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The map label for this gene is menB [H]

Identifier: 119718518

GI number: 119718518

Start: 4541839

End: 4542636

Strand: Reverse

Name: menB [H]

Synonym: Noca_4299

Alternate gene names: 119718518

Gene position: 4542636-4541839 (Counterclockwise)

Preceding gene: 119718520

Following gene: 119718517

Centisome position: 91.11

GC content: 68.55

Gene sequence:

>798_bases
GTGACCGACTTCGAGGACATCACCTACGTCGTGGAGGATTCGGCGGCGATCATCACGATCAGCCGGCCGGAGCGGTACAA
CGCCTTCCGGGCGAAGACCGTCGACGAGCTGATCAAGGCGTTCCGGCTCGCGTGGGCGGACCGGCAGGTGCAGTCGGTGA
TCCTCACCGGCTCCGGCGAGAAGGCGTTCTGCACCGGTGGCGACGTCAAGCAGCGCGCGGAGACCGGCGACTACGGTCCG
AGCGAGAGCGGCATGTTCGAGATCGGCAACCTGCACAAGCTGATCCGAGACATCCCCAAGCCCGTGATCGCGGCGGTCAA
CGGGATCGCGGTCGGTGGCGGCCACGTGCTGCACGTGCTCTGCGACGTGTCGATCGCGAGCGAGAACGCGCGCTTCGGCC
AAGCGGGGCCCCGGGTCGGCTCCTTCGACGCCGGCTTCGGCTCGGCGTACCTCGCCCGGGTCGTGGGGGAGAAGAAGGCC
CGCGAGATCTGGTTCTGGTGCCGCCAGTACGACGCCTCCGAGGCGCTCGCGATGGGCCTGGTGAACAAGGTGGTCCCGGC
CGACCGGTTGCTCGACGAGGCCAAGGAGTGGGCGGCGGAGGTCGCCGAGAAGAGCCCCACGGCCATCCGCTTCCTCAAGC
AGTCCTTCAACGCCGACACCGACCACCAGGCCGGTCTCAGCAACCTGGCGATGAGCGCGCTCGACCTGTTCACCGCCTCG
CCCGAGGGCCTCGAGGGCGCCGCCGCCTTCGCGGAGAAGCGCAAGCCCGACTTCAACCAGCACGTCAACTGGCACTGA

Upstream 100 bases:

>100_bases
GCGTTCACTTTAGGGCATCGAAGGTCTTGACGCGCCGGATGTGATGAACCTATCTTCATCGTAAGTGAACGGATATTCAT
TTTCGTCGAGAGGGCAGCAC

Downstream 100 bases:

>100_bases
CGCGCAGGAGGCGAACCGACCATGGACTACGGATTCGACGAGGACCAGGAGGCGTTCCGCCAGGAGGTCCGGCGGTTCGC
CGCCAAGACCCTGGCGCCGC

Product: 1,4-dihydroxy-2-naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTDFEDITYVVEDSAAIITISRPERYNAFRAKTVDELIKAFRLAWADRQVQSVILTGSGEKAFCTGGDVKQRAETGDYGP
SESGMFEIGNLHKLIRDIPKPVIAAVNGIAVGGGHVLHVLCDVSIASENARFGQAGPRVGSFDAGFGSAYLARVVGEKKA
REIWFWCRQYDASEALAMGLVNKVVPADRLLDEAKEWAAEVAEKSPTAIRFLKQSFNADTDHQAGLSNLAMSALDLFTAS
PEGLEGAAAFAEKRKPDFNQHVNWH

Sequences:

>Translated_265_residues
MTDFEDITYVVEDSAAIITISRPERYNAFRAKTVDELIKAFRLAWADRQVQSVILTGSGEKAFCTGGDVKQRAETGDYGP
SESGMFEIGNLHKLIRDIPKPVIAAVNGIAVGGGHVLHVLCDVSIASENARFGQAGPRVGSFDAGFGSAYLARVVGEKKA
REIWFWCRQYDASEALAMGLVNKVVPADRLLDEAKEWAAEVAEKSPTAIRFLKQSFNADTDHQAGLSNLAMSALDLFTAS
PEGLEGAAAFAEKRKPDFNQHVNWH
>Mature_264_residues
TDFEDITYVVEDSAAIITISRPERYNAFRAKTVDELIKAFRLAWADRQVQSVILTGSGEKAFCTGGDVKQRAETGDYGPS
ESGMFEIGNLHKLIRDIPKPVIAAVNGIAVGGGHVLHVLCDVSIASENARFGQAGPRVGSFDAGFGSAYLARVVGEKKAR
EIWFWCRQYDASEALAMGLVNKVVPADRLLDEAKEWAAEVAEKSPTAIRFLKQSFNADTDHQAGLSNLAMSALDLFTASP
EGLEGAAAFAEKRKPDFNQHVNWH

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=252, Percent_Identity=32.9365079365079, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI31542718, Length=243, Percent_Identity=32.9218106995885, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4502327, Length=252, Percent_Identity=30.1587301587302, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI45643119, Length=216, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI260275230, Length=216, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI260274832, Length=216, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI70995211, Length=231, Percent_Identity=29.4372294372294, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI150378541, Length=247, Percent_Identity=27.9352226720648, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI157694516, Length=213, Percent_Identity=25.8215962441315, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI213417737, Length=213, Percent_Identity=25.8215962441315, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI68989263, Length=208, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI25453481, Length=261, Percent_Identity=25.2873563218391, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI51538573, Length=261, Percent_Identity=25.2873563218391, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI20127408, Length=211, Percent_Identity=26.5402843601896, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4757966, Length=215, Percent_Identity=27.4418604651163, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI51538581, Length=215, Percent_Identity=27.4418604651163, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4757968, Length=260, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI49355787, Length=260, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI37594471, Length=155, Percent_Identity=26.4516129032258, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1788597, Length=260, Percent_Identity=53.0769230769231, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1787659, Length=250, Percent_Identity=32, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI221142681, Length=249, Percent_Identity=34.5381526104418, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=31.0344827586207, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082183, Length=267, Percent_Identity=26.9662921348315, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788682, Length=202, Percent_Identity=26.2376237623762, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790281, Length=239, Percent_Identity=28.0334728033473, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=34.5381526104418, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25145438, Length=247, Percent_Identity=36.4372469635627, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17540714, Length=221, Percent_Identity=28.5067873303167, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17536985, Length=263, Percent_Identity=29.277566539924, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=203, Percent_Identity=29.5566502463054, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=240, Percent_Identity=28.3333333333333, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=251, Percent_Identity=30.2788844621514, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=217, Percent_Identity=28.110599078341, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=205, Percent_Identity=24.8780487804878, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=153, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=153, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=200, Percent_Identity=26, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129971, Length=247, Percent_Identity=35.2226720647773, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24653477, Length=247, Percent_Identity=35.2226720647773, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24653139, Length=252, Percent_Identity=30.1587301587302, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922422, Length=257, Percent_Identity=28.0155642023346, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19920382, Length=232, Percent_Identity=28.8793103448276, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357171, Length=247, Percent_Identity=27.1255060728745, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650670, Length=248, Percent_Identity=27.0161290322581, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571729, Length=141, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571730, Length=141, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 28849; Mature: 28718

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFEDITYVVEDSAAIITISRPERYNAFRAKTVDELIKAFRLAWADRQVQSVILTGSGE
CCCHHHEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
KAFCTGGDVKQRAETGDYGPSESGMFEIGNLHKLIRDIPKPVIAAVNGIAVGGGHVLHVL
EEEECCCCHHHHHCCCCCCCCCCCCEEHHHHHHHHHHCCHHHHHHHCCEEECCHHHHHHH
CDVSIASENARFGQAGPRVGSFDAGFGSAYLARVVGEKKAREIWFWCRQYDASEALAMGL
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VNKVVPADRLLDEAKEWAAEVAEKSPTAIRFLKQSFNADTDHQAGLSNLAMSALDLFTAS
HHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
PEGLEGAAAFAEKRKPDFNQHVNWH
CCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TDFEDITYVVEDSAAIITISRPERYNAFRAKTVDELIKAFRLAWADRQVQSVILTGSGE
CCHHHEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
KAFCTGGDVKQRAETGDYGPSESGMFEIGNLHKLIRDIPKPVIAAVNGIAVGGGHVLHVL
EEEECCCCHHHHHCCCCCCCCCCCCEEHHHHHHHHHHCCHHHHHHHCCEEECCHHHHHHH
CDVSIASENARFGQAGPRVGSFDAGFGSAYLARVVGEKKAREIWFWCRQYDASEALAMGL
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VNKVVPADRLLDEAKEWAAEVAEKSPTAIRFLKQSFNADTDHQAGLSNLAMSALDLFTAS
HHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
PEGLEGAAAFAEKRKPDFNQHVNWH
CCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]