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The map label for this gene is fadA [H]

Identifier: 119718782

GI number: 119718782

Start: 4830422

End: 4831633

Strand: Reverse

Name: fadA [H]

Synonym: Noca_4563

Alternate gene names: 119718782

Gene position: 4831633-4830422 (Counterclockwise)

Preceding gene: 119718784

Following gene: 119718781

Centisome position: 96.91

GC content: 71.95

Gene sequence:

>1212_bases
ATGGCTGAGGCATTCGTGTACGACCACATCCGCACGCCCCGCGGCAAGGGCAAGAAGGTCGGCTCCCTCCACGAGGTGAA
GCCCGTCGACCTGATCGTCGGGCTCCTCGACGAGATCAAGGAGCGCAACCCCTCCCTCGACCCCGAGCGCGTCGACGACG
TGGTCCTCGGCGTCGTGACCCCGATCGGCGAGCAGGGCGGGGACATCGCGAAGACCGCCGCGCTCAAGGCCGGCTACCCC
GAGACGGTCGCCGGCGTGCAGCTCAACCGCTTCTGCGCCTCCGGCCTGGAGGCGGTCAACCAGGCGGCCTCCCGGGTCCG
CGGCGGCTTCGAGGACCTGATCCTCGCCGGCGGCGTGGAGTCGATGAGCCGGGTGCCGATGGGCTCCGACGGCGGCGCCT
GGGCCTCCGACCCGGCCACCGCGCTGCAGACCGGCTTCGTGCCCCAGGGCATCGGTGCCGACCTGATCGCCACGCTCGAG
GGCTGGACCCGAGACGACGTGGACGCATACGCCGCCGAGTCGCACCACCGGGCCGCCAAGGCCTGGGCCAACGGCTACTT
CAGCGGAGCGGTCATCCCGGTCCGCGACCAGAACGGCCTGGTCGTGCTCGACCACGACGAGACGATCCGGCCCGACACGA
CCGCCGAGGGCCTGGCCGGCCTCAAGCCGAGCTTCGCCGACATCGGTGCGCAGGCGGGCTTCGACGACGTGGCACTGGAG
AAGTACCACTGGGTCGAGCGGATCGACCACGTCCACCACGCCGGCAACTCCTCGGGCATCGTCGACGGCGCCTCGCTGGT
CGCGATCGGCACCGAGGAGATCGGGACCGCGCTCGGCCTCACCCCGCGGGCCCGGATCGTCTCGGCCGCGGTGTCCGGCG
CCGACCCGACGATCATGCTCACCGGTCCCGCGCCGGCCGCCCGCAAGGCACTGGCCCGGGCCGGGCTCGAGGTCGGGGAC
ATCGACCTGTTCGAGATCAACGAGGCCTTCGCCGCCGTCGCGATGCGCTTCATGCGCGACCTGGGCATCAGCCACGACAT
CACCAACGTCAACGGCGGCGCGATCGCCATGGGCCACCCGCTCGGTGCCACCGGCGCGATGATCCTCGGCACCCTCGTCG
ACGAGCTCCAGCGCCGCGACCTGCGCCGCGGCCTCGCCACGCTCTGCGTGGGTGGGGGCATGGGCATCGCGACCATCGTC
GAGATCGTGTGA

Upstream 100 bases:

>100_bases
TCAGCAGCTCACGGACCGATTCGACCGGCGCGACGTTCTCGTCCATGACCCTCCTCACACTCTTCCTTGACGGTGACAGT
AATAGTGTCACAATCGGTCC

Downstream 100 bases:

>100_bases
CGCCCGGCTCCGCCCTACCCTTCCGCTTCGGTGGTTTCGAGGCTCGGCGCTAGCGCGCAACGCACCTCAACCACCGCGCT
CCCCAGACAGGAACACGCAT

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAEAFVYDHIRTPRGKGKKVGSLHEVKPVDLIVGLLDEIKERNPSLDPERVDDVVLGVVTPIGEQGGDIAKTAALKAGYP
ETVAGVQLNRFCASGLEAVNQAASRVRGGFEDLILAGGVESMSRVPMGSDGGAWASDPATALQTGFVPQGIGADLIATLE
GWTRDDVDAYAAESHHRAAKAWANGYFSGAVIPVRDQNGLVVLDHDETIRPDTTAEGLAGLKPSFADIGAQAGFDDVALE
KYHWVERIDHVHHAGNSSGIVDGASLVAIGTEEIGTALGLTPRARIVSAAVSGADPTIMLTGPAPAARKALARAGLEVGD
IDLFEINEAFAAVAMRFMRDLGISHDITNVNGGAIAMGHPLGATGAMILGTLVDELQRRDLRRGLATLCVGGGMGIATIV
EIV

Sequences:

>Translated_403_residues
MAEAFVYDHIRTPRGKGKKVGSLHEVKPVDLIVGLLDEIKERNPSLDPERVDDVVLGVVTPIGEQGGDIAKTAALKAGYP
ETVAGVQLNRFCASGLEAVNQAASRVRGGFEDLILAGGVESMSRVPMGSDGGAWASDPATALQTGFVPQGIGADLIATLE
GWTRDDVDAYAAESHHRAAKAWANGYFSGAVIPVRDQNGLVVLDHDETIRPDTTAEGLAGLKPSFADIGAQAGFDDVALE
KYHWVERIDHVHHAGNSSGIVDGASLVAIGTEEIGTALGLTPRARIVSAAVSGADPTIMLTGPAPAARKALARAGLEVGD
IDLFEINEAFAAVAMRFMRDLGISHDITNVNGGAIAMGHPLGATGAMILGTLVDELQRRDLRRGLATLCVGGGMGIATIV
EIV
>Mature_402_residues
AEAFVYDHIRTPRGKGKKVGSLHEVKPVDLIVGLLDEIKERNPSLDPERVDDVVLGVVTPIGEQGGDIAKTAALKAGYPE
TVAGVQLNRFCASGLEAVNQAASRVRGGFEDLILAGGVESMSRVPMGSDGGAWASDPATALQTGFVPQGIGADLIATLEG
WTRDDVDAYAAESHHRAAKAWANGYFSGAVIPVRDQNGLVVLDHDETIRPDTTAEGLAGLKPSFADIGAQAGFDDVALEK
YHWVERIDHVHHAGNSSGIVDGASLVAIGTEEIGTALGLTPRARIVSAAVSGADPTIMLTGPAPAARKALARAGLEVGDI
DLFEINEAFAAVAMRFMRDLGISHDITNVNGGAIAMGHPLGATGAMILGTLVDELQRRDLRRGLATLCVGGGMGIATIVE
IV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=373, Percent_Identity=35.3887399463807, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=35.8974358974359, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=35.5329949238579, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI4557237, Length=370, Percent_Identity=31.6216216216216, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=29.5964125560538, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI194353979, Length=114, Percent_Identity=44.7368421052632, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787663, Length=424, Percent_Identity=41.7452830188679, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI48994986, Length=409, Percent_Identity=39.8533007334963, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788554, Length=417, Percent_Identity=38.1294964028777, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI87082165, Length=415, Percent_Identity=36.6265060240964, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1788683, Length=439, Percent_Identity=28.9293849658314, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI133906874, Length=403, Percent_Identity=36.9727047146402, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=414, Percent_Identity=31.6425120772947, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147385, Length=408, Percent_Identity=30.3921568627451, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17551802, Length=448, Percent_Identity=27.2321428571429, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=26.0759493670886, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=34.9246231155779, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325229, Length=418, Percent_Identity=28.2296650717703, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24655093, Length=415, Percent_Identity=35.1807228915663, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17648125, Length=376, Percent_Identity=34.8404255319149, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24640423, Length=365, Percent_Identity=31.5068493150685, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17137578, Length=441, Percent_Identity=29.4784580498866, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41926; Mature: 41795

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAFVYDHIRTPRGKGKKVGSLHEVKPVDLIVGLLDEIKERNPSLDPERVDDVVLGVVT
CCCCEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
PIGEQGGDIAKTAALKAGYPETVAGVQLNRFCASGLEAVNQAASRVRGGFEDLILAGGVE
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
SMSRVPMGSDGGAWASDPATALQTGFVPQGIGADLIATLEGWTRDDVDAYAAESHHRAAK
HHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AWANGYFSGAVIPVRDQNGLVVLDHDETIRPDTTAEGLAGLKPSFADIGAQAGFDDVALE
HHHCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHCCCCCHHHHCCCCCCCHHHHH
KYHWVERIDHVHHAGNSSGIVDGASLVAIGTEEIGTALGLTPRARIVSAAVSGADPTIML
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHCCCCHHHHHHHHHCCCCCEEEE
TGPAPAARKALARAGLEVGDIDLFEINEAFAAVAMRFMRDLGISHDITNVNGGAIAMGHP
ECCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCC
LGATGAMILGTLVDELQRRDLRRGLATLCVGGGMGIATIVEIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
AEAFVYDHIRTPRGKGKKVGSLHEVKPVDLIVGLLDEIKERNPSLDPERVDDVVLGVVT
CCCEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
PIGEQGGDIAKTAALKAGYPETVAGVQLNRFCASGLEAVNQAASRVRGGFEDLILAGGVE
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
SMSRVPMGSDGGAWASDPATALQTGFVPQGIGADLIATLEGWTRDDVDAYAAESHHRAAK
HHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AWANGYFSGAVIPVRDQNGLVVLDHDETIRPDTTAEGLAGLKPSFADIGAQAGFDDVALE
HHHCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHCCCCCHHHHCCCCCCCHHHHH
KYHWVERIDHVHHAGNSSGIVDGASLVAIGTEEIGTALGLTPRARIVSAAVSGADPTIML
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHCCCCHHHHHHHHHCCCCCEEEE
TGPAPAARKALARAGLEVGDIDLFEINEAFAAVAMRFMRDLGISHDITNVNGGAIAMGHP
ECCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCC
LGATGAMILGTLVDELQRRDLRRGLATLCVGGGMGIATIVEIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]