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The map label for this gene is adhE [H]

Identifier: 119718250

GI number: 119718250

Start: 4254499

End: 4256034

Strand: Reverse

Name: adhE [H]

Synonym: Noca_4031

Alternate gene names: 119718250

Gene position: 4256034-4254499 (Counterclockwise)

Preceding gene: 119718251

Following gene: 119718249

Centisome position: 85.36

GC content: 72.4

Gene sequence:

>1536_bases
ATGACGCACGACGAGCTCGACAGCGACCTGCGCTCGATCCAGGAGGCCCGCCGCCTCGCCACGGCGGCCCGGGCGGCTCA
GCGGGAGTTCGCCCACGCCTCGCAGGCCGAGGTGGACCGGATCTGCGCGGCGATGGCCGACGCGGTCTACCGTGAGGCCG
CCCGCCTCGGGCAGCTGGCGACCGACGAGACCGGGTACGGCGTACCCGCCCACAAGCGGCTCAAGGTCGAGTTCGCCTCG
CGCACGGTGTGGGAGTCGATCCGCGACGTGCCGACCGTGGGCGTGCTGCGCCGAGACGAGGCGAAGGGGATCGTCGAGAT
CGGCTGGCCGGTCGGCGTGATCGTCGGCCTGTGCCCCTCCACCAACCCCAACTCGACGGCGATCTACAAGGTGCTGATCT
CGGTCAAGGCGCGCAACGCCTGCATCATCGCCCCGCACCCCTCGGCCAAGGCCGCCACCTACGAGGCGGTGCGGATCATG
ATCGAGGCGGGGGAGCGGGCCGGCATGCCCAAGGGCCTGGTCGGCTGCATGCAGGAGGTCAGCCTCCCCGGCTCCCAGGA
GCTGATGCGGCACTACGCGACGTCGATGATCCTGGCCACCGGCGGCACGCCGATGGTGCGCGCGGCCCACAGCATGGGCA
AGCCCGCGCTCGGCGTCGGGCCCGGCAACGTCCCGGCGTACGTCGACCGCAGTGCGGACGTGCTGGCGGCCGCCACCGCG
ATCGTCAACAGCAAGTCCTTCGACTGCTCCACGATCTGTGCGACCGAGCAGGCGGTCGTAGCGGACGCGCCGATCGCCGG
CGCGCTGCGCGCCGAGATGGAGCGCCTCGGCGCCTACTTCGTCTCTGCGGAGGAGAAGGCGGCGCTCGAGCGCACCGTGT
TCAACCCGGGCGGCGCGATGAACCCCAAGGCGGTCGGGAAGTCGCCGCAGGCCCTGGCGGCGCTGGCGGGCATCCAGGTC
CCCGAGCATGCCCGGATCCTCGTTGCCGAGCTGGGCAGCGTCGGTCCGCAGGAGCCGCTCAGCGCCGAGAAGCTCACCAC
CGTGCTCGGCTGGTACGTCGAGGACGGCTGGCGGGCCGGCTGCGAGCGGTCGATCGAGCTGCTGAAGTTCGGCGGCGACG
GGCACTCGCTGGTGATCCACGCGACCGACGAGGAGGTGATCATGGCGTTCGGGCTAGAGAAGCCCGCCTTCCGGATCCTC
GTCAACACCTGGGGCACCCTCGGCGCGATCGGTGCGACGACCGGCGTGATGCCGGCGCTGACGCTCGCCCCGGGCGGGAT
CGGCGGTGCCGTGGTCAGCGACAACATCACCGTTACGCACCTGCTCAACGTCAAGCGTCTGGCCTTCAAGCTGCACGAGC
CGCCCGCCGCGGCGTACGAGCACGCACCCGACGTGCGGGGCGCCCCCCGCCACGACGGCCCCCGCTCGGCCGAGGCGACC
CCGGCGGCGCGCGTCGCCGAACCCGCTGCGGTGAGCGGGGACCAGGTGGAACGCATCGTCCGCCGGGTGCTCAGCGAGCT
CGGAGCCGGCCGATGA

Upstream 100 bases:

>100_bases
CCGGAGGGTTCCTGGTCGGTTCCCAAAGCGCCGTGGTGGCCGCGTGCAACGCGTTCCGCGACGGTGTTCTCGAGATTGCG
GCACAGCCGCGGGAGGTCTG

Downstream 100 bases:

>100_bases
CCGGCGCGCACGGCATCCGAGGGCCGGCCCCGCCGGCTCGAGCCCAACCGCCACCGATGGCGGGACCGCAGCTTCAGCAC
CTCGACTTCGTAGCACCCCG

Product: acetaldehyde dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTHDELDSDLRSIQEARRLATAARAAQREFAHASQAEVDRICAAMADAVYREAARLGQLATDETGYGVPAHKRLKVEFAS
RTVWESIRDVPTVGVLRRDEAKGIVEIGWPVGVIVGLCPSTNPNSTAIYKVLISVKARNACIIAPHPSAKAATYEAVRIM
IEAGERAGMPKGLVGCMQEVSLPGSQELMRHYATSMILATGGTPMVRAAHSMGKPALGVGPGNVPAYVDRSADVLAAATA
IVNSKSFDCSTICATEQAVVADAPIAGALRAEMERLGAYFVSAEEKAALERTVFNPGGAMNPKAVGKSPQALAALAGIQV
PEHARILVAELGSVGPQEPLSAEKLTTVLGWYVEDGWRAGCERSIELLKFGGDGHSLVIHATDEEVIMAFGLEKPAFRIL
VNTWGTLGAIGATTGVMPALTLAPGGIGGAVVSDNITVTHLLNVKRLAFKLHEPPAAAYEHAPDVRGAPRHDGPRSAEAT
PAARVAEPAAVSGDQVERIVRRVLSELGAGR

Sequences:

>Translated_511_residues
MTHDELDSDLRSIQEARRLATAARAAQREFAHASQAEVDRICAAMADAVYREAARLGQLATDETGYGVPAHKRLKVEFAS
RTVWESIRDVPTVGVLRRDEAKGIVEIGWPVGVIVGLCPSTNPNSTAIYKVLISVKARNACIIAPHPSAKAATYEAVRIM
IEAGERAGMPKGLVGCMQEVSLPGSQELMRHYATSMILATGGTPMVRAAHSMGKPALGVGPGNVPAYVDRSADVLAAATA
IVNSKSFDCSTICATEQAVVADAPIAGALRAEMERLGAYFVSAEEKAALERTVFNPGGAMNPKAVGKSPQALAALAGIQV
PEHARILVAELGSVGPQEPLSAEKLTTVLGWYVEDGWRAGCERSIELLKFGGDGHSLVIHATDEEVIMAFGLEKPAFRIL
VNTWGTLGAIGATTGVMPALTLAPGGIGGAVVSDNITVTHLLNVKRLAFKLHEPPAAAYEHAPDVRGAPRHDGPRSAEAT
PAARVAEPAAVSGDQVERIVRRVLSELGAGR
>Mature_510_residues
THDELDSDLRSIQEARRLATAARAAQREFAHASQAEVDRICAAMADAVYREAARLGQLATDETGYGVPAHKRLKVEFASR
TVWESIRDVPTVGVLRRDEAKGIVEIGWPVGVIVGLCPSTNPNSTAIYKVLISVKARNACIIAPHPSAKAATYEAVRIMI
EAGERAGMPKGLVGCMQEVSLPGSQELMRHYATSMILATGGTPMVRAAHSMGKPALGVGPGNVPAYVDRSADVLAAATAI
VNSKSFDCSTICATEQAVVADAPIAGALRAEMERLGAYFVSAEEKAALERTVFNPGGAMNPKAVGKSPQALAALAGIQVP
EHARILVAELGSVGPQEPLSAEKLTTVLGWYVEDGWRAGCERSIELLKFGGDGHSLVIHATDEEVIMAFGLEKPAFRILV
NTWGTLGAIGATTGVMPALTLAPGGIGGAVVSDNITVTHLLNVKRLAFKLHEPPAAAYEHAPDVRGAPRHDGPRSAEATP
AARVAEPAAVSGDQVERIVRRVLSELGAGR

Specific function: This enzyme has probably two activities:ADH, and ACDH [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787493, Length=459, Percent_Identity=37.9084967320261, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1788797, Length=299, Percent_Identity=31.1036789297659, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 53703; Mature: 53572

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDELDSDLRSIQEARRLATAARAAQREFAHASQAEVDRICAAMADAVYREAARLGQLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TDETGYGVPAHKRLKVEFASRTVWESIRDVPTVGVLRRDEAKGIVEIGWPVGVIVGLCPS
CCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEECCCCCCEEEECCHHHHHEECCCC
TNPNSTAIYKVLISVKARNACIIAPHPSAKAATYEAVRIMIEAGERAGMPKGLVGCMQEV
CCCCCHHEEHEEEEEECCCEEEECCCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHH
SLPGSQELMRHYATSMILATGGTPMVRAAHSMGKPALGVGPGNVPAYVDRSADVLAAATA
CCCCHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCEECCCCHHHHHHHH
IVNSKSFDCSTICATEQAVVADAPIAGALRAEMERLGAYFVSAEEKAALERTVFNPGGAM
HHCCCCCCCHHHHCCCCHHEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCC
NPKAVGKSPQALAALAGIQVPEHARILVAELGSVGPQEPLSAEKLTTVLGWYVEDGWRAG
CCHHCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
CERSIELLKFGGDGHSLVIHATDEEVIMAFGLEKPAFRILVNTWGTLGAIGATTGVMPAL
HHHCEEEEEECCCCCEEEEEECCCCEEEEECCCCCHHEEEECCCCHHHHHHHHHCCCHHH
TLAPGGIGGAVVSDNITVTHLLNVKRLAFKLHEPPAAAYEHAPDVRGAPRHDGPRSAEAT
HCCCCCCCCCEEECCEEEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
PAARVAEPAAVSGDQVERIVRRVLSELGAGR
CHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THDELDSDLRSIQEARRLATAARAAQREFAHASQAEVDRICAAMADAVYREAARLGQLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TDETGYGVPAHKRLKVEFASRTVWESIRDVPTVGVLRRDEAKGIVEIGWPVGVIVGLCPS
CCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEECCCCCCEEEECCHHHHHEECCCC
TNPNSTAIYKVLISVKARNACIIAPHPSAKAATYEAVRIMIEAGERAGMPKGLVGCMQEV
CCCCCHHEEHEEEEEECCCEEEECCCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHH
SLPGSQELMRHYATSMILATGGTPMVRAAHSMGKPALGVGPGNVPAYVDRSADVLAAATA
CCCCHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCEECCCCHHHHHHHH
IVNSKSFDCSTICATEQAVVADAPIAGALRAEMERLGAYFVSAEEKAALERTVFNPGGAM
HHCCCCCCCHHHHCCCCHHEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCC
NPKAVGKSPQALAALAGIQVPEHARILVAELGSVGPQEPLSAEKLTTVLGWYVEDGWRAG
CCHHCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
CERSIELLKFGGDGHSLVIHATDEEVIMAFGLEKPAFRILVNTWGTLGAIGATTGVMPAL
HHHCEEEEEECCCCCEEEEEECCCCEEEEECCCCCHHEEEECCCCHHHHHHHHHCCCHHH
TLAPGGIGGAVVSDNITVTHLLNVKRLAFKLHEPPAAAYEHAPDVRGAPRHDGPRSAEAT
HCCCCCCCCCEEECCEEEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
PAARVAEPAAVSGDQVERIVRRVLSELGAGR
CHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226639; 8300540; 11466286 [H]