Click here to switch to the map view.

The map label for this gene is menB [H]

Identifier: 119718751

GI number: 119718751

Start: 4795615

End: 4796382

Strand: Reverse

Name: menB [H]

Synonym: Noca_4532

Alternate gene names: 119718751

Gene position: 4796382-4795615 (Counterclockwise)

Preceding gene: 119718759

Following gene: 119718750

Centisome position: 96.2

GC content: 73.05

Gene sequence:

>768_bases
ATGTCCGGCATGCCCGCCTCCGACGCCGAACTCGTGCACTACGCCGTCTCCGAGGGAGTCGCGACCCTCACCCTGGACTC
CCCGCACAACCGCAACGCGCTGTCGCGCCAGCTCGTGACCGAGCTGTTCGCGGGCCTGGAGCGCGCCGCGGCCGACGACG
CCGTGAAGGTGGTGCTGATCGGCGCGGAGGGCCGGGTGTTCTGTTCCGGCGCCGACCTGTCCGAAGCCTCGAGCGGCGGC
ATGGAGGAGGGCACCCGCCGGATCGTCGACCTGCAGCGGCTCATCGTCACCCTCGACAAGCCCGTGGTGACCCGGGTGTA
CGGCGCGGTCCGGGCCGGCGGCATCGGCATCGTGGCGGCCTCGGACATCGCCATCGCGGCCGAGGACGCGACCTTCGCGC
TCACCGAGGTCAAGCTCGGGCTCGCGGCCGCGATCATCTCGCTGACCGTCCATCACCGGATGACCCCGCGCGCGGCGGCG
CTCACCACCCTCGGCGGTGAGGTGTTCACCGGCGCCCAGGCCGCGGCGTACGGCCTGGTCACCACCGCGGTGCCCGCCGA
GTCGCTCGACGACGAGGTGGCCCGGGTCTGCGCCTCCCTGGCCACCGGCGCCGCCCAGGGCCTGCGCGAGTCCAAGCGGA
TCCTCAACCGCGACCTGGTCGCCCGGATCGACGCCCACGGCACGGAGATGGCCGAGCTCTCCACCCGTCTGTTCGCCTCC
GACGAGGCCCGCGAGGCGATGACCGCGTTCCTCTCCCGGGGCAAATAG

Upstream 100 bases:

>100_bases
AGGGTGGCCAGGACTCCGAGACCGGCGTGGGCGAGTCGGTTCCACATGAGGGGTGTTCGGAGTGGAGCGCGCTCCGGATG
GCCCCACGGTGTGGGGCAGG

Downstream 100 bases:

>100_bases
GGCGGGCGGTTTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAACTTCGCCCGAGAAGTTCCGGTTTCGCCTG
AGAAGTCCGGGGCCGAACCC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSGMPASDAELVHYAVSEGVATLTLDSPHNRNALSRQLVTELFAGLERAAADDAVKVVLIGAEGRVFCSGADLSEASSGG
MEEGTRRIVDLQRLIVTLDKPVVTRVYGAVRAGGIGIVAASDIAIAAEDATFALTEVKLGLAAAIISLTVHHRMTPRAAA
LTTLGGEVFTGAQAAAYGLVTTAVPAESLDDEVARVCASLATGAAQGLRESKRILNRDLVARIDAHGTEMAELSTRLFAS
DEAREAMTAFLSRGK

Sequences:

>Translated_255_residues
MSGMPASDAELVHYAVSEGVATLTLDSPHNRNALSRQLVTELFAGLERAAADDAVKVVLIGAEGRVFCSGADLSEASSGG
MEEGTRRIVDLQRLIVTLDKPVVTRVYGAVRAGGIGIVAASDIAIAAEDATFALTEVKLGLAAAIISLTVHHRMTPRAAA
LTTLGGEVFTGAQAAAYGLVTTAVPAESLDDEVARVCASLATGAAQGLRESKRILNRDLVARIDAHGTEMAELSTRLFAS
DEAREAMTAFLSRGK
>Mature_254_residues
SGMPASDAELVHYAVSEGVATLTLDSPHNRNALSRQLVTELFAGLERAAADDAVKVVLIGAEGRVFCSGADLSEASSGGM
EEGTRRIVDLQRLIVTLDKPVVTRVYGAVRAGGIGIVAASDIAIAAEDATFALTEVKLGLAAAIISLTVHHRMTPRAAAL
TTLGGEVFTGAQAAAYGLVTTAVPAESLDDEVARVCASLATGAAQGLRESKRILNRDLVARIDAHGTEMAELSTRLFASD
EAREAMTAFLSRGK

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI260274832, Length=244, Percent_Identity=26.6393442622951, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI45643119, Length=244, Percent_Identity=26.6393442622951, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI260275230, Length=244, Percent_Identity=26.6393442622951, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI31542718, Length=243, Percent_Identity=27.1604938271605, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI194097323, Length=242, Percent_Identity=26.0330578512397, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4757968, Length=230, Percent_Identity=25.6521739130435, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI49355787, Length=230, Percent_Identity=25.6521739130435, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI221136756, Length=242, Percent_Identity=25.6198347107438, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI221136753, Length=242, Percent_Identity=25.6198347107438, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI70995211, Length=186, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI116235487, Length=243, Percent_Identity=27.5720164609054, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI221307494, Length=242, Percent_Identity=25.6198347107438, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI25453481, Length=229, Percent_Identity=25.764192139738, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI51538573, Length=229, Percent_Identity=25.764192139738, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4757966, Length=225, Percent_Identity=26.2222222222222, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI51538581, Length=225, Percent_Identity=26.2222222222222, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1788597, Length=257, Percent_Identity=31.1284046692607, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787659, Length=238, Percent_Identity=28.1512605042017, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87082183, Length=266, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787660, Length=254, Percent_Identity=29.5275590551181, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=239, Percent_Identity=28.0334728033473, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=253, Percent_Identity=24.901185770751, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=189, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=186, Percent_Identity=29.5698924731183, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=26.3779527559055, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=199, Percent_Identity=28.1407035175879, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922422, Length=194, Percent_Identity=27.319587628866, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653139, Length=249, Percent_Identity=25.7028112449799, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19920382, Length=182, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 26460; Mature: 26329

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGMPASDAELVHYAVSEGVATLTLDSPHNRNALSRQLVTELFAGLERAAADDAVKVVLI
CCCCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GAEGRVFCSGADLSEASSGGMEEGTRRIVDLQRLIVTLDKPVVTRVYGAVRAGGIGIVAA
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEE
SDIAIAAEDATFALTEVKLGLAAAIISLTVHHRMTPRAAALTTLGGEVFTGAQAAAYGLV
CCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHCCCHHHHHHHH
TTAVPAESLDDEVARVCASLATGAAQGLRESKRILNRDLVARIDAHGTEMAELSTRLFAS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
DEAREAMTAFLSRGK
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGMPASDAELVHYAVSEGVATLTLDSPHNRNALSRQLVTELFAGLERAAADDAVKVVLI
CCCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GAEGRVFCSGADLSEASSGGMEEGTRRIVDLQRLIVTLDKPVVTRVYGAVRAGGIGIVAA
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEE
SDIAIAAEDATFALTEVKLGLAAAIISLTVHHRMTPRAAALTTLGGEVFTGAQAAAYGLV
CCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHCCCHHHHHHHH
TTAVPAESLDDEVARVCASLATGAAQGLRESKRILNRDLVARIDAHGTEMAELSTRLFAS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
DEAREAMTAFLSRGK
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA