=6e-90,
Organism=Escherichia coli, GI145693204, Length=166, Percent_Identity=50.6024096385542, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147659, Length=404, Percent_Identity=29.9504950495049, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=342, Percent_Identity=27.4853801169591, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17136978, Length=352, Percent_Identity=32.3863636363636, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24638841, Length=352, Percent_Identity=32.3863636363636, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 64311; Mature: 64179

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAFRNPLPVPVLGFCAYSGTGKTTLLLKLIPELNRRGLKLAVVKHAHHDFDVDIPGKD
CCCCCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
SYELRKAGARQMLVASHVRWALMTEDARDSDPELPHLLNQIEADKVDIVLVEGFKKLSLP
CHHHHHHCHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHCCCC
KIELHRAAHGKPFIHTQDPDILAVACCDDTQLPSDLPRLDINNVAEIADFVQQYIANWCP
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
ATPSLPLAPACGCEADMSKTLSVRQGMDAILAKVVPVSETDLAPLDELDGRVLACDAISP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEECCCCC
VDVPQQTNSAMDGFAFRFADPMPDALNIVGASFAGHGFADTLKPGEAVRIMTGAPLPAGA
CCCCCCCCCHHCCEEEEECCCCCHHHHHHHCCCCCCCCHHCCCCCCEEEEEECCCCCCCC
DTVQPRELADDRGDTVSLQGKLEVGQHVRLAGEDITKGAVALGAGERIDAAATGLLASLG
CCCCCHHHHCCCCCEEEEEEEECCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCC
FDKVQVKRRPRVAVFSTGDEVSAPGEPLAPSCIYDSNRFTIKNMAKRLGCEVIDLGIIED
CCCEECCCCCCEEEEECCCCCCCCCCCCCCCEEECCCCEEHHHHHHHCCCEEEEEEEECC
SEASLMAALEQGASCADVVISSGGVSVGDADYIKTALEKLGQIGFWRINMRPGRPLAFGE
CHHHHHHHHHCCCCEEHHEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
INRALFFGLPGNPVAVMVSFLQFVQPALRKLAGENQYQPRFIPAITDEVLRSRIGRTEFF
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHH
RGIYHLGDDGQLHVKTTGAQGSGMLSSMVKGNCLIVLAEPDEQLAIGSRVYIQPFADLL
HHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCEECCCEEEECCHHHCC
>Mature Secondary Structure 
TTAFRNPLPVPVLGFCAYSGTGKTTLLLKLIPELNRRGLKLAVVKHAHHDFDVDIPGKD
CCCCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
SYELRKAGARQMLVASHVRWALMTEDARDSDPELPHLLNQIEADKVDIVLVEGFKKLSLP
CHHHHHHCHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHCCCC
KIELHRAAHGKPFIHTQDPDILAVACCDDTQLPSDLPRLDINNVAEIADFVQQYIANWCP
HHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
ATPSLPLAPACGCEADMSKTLSVRQGMDAILAKVVPVSETDLAPLDELDGRVLACDAISP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEECCCCC
VDVPQQTNSAMDGFAFRFADPMPDALNIVGASFAGHGFADTLKPGEAVRIMTGAPLPAGA
CCCCCCCCCHHCCEEEEECCCCCHHHHHHHCCCCCCCCHHCCCCCCEEEEEECCCCCCCC
DTVQPRELADDRGDTVSLQGKLEVGQHVRLAGEDITKGAVALGAGERIDAAATGLLASLG
CCCCCHHHHCCCCCEEEEEEEECCCCEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHCC
FDKVQVKRRPRVAVFSTGDEVSAPGEPLAPSCIYDSNRFTIKNMAKRLGCEVIDLGIIED
CCCEECCCCCCEEEEECCCCCCCCCCCCCCCEEECCCCEEHHHHHHHCCCEEEEEEEECC
SEASLMAALEQGASCADVVISSGGVSVGDADYIKTALEKLGQIGFWRINMRPGRPLAFGE
CHHHHHHHHHCCCCEEHHEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
INRALFFGLPGNPVAVMVSFLQFVQPALRKLAGENQYQPRFIPAITDEVLRSRIGRTEFF
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHH
RGIYHLGDDGQLHVKTTGAQGSGMLSSMVKGNCLIVLAEPDEQLAIGSRVYIQPFADLL
HHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCEECCCEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]