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The map label for this gene is livH [H]

Identifier: 119718323

GI number: 119718323

Start: 4335890

End: 4336762

Strand: Reverse

Name: livH [H]

Synonym: Noca_4104

Alternate gene names: 119718323

Gene position: 4336762-4335890 (Counterclockwise)

Preceding gene: 119718324

Following gene: 119718322

Centisome position: 86.98

GC content: 65.64

Gene sequence:

>873_bases
GTGGGAACGCAGATCCTGATCGTCAGCCAGGCCCTCTACCTCGGGGGTGTCTTCGCGCTCATCGCGCTCGGCTTGACGAT
CAGTTACTCGTCGACCAGGGTGGTCAACTTCGCTCAGGGCGAGTACTTCGTCTTCGGCGCCGGGGTCGCCTACTACATGC
AGTCGGTGCACGGGCAGCCCGCATGGGTCGCCCTGCTCGTGGTGTTGGCCGGAGCCGCCGCGTTCGGACTGGTCAGCGAG
CGCGCGATCATGCTGCCCATCCACCGCTCAGGCATCCATTACGCGTGGATCATCTCGACGCTCGCGGTGGCTCTGACGAT
GCAGAGCGTGTACTCCAAGGTCTTCGAAGGCGCGCTGCTTCGGCCGCCGCCCCTCGTCGCGGGCGCGGTCGACGTGCTCG
GTGGCAAGGTCGCGTACCAGATCTTCATCGTGATCGGCGCAGCGGTCGTCATCATGGTCGCCTACGACCAGATGCTTCGT
CGGACGTCGTACGGCGCCGCCGTGCGGGCGACCGCACACGACCCCGACACGACCTCGACCTTCGGCATCAGCGTCCGTGG
GATCGTGGTGGTCAGCTTCGTGGTGAGCGCGATGATCACGGCAGTCGCCGGAATGCTCGTCTCCCCGGTTCTCTTCGTCG
AGCCCACAGTTGGCCTGGCCTACACGACCAACGGCTTCGTCGCCATGGTCATCGGCGGTCTGGGATCGGTTCGGGGTGCC
ATCGCCGGAGGATTCATCGTCGGGATCCTCAATGCGCTGGTCGTCAACCTCATCGGTCCCAACTACGGTCAGATCACCGT
GGTCTGCGTGCTCGCCGTCATCTTGCTGGTCCGGCCCACGGGCCTCTTCGCATCCCCAGCGGCGGCGCACTGA

Upstream 100 bases:

>100_bases
GCGAGTAAGTCGAGTCGGCATGCCGGGTCCAGGTCCCTCCGGAACCTGGACCCGGCAGCCGGTCACGTCCTGATTGGCAA
AGAGAGGTGGTGATCCACTC

Downstream 100 bases:

>100_bases
GATGGCGTCCTTCGACCTGCGCTCTCGCAGCTCCGCCCGGATCGTCAGCGCGCTCGCGGCCGTCGCGTGCCTGGGCGTGC
TGGCACTCTGGCCCCAGATC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MGTQILIVSQALYLGGVFALIALGLTISYSSTRVVNFAQGEYFVFGAGVAYYMQSVHGQPAWVALLVVLAGAAAFGLVSE
RAIMLPIHRSGIHYAWIISTLAVALTMQSVYSKVFEGALLRPPPLVAGAVDVLGGKVAYQIFIVIGAAVVIMVAYDQMLR
RTSYGAAVRATAHDPDTTSTFGISVRGIVVVSFVVSAMITAVAGMLVSPVLFVEPTVGLAYTTNGFVAMVIGGLGSVRGA
IAGGFIVGILNALVVNLIGPNYGQITVVCVLAVILLVRPTGLFASPAAAH

Sequences:

>Translated_290_residues
MGTQILIVSQALYLGGVFALIALGLTISYSSTRVVNFAQGEYFVFGAGVAYYMQSVHGQPAWVALLVVLAGAAAFGLVSE
RAIMLPIHRSGIHYAWIISTLAVALTMQSVYSKVFEGALLRPPPLVAGAVDVLGGKVAYQIFIVIGAAVVIMVAYDQMLR
RTSYGAAVRATAHDPDTTSTFGISVRGIVVVSFVVSAMITAVAGMLVSPVLFVEPTVGLAYTTNGFVAMVIGGLGSVRGA
IAGGFIVGILNALVVNLIGPNYGQITVVCVLAVILLVRPTGLFASPAAAH
>Mature_289_residues
GTQILIVSQALYLGGVFALIALGLTISYSSTRVVNFAQGEYFVFGAGVAYYMQSVHGQPAWVALLVVLAGAAAFGLVSER
AIMLPIHRSGIHYAWIISTLAVALTMQSVYSKVFEGALLRPPPLVAGAVDVLGGKVAYQIFIVIGAAVVIMVAYDQMLRR
TSYGAAVRATAHDPDTTSTFGISVRGIVVVSFVVSAMITAVAGMLVSPVLFVEPTVGLAYTTNGFVAMVIGGLGSVRGAI
AGGFIVGILNALVVNLIGPNYGQITVVCVLAVILLVRPTGLFASPAAAH

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=308, Percent_Identity=30.1948051948052, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30018; Mature: 29887

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTQILIVSQALYLGGVFALIALGLTISYSSTRVVNFAQGEYFVFGAGVAYYMQSVHGQP
CCCEEEEEHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCEEEEECHHHHHHHHHCCCH
AWVALLVVLAGAAAFGLVSERAIMLPIHRSGIHYAWIISTLAVALTMQSVYSKVFEGALL
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPPPLVAGAVDVLGGKVAYQIFIVIGAAVVIMVAYDQMLRRTSYGAAVRATAHDPDTTST
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCE
FGISVRGIVVVSFVVSAMITAVAGMLVSPVLFVEPTVGLAYTTNGFVAMVIGGLGSVRGA
ECEEHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCEEEECCCEEEEHHHHHHHHHHH
IAGGFIVGILNALVVNLIGPNYGQITVVCVLAVILLVRPTGLFASPAAAH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GTQILIVSQALYLGGVFALIALGLTISYSSTRVVNFAQGEYFVFGAGVAYYMQSVHGQP
CCEEEEEHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCEEEEECHHHHHHHHHCCCH
AWVALLVVLAGAAAFGLVSERAIMLPIHRSGIHYAWIISTLAVALTMQSVYSKVFEGALL
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPPPLVAGAVDVLGGKVAYQIFIVIGAAVVIMVAYDQMLRRTSYGAAVRATAHDPDTTST
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCE
FGISVRGIVVVSFVVSAMITAVAGMLVSPVLFVEPTVGLAYTTNGFVAMVIGGLGSVRGA
ECEEHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCEEEECCCEEEEHHHHHHHHHHH
IAGGFIVGILNALVVNLIGPNYGQITVVCVLAVILLVRPTGLFASPAAAH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]