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The map label for this gene is pccB [H]

Identifier: 119718355

GI number: 119718355

Start: 4367349

End: 4368917

Strand: Reverse

Name: pccB [H]

Synonym: Noca_4136

Alternate gene names: 119718355

Gene position: 4368917-4367349 (Counterclockwise)

Preceding gene: 119718360

Following gene: 119718354

Centisome position: 87.63

GC content: 73.17

Gene sequence:

>1569_bases
GTGACCAACCACCTTCAGACCGGGCCGAGCGCGTCGCGGCGCGAGCTCGAGCGGCGGTTGTCCGACGCCGTCCCCGAGCC
GCGCGGGGGCCGTCGCCGCACCGCGCTCGAGCGGGCCCAGGCACTCTGCGACGACGGTTCGTTCGCGCCCACCGGCGCGC
TGCGCCAGAGCACCAGCCGGAACGCGGACAAGCTCCACGACGGCGACGGTGTCGTCACCGGCTTCGGGACCGTCGACGGG
CGCCCGGTGGCGGTCGTCAGCCACGAGTTCTCCCACAGCGGCGGGTCGATCGGCTCCGGGTTCGCGCTCAAGGTGGCCGA
CCTCCAGGACCGCGCGATCTCGCTCCGGATGCCGATCGTCTACCTCAACGACTCCGGCGGCGCCCGCATCAACGAAGGCA
TCGACTCGCTCGACGGGTGCGGGCAGATGTTCCGGCGCAACGTGCGCGCGAAGGGCCTGGTCCCGCAGGTCTCGGTGATC
CTCGGCCCGTGCGCCGGGGCCGCGGCGTACTCGCCCGCTCTCACCGACTGGACGATCATGGTCCGCGGGACCAGCCACAT
GTTCCTGACCGGACCGGACGTGGTCCGCGCGGCGATCGGCGAGGAGGTCTCCTCGGCCGACCTCGGCGGCGCCGAGCTGC
ACACCATCCGCAGCGGCGTCGCCCACCTCGCGGTCGACACCGAGGAGGAGGCCTTCGACCGGGTCCGCGAGCTGCTGTCC
TTCGTGCCGACCAACAGCGCGGACGAGCTGCCGCTCACCGCCCCCTGTGAGCCGGCCCCCCAGCACGCCCGCGAGATCGC
GACCGTGGTCCCGCGACGCGGCAGCGAGGTCTTCGACATGCACCGGCTGGTGCGAGCCGTCGTCGACGGGTCCGAGTCCT
TCGAGATGATGCCGGACTACGGCACCAGCGTGATCACGGCGTTCGCCCGGCTCGGCGGCGTGCCGGTCGGGATCGTCGCC
TCGCAGCCGCACCGGCGGGGCGGGATCCTCGAGATCACCAGCTCGCGCAAGATCGCCCGGTTCGTGCGCTTCTGCGGCCG
GTTCCACCTCCCGATCGTGACGTTCGTGGACGTGCCCGGGTTCATGCCCGGCGCGGCGCAGGAGAGCGGCGGCATCATCG
CGGAGGGCGCCGAGGTGCTCGACGCCTATGTCGACGCCGACAGCCCCCGGCTCACCGTCGTCGCGCGGAAGGCCTACGGC
GGCGCCTTCATCGCGATGGGATCGAAGTCGCTCGGGGCCGACTTCGCCTGGGCCTACCCGGACGCCGAGCTCGCCGTCAT
GGGACCGGGCGGCGCGGTGAACATCTTGCACCGGCGCGAGCTCGCCGCCGCCGAGGACCCGGAGCTGCTGCGCGCACGCC
TGGCCGAGGAGTACCGCGAGACCGTCACTCGGCCGTTCGCAGCGGCTGAGGCCGGCATCATCGATGACATCATCCGCCCC
GAGGACACCCGGGCGACGCTGCTGGCAGCGCTGCGGCTGTGGCACCCCTCGGCGGCCGCCGCGCCGGCCAAGCGCCTGGT
CGAGGCGTCGAACGAGGCGGCCTCGAGCTCCAGGACGGGTGCCGCATGA

Upstream 100 bases:

>100_bases
CCCCGACGTCAGTATCGGCGCTCGGCCCCGCCCGAGCGGATCGTCATCGTACGATGAGATTGAACTTGACGTCAATATCA
AAAGAGCCTACGGTGCAGGC

Downstream 100 bases:

>100_bases
CCGTGTTCGCGTCCCGCGCCGAGCTGCTCGCCGGCGCCGGCACCGACCTGGGGGCCACCGGCTGGACCACGATCGACCAG
GCCCGGATCCAGCTGTTCGC

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MTNHLQTGPSASRRELERRLSDAVPEPRGGRRRTALERAQALCDDGSFAPTGALRQSTSRNADKLHDGDGVVTGFGTVDG
RPVAVVSHEFSHSGGSIGSGFALKVADLQDRAISLRMPIVYLNDSGGARINEGIDSLDGCGQMFRRNVRAKGLVPQVSVI
LGPCAGAAAYSPALTDWTIMVRGTSHMFLTGPDVVRAAIGEEVSSADLGGAELHTIRSGVAHLAVDTEEEAFDRVRELLS
FVPTNSADELPLTAPCEPAPQHAREIATVVPRRGSEVFDMHRLVRAVVDGSESFEMMPDYGTSVITAFARLGGVPVGIVA
SQPHRRGGILEITSSRKIARFVRFCGRFHLPIVTFVDVPGFMPGAAQESGGIIAEGAEVLDAYVDADSPRLTVVARKAYG
GAFIAMGSKSLGADFAWAYPDAELAVMGPGGAVNILHRRELAAAEDPELLRARLAEEYRETVTRPFAAAEAGIIDDIIRP
EDTRATLLAALRLWHPSAAAAPAKRLVEASNEAASSSRTGAA

Sequences:

>Translated_522_residues
MTNHLQTGPSASRRELERRLSDAVPEPRGGRRRTALERAQALCDDGSFAPTGALRQSTSRNADKLHDGDGVVTGFGTVDG
RPVAVVSHEFSHSGGSIGSGFALKVADLQDRAISLRMPIVYLNDSGGARINEGIDSLDGCGQMFRRNVRAKGLVPQVSVI
LGPCAGAAAYSPALTDWTIMVRGTSHMFLTGPDVVRAAIGEEVSSADLGGAELHTIRSGVAHLAVDTEEEAFDRVRELLS
FVPTNSADELPLTAPCEPAPQHAREIATVVPRRGSEVFDMHRLVRAVVDGSESFEMMPDYGTSVITAFARLGGVPVGIVA
SQPHRRGGILEITSSRKIARFVRFCGRFHLPIVTFVDVPGFMPGAAQESGGIIAEGAEVLDAYVDADSPRLTVVARKAYG
GAFIAMGSKSLGADFAWAYPDAELAVMGPGGAVNILHRRELAAAEDPELLRARLAEEYRETVTRPFAAAEAGIIDDIIRP
EDTRATLLAALRLWHPSAAAAPAKRLVEASNEAASSSRTGAA
>Mature_521_residues
TNHLQTGPSASRRELERRLSDAVPEPRGGRRRTALERAQALCDDGSFAPTGALRQSTSRNADKLHDGDGVVTGFGTVDGR
PVAVVSHEFSHSGGSIGSGFALKVADLQDRAISLRMPIVYLNDSGGARINEGIDSLDGCGQMFRRNVRAKGLVPQVSVIL
GPCAGAAAYSPALTDWTIMVRGTSHMFLTGPDVVRAAIGEEVSSADLGGAELHTIRSGVAHLAVDTEEEAFDRVRELLSF
VPTNSADELPLTAPCEPAPQHAREIATVVPRRGSEVFDMHRLVRAVVDGSESFEMMPDYGTSVITAFARLGGVPVGIVAS
QPHRRGGILEITSSRKIARFVRFCGRFHLPIVTFVDVPGFMPGAAQESGGIIAEGAEVLDAYVDADSPRLTVVARKAYGG
AFIAMGSKSLGADFAWAYPDAELAVMGPGGAVNILHRRELAAAEDPELLRARLAEEYRETVTRPFAAAEAGIIDDIIRPE
DTRATLLAALRLWHPSAAAAPAKRLVEASNEAASSSRTGAA

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=492, Percent_Identity=44.3089430894309, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI295821216, Length=512, Percent_Identity=42.578125, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI11545863, Length=426, Percent_Identity=30.9859154929577, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI134142062, Length=348, Percent_Identity=24.4252873563218, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI38679971, Length=423, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679974, Length=423, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679960, Length=423, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679977, Length=423, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679967, Length=423, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1788655, Length=211, Percent_Identity=27.4881516587678, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=490, Percent_Identity=44.2857142857143, Blast_Score=413, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI25147359, Length=490, Percent_Identity=44.2857142857143, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17552936, Length=485, Percent_Identity=30.5154639175258, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=383, Percent_Identity=24.5430809399478, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI133931226, Length=310, Percent_Identity=22.258064516129, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323863, Length=345, Percent_Identity=22.0289855072464, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324343, Length=373, Percent_Identity=23.0563002680965, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24586065, Length=490, Percent_Identity=32.2448979591837, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI161076409, Length=368, Percent_Identity=24.1847826086957, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161076407, Length=368, Percent_Identity=24.1847826086957, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24586460, Length=368, Percent_Identity=24.1847826086957, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24586458, Length=368, Percent_Identity=24.1847826086957, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55314; Mature: 55183

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00142 ZINC_PROTEASE ; PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHLQTGPSASRRELERRLSDAVPEPRGGRRRTALERAQALCDDGSFAPTGALRQSTSR
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
NADKLHDGDGVVTGFGTVDGRPVAVVSHEFSHSGGSIGSGFALKVADLQDRAISLRMPIV
CCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEEEEE
YLNDSGGARINEGIDSLDGCGQMFRRNVRAKGLVPQVSVILGPCAGAAAYSPALTDWTIM
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHEEECCCCCHHCCCCCCCEEEE
VRGTSHMFLTGPDVVRAAIGEEVSSADLGGAELHTIRSGVAHLAVDTEEEAFDRVRELLS
EECCCEEEEECHHHHHHHHCCCHHCCCCCCHHHHHHHHCHHHEEECCHHHHHHHHHHHHH
FVPTNSADELPLTAPCEPAPQHAREIATVVPRRGSEVFDMHRLVRAVVDGSESFEMMPDY
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
GTSVITAFARLGGVPVGIVASQPHRRGGILEITSSRKIARFVRFCGRFHLPIVTFVDVPG
CHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCCC
FMPGAAQESGGIIAEGAEVLDAYVDADSPRLTVVARKAYGGAFIAMGSKSLGADFAWAYP
CCCCCCCCCCCEEECCHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEECC
DAELAVMGPGGAVNILHRRELAAAEDPELLRARLAEEYRETVTRPFAAAEAGIIDDIIRP
CCCEEEECCCCCEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHCCC
EDTRATLLAALRLWHPSAAAAPAKRLVEASNEAASSSRTGAA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCCCC
>Mature Secondary Structure 
TNHLQTGPSASRRELERRLSDAVPEPRGGRRRTALERAQALCDDGSFAPTGALRQSTSR
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
NADKLHDGDGVVTGFGTVDGRPVAVVSHEFSHSGGSIGSGFALKVADLQDRAISLRMPIV
CCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEEEEE
YLNDSGGARINEGIDSLDGCGQMFRRNVRAKGLVPQVSVILGPCAGAAAYSPALTDWTIM
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHEEECCCCCHHCCCCCCCEEEE
VRGTSHMFLTGPDVVRAAIGEEVSSADLGGAELHTIRSGVAHLAVDTEEEAFDRVRELLS
EECCCEEEEECHHHHHHHHCCCHHCCCCCCHHHHHHHHCHHHEEECCHHHHHHHHHHHHH
FVPTNSADELPLTAPCEPAPQHAREIATVVPRRGSEVFDMHRLVRAVVDGSESFEMMPDY
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
GTSVITAFARLGGVPVGIVASQPHRRGGILEITSSRKIARFVRFCGRFHLPIVTFVDVPG
CHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCCC
FMPGAAQESGGIIAEGAEVLDAYVDADSPRLTVVARKAYGGAFIAMGSKSLGADFAWAYP
CCCCCCCCCCCEEECCHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEECC
DAELAVMGPGGAVNILHRRELAAAEDPELLRARLAEEYRETVTRPFAAAEAGIIDDIIRP
CCCEEEECCCCCEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHCCC
EDTRATLLAALRLWHPSAAAAPAKRLVEASNEAASSSRTGAA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]