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The map label for this gene is pdhB [H]

Identifier: 119718673

GI number: 119718673

Start: 4708376

End: 4710556

Strand: Reverse

Name: pdhB [H]

Synonym: Noca_4454

Alternate gene names: 119718673

Gene position: 4710556-4708376 (Counterclockwise)

Preceding gene: 119718681

Following gene: 119718672

Centisome position: 94.48

GC content: 71.99

Gene sequence:

>2181_bases
ATGCCCGAGCACCACCCCCTCGCCCCCGCGTCGCCGTGGGTCGAGGTCGTCGCGACCGAGGCGGACTGGGACGCCGCCGA
CCCGCAGCTGCTGCGCACGATCTACGCCCAGCTGGTCTGGATCCGGACCTTCGAGCAGTACGTCCTCGACCTGGCGGCGA
GCGGCCTGATCCACGGCCCCGCCCACTCCAGCATCGGCCAGGAGGGCGGCGCGGTCGGGTCGGTCCTCGCGCTCACCAGC
GCCGACTCGGTCAACGGGTCGCACCGCGGCCACCACCAGTTCCTCGCCAAGGCGCTCCACCACGTCGAGCCGAAGGGGAT
GGACCCGCTCGAGGCGCCCTCGGAGCAGGTCCGCGACGTGCTGCTGCGCACCCTCGCCGAGATCTGCGGCCTGGACCGCG
GCTGGAGCCACGGTCGCGGCGGGTCGATGCACCTGCAGTGGAAGGAGGCCGGCGCGATGGGCACCAACGCCATCGTCGGC
GGCGGCGTCCCGCAGGCGGCCGGGTTCGCGTGGTCGCACCGCCAGGCGGGCACCGACGCGGTGTCGGTGACCTACTTCGG
CGACGGGGCGGTCAACATCGGCTCCACCCTGGAGACCATGAACCTGGCCGGCGCCTGGTCGCTGCCGGTGTGCTTCTTCA
TCGAGAACAACCGGTACGCCGTGTCCACGTCGGTCGACGAGGCCACCGCGGAGCCGCGGCTCTCGGCGCGCGGGCTCGGC
TTCAACCTCGCCAGCTGGAAGGTCGACGGGATGGACCCGCTGGCCGTGCACCTCGCGATGTCCGAGGCCGTCGAGCACAT
GCGGCGTGGCCGGGGCGCGACCGTCGTCGAGGTCGACACCTACCGCTTCTTCCACCAGAACGGCGGGTTCGCGGGCAGCG
CGTTCGGCTACCGCGACAAGGAGGAGGAGCGGGCCTGGCGCGCCCGGGACCCGCTCACGCAGACCGCCGCCCACCTCGAG
CGGCGCGGCATCATGACCGCCGAGGAGACCGCCGAGGCGATCACCCGGGCCAAGGCCGTGATGGAGGAGATCGGCCGCGA
GCTGGTCGAGCCGCTGCCCGACGGCAAGCCCGGGCAGCGCCGGATCCGGCCCGCGGAGTGGCCCGACCCGGACTGGGTGG
ACGTCGGCGTGCGCGGCGACCTCAGCGAGCTCGACGGCGCCCGGATCGTCGCGGCCGACGGATTCGCCGTACCCGTGCAG
GAGACGAAGTTCATCGACGCGGTCGCCGCCGTCATGGGCCGCCGCATGGAGACCGACCAGGGCATCGTCGTGATGGGCGA
GGACGTGCACCGGCTCAACGGCGGCACCAACGGCGCCACCCGTGGCCTCACCGAGCTGTTCCCCGGCCGGATCCTCGGCA
CCCCCATCAGCGAGAACGCGTTCACCGGCCTGGCCGGCGGCATCGCGCTCGACGGTCGCTACACGCCGGTCGTGGAGTTC
ATGTACGCCGACTTCATGTGGGTCGCGGCCGACCAGCTGTTCAACCAGATCGGCAAGGCCCGGCACATGTACGGCGGGGC
GTCCGGCGTCCCACTGGTGCTGCGCAGCAAGGTGGCGATGGGCACCGGCTACGGGTCGCAGCACTCGATGGACCCGGCCG
GCATCTTCGCCACGAACCCGGGCTGGCGGATCGTCGCGCCGTCCACGCCGTACGACTACGTGGGGCTGATGAACACCGCG
CTGCGCTGCGCGGACCCGGTGGTCGTGCTCGAGCACGTCGACCTCTACGGCTCGACCGGCCCGGGGCCGGTCGACGACTA
CGACTACTGCCTGCCGGTCGGCAAGGCCGCGATCCGGCGTCCCGGCAAGGACGTCACGATCCTCACCTACCTCGGGATGG
TGCCGTTCGTGCTGGGCGCGGTCGAGGAGTTCGGGCAGGTCGACGCCGAGGTGATCGACCTGCGCTGGCTGGACCGCGCG
AGCATCGACTGGGACACGATCGAGGAGAGCCTGACCAAGACCAACCAGGTGTTGATCGCCGAGCAGGGCGCGGTCGGGAC
GTCGTACGGCGGCTGGCTCGCCGACGAGATCCACCGGCGGTTCTTCGACCTGCTCGACGCCCCGGTCCGACGGGTGACCG
GTGCCGAGGCGTCGCCGAGCATCAGCAAGGTGCTCGAGCGGGCCGCGATCGCCCAGCAGGACGAGGTCATCGCCGAGCTC
GCCGAGATCGCGAGGTACTGA

Upstream 100 bases:

>100_bases
AGCACGCCAAGGACGTGGCGTCCATCACTTCGTGGGGTGGATTTTGGATCCAATTCTGTGTCATCGTGGATCGCAGCACC
CCCGGCCTAGGAGCGCCCGC

Downstream 100 bases:

>100_bases
CGTGCCCCGGGTGCTGCGCATGCCCGAGGTCGCCGCGAACGCGACCGAGGCCGTCCTGGCCGAGTGGCTGGTCTCCGAGA
ACGCCGAGTTCGGCGCGCTC

Product: dehydrogenase, E1 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 726; Mature: 725

Protein sequence:

>726_residues
MPEHHPLAPASPWVEVVATEADWDAADPQLLRTIYAQLVWIRTFEQYVLDLAASGLIHGPAHSSIGQEGGAVGSVLALTS
ADSVNGSHRGHHQFLAKALHHVEPKGMDPLEAPSEQVRDVLLRTLAEICGLDRGWSHGRGGSMHLQWKEAGAMGTNAIVG
GGVPQAAGFAWSHRQAGTDAVSVTYFGDGAVNIGSTLETMNLAGAWSLPVCFFIENNRYAVSTSVDEATAEPRLSARGLG
FNLASWKVDGMDPLAVHLAMSEAVEHMRRGRGATVVEVDTYRFFHQNGGFAGSAFGYRDKEEERAWRARDPLTQTAAHLE
RRGIMTAEETAEAITRAKAVMEEIGRELVEPLPDGKPGQRRIRPAEWPDPDWVDVGVRGDLSELDGARIVAADGFAVPVQ
ETKFIDAVAAVMGRRMETDQGIVVMGEDVHRLNGGTNGATRGLTELFPGRILGTPISENAFTGLAGGIALDGRYTPVVEF
MYADFMWVAADQLFNQIGKARHMYGGASGVPLVLRSKVAMGTGYGSQHSMDPAGIFATNPGWRIVAPSTPYDYVGLMNTA
LRCADPVVVLEHVDLYGSTGPGPVDDYDYCLPVGKAAIRRPGKDVTILTYLGMVPFVLGAVEEFGQVDAEVIDLRWLDRA
SIDWDTIEESLTKTNQVLIAEQGAVGTSYGGWLADEIHRRFFDLLDAPVRRVTGAEASPSISKVLERAAIAQQDEVIAEL
AEIARY

Sequences:

>Translated_726_residues
MPEHHPLAPASPWVEVVATEADWDAADPQLLRTIYAQLVWIRTFEQYVLDLAASGLIHGPAHSSIGQEGGAVGSVLALTS
ADSVNGSHRGHHQFLAKALHHVEPKGMDPLEAPSEQVRDVLLRTLAEICGLDRGWSHGRGGSMHLQWKEAGAMGTNAIVG
GGVPQAAGFAWSHRQAGTDAVSVTYFGDGAVNIGSTLETMNLAGAWSLPVCFFIENNRYAVSTSVDEATAEPRLSARGLG
FNLASWKVDGMDPLAVHLAMSEAVEHMRRGRGATVVEVDTYRFFHQNGGFAGSAFGYRDKEEERAWRARDPLTQTAAHLE
RRGIMTAEETAEAITRAKAVMEEIGRELVEPLPDGKPGQRRIRPAEWPDPDWVDVGVRGDLSELDGARIVAADGFAVPVQ
ETKFIDAVAAVMGRRMETDQGIVVMGEDVHRLNGGTNGATRGLTELFPGRILGTPISENAFTGLAGGIALDGRYTPVVEF
MYADFMWVAADQLFNQIGKARHMYGGASGVPLVLRSKVAMGTGYGSQHSMDPAGIFATNPGWRIVAPSTPYDYVGLMNTA
LRCADPVVVLEHVDLYGSTGPGPVDDYDYCLPVGKAAIRRPGKDVTILTYLGMVPFVLGAVEEFGQVDAEVIDLRWLDRA
SIDWDTIEESLTKTNQVLIAEQGAVGTSYGGWLADEIHRRFFDLLDAPVRRVTGAEASPSISKVLERAAIAQQDEVIAEL
AEIARY
>Mature_725_residues
PEHHPLAPASPWVEVVATEADWDAADPQLLRTIYAQLVWIRTFEQYVLDLAASGLIHGPAHSSIGQEGGAVGSVLALTSA
DSVNGSHRGHHQFLAKALHHVEPKGMDPLEAPSEQVRDVLLRTLAEICGLDRGWSHGRGGSMHLQWKEAGAMGTNAIVGG
GVPQAAGFAWSHRQAGTDAVSVTYFGDGAVNIGSTLETMNLAGAWSLPVCFFIENNRYAVSTSVDEATAEPRLSARGLGF
NLASWKVDGMDPLAVHLAMSEAVEHMRRGRGATVVEVDTYRFFHQNGGFAGSAFGYRDKEEERAWRARDPLTQTAAHLER
RGIMTAEETAEAITRAKAVMEEIGRELVEPLPDGKPGQRRIRPAEWPDPDWVDVGVRGDLSELDGARIVAADGFAVPVQE
TKFIDAVAAVMGRRMETDQGIVVMGEDVHRLNGGTNGATRGLTELFPGRILGTPISENAFTGLAGGIALDGRYTPVVEFM
YADFMWVAADQLFNQIGKARHMYGGASGVPLVLRSKVAMGTGYGSQHSMDPAGIFATNPGWRIVAPSTPYDYVGLMNTAL
RCADPVVVLEHVDLYGSTGPGPVDDYDYCLPVGKAAIRRPGKDVTILTYLGMVPFVLGAVEEFGQVDAEVIDLRWLDRAS
IDWDTIEESLTKTNQVLIAEQGAVGTSYGGWLADEIHRRFFDLLDAPVRRVTGAEASPSISKVLERAAIAQQDEVIAELA
EIARY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=34.6625766871166, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=32.8220858895706, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI4885543, Length=321, Percent_Identity=31.7757009345794, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4505685, Length=310, Percent_Identity=31.2903225806452, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI291084742, Length=310, Percent_Identity=31.2903225806452, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4557353, Length=304, Percent_Identity=29.2763157894737, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI34101272, Length=304, Percent_Identity=29.2763157894737, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI291084744, Length=317, Percent_Identity=30.5993690851735, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI11386135, Length=337, Percent_Identity=27.5964391691395, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI258645172, Length=337, Percent_Identity=27.5964391691395, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI291084757, Length=310, Percent_Identity=26.7741935483871, Blast_Score=83, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538422, Length=318, Percent_Identity=34.9056603773585, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17536047, Length=320, Percent_Identity=32.5, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=319, Percent_Identity=32.6018808777429, Blast_Score=128, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17506935, Length=303, Percent_Identity=29.042904290429, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI86563357, Length=345, Percent_Identity=26.6666666666667, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=345, Percent_Identity=26.6666666666667, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319698, Length=325, Percent_Identity=33.2307692307692, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321026, Length=338, Percent_Identity=35.207100591716, Blast_Score=156, Evalue=9e-39,
Organism=Drosophila melanogaster, GI21358145, Length=333, Percent_Identity=33.9339339339339, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24650940, Length=333, Percent_Identity=33.9339339339339, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24639748, Length=290, Percent_Identity=33.448275862069, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24639744, Length=310, Percent_Identity=31.2903225806452, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28571106, Length=310, Percent_Identity=31.2903225806452, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24639740, Length=310, Percent_Identity=31.2903225806452, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24639746, Length=304, Percent_Identity=31.25, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI160714832, Length=335, Percent_Identity=29.2537313432836, Blast_Score=123, Evalue=6e-28,
Organism=Drosophila melanogaster, GI160714828, Length=303, Percent_Identity=31.3531353135314, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21355903, Length=357, Percent_Identity=24.3697478991597, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 78384; Mature: 78253

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEHHPLAPASPWVEVVATEADWDAADPQLLRTIYAQLVWIRTFEQYVLDLAASGLIHGP
CCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AHSSIGQEGGAVGSVLALTSADSVNGSHRGHHQFLAKALHHVEPKGMDPLEAPSEQVRDV
CCCCCCCCCCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LLRTLAEICGLDRGWSHGRGGSMHLQWKEAGAMGTNAIVGGGVPQAAGFAWSHRQAGTDA
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCCHHCCCCCCCCCCCCCE
VSVTYFGDGAVNIGSTLETMNLAGAWSLPVCFFIENNRYAVSTSVDEATAEPRLSARGLG
EEEEEECCCCEECCCHHHHHCCCCCCCCCEEEEEECCEEEEECCCHHHCCCCCCCCCCCC
FNLASWKVDGMDPLAVHLAMSEAVEHMRRGRGATVVEVDTYRFFHQNGGFAGSAFGYRDK
CEECCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCCCCCCCCC
EEERAWRARDPLTQTAAHLERRGIMTAEETAEAITRAKAVMEEIGRELVEPLPDGKPGQR
HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RIRPAEWPDPDWVDVGVRGDLSELDGARIVAADGFAVPVQETKFIDAVAAVMGRRMETDQ
CCCCCCCCCCCEEEECCCCCHHHCCCCEEEEECCEEECCHHHHHHHHHHHHHCCCCCCCC
GIVVMGEDVHRLNGGTNGATRGLTELFPGRILGTPISENAFTGLAGGIALDGRYTPVVEF
CEEEECCCHHHHCCCCCHHHHCHHHHCCCCEECCCCCCCCCCCCCCCEEECCCCHHHHHH
MYADFMWVAADQLFNQIGKARHMYGGASGVPLVLRSKVAMGTGYGSQHSMDPAGIFATNP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEECCC
GWRIVAPSTPYDYVGLMNTALRCADPVVVLEHVDLYGSTGPGPVDDYDYCLPVGKAAIRR
CCEEECCCCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCCHHHHCCHHHHHC
PGKDVTILTYLGMVPFVLGAVEEFGQVDAEVIDLRWLDRASIDWDTIEESLTKTNQVLIA
CCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCEEEEE
EQGAVGTSYGGWLADEIHRRFFDLLDAPVRRVTGAEASPSISKVLERAAIAQQDEVIAEL
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEIARY
HHHHCC
>Mature Secondary Structure 
PEHHPLAPASPWVEVVATEADWDAADPQLLRTIYAQLVWIRTFEQYVLDLAASGLIHGP
CCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AHSSIGQEGGAVGSVLALTSADSVNGSHRGHHQFLAKALHHVEPKGMDPLEAPSEQVRDV
CCCCCCCCCCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LLRTLAEICGLDRGWSHGRGGSMHLQWKEAGAMGTNAIVGGGVPQAAGFAWSHRQAGTDA
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCCHHCCCCCCCCCCCCCE
VSVTYFGDGAVNIGSTLETMNLAGAWSLPVCFFIENNRYAVSTSVDEATAEPRLSARGLG
EEEEEECCCCEECCCHHHHHCCCCCCCCCEEEEEECCEEEEECCCHHHCCCCCCCCCCCC
FNLASWKVDGMDPLAVHLAMSEAVEHMRRGRGATVVEVDTYRFFHQNGGFAGSAFGYRDK
CEECCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCCCCCCCCC
EEERAWRARDPLTQTAAHLERRGIMTAEETAEAITRAKAVMEEIGRELVEPLPDGKPGQR
HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RIRPAEWPDPDWVDVGVRGDLSELDGARIVAADGFAVPVQETKFIDAVAAVMGRRMETDQ
CCCCCCCCCCCEEEECCCCCHHHCCCCEEEEECCEEECCHHHHHHHHHHHHHCCCCCCCC
GIVVMGEDVHRLNGGTNGATRGLTELFPGRILGTPISENAFTGLAGGIALDGRYTPVVEF
CEEEECCCHHHHCCCCCHHHHCHHHHCCCCEECCCCCCCCCCCCCCCEEECCCCHHHHHH
MYADFMWVAADQLFNQIGKARHMYGGASGVPLVLRSKVAMGTGYGSQHSMDPAGIFATNP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEECCC
GWRIVAPSTPYDYVGLMNTALRCADPVVVLEHVDLYGSTGPGPVDDYDYCLPVGKAAIRR
CCEEECCCCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCCHHHHCCHHHHHC
PGKDVTILTYLGMVPFVLGAVEEFGQVDAEVIDLRWLDRASIDWDTIEESLTKTNQVLIA
CCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCEEEEE
EQGAVGTSYGGWLADEIHRRFFDLLDAPVRRVTGAEASPSISKVLERAAIAQQDEVIAEL
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AEIARY
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]