Click here to switch to the map view.

The map label for this gene is czcD [H]

Identifier: 119718729

GI number: 119718729

Start: 4770234

End: 4770977

Strand: Reverse

Name: czcD [H]

Synonym: Noca_4510

Alternate gene names: 119718729

Gene position: 4770977-4770234 (Counterclockwise)

Preceding gene: 119718731

Following gene: 119718728

Centisome position: 95.69

GC content: 73.52

Gene sequence:

>744_bases
GTGGTGCTCGCGCTGGGGGCGTCGTACGTCGCGTCCCGGGGCGGTGGGCCGCGGTCCACGTTCGGCCTGCACCGCGCCGA
GATCCTGGCCGCGCTGGTGAACGCGCTCGCGCTCCTGGTGGTCTGCGGCTACCTCGCCTGGGCCGGCATCTCCCGGCTCG
CCGACCCGGTGTCGGTGGACGCCGGGCCGATGGTCGCGTTCGCGGCGGTCGGCCTGGTCGCGAACGCGGTGTCGCTGGTG
ATCCTCAACCGCTCCGAGACCGGGTCGCTCAACCTGCGCGGCGCGGCCAACGAGGTGTTCGCCGACCTGGTCGGCTCGGT
CCTCGCGGTGCTCGCCGGCGCGGTGATCTGGGTGTGGGGTCTTGACCGGGCGGACCCGATCGCGTCCCTGGTCATCGCGG
CGCTGATCCTGCCGCGCTCGCTGGTGCTGCTCCGCGAGTCGGCCGCCATCCTGCTCGAGGTCGCGCCGCGCGGCCTCGAC
CTGGACGACGTACGCCGCCACCTGCTCGCGATGCCCGGCGTGCTCGACGTCCACGACCTGCACGCCTGGACCATCACCAG
CGGGATGCCCAGCCTGTCGGCCCACGTGACCGTCACCGAGGAGGCGCTCGCCGAGCTCGGCGTCGGCGGCGTCCTGGACC
GGCTCTCCGAGTGCACGGCCGAGCACTTCGACGTGCGGCACTCGACCTTCCAGGTCGAGCCGGTCACCCATCGCGAGCAC
GAGGACCTCGGCGAGGTCCACTGA

Upstream 100 bases:

>100_bases
CACCGTCGTCGTGATGGCGGTCGAGGTGGTGGGCGCGCTGCTCACCGGCTCGCTCGCGCTGCTCGCGGACGCCGGGCACA
TGGCCACCGACGCCGCGGCC

Downstream 100 bases:

>100_bases
CGACGGGCGGGCGCCCGACGATTACCCCGGTTGATTGGCGGCGCCGACGATGGCACCGGTAGGTTGAACGTGCACGATTG
TGTTCCGGGTCACAGGGCGC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MVLALGASYVASRGGGPRSTFGLHRAEILAALVNALALLVVCGYLAWAGISRLADPVSVDAGPMVAFAAVGLVANAVSLV
ILNRSETGSLNLRGAANEVFADLVGSVLAVLAGAVIWVWGLDRADPIASLVIAALILPRSLVLLRESAAILLEVAPRGLD
LDDVRRHLLAMPGVLDVHDLHAWTITSGMPSLSAHVTVTEEALAELGVGGVLDRLSECTAEHFDVRHSTFQVEPVTHREH
EDLGEVH

Sequences:

>Translated_247_residues
MVLALGASYVASRGGGPRSTFGLHRAEILAALVNALALLVVCGYLAWAGISRLADPVSVDAGPMVAFAAVGLVANAVSLV
ILNRSETGSLNLRGAANEVFADLVGSVLAVLAGAVIWVWGLDRADPIASLVIAALILPRSLVLLRESAAILLEVAPRGLD
LDDVRRHLLAMPGVLDVHDLHAWTITSGMPSLSAHVTVTEEALAELGVGGVLDRLSECTAEHFDVRHSTFQVEPVTHREH
EDLGEVH
>Mature_247_residues
MVLALGASYVASRGGGPRSTFGLHRAEILAALVNALALLVVCGYLAWAGISRLADPVSVDAGPMVAFAAVGLVANAVSLV
ILNRSETGSLNLRGAANEVFADLVGSVLAVLAGAVIWVWGLDRADPIASLVIAALILPRSLVLLRESAAILLEVAPRGLD
LDDVRRHLLAMPGVLDVHDLHAWTITSGMPSLSAHVTVTEEALAELGVGGVLDRLSECTAEHFDVRHSTFQVEPVTHREH
EDLGEVH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=260, Percent_Identity=28.0769230769231, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI64762489, Length=194, Percent_Identity=31.9587628865979, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI289803013, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI289803009, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI289803007, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI289803003, Length=231, Percent_Identity=29.004329004329, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI14210520, Length=220, Percent_Identity=28.6363636363636, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI21361112, Length=260, Percent_Identity=27.3076923076923, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI52351208, Length=169, Percent_Identity=26.0355029585799, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786966, Length=218, Percent_Identity=37.1559633027523, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193210990, Length=256, Percent_Identity=26.953125, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17555794, Length=260, Percent_Identity=27.6923076923077, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17555796, Length=260, Percent_Identity=27.6923076923077, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI32564488, Length=272, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=114, Percent_Identity=35.9649122807018, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324892, Length=157, Percent_Identity=28.6624203821656, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24583858, Length=276, Percent_Identity=22.8260869565217, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585900, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585898, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585896, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921672, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584409, Length=152, Percent_Identity=25.6578947368421, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28574430, Length=152, Percent_Identity=25.6578947368421, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 25898; Mature: 25898

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLALGASYVASRGGGPRSTFGLHRAEILAALVNALALLVVCGYLAWAGISRLADPVSVD
CEEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGPMVAFAAVGLVANAVSLVILNRSETGSLNLRGAANEVFADLVGSVLAVLAGAVIWVWG
CCHHHHHHHHHHHHHHHHEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
LDRADPIASLVIAALILPRSLVLLRESAAILLEVAPRGLDLDDVRRHLLAMPGVLDVHDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCCCHHHC
HAWTITSGMPSLSAHVTVTEEALAELGVGGVLDRLSECTAEHFDVRHSTFQVEPVTHREH
CEEEECCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCH
EDLGEVH
HHCCCCC
>Mature Secondary Structure
MVLALGASYVASRGGGPRSTFGLHRAEILAALVNALALLVVCGYLAWAGISRLADPVSVD
CEEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGPMVAFAAVGLVANAVSLVILNRSETGSLNLRGAANEVFADLVGSVLAVLAGAVIWVWG
CCHHHHHHHHHHHHHHHHEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
LDRADPIASLVIAALILPRSLVLLRESAAILLEVAPRGLDLDDVRRHLLAMPGVLDVHDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCCCCCHHHC
HAWTITSGMPSLSAHVTVTEEALAELGVGGVLDRLSECTAEHFDVRHSTFQVEPVTHREH
CEEEECCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCH
EDLGEVH
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]