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The map label for this gene is fadA

Identifier: 119773173

GI number: 119773173

Start: 33194

End: 34357

Strand: Reverse

Name: fadA

Synonym: Sama_0031

Alternate gene names: 119773173

Gene position: 34357-33194 (Counterclockwise)

Preceding gene: 119773174

Following gene: 119773171

Centisome position: 0.8

GC content: 55.67

Gene sequence:

>1164_bases
ATGAAACAAGCCGTTATCGTAGATTGCATCCGCACTCCCATGGGCCGTTCCAAGGGTGGTGTATTCCGTAATGTTCGCGC
CGAGACACTGTCTGCCGAGTTGATGAAAGCCCTGTTGCTGCGTAACCCCGGCGTTGACCCAAACACCATTGAAGATGTGA
TTTGGGGCTGTGTTCAGCAAACGCTGGAGCAAGGCTTTAACATAGCCCGCAACGCTTCACTGCTGGCTGGAGTGCCTAAA
ACTGCCGGTGCTGTGACAGTTAACCGCCTCTGTGGTTCTTCCATGGAAGCCCTGCATCAGGCTTCCCGTGCCATCATGAC
AGGTATGGGTGACACCTTTATCATCGGTGGTGTCGAGCACATGGGTCATGTACCTATGAACCACGGTGTGGACTTCCACC
CTGGCCTCGCTGCCAATGTAGCCAAGGCCTCAGGTATGATGGGCCTGACTGCCGAAATGCTGGGTAAGCTGCACGGTATC
AGCCGTGAAATGCAGGACCAGTTTGCTGTGCGCTCACATCAGCGCGCCCATGCTGCATCCATTGAAGGCCGCTTCGCTAA
CGAGATATATGCCATTGAAGGCCACGATGCCAACGGCGCCCTTATCAAGGTGGATTACGACGAAGTTATCCGTCCGGAAA
CTACGCTTGAATCTCTGGCTGGTCTGCGCCCTGTATTCGATCCTGCCAATGGAACCGTGACCGCAGGTACGTCTTCAGCC
CTGTCGGACGGCGCCGCAGCCATGTTGGTGATGGAAGAAGAAAAAGCCCGCGCCTTGGGTCTGACGATTCGAGCCCGGGT
TCGCTCCATGGCCGTAGCCGGTTGTGACGCCGCTATCATGGGTTATGGCCCAGTGCCCGCAACCCAGAAAGCACTGGCTC
GTGCCGGTCTCAGCATTCAGGACATGGATGTGATTGAGCTGAACGAAGCCTTTGCCGCCCAATCTCTGCCATGCGTGAAA
GACTTGGGGCTAATGGATGTGGTGGAAGACAAGGTGAACCTCAATGGTGGTGCAATTGCATTGGGTCACCCTCTGGGCTG
CTCCGGAGCCCGTATCTCCACCACCCTGATCAACCTGATGGAACACAAGGACGCCACTCTGGGCCTGGCAACTATGTGTA
TCGGTTTGGGTCAAGGCATAGCCACTGTGTTTGAACGTGTTTAA

Upstream 100 bases:

>100_bases
CATCTGGGCGGCCTGTATCAGGTGACCGACGCCATGCGCGAACTTGCCAGTAACAATGGCAGCTACTATCCAAAGGCCTG
ATTAGGGAAGGATTATCAAA

Downstream 100 bases:

>100_bases
CACCACCAAAACCAAATAAAAAAGCCGACCTTTGGGTCGGCTTTTTGTTTCACGTGAAACAGCATCAGATGTTAAAGCGG
CCAGTAATGCTCTTTAAATC

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKQAVIVDCIRTPMGRSKGGVFRNVRAETLSAELMKALLLRNPGVDPNTIEDVIWGCVQQTLEQGFNIARNASLLAGVPK
TAGAVTVNRLCGSSMEALHQASRAIMTGMGDTFIIGGVEHMGHVPMNHGVDFHPGLAANVAKASGMMGLTAEMLGKLHGI
SREMQDQFAVRSHQRAHAASIEGRFANEIYAIEGHDANGALIKVDYDEVIRPETTLESLAGLRPVFDPANGTVTAGTSSA
LSDGAAAMLVMEEEKARALGLTIRARVRSMAVAGCDAAIMGYGPVPATQKALARAGLSIQDMDVIELNEAFAAQSLPCVK
DLGLMDVVEDKVNLNGGAIALGHPLGCSGARISTTLINLMEHKDATLGLATMCIGLGQGIATVFERV

Sequences:

>Translated_387_residues
MKQAVIVDCIRTPMGRSKGGVFRNVRAETLSAELMKALLLRNPGVDPNTIEDVIWGCVQQTLEQGFNIARNASLLAGVPK
TAGAVTVNRLCGSSMEALHQASRAIMTGMGDTFIIGGVEHMGHVPMNHGVDFHPGLAANVAKASGMMGLTAEMLGKLHGI
SREMQDQFAVRSHQRAHAASIEGRFANEIYAIEGHDANGALIKVDYDEVIRPETTLESLAGLRPVFDPANGTVTAGTSSA
LSDGAAAMLVMEEEKARALGLTIRARVRSMAVAGCDAAIMGYGPVPATQKALARAGLSIQDMDVIELNEAFAAQSLPCVK
DLGLMDVVEDKVNLNGGAIALGHPLGCSGARISTTLINLMEHKDATLGLATMCIGLGQGIATVFERV
>Mature_387_residues
MKQAVIVDCIRTPMGRSKGGVFRNVRAETLSAELMKALLLRNPGVDPNTIEDVIWGCVQQTLEQGFNIARNASLLAGVPK
TAGAVTVNRLCGSSMEALHQASRAIMTGMGDTFIIGGVEHMGHVPMNHGVDFHPGLAANVAKASGMMGLTAEMLGKLHGI
SREMQDQFAVRSHQRAHAASIEGRFANEIYAIEGHDANGALIKVDYDEVIRPETTLESLAGLRPVFDPANGTVTAGTSSA
LSDGAAAMLVMEEEKARALGLTIRARVRSMAVAGCDAAIMGYGPVPATQKALARAGLSIQDMDVIELNEAFAAQSLPCVK
DLGLMDVVEDKVNLNGGAIALGHPLGCSGARISTTLINLMEHKDATLGLATMCIGLGQGIATVFERV

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family

Homologues:

Organism=Homo sapiens, GI167614485, Length=398, Percent_Identity=38.6934673366834, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=40, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=38.5390428211587, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=32.6633165829146, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=32.093023255814, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI194353979, Length=385, Percent_Identity=29.6103896103896, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI48994986, Length=387, Percent_Identity=73.1266149870801, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1787663, Length=406, Percent_Identity=47.7832512315271, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=42.8927680798005, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788554, Length=401, Percent_Identity=44.3890274314214, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=32.5242718446602, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=38.8471177944862, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=35.4114713216958, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=433, Percent_Identity=32.5635103926097, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=32.7455919395466, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=389, Percent_Identity=29.0488431876607, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6322031, Length=388, Percent_Identity=38.4020618556701, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=33.0864197530864, Blast_Score=182, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=38.1546134663342, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI17648125, Length=358, Percent_Identity=38.268156424581, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=33.2552693208431, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=32.0707070707071, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FADA_SHEAM (A1S1I7)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_925913.1
- ProteinModelPortal:   A1S1I7
- SMR:   A1S1I7
- STRING:   A1S1I7
- GeneID:   4602288
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0031
- NMPDR:   fig|326297.7.peg.27
- eggNOG:   COG0183
- HOGENOM:   HBG370930
- OMA:   MLVMEEE
- PhylomeDB:   A1S1I7
- ProtClustDB:   PRK08947
- GO:   GO:0005737
- HAMAP:   MF_01620
- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR18919
- PIRSF:   PIRSF000429
- TIGRFAMs:   TIGR01930
- TIGRFAMs:   TIGR02445

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N; SSF53901 Thiolase-like

EC number: =2.3.1.16

Molecular weight: Translated: 40636; Mature: 40636

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00098 THIOLASE_1; PS00737 THIOLASE_2; PS00099 THIOLASE_3; PS00178 AA_TRNA_LIGASE_I

Important sites: ACT_SITE 91-91 ACT_SITE 343-343 ACT_SITE 373-373

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAVIVDCIRTPMGRSKGGVFRNVRAETLSAELMKALLLRNPGVDPNTIEDVIWGCVQQ
CCCCEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
TLEQGFNIARNASLLAGVPKTAGAVTVNRLCGSSMEALHQASRAIMTGMGDTFIIGGVEH
HHHHCCCHHCCCHHHCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEECHHH
MGHVPMNHGVDFHPGLAANVAKASGMMGLTAEMLGKLHGISREMQDQFAVRSHQRAHAAS
HCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGRFANEIYAIEGHDANGALIKVDYDEVIRPETTLESLAGLRPVFDPANGTVTAGTSSA
CCCCCCCEEEEEECCCCCCCEEEECHHHHHCCHHHHHHHHCCCCCCCCCCCEEECCCCHH
LSDGAAAMLVMEEEKARALGLTIRARVRSMAVAGCDAAIMGYGPVPATQKALARAGLSIQ
HCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCC
DMDVIELNEAFAAQSLPCVKDLGLMDVVEDKVNLNGGAIALGHPLGCSGARISTTLINLM
CCCCEEHHHHHHHCCCCHHHHCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHH
EHKDATLGLATMCIGLGQGIATVFERV
HHCCCHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MKQAVIVDCIRTPMGRSKGGVFRNVRAETLSAELMKALLLRNPGVDPNTIEDVIWGCVQQ
CCCCEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
TLEQGFNIARNASLLAGVPKTAGAVTVNRLCGSSMEALHQASRAIMTGMGDTFIIGGVEH
HHHHCCCHHCCCHHHCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEECHHH
MGHVPMNHGVDFHPGLAANVAKASGMMGLTAEMLGKLHGISREMQDQFAVRSHQRAHAAS
HCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGRFANEIYAIEGHDANGALIKVDYDEVIRPETTLESLAGLRPVFDPANGTVTAGTSSA
CCCCCCCEEEEEECCCCCCCEEEECHHHHHCCHHHHHHHHCCCCCCCCCCCEEECCCCHH
LSDGAAAMLVMEEEKARALGLTIRARVRSMAVAGCDAAIMGYGPVPATQKALARAGLSIQ
HCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCC
DMDVIELNEAFAAQSLPCVKDLGLMDVVEDKVNLNGGAIALGHPLGCSGARISTTLINLM
CCCCEEHHHHHHHCCCCHHHHCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHH
EHKDATLGLATMCIGLGQGIATVFERV
HHCCCHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA