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The map label for this gene is moaA [H]

Identifier: 119773261

GI number: 119773261

Start: 132579

End: 133562

Strand: Reverse

Name: moaA [H]

Synonym: Sama_0119

Alternate gene names: 119773261

Gene position: 133562-132579 (Counterclockwise)

Preceding gene: 119773262

Following gene: 119773260

Centisome position: 3.1

GC content: 55.69

Gene sequence:

>984_bases
ATGTCTGCCCTGTGCGACAGTTTTGGCCGCAAGGTCGAGTACCTGAGGCTATCGGTCACAGACCGCTGTGATTTCCGCTG
TGTCTATTGCATGGAAGAAGACCCCTGCTTCCTTACACGGGAGCAGGTGCTCAGTTTTGAGGAACTGGCGCTCATTGGTA
AAGCCTTTACCGAGCTGGGGGTGAAGAAGATTCGCCTCACCGGCGGCGAGCCGCTGGTCAGAACCGATTGCACGGACCTG
GTGGCGCAACTGGGGCAACTGCCCGGTCTGCAGGAGCTGTCGATGACCACCAACGGCTCGCGACTGGCCAAACTGGCACC
GGCCCTTAGGGCTGCCGGACTCAGGCGCCTCAATATCAGCCTGGATACCCTTAACCCCGAGCGCTTTGAACAGATCACCC
GTAATGGCAAACTTGAGAGGGTAATAGCAGGCATCGATGCCGCCAAACAGGCCGGTTTCGAGCGCATTAAACTCAATGCC
GTTATCCTCAAGGGACGAAACGACGATGAAGTGTTGGACCTGGTGGACTTTTGCCGCAGCCGCCAGCTCGACATCGCCTT
TATCGAAGAAATGCCCATAGGTTTGATGGACGAACGCGAAACGGCCCGTCACCTGTCCAGTGACCAGGTGCGCACCCTCA
TCGAAAACCGTTATCCACTGACGCTTTCAGACAAGCGAACCGGTGGGCCTGCGCGTTATTATCAGATGTCGGACAGCCCG
ATACATATCGGCTTTATCTCGCCCCACAGCCATAACTTTTGCCATGAATGTAACAGGGTGAGGGTCACGGTTGAGGGCCG
TTTACTGTTGTGCCTCGGAAACGAACACTCTGTCGACCTCAAGGCCATTCTCAGAAGCCATCCAGGCGACACCGAAGCCT
TGAAATCCGCCATTCTTGCAGCTATGCCTCAAAAGCCCAAATCCCACGAATTCGATACAGGTGCCGTGCAAATATTGCGC
TTTATGAATGCGACCGGAGGCTGA

Upstream 100 bases:

>100_bases
AGGCAACTGCCTGATTGTGCTGGCAGAGCCGGATGAACAGCTCGCCATCGGCAGCAGGGTTTATATCCAGCCCTTTGCTG
ATTTACTCTGAGGCCGGTTC

Downstream 100 bases:

>100_bases
ATCTTCAACCCGGGGCATCTCGTGTTACACTCAACACCAGGGTTTCGCTTGATTTTTTCCCATGGGACTTAAACGCCGTA
CCTGGAACAACATCATTATC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSALCDSFGRKVEYLRLSVTDRCDFRCVYCMEEDPCFLTREQVLSFEELALIGKAFTELGVKKIRLTGGEPLVRTDCTDL
VAQLGQLPGLQELSMTTNGSRLAKLAPALRAAGLRRLNISLDTLNPERFEQITRNGKLERVIAGIDAAKQAGFERIKLNA
VILKGRNDDEVLDLVDFCRSRQLDIAFIEEMPIGLMDERETARHLSSDQVRTLIENRYPLTLSDKRTGGPARYYQMSDSP
IHIGFISPHSHNFCHECNRVRVTVEGRLLLCLGNEHSVDLKAILRSHPGDTEALKSAILAAMPQKPKSHEFDTGAVQILR
FMNATGG

Sequences:

>Translated_327_residues
MSALCDSFGRKVEYLRLSVTDRCDFRCVYCMEEDPCFLTREQVLSFEELALIGKAFTELGVKKIRLTGGEPLVRTDCTDL
VAQLGQLPGLQELSMTTNGSRLAKLAPALRAAGLRRLNISLDTLNPERFEQITRNGKLERVIAGIDAAKQAGFERIKLNA
VILKGRNDDEVLDLVDFCRSRQLDIAFIEEMPIGLMDERETARHLSSDQVRTLIENRYPLTLSDKRTGGPARYYQMSDSP
IHIGFISPHSHNFCHECNRVRVTVEGRLLLCLGNEHSVDLKAILRSHPGDTEALKSAILAAMPQKPKSHEFDTGAVQILR
FMNATGG
>Mature_326_residues
SALCDSFGRKVEYLRLSVTDRCDFRCVYCMEEDPCFLTREQVLSFEELALIGKAFTELGVKKIRLTGGEPLVRTDCTDLV
AQLGQLPGLQELSMTTNGSRLAKLAPALRAAGLRRLNISLDTLNPERFEQITRNGKLERVIAGIDAAKQAGFERIKLNAV
ILKGRNDDEVLDLVDFCRSRQLDIAFIEEMPIGLMDERETARHLSSDQVRTLIENRYPLTLSDKRTGGPARYYQMSDSPI
HIGFISPHSHNFCHECNRVRVTVEGRLLLCLGNEHSVDLKAILRSHPGDTEALKSAILAAMPQKPKSHEFDTGAVQILRF
MNATGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=308, Percent_Identity=38.961038961039, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI116734668, Length=308, Percent_Identity=38.961038961039, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI1786999, Length=328, Percent_Identity=36.5853658536585, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17561210, Length=309, Percent_Identity=37.2168284789644, Blast_Score=203, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI32566331, Length=308, Percent_Identity=36.6883116883117, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI32566329, Length=308, Percent_Identity=36.6883116883117, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=41.7197452229299, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI28574488, Length=314, Percent_Identity=41.7197452229299, Blast_Score=224, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36545; Mature: 36413

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALCDSFGRKVEYLRLSVTDRCDFRCVYCMEEDPCFLTREQVLSFEELALIGKAFTELG
CCHHHHHHCCEEEEEEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCC
VKKIRLTGGEPLVRTDCTDLVAQLGQLPGLQELSMTTNGSRLAKLAPALRAAGLRRLNIS
CEEEEECCCCCEEECCHHHHHHHHHCCCCCCHHEECCCCHHHHHHHHHHHHCCCEEEEEE
LDTLNPERFEQITRNGKLERVIAGIDAAKQAGFERIKLNAVILKGRNDDEVLDLVDFCRS
EECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHC
RQLDIAFIEEMPIGLMDERETARHLSSDQVRTLIENRYPLTLSDKRTGGPARYYQMSDSP
CCCCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCC
IHIGFISPHSHNFCHECNRVRVTVEGRLLLCLGNEHSVDLKAILRSHPGDTEALKSAILA
EEEEEECCCCCCHHHCCCEEEEEECCEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHH
AMPQKPKSHEFDTGAVQILRFMNATGG
HCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SALCDSFGRKVEYLRLSVTDRCDFRCVYCMEEDPCFLTREQVLSFEELALIGKAFTELG
CHHHHHHCCEEEEEEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCC
VKKIRLTGGEPLVRTDCTDLVAQLGQLPGLQELSMTTNGSRLAKLAPALRAAGLRRLNIS
CEEEEECCCCCEEECCHHHHHHHHHCCCCCCHHEECCCCHHHHHHHHHHHHCCCEEEEEE
LDTLNPERFEQITRNGKLERVIAGIDAAKQAGFERIKLNAVILKGRNDDEVLDLVDFCRS
EECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCHHHHHHHHHHHC
RQLDIAFIEEMPIGLMDERETARHLSSDQVRTLIENRYPLTLSDKRTGGPARYYQMSDSP
CCCCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCC
IHIGFISPHSHNFCHECNRVRVTVEGRLLLCLGNEHSVDLKAILRSHPGDTEALKSAILA
EEEEEECCCCCCHHHCCCEEEEEECCEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHH
AMPQKPKSHEFDTGAVQILRFMNATGG
HCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA