Click here to switch to the map view.

The map label for this gene is pdhA [H]

Identifier: 119718728

GI number: 119718728

Start: 4768856

End: 4770052

Strand: Reverse

Name: pdhA [H]

Synonym: Noca_4509

Alternate gene names: 119718728

Gene position: 4770052-4768856 (Counterclockwise)

Preceding gene: 119718729

Following gene: 119718727

Centisome position: 95.67

GC content: 71.6

Gene sequence:

>1197_bases
GTGACCCAGCAGGCAGCGGGAGGCAACCCCGCACACACGGCTGGCTTCGGCCCCGACCTCGCCGAGGTCTTCGGGCCCGC
CCAGCAGGACGGCGGACCCGAGCTGGTCCAGCTGCTCACCCCCGAGGGAGAGCGGGTCGAGCACCCCGACTTCTCCTTCG
ATCTCGGCGACGACACCATCCTCGGCTTCTACCGCGACATGGTGCTGACCCGGCGCATCGACACCGAGGCGACCGCGCTG
CAGCGGCACGGCGAGCTCGGCATCTGGGCCCAGCTGCTCGGCCAGGAGGCCGCGCAGATCGGCGCCGGCCGCGCGCTGCG
CCCGCAGGACTTCGTGTTCCCGACCTACCGCGAGCACGGCGTCGCCTGGTGCCGCGGCATCGACCCGCTGGATCTGCTCG
GCCTGTTCCGCGGCGTCGACCAGGGCTCGTGGGACCCGAAGGACAAGAACTTCGGCCTTTACACGATCGTGATCGGCGCC
CAGACCCTGCACGCCACCGGCTACGCCATGGGCATGCAGCGCGACGGCGTCGTCGGCACCGGCGACCCCGACCGCGACGC
CGCGGTGATCGCGCACTTCGGCGACGGCGCGTCCTCGCAGGGCGACGTCAACGAGTCGTTCGTCTTCGCCGCCTCCTACA
ACGCGCCGGTGGTGTTCTTCTGCCAGAACAACCAGTGGGCGATCTCCGAGCCGTTCGAGCGGCAGAGTCGGATCCCGCTC
TACCAGCGGGCGCTCGGCTTCGGCTTCCCCGGCGTGCGCGTCGACGGCAACGACGTGCTCGCGACGTACGCCGTCACCCA
GGCGGCGCTCGACCGGGCCCGCGACGGCCAGGGCCCGACGTTCGTGGAGGCGTACACCTACCGGATGGGCGCGCACACCA
CGACCGACGACCCGACCCGCTACCGGCTCTCCGACGACCTGGAGCGCTGGAAGCTCAAGGACCCGATCGCCCGCGTCGAG
GCCTACCTGCGCCGCAACGGCATCGCCGACGACGCGTTCTTCGCCGGCGTCCAGGAGGAGGCCGCCGACCTCGGCGTCCG
ACTGCGCGAGGGCTGCCGGGCGCTGCCCGACCCCTCGCCGCTGAGCATCTTCGACCACGTCTACACAGAGCTCACCGAGG
AGCTCGAGCAGCAGCGGGAGGCGTTCGCCGCCTACCTTGCCAGCTTCGATGGCGCGGACTTCGAGGGGGCGCACTGA

Upstream 100 bases:

>100_bases
GTTCCGGGTCACAGGGCGCACCACCCCCGCGCCCCGCGTCCGGACCGGCTGACATCGGCACGCGGAGACCCCGTACCGCC
GACGACTCGAAGGAGCGCAC

Downstream 100 bases:

>100_bases
CATGACGCAGAAGATCACGTTGGCCAAGGGCCTCAACATGGGGCTGCGCAAGGCGATGGAGGACGACCCCAAGGTCCTGC
TCATGGGCGAGGACGTCGGC

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTQQAAGGNPAHTAGFGPDLAEVFGPAQQDGGPELVQLLTPEGERVEHPDFSFDLGDDTILGFYRDMVLTRRIDTEATAL
QRHGELGIWAQLLGQEAAQIGAGRALRPQDFVFPTYREHGVAWCRGIDPLDLLGLFRGVDQGSWDPKDKNFGLYTIVIGA
QTLHATGYAMGMQRDGVVGTGDPDRDAAVIAHFGDGASSQGDVNESFVFAASYNAPVVFFCQNNQWAISEPFERQSRIPL
YQRALGFGFPGVRVDGNDVLATYAVTQAALDRARDGQGPTFVEAYTYRMGAHTTTDDPTRYRLSDDLERWKLKDPIARVE
AYLRRNGIADDAFFAGVQEEAADLGVRLREGCRALPDPSPLSIFDHVYTELTEELEQQREAFAAYLASFDGADFEGAH

Sequences:

>Translated_398_residues
MTQQAAGGNPAHTAGFGPDLAEVFGPAQQDGGPELVQLLTPEGERVEHPDFSFDLGDDTILGFYRDMVLTRRIDTEATAL
QRHGELGIWAQLLGQEAAQIGAGRALRPQDFVFPTYREHGVAWCRGIDPLDLLGLFRGVDQGSWDPKDKNFGLYTIVIGA
QTLHATGYAMGMQRDGVVGTGDPDRDAAVIAHFGDGASSQGDVNESFVFAASYNAPVVFFCQNNQWAISEPFERQSRIPL
YQRALGFGFPGVRVDGNDVLATYAVTQAALDRARDGQGPTFVEAYTYRMGAHTTTDDPTRYRLSDDLERWKLKDPIARVE
AYLRRNGIADDAFFAGVQEEAADLGVRLREGCRALPDPSPLSIFDHVYTELTEELEQQREAFAAYLASFDGADFEGAH
>Mature_397_residues
TQQAAGGNPAHTAGFGPDLAEVFGPAQQDGGPELVQLLTPEGERVEHPDFSFDLGDDTILGFYRDMVLTRRIDTEATALQ
RHGELGIWAQLLGQEAAQIGAGRALRPQDFVFPTYREHGVAWCRGIDPLDLLGLFRGVDQGSWDPKDKNFGLYTIVIGAQ
TLHATGYAMGMQRDGVVGTGDPDRDAAVIAHFGDGASSQGDVNESFVFAASYNAPVVFFCQNNQWAISEPFERQSRIPLY
QRALGFGFPGVRVDGNDVLATYAVTQAALDRARDGQGPTFVEAYTYRMGAHTTTDDPTRYRLSDDLERWKLKDPIARVEA
YLRRNGIADDAFFAGVQEEAADLGVRLREGCRALPDPSPLSIFDHVYTELTEELEQQREAFAAYLASFDGADFEGAH

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI258645172, Length=382, Percent_Identity=31.413612565445, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI11386135, Length=383, Percent_Identity=31.331592689295, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI4885543, Length=325, Percent_Identity=29.2307692307692, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4505685, Length=328, Percent_Identity=27.7439024390244, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI291084742, Length=328, Percent_Identity=27.7439024390244, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI291084744, Length=335, Percent_Identity=27.1641791044776, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI291084757, Length=321, Percent_Identity=26.1682242990654, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI86563357, Length=353, Percent_Identity=31.4447592067989, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI86563355, Length=353, Percent_Identity=31.4447592067989, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17536047, Length=302, Percent_Identity=29.1390728476821, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=302, Percent_Identity=29.1390728476821, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=357, Percent_Identity=33.0532212885154, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355903, Length=349, Percent_Identity=30.0859598853868, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24639744, Length=280, Percent_Identity=31.0714285714286, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28571106, Length=280, Percent_Identity=31.0714285714286, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24639740, Length=280, Percent_Identity=31.0714285714286, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24639748, Length=293, Percent_Identity=29.3515358361775, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639746, Length=260, Percent_Identity=31.1538461538462, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 43634; Mature: 43503

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQAAGGNPAHTAGFGPDLAEVFGPAQQDGGPELVQLLTPEGERVEHPDFSFDLGDDTI
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHEECCCCCCCCCCCCCEECCCCHH
LGFYRDMVLTRRIDTEATALQRHGELGIWAQLLGQEAAQIGAGRALRPQDFVFPTYREHG
HHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCC
VAWCRGIDPLDLLGLFRGVDQGSWDPKDKNFGLYTIVIGAQTLHATGYAMGMQRDGVVGT
CHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHEECCCCCCEECC
GDPDRDAAVIAHFGDGASSQGDVNESFVFAASYNAPVVFFCQNNQWAISEPFERQSRIPL
CCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEECCCCEECCCCHHHHCCCCH
YQRALGFGFPGVRVDGNDVLATYAVTQAALDRARDGQGPTFVEAYTYRMGAHTTTDDPTR
HHHHHHCCCCCEEECCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCE
YRLSDDLERWKLKDPIARVEAYLRRNGIADDAFFAGVQEEAADLGVRLREGCRALPDPSP
ECHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCCCC
LSIFDHVYTELTEELEQQREAFAAYLASFDGADFEGAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TQQAAGGNPAHTAGFGPDLAEVFGPAQQDGGPELVQLLTPEGERVEHPDFSFDLGDDTI
CCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHEECCCCCCCCCCCCCEECCCCHH
LGFYRDMVLTRRIDTEATALQRHGELGIWAQLLGQEAAQIGAGRALRPQDFVFPTYREHG
HHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCC
VAWCRGIDPLDLLGLFRGVDQGSWDPKDKNFGLYTIVIGAQTLHATGYAMGMQRDGVVGT
CHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHEECCCCCCEECC
GDPDRDAAVIAHFGDGASSQGDVNESFVFAASYNAPVVFFCQNNQWAISEPFERQSRIPL
CCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEECCCCEECCCCHHHHCCCCH
YQRALGFGFPGVRVDGNDVLATYAVTQAALDRARDGQGPTFVEAYTYRMGAHTTTDDPTR
HHHHHHCCCCCEEECCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCE
YRLSDDLERWKLKDPIARVEAYLRRNGIADDAFFAGVQEEAADLGVRLREGCRALPDPSP
ECHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCCCC
LSIFDHVYTELTEELEQQREAFAAYLASFDGADFEGAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA