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The map label for this gene is lip2 [H]

Identifier: 119718475

GI number: 119718475

Start: 4495266

End: 4496309

Strand: Reverse

Name: lip2 [H]

Synonym: Noca_4256

Alternate gene names: 119718475

Gene position: 4496309-4495266 (Counterclockwise)

Preceding gene: 119718479

Following gene: 119718471

Centisome position: 90.18

GC content: 76.34

Gene sequence:

>1044_bases
GTGACCAACGCCCCGCGCTGGACCGAGCGCCTGCAGATCCGTGTCGAGACGCTGGCTCTGCGGGCTGCGATGGGGCTGCC
CGAGCGGGTGCAGCGGCTGCTGGGCGGCCGGGCGATCGTCCGCGACGGCCAGACCCTCGCGGCCGATACCCAGCTGATGC
TGCGGATGCAGCGGCTGGTGCGCGAGCCCGGCGCCGAGACGCTGCCGATCCCCGAGGGCCGGGCCGCCATCCGGCGGCAC
GCCGGCATGACCGGCGGCCGGCAGCGGATCGGCGCCGTCCGCGACCTCACCGTGGCCGACCGCCCGGCCCGGCTCTACAC
GCCGACCGGCGCCGCGGCCTCGGGCCCGCTGTTGCTGTTCTTCCACGGCGGCGGCTTCATGTACGGCGACCTGGGCTCCC
ACGACGCGTCCTGCCGGTTCCTGGCCGAGCGGTCCGGGGTGCGGGTGCTCGCGGTCGGCTACCGGCTCGGGCCCGAGCGG
CCGTTCCCGGCGGCGTACGACGACGCGCTCGCCGCCCACGGCTGGCTCGTCGACCACGCGAGCGAGGTGGGCGCCGACCC
CGCCCGGCTCGCCGTCGGCGGCGACTCCGCGGGCGGCAACCTGGCCGCGGTGGTGGCCATCGAGGCGGCCCGCGCCGGGC
TGCCGCTGGCGTTCCAGCTGCTCGTCTACCCGGCGACCGACGCGGTCCGCGAGACCGCCAGCGCCGAGCTGTTCGCCGAC
GGGTTCTACCTCACCAAGGCGTTCATGGACCTCGCCAACACCTCCTACATCGGCCGCACCGACCCCCGCGACCCGCGGGT
CTCGCCGCTGTACGCCGAGCTGCCGGCCGGCCTGGCGCCGGCGTACGTCGCGACCGCCGGTTTCGACCCGCTCCGCGACG
AGGGCGAGGCCTACGCCCGCCGGCTCTCCGAGGCCGGGGCCACGGTCGAGCTGCGGCGCTTCACCGACCAGATCCACGGC
TTCTTCAACATCGTCGGCGCCGGCCGCACCAGCCGCGCCGCCACCGCCGAGATCGCCGCGAAGCTCAAGTCCGCGCTGCA
CTGA

Upstream 100 bases:

>100_bases
CGGGACCTCCTCGCCGCGGCTGGAGACGGCGTCCGAGGGCAGGCTCTCCAGGCTCATGCCGGCCAGTCTGGCACTACGGC
GTGAACGGTAGGTTGCGTTC

Downstream 100 bases:

>100_bases
GCGGGCTGGGGCGCCGGTAGGGGGCCCGCGCCCGTACGCCCGGAAAGCGCGGTGGATCGGATCAGCCCGCTGGTTCATCC
GACCCACCGCACTTCTCGCA

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTNAPRWTERLQIRVETLALRAAMGLPERVQRLLGGRAIVRDGQTLAADTQLMLRMQRLVREPGAETLPIPEGRAAIRRH
AGMTGGRQRIGAVRDLTVADRPARLYTPTGAAASGPLLLFFHGGGFMYGDLGSHDASCRFLAERSGVRVLAVGYRLGPER
PFPAAYDDALAAHGWLVDHASEVGADPARLAVGGDSAGGNLAAVVAIEAARAGLPLAFQLLVYPATDAVRETASAELFAD
GFYLTKAFMDLANTSYIGRTDPRDPRVSPLYAELPAGLAPAYVATAGFDPLRDEGEAYARRLSEAGATVELRRFTDQIHG
FFNIVGAGRTSRAATAEIAAKLKSALH

Sequences:

>Translated_347_residues
MTNAPRWTERLQIRVETLALRAAMGLPERVQRLLGGRAIVRDGQTLAADTQLMLRMQRLVREPGAETLPIPEGRAAIRRH
AGMTGGRQRIGAVRDLTVADRPARLYTPTGAAASGPLLLFFHGGGFMYGDLGSHDASCRFLAERSGVRVLAVGYRLGPER
PFPAAYDDALAAHGWLVDHASEVGADPARLAVGGDSAGGNLAAVVAIEAARAGLPLAFQLLVYPATDAVRETASAELFAD
GFYLTKAFMDLANTSYIGRTDPRDPRVSPLYAELPAGLAPAYVATAGFDPLRDEGEAYARRLSEAGATVELRRFTDQIHG
FFNIVGAGRTSRAATAEIAAKLKSALH
>Mature_346_residues
TNAPRWTERLQIRVETLALRAAMGLPERVQRLLGGRAIVRDGQTLAADTQLMLRMQRLVREPGAETLPIPEGRAAIRRHA
GMTGGRQRIGAVRDLTVADRPARLYTPTGAAASGPLLLFFHGGGFMYGDLGSHDASCRFLAERSGVRVLAVGYRLGPERP
FPAAYDDALAAHGWLVDHASEVGADPARLAVGGDSAGGNLAAVVAIEAARAGLPLAFQLLVYPATDAVRETASAELFADG
FYLTKAFMDLANTSYIGRTDPRDPRVSPLYAELPAGLAPAYVATAGFDPLRDEGEAYARRLSEAGATVELRRFTDQIHGF
FNIVGAGRTSRAATAEIAAKLKSALH

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=313, Percent_Identity=25.2396166134185, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI61966717, Length=300, Percent_Identity=27, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI21328446, Length=120, Percent_Identity=36.6666666666667, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI206597554, Length=141, Percent_Identity=35.4609929078014, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI68299767, Length=140, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786682, Length=246, Percent_Identity=28.0487804878049, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17567059, Length=282, Percent_Identity=25.886524822695, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17540028, Length=133, Percent_Identity=37.593984962406, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71996133, Length=131, Percent_Identity=36.6412213740458, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI72001146, Length=115, Percent_Identity=35.6521739130435, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533410, Length=129, Percent_Identity=30.2325581395349, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533412, Length=129, Percent_Identity=30.2325581395349, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656084, Length=101, Percent_Identity=35.6435643564356, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656076, Length=101, Percent_Identity=35.6435643564356, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20130169, Length=101, Percent_Identity=35.6435643564356, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 37000; Mature: 36868

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS01173 LIPASE_GDXG_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAPRWTERLQIRVETLALRAAMGLPERVQRLLGGRAIVRDGQTLAADTQLMLRMQRLV
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHH
REPGAETLPIPEGRAAIRRHAGMTGGRQRIGAVRDLTVADRPARLYTPTGAAASGPLLLF
HCCCCCCCCCCCCHHHHHHHCCCCCCHHHHCHHHCCEECCCCCEEECCCCCCCCCCEEEE
FHGGGFMYGDLGSHDASCRFLAERSGVRVLAVGYRLGPERPFPAAYDDALAAHGWLVDHA
EECCCEEECCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHCCHHHHHH
SEVGADPARLAVGGDSAGGNLAAVVAIEAARAGLPLAFQLLVYPATDAVRETASAELFAD
HHHCCCCCEEEECCCCCCCCEEEEEEEEHHHCCCCEEEEEEEECCHHHHHHHHCHHHHHC
GFYLTKAFMDLANTSYIGRTDPRDPRVSPLYAELPAGLAPAYVATAGFDPLRDEGEAYAR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHH
RLSEAGATVELRRFTDQIHGFFNIVGAGRTSRAATAEIAAKLKSALH
HHHHCCCEEEHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNAPRWTERLQIRVETLALRAAMGLPERVQRLLGGRAIVRDGQTLAADTQLMLRMQRLV
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHH
REPGAETLPIPEGRAAIRRHAGMTGGRQRIGAVRDLTVADRPARLYTPTGAAASGPLLLF
HCCCCCCCCCCCCHHHHHHHCCCCCCHHHHCHHHCCEECCCCCEEECCCCCCCCCCEEEE
FHGGGFMYGDLGSHDASCRFLAERSGVRVLAVGYRLGPERPFPAAYDDALAAHGWLVDHA
EECCCEEECCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHCCHHHHHH
SEVGADPARLAVGGDSAGGNLAAVVAIEAARAGLPLAFQLLVYPATDAVRETASAELFAD
HHHCCCCCEEEECCCCCCCCEEEEEEEEHHHCCCCEEEEEEEECCHHHHHHHHCHHHHHC
GFYLTKAFMDLANTSYIGRTDPRDPRVSPLYAELPAGLAPAYVATAGFDPLRDEGEAYAR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHH
RLSEAGATVELRRFTDQIHGFFNIVGAGRTSRAATAEIAAKLKSALH
HHHHCCCEEEHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]