Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 119718824

GI number: 119718824

Start: 4881303

End: 4882529

Strand: Reverse

Name: acdA [H]

Synonym: Noca_4607

Alternate gene names: 119718824

Gene position: 4882529-4881303 (Counterclockwise)

Preceding gene: 119718825

Following gene: 119718820

Centisome position: 97.93

GC content: 71.56

Gene sequence:

>1227_bases
GTGCCGCGCGTGACGCCGTCCTTCGAGCTCGACCAGGACCACCTCGACCTGCGCACCTGGGTGCACGACTTCGCCGAGGA
GGTGGTGCGCCCGGCCGCTGCCGAGTGGGACGAGCGGGAGGAGTTCCCGTGGCCGGTGGTCGAGGAGGCCGCGAAGGTCG
GCCTCTACTCGGTCGACTTCATCGTCACCCAGGCGCTCGACGAGACCGGGCTCGGCTTCCCGATCACGATGGAGGAGCTG
TTCTGGGGCGACGCCGGGATCGGGCTCTCGATCGTCGGCACGTCCCTGGCGGCCGCCGGCGTACGCGCCAACGGCACCGA
CGAGCAGGTCGCGGAGTGGATCCCCGCCATGTACGGCGCTCCCGGTGACCTCAAGCTCGGCGCGTTCTGCTCCTCCGAGC
CCGATGCCGGCTCCGACGTGGGCGCGATGCGCACCCGCGCGACGTACGACGAAGCAGGCGACGAGTGGGTCCTCAACGGC
ACCAAGACCTGGGCGACCAACGGCGGCATCGCGGACGTCCACGTGGTGACCGCCGTGGTCGATCCCGAGCTGCGCACCCG
CGGCCAGGCCAGCTTCGTCGTCCCGCCCGGCACCAAGGGGCTCAGCCAGGGCCAGAAGTTCCACAAGCACGGGATCCGCG
CCTCGCACACCGCCGAGGTGGTGCTCGACCAGGTGCGGGTGCCCGGCCGCTGCCTGCTCGGCGGCAAGGAGAAGCTGGAC
GCCCGGCTGGCCCGGGCCCGTGAGGGTGCCCGCAGCGCCGGGTCCTCGAACGCCTCGATGGCGACCTTCGAGCGCACCCG
GCCGGCGGTGGGTGCGCAGGCGATCGGCATCGCCCGCGCGGCGTACGAGGTGGCCTTGGACTACGCGAAGACCCGCGAGC
AGTTCGGAAGGGCGATCATCGAGAACCAGGCGATCGCCTTCACCCTCGCCGACATGGCCACCTCGATCGAGGCGTCGCGG
CTGCTGGTGTGGCGCGCGGCCTGGATGGCCCGGCAGGGCAAGCGCTTCGAGCAGGCCGAGGGGTCGATGTCCAAGCTGTT
CGCCGGTGAGACCGCCGTGCGGGTCACCGGCCAGGCGATGCAGATCCTCGGCGGCAACGGCTTCACCCGCGAGTACCCCG
TCGAGCGGATGGCCCGCGACGCCAAGATCTACACGATCTTCGAGGGGACCTCGGAGATCCAGCGCCTGGTCATCGCCCGG
TCCATCTCCGGGGCGCCGATCCGCTGA

Upstream 100 bases:

>100_bases
CTCGAGCCGCACGAGAGCGTCCGCGCCTGAGGGCGGGTCGTGTGCCTGAGCACGCGCCATGGCGCGTTCTCGGGCACACG
ACCCTGCACGGGTCGGTAAC

Downstream 100 bases:

>100_bases
CGCGGCGAGCGGTCAGACGCGGATGGCGCGGTTGACCCAGGTCGACGAGACGACCATCCCCACCTTCTCGTAGAGGCTCA
GCGCCCCGGTGCGGGAGTCG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MPRVTPSFELDQDHLDLRTWVHDFAEEVVRPAAAEWDEREEFPWPVVEEAAKVGLYSVDFIVTQALDETGLGFPITMEEL
FWGDAGIGLSIVGTSLAAAGVRANGTDEQVAEWIPAMYGAPGDLKLGAFCSSEPDAGSDVGAMRTRATYDEAGDEWVLNG
TKTWATNGGIADVHVVTAVVDPELRTRGQASFVVPPGTKGLSQGQKFHKHGIRASHTAEVVLDQVRVPGRCLLGGKEKLD
ARLARAREGARSAGSSNASMATFERTRPAVGAQAIGIARAAYEVALDYAKTREQFGRAIIENQAIAFTLADMATSIEASR
LLVWRAAWMARQGKRFEQAEGSMSKLFAGETAVRVTGQAMQILGGNGFTREYPVERMARDAKIYTIFEGTSEIQRLVIAR
SISGAPIR

Sequences:

>Translated_408_residues
MPRVTPSFELDQDHLDLRTWVHDFAEEVVRPAAAEWDEREEFPWPVVEEAAKVGLYSVDFIVTQALDETGLGFPITMEEL
FWGDAGIGLSIVGTSLAAAGVRANGTDEQVAEWIPAMYGAPGDLKLGAFCSSEPDAGSDVGAMRTRATYDEAGDEWVLNG
TKTWATNGGIADVHVVTAVVDPELRTRGQASFVVPPGTKGLSQGQKFHKHGIRASHTAEVVLDQVRVPGRCLLGGKEKLD
ARLARAREGARSAGSSNASMATFERTRPAVGAQAIGIARAAYEVALDYAKTREQFGRAIIENQAIAFTLADMATSIEASR
LLVWRAAWMARQGKRFEQAEGSMSKLFAGETAVRVTGQAMQILGGNGFTREYPVERMARDAKIYTIFEGTSEIQRLVIAR
SISGAPIR
>Mature_407_residues
PRVTPSFELDQDHLDLRTWVHDFAEEVVRPAAAEWDEREEFPWPVVEEAAKVGLYSVDFIVTQALDETGLGFPITMEELF
WGDAGIGLSIVGTSLAAAGVRANGTDEQVAEWIPAMYGAPGDLKLGAFCSSEPDAGSDVGAMRTRATYDEAGDEWVLNGT
KTWATNGGIADVHVVTAVVDPELRTRGQASFVVPPGTKGLSQGQKFHKHGIRASHTAEVVLDQVRVPGRCLLGGKEKLDA
RLARAREGARSAGSSNASMATFERTRPAVGAQAIGIARAAYEVALDYAKTREQFGRAIIENQAIAFTLADMATSIEASRL
LVWRAAWMARQGKRFEQAEGSMSKLFAGETAVRVTGQAMQILGGNGFTREYPVERMARDAKIYTIFEGTSEIQRLVIARS
ISGAPIR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=405, Percent_Identity=37.037037037037, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI4557231, Length=405, Percent_Identity=37.037037037037, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI4557233, Length=400, Percent_Identity=40, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI4501859, Length=394, Percent_Identity=33.756345177665, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI7656849, Length=409, Percent_Identity=30.0733496332518, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI21361497, Length=412, Percent_Identity=32.0388349514563, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4501857, Length=398, Percent_Identity=30.1507537688442, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI226958412, Length=405, Percent_Identity=29.3827160493827, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI76496475, Length=390, Percent_Identity=33.5897435897436, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI4557235, Length=390, Percent_Identity=33.5897435897436, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=30.791788856305, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=28.463476070529, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI7669494, Length=381, Percent_Identity=27.8215223097113, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI38505218, Length=305, Percent_Identity=25.5737704918033, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI211971008, Length=417, Percent_Identity=26.6187050359712, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48976061, Length=417, Percent_Identity=26.6187050359712, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786223, Length=298, Percent_Identity=28.5234899328859, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87081958, Length=281, Percent_Identity=33.0960854092527, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082384, Length=297, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17569725, Length=407, Percent_Identity=36.6093366093366, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17534899, Length=402, Percent_Identity=36.0696517412935, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17570075, Length=401, Percent_Identity=34.9127182044888, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17506239, Length=401, Percent_Identity=34.6633416458853, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17538396, Length=408, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=402, Percent_Identity=32.8358208955224, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=405, Percent_Identity=28.1481481481481, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71985184, Length=371, Percent_Identity=31.5363881401617, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17534353, Length=402, Percent_Identity=27.6119402985075, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71990804, Length=275, Percent_Identity=33.4545454545455, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17551932, Length=403, Percent_Identity=26.302729528536, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=34.051724137931, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=402, Percent_Identity=27.363184079602, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71985192, Length=318, Percent_Identity=28.9308176100629, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=260, Percent_Identity=32.3076923076923, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71982178, Length=304, Percent_Identity=28.6184210526316, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17531913, Length=96, Percent_Identity=42.7083333333333, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562446, Length=304, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24660351, Length=401, Percent_Identity=38.4039900249377, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI21356377, Length=398, Percent_Identity=37.1859296482412, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24646207, Length=397, Percent_Identity=36.272040302267, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24666513, Length=398, Percent_Identity=31.6582914572864, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21355753, Length=407, Percent_Identity=32.4324324324324, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI281363737, Length=323, Percent_Identity=32.5077399380805, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI19920834, Length=399, Percent_Identity=27.8195488721804, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 44146; Mature: 44015

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVTPSFELDQDHLDLRTWVHDFAEEVVRPAAAEWDEREEFPWPVVEEAAKVGLYSVDF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHCCCCHHHH
IVTQALDETGLGFPITMEELFWGDAGIGLSIVGTSLAAAGVRANGTDEQVAEWIPAMYGA
HHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PGDLKLGAFCSSEPDAGSDVGAMRTRATYDEAGDEWVLNGTKTWATNGGIADVHVVTAVV
CCCCEEEEEECCCCCCCCCCHHHHHCCCHHCCCCEEEECCCEEEECCCCCCEEEEEEEEE
DPELRTRGQASFVVPPGTKGLSQGQKFHKHGIRASHTAEVVLDQVRVPGRCLLGGKEKLD
CCHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECCHHHHH
ARLARAREGARSAGSSNASMATFERTRPAVGAQAIGIARAAYEVALDYAKTREQFGRAII
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENQAIAFTLADMATSIEASRLLVWRAAWMARQGKRFEQAEGSMSKLFAGETAVRVTGQAM
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHCCCCEEEECHHHH
QILGGNGFTREYPVERMARDAKIYTIFEGTSEIQRLVIARSISGAPIR
HHHCCCCCCCCCCHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PRVTPSFELDQDHLDLRTWVHDFAEEVVRPAAAEWDEREEFPWPVVEEAAKVGLYSVDF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHCCCCHHHH
IVTQALDETGLGFPITMEELFWGDAGIGLSIVGTSLAAAGVRANGTDEQVAEWIPAMYGA
HHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PGDLKLGAFCSSEPDAGSDVGAMRTRATYDEAGDEWVLNGTKTWATNGGIADVHVVTAVV
CCCCEEEEEECCCCCCCCCCHHHHHCCCHHCCCCEEEECCCEEEECCCCCCEEEEEEEEE
DPELRTRGQASFVVPPGTKGLSQGQKFHKHGIRASHTAEVVLDQVRVPGRCLLGGKEKLD
CCHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECCHHHHH
ARLARAREGARSAGSSNASMATFERTRPAVGAQAIGIARAAYEVALDYAKTREQFGRAII
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENQAIAFTLADMATSIEASRLLVWRAAWMARQGKRFEQAEGSMSKLFAGETAVRVTGQAM
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHCCCCEEEECHHHH
QILGGNGFTREYPVERMARDAKIYTIFEGTSEIQRLVIARSISGAPIR
HHHCCCCCCCCCCHHHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]