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The map label for this gene is pdhC [H]

Identifier: 119718672

GI number: 119718672

Start: 4707091

End: 4708374

Strand: Reverse

Name: pdhC [H]

Synonym: Noca_4453

Alternate gene names: 119718672

Gene position: 4708374-4707091 (Counterclockwise)

Preceding gene: 119718673

Following gene: 119718670

Centisome position: 94.43

GC content: 74.14

Gene sequence:

>1284_bases
GTGCCCCGGGTGCTGCGCATGCCCGAGGTCGCCGCGAACGCGACCGAGGCCGTCCTGGCCGAGTGGCTGGTCTCCGAGAA
CGCCGAGTTCGGCGCGCTCGACACGATCGCCACCGTCGAGACCGAGAAGGCGTTGGTCGACGTCGAGGCCGAGGACGCCG
GCGTCGTGCTGAAGACGCTGGTGCCGCCCGGTGCCTTGGTGGAGGTCGGTGCGCCGATCGCCGTCCTGGGTGCGCCCGGC
GAGGCGGTCGGTGACCTGGGCGCCGTCCTCGCCGAGCTGGGTGTCGCCGAACCCGTCGACCACGTCCTCCCCGAGCGCCG
CTCGTTGGTCGAGCCTGTCGATCCGGTGGTCGAGCCTGTCGAGGCCCCCGCACCGACGCAGGGCAGCAACCACCGCGTCT
TCGCCAGCCCGCTGGCCCGCAGGCTCGCGCGGCTCGCGGAGATCCCGGTGGAGGAGATCGCCGGCACCGGTCCGCGTGGC
CGGATCCTGCGCCGCGACGTCGAGGCCGCCGTCGCCGCGCGCCCGGCCACGCCGGTGGTCGAGCAGCGAGCGCCAGCGAG
CGTCGTCGAGACCCCCGCACCGACCCAGGGCAGTGCCTCGAAGGTCGAGCCCGTCGACGTCCCCCACTCCCGGCTCCGGC
GCGCCGTCGCCAACCGGCTGGCGGAGAGCAAGCAGACCGCGCCGCACTTCTATCTGCGGGCGACGGTGCGCGCCGATCGC
CTCGTCGACCTGCGCGCCGAGCTGAACGAGGGCGCCGAGACCCGAGTCTCGCTCAACGACCTGGTGGTCAAGGCGGTCGC
GGCCGCGCACGCCCGGGTGCCCGAGATGAACGTGGTCTGGACGCCCGATGCGGTCCGGTCGTTCTCCTCGGTCGACGTCG
CGGTCGCGGTCGCGACCGACCGCGGTCTGGTCACGCCGGTGCTGCGCGACGTGACGTCCCTGACCGTCACCGCCGTCGCC
GCGAAGGTCCAGGACCTGGCCGCCCGCGCCCGCGAGGGCCGGCTCAAGCAGGACGAGCTCGAGGGCGGCACGATCAGCGT
CACGAACCTGGGAATGTATGGGGTCGAGGAGTTCGCAGCGATCATCAACCCGCCCCACGCCGCGATCCTCGCGGTCGGCG
CGGTGCGCGAGGAGCCCGTGGTCGAGGACGGCGCGGTCGTCCCCGGCAAGGTGCTGACCGTGACCCTCTCCGTCGACCAC
CGCCCGGTCGACGGCGTGGTCGCCGCCCGCTGGCTCGCGGCCTTCGTCGACCTCGTCGAGCACCCCGCCCGCATCCTCGC
CTGA

Upstream 100 bases:

>100_bases
GCCGAGGCGTCGCCGAGCATCAGCAAGGTGCTCGAGCGGGCCGCGATCGCCCAGCAGGACGAGGTCATCGCCGAGCTCGC
CGAGATCGCGAGGTACTGAC

Downstream 100 bases:

>100_bases
CACCGCTGGTCGAGCTCGTGAGCCGGTGGTCGAGCTTGTCGGGACCCCGGAAGTGGAGGCAGGGCCTCGTGCCCTGACAG
CTGGCTCCGGTCGCCGTCGC

Product: dehydrogenase catalytic domain-containing protein

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MPRVLRMPEVAANATEAVLAEWLVSENAEFGALDTIATVETEKALVDVEAEDAGVVLKTLVPPGALVEVGAPIAVLGAPG
EAVGDLGAVLAELGVAEPVDHVLPERRSLVEPVDPVVEPVEAPAPTQGSNHRVFASPLARRLARLAEIPVEEIAGTGPRG
RILRRDVEAAVAARPATPVVEQRAPASVVETPAPTQGSASKVEPVDVPHSRLRRAVANRLAESKQTAPHFYLRATVRADR
LVDLRAELNEGAETRVSLNDLVVKAVAAAHARVPEMNVVWTPDAVRSFSSVDVAVAVATDRGLVTPVLRDVTSLTVTAVA
AKVQDLAARAREGRLKQDELEGGTISVTNLGMYGVEEFAAIINPPHAAILAVGAVREEPVVEDGAVVPGKVLTVTLSVDH
RPVDGVVAARWLAAFVDLVEHPARILA

Sequences:

>Translated_427_residues
MPRVLRMPEVAANATEAVLAEWLVSENAEFGALDTIATVETEKALVDVEAEDAGVVLKTLVPPGALVEVGAPIAVLGAPG
EAVGDLGAVLAELGVAEPVDHVLPERRSLVEPVDPVVEPVEAPAPTQGSNHRVFASPLARRLARLAEIPVEEIAGTGPRG
RILRRDVEAAVAARPATPVVEQRAPASVVETPAPTQGSASKVEPVDVPHSRLRRAVANRLAESKQTAPHFYLRATVRADR
LVDLRAELNEGAETRVSLNDLVVKAVAAAHARVPEMNVVWTPDAVRSFSSVDVAVAVATDRGLVTPVLRDVTSLTVTAVA
AKVQDLAARAREGRLKQDELEGGTISVTNLGMYGVEEFAAIINPPHAAILAVGAVREEPVVEDGAVVPGKVLTVTLSVDH
RPVDGVVAARWLAAFVDLVEHPARILA
>Mature_426_residues
PRVLRMPEVAANATEAVLAEWLVSENAEFGALDTIATVETEKALVDVEAEDAGVVLKTLVPPGALVEVGAPIAVLGAPGE
AVGDLGAVLAELGVAEPVDHVLPERRSLVEPVDPVVEPVEAPAPTQGSNHRVFASPLARRLARLAEIPVEEIAGTGPRGR
ILRRDVEAAVAARPATPVVEQRAPASVVETPAPTQGSASKVEPVDVPHSRLRRAVANRLAESKQTAPHFYLRATVRADRL
VDLRAELNEGAETRVSLNDLVVKAVAAAHARVPEMNVVWTPDAVRSFSSVDVAVAVATDRGLVTPVLRDVTSLTVTAVAA
KVQDLAARAREGRLKQDELEGGTISVTNLGMYGVEEFAAIINPPHAAILAVGAVREEPVVEDGAVVPGKVLTVTLSVDHR
PVDGVVAARWLAAFVDLVEHPARILA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=435, Percent_Identity=35.8620689655172, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI203098816, Length=454, Percent_Identity=30.3964757709251, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI203098753, Length=454, Percent_Identity=30.3964757709251, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI260898739, Length=168, Percent_Identity=38.0952380952381, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI110671329, Length=443, Percent_Identity=24.1534988713318, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI19923748, Length=223, Percent_Identity=30.9417040358744, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786946, Length=373, Percent_Identity=33.2439678284182, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1786305, Length=295, Percent_Identity=30.1694915254237, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17560088, Length=448, Percent_Identity=33.4821428571429, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17538894, Length=287, Percent_Identity=38.6759581881533, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17537937, Length=436, Percent_Identity=27.2935779816514, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25146366, Length=412, Percent_Identity=28.1553398058252, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324258, Length=453, Percent_Identity=32.4503311258278, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320352, Length=428, Percent_Identity=28.5046728971963, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24582497, Length=301, Percent_Identity=39.8671096345515, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI20129315, Length=301, Percent_Identity=39.8671096345515, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI18859875, Length=439, Percent_Identity=24.8291571753986, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24645909, Length=225, Percent_Identity=30.2222222222222, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR006257
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 44843; Mature: 44712

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVLRMPEVAANATEAVLAEWLVSENAEFGALDTIATVETEKALVDVEAEDAGVVLKTL
CCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHEEEECCCCCCEEEEEC
VPPGALVEVGAPIAVLGAPGEAVGDLGAVLAELGVAEPVDHVLPERRSLVEPVDPVVEPV
CCCCCEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHCCC
EAPAPTQGSNHRVFASPLARRLARLAEIPVEEIAGTGPRGRILRRDVEAAVAARPATPVV
CCCCCCCCCCCEEEHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHH
EQRAPASVVETPAPTQGSASKVEPVDVPHSRLRRAVANRLAESKQTAPHFYLRATVRADR
HCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHH
LVDLRAELNEGAETRVSLNDLVVKAVAAAHARVPEMNVVWTPDAVRSFSSVDVAVAVATD
HHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCEEEEEEECC
RGLVTPVLRDVTSLTVTAVAAKVQDLAARAREGRLKQDELEGGTISVTNLGMYGVEEFAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCHHHHHHHHH
IINPPHAAILAVGAVREEPVVEDGAVVPGKVLTVTLSVDHRPVDGVVAARWLAAFVDLVE
HHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
HPARILA
HHHHHCC
>Mature Secondary Structure 
PRVLRMPEVAANATEAVLAEWLVSENAEFGALDTIATVETEKALVDVEAEDAGVVLKTL
CCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHEEEECCCCCCEEEEEC
VPPGALVEVGAPIAVLGAPGEAVGDLGAVLAELGVAEPVDHVLPERRSLVEPVDPVVEPV
CCCCCEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHCCC
EAPAPTQGSNHRVFASPLARRLARLAEIPVEEIAGTGPRGRILRRDVEAAVAARPATPVV
CCCCCCCCCCCEEEHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHH
EQRAPASVVETPAPTQGSASKVEPVDVPHSRLRRAVANRLAESKQTAPHFYLRATVRADR
HCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHH
LVDLRAELNEGAETRVSLNDLVVKAVAAAHARVPEMNVVWTPDAVRSFSSVDVAVAVATD
HHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCEEEEEEECC
RGLVTPVLRDVTSLTVTAVAAKVQDLAARAREGRLKQDELEGGTISVTNLGMYGVEEFAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCHHHHHHHHH
IINPPHAAILAVGAVREEPVVEDGAVVPGKVLTVTLSVDHRPVDGVVAARWLAAFVDLVE
HHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
HPARILA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA