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The map label for this gene is yngE [H]

Identifier: 119718771

GI number: 119718771

Start: 4816537

End: 4818141

Strand: Reverse

Name: yngE [H]

Synonym: Noca_4552

Alternate gene names: 119718771

Gene position: 4818141-4816537 (Counterclockwise)

Preceding gene: 119718772

Following gene: 119718770

Centisome position: 96.64

GC content: 68.97

Gene sequence:

>1605_bases
GTGAGCGCCAACCGTGAGGCGATGCTGGACAAGCTCGCCGACCTCGACACCGAGCACGGCAAGGCGGTCGCCGGCGGCGG
CGAGAAGTACGTCGCGCGGCACCACGCCCGCGGCAAGCTGCTGCCCCGCGAGCGGATCGAGCTACTCGTCGACGAGGGCT
CGGCGTTCCTGGAGCTCAGCCCGCTCGCCGGCTGGGGGTCGGACTTCCCCGTCGGCGCATCCGTGGTCACCGGCATCGGG
GTGATCGAGGGCGTCGAGTGCATGATCACCGCCAACGACCCGACCGTGAAGGGTGGCGCGAGCAACCCCTGGACGGTGAA
GAAGATCTTCCGGGCCTCGCAGATCGCCGAGGAGAACGGGCTGCCCACCGTCTCGCTGGTCGAGTCCGGCGGCGCGGACC
TGCCGACCCAGAAAGAGATCTTCATCCCGGGCGGCAAGCTGTTCCGCGACATCACCCGGGCCAGCGCGCGCAAGCAGCCC
ACGGTCGCGCTGGTCTTCGGCAACTCGACCGCGGGCGGCGCCTACGTGCCGGGCATGTCGGACTACACGGTCATGGTCAA
GGAGCAGGCGAAGGTGTTCCTCGGCGGACCGCCGCTGGTGAAGATGGCGACCGGCGAGGAGTCCGACGACGAGTCGCTCG
GTGGAGCGGAGATGCACGCCCGGATCTCCGGGTTGGCCGACTACCTCGCCGAGGACGAGCGGGACGCGATCCGGATCGGC
CGGCGGATCGTCGCCCGACTGAACTGGCGCAAGCGAGGCCCTGCCCACCCTGCGGGGATCTCGACAAGCTCGATCACCGG
GCCGTCGTACGCCGAGCCGGAGGAGGATCCGGAAGGGCTGCTCGACCTGATCCCCGGCGACCTCAAGGAGCCGTTCGACC
CGCGCGAGGTGATCCGGCGCATCTGCGACGGGGTGTCCGCCACGAACGGTGCCGTGTTCGACGAGTTCAAGCCGCTCTAC
GGCAGCTCGCTGGTCACCGGCTGGGCGCGGATCCACGGCCGGCCGGTCGGCATCCTCGCCAACGCCCAGGGCGTGCTGTT
CTCCGAGGAGGCGCAGAAGGCCACCCAGTTCGTGCAGCTCGCCAACCAGAGCGACACCCCGCTGCTGTTCCTGCACAACA
CCACCGGCTACATGGTCGGCAAGGAGTACGAGCAGGGCGGCATCATCAAGCACGGCGCGATGATGATCAACGCGATCAGC
AACTCCACGGTCCCGCACCTGAGCGTGATCATGGGCGCGTCCTACGGCGCCGGCAACTACGGCATGAACGGCCGCGCCTA
CGACCCGCGGTTCCTGTTCACCTGGCCCTCGGCGAAGTCCGCCGTGATGGGGCCCCAGCAGCTCGCCGGCGTGCTCGAGA
TCGTGGCGCAGCAGTCGGCCGAGGCGAAGGGCGAGGTCTTCGACGCCGAGGGCTTCAAGGGGATCAAGGAGCTCGTCGAG
GCGCAGATCGAGGAGCAGTCGCTGCCGCACTTCCTCTCCGGGATGCTCTACGACGACGGCGTGATCGACCCGCGCGACAC
CCGCACGATCCTGGGCATCTGCCTGTCCGTCATCGAGAACCAGCCGTACGTCGGCACCGACCGATTCGGGGTGTTCCGGC
CATGA

Upstream 100 bases:

>100_bases
ACCTGCGGGCGTACTGGCTGCTGCTCGGCCGGCTCCGCGGCCGGACCAACGAGCGCGGCATGCGCACCACCCTGGAGCGG
ATGAAGGCGGTGATCGAGTC

Downstream 100 bases:

>100_bases
CATACGGCTTCGCCGTAGGCGGCTACGCCGCCGAAAGGCTTGGCGGCTTCGCCGCCGAAATGCATCGAGCGGCTTCGCCG
CGGCCCTTGTCTGTTCCGTC

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MSANREAMLDKLADLDTEHGKAVAGGGEKYVARHHARGKLLPRERIELLVDEGSAFLELSPLAGWGSDFPVGASVVTGIG
VIEGVECMITANDPTVKGGASNPWTVKKIFRASQIAEENGLPTVSLVESGGADLPTQKEIFIPGGKLFRDITRASARKQP
TVALVFGNSTAGGAYVPGMSDYTVMVKEQAKVFLGGPPLVKMATGEESDDESLGGAEMHARISGLADYLAEDERDAIRIG
RRIVARLNWRKRGPAHPAGISTSSITGPSYAEPEEDPEGLLDLIPGDLKEPFDPREVIRRICDGVSATNGAVFDEFKPLY
GSSLVTGWARIHGRPVGILANAQGVLFSEEAQKATQFVQLANQSDTPLLFLHNTTGYMVGKEYEQGGIIKHGAMMINAIS
NSTVPHLSVIMGASYGAGNYGMNGRAYDPRFLFTWPSAKSAVMGPQQLAGVLEIVAQQSAEAKGEVFDAEGFKGIKELVE
AQIEEQSLPHFLSGMLYDDGVIDPRDTRTILGICLSVIENQPYVGTDRFGVFRP

Sequences:

>Translated_534_residues
MSANREAMLDKLADLDTEHGKAVAGGGEKYVARHHARGKLLPRERIELLVDEGSAFLELSPLAGWGSDFPVGASVVTGIG
VIEGVECMITANDPTVKGGASNPWTVKKIFRASQIAEENGLPTVSLVESGGADLPTQKEIFIPGGKLFRDITRASARKQP
TVALVFGNSTAGGAYVPGMSDYTVMVKEQAKVFLGGPPLVKMATGEESDDESLGGAEMHARISGLADYLAEDERDAIRIG
RRIVARLNWRKRGPAHPAGISTSSITGPSYAEPEEDPEGLLDLIPGDLKEPFDPREVIRRICDGVSATNGAVFDEFKPLY
GSSLVTGWARIHGRPVGILANAQGVLFSEEAQKATQFVQLANQSDTPLLFLHNTTGYMVGKEYEQGGIIKHGAMMINAIS
NSTVPHLSVIMGASYGAGNYGMNGRAYDPRFLFTWPSAKSAVMGPQQLAGVLEIVAQQSAEAKGEVFDAEGFKGIKELVE
AQIEEQSLPHFLSGMLYDDGVIDPRDTRTILGICLSVIENQPYVGTDRFGVFRP
>Mature_533_residues
SANREAMLDKLADLDTEHGKAVAGGGEKYVARHHARGKLLPRERIELLVDEGSAFLELSPLAGWGSDFPVGASVVTGIGV
IEGVECMITANDPTVKGGASNPWTVKKIFRASQIAEENGLPTVSLVESGGADLPTQKEIFIPGGKLFRDITRASARKQPT
VALVFGNSTAGGAYVPGMSDYTVMVKEQAKVFLGGPPLVKMATGEESDDESLGGAEMHARISGLADYLAEDERDAIRIGR
RIVARLNWRKRGPAHPAGISTSSITGPSYAEPEEDPEGLLDLIPGDLKEPFDPREVIRRICDGVSATNGAVFDEFKPLYG
SSLVTGWARIHGRPVGILANAQGVLFSEEAQKATQFVQLANQSDTPLLFLHNTTGYMVGKEYEQGGIIKHGAMMINAISN
STVPHLSVIMGASYGAGNYGMNGRAYDPRFLFTWPSAKSAVMGPQQLAGVLEIVAQQSAEAKGEVFDAEGFKGIKELVEA
QIEEQSLPHFLSGMLYDDGVIDPRDTRTILGICLSVIENQPYVGTDRFGVFRP

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=540, Percent_Identity=47.037037037037, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI119943100, Length=525, Percent_Identity=30.0952380952381, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI295821216, Length=545, Percent_Identity=29.1743119266055, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI310133460, Length=128, Percent_Identity=50.78125, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17552936, Length=540, Percent_Identity=44.2592592592593, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI25147362, Length=523, Percent_Identity=29.4455066921606, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI25147359, Length=523, Percent_Identity=29.4455066921606, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24586065, Length=542, Percent_Identity=45.0184501845018, Blast_Score=461, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57216; Mature: 57084

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANREAMLDKLADLDTEHGKAVAGGGEKYVARHHARGKLLPRERIELLVDEGSAFLELS
CCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHCCCCCCCHHHHHEEEECCCCEEEEC
PLAGWGSDFPVGASVVTGIGVIEGVECMITANDPTVKGGASNPWTVKKIFRASQIAEENG
CCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
LPTVSLVESGGADLPTQKEIFIPGGKLFRDITRASARKQPTVALVFGNSTAGGAYVPGMS
CCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCC
DYTVMVKEQAKVFLGGPPLVKMATGEESDDESLGGAEMHARISGLADYLAEDERDAIRIG
CEEEEEEECCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RRIVARLNWRKRGPAHPAGISTSSITGPSYAEPEEDPEGLLDLIPGDLKEPFDPREVIRR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHH
ICDGVSATNGAVFDEFKPLYGSSLVTGWARIHGRPVGILANAQGVLFSEEAQKATQFVQL
HHCCCCCCCCCHHHHCCHHCCCHHHHHHHHHCCCCEEEEECCCCCEECHHHHHHHHHHHH
ANQSDTPLLFLHNTTGYMVGKEYEQGGIIKHGAMMINAISNSTVPHLSVIMGASYGAGNY
HCCCCCCEEEEECCCCEEECCCCCCCCCEECCCEEEEECCCCCCCCEEEEEECCCCCCCC
GMNGRAYDPRFLFTWPSAKSAVMGPQQLAGVLEIVAQQSAEAKGEVFDAEGFKGIKELVE
CCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHH
AQIEEQSLPHFLSGMLYDDGVIDPRDTRTILGICLSVIENQPYVGTDRFGVFRP
HHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SANREAMLDKLADLDTEHGKAVAGGGEKYVARHHARGKLLPRERIELLVDEGSAFLELS
CCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHCCCCCCCHHHHHEEEECCCCEEEEC
PLAGWGSDFPVGASVVTGIGVIEGVECMITANDPTVKGGASNPWTVKKIFRASQIAEENG
CCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
LPTVSLVESGGADLPTQKEIFIPGGKLFRDITRASARKQPTVALVFGNSTAGGAYVPGMS
CCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCC
DYTVMVKEQAKVFLGGPPLVKMATGEESDDESLGGAEMHARISGLADYLAEDERDAIRIG
CEEEEEEECCEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RRIVARLNWRKRGPAHPAGISTSSITGPSYAEPEEDPEGLLDLIPGDLKEPFDPREVIRR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHH
ICDGVSATNGAVFDEFKPLYGSSLVTGWARIHGRPVGILANAQGVLFSEEAQKATQFVQL
HHCCCCCCCCCHHHHCCHHCCCHHHHHHHHHCCCCEEEEECCCCCEECHHHHHHHHHHHH
ANQSDTPLLFLHNTTGYMVGKEYEQGGIIKHGAMMINAISNSTVPHLSVIMGASYGAGNY
HCCCCCCEEEEECCCCEEECCCCCCCCCEECCCEEEEECCCCCCCCEEEEEECCCCCCCC
GMNGRAYDPRFLFTWPSAKSAVMGPQQLAGVLEIVAQQSAEAKGEVFDAEGFKGIKELVE
CCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHH
AQIEEQSLPHFLSGMLYDDGVIDPRDTRTILGICLSVIENQPYVGTDRFGVFRP
HHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]