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The map label for this gene is lon [H]

Identifier: 119718207

GI number: 119718207

Start: 4207766

End: 4210075

Strand: Reverse

Name: lon [H]

Synonym: Noca_3988

Alternate gene names: 119718207

Gene position: 4210075-4207766 (Counterclockwise)

Preceding gene: 119718208

Following gene: 119718206

Centisome position: 84.44

GC content: 73.77

Gene sequence:

>2310_bases
ATGGCACTCAAGCTCCCCGTCCTCTTCGTCCCGGACGTCGTCCTCCTCCCCGGCATGGTCGTTCCCCTCGAGCTCGACGA
GTCCTCCCAGGCCGCCATCGACGCCGCCCGCGCGGGCAGCGACAGCCAGGTGCTGGTCGCGCCGCGGCTGGACGACCGCT
ACGCGTCGTACGGCGTCATCGCGACCATCGAGCGCGTCGGCAAGTTCTCGGGCGGCTCCCCGGCCGCGGTCCTCAAGGCC
GGTCCCCGGGCCGCCATCGGCAGCGGCGTCACCGGGCCCGGGGCGGCCCTGTGGGTCGAGGTCGAGCCGGCCGAGGACGT
CGTGACCCCGCGCGCCCGCGAGCTCGCCGAGGAGTACAAGCGGCTGGTCGTCGCCGTGCTCCAGCGCCGCGAGGCCTGGC
AGATCGTCGACCAGGTGCACCAGATGACCGACCCGAGCGCGATCGCCGACACCGCGGGCTACGCGCCGTACCTCTCCACC
GAGCGCAAGCGCGAGCTGCTCGAGGACCCCGACGTGGAGTCCCGGCTGCTGCGCGTCATCGGCTGGACCCGCGACTACCT
CGCCGAGGCCGAGCTGACCGACAAGATCGGTGAGGAGGTCCGCGACGGGATGGAGAAGCAGCAGCGCGAGTACCTCCTGC
GTCAGCAGCTCGCCGCGATCCGCAAGGAGCTCGGCGAGGGCGAGCCGGAAGGGGCCGACGACTACCGGGCTCGCGTCGAG
GCCGCCGACGTGCCCGACGCGGTGCGCGAGGCGCTGCTGCGCGAGGTCGGCAAGCTCGAGCGCTCCAGCGACCAGAACCC
CGAGGCCGCGTGGATCCGGACCTGGCTCGACACGGTGCTCGAGCTGCCGTGGAGCACCACCACCGAGGACGCGAACGACG
TCGCCGGCGCCCGCGCCGTCCTGGACGCCGACCACCACGGCCTGGACGAGGTCAAGGAGCGGATCGTGGAGTACCTCGCG
GTCCGGGCCCGTCGCGCGGAGCGCGGCCTGCAGGTCGTCGGAGGCCGCGGCTCGGGCGCCGTGATCCTGCTGGCCGGGCC
TCCCGGTGTCGGCAAGACCTCGCTGGGCGAGTCCGTGGCCCGGGCGCTCGGCCGCAGGTTCGTCCGGGTCGCCCTGGGCG
GCGTGCGCGACGAGGCCGAGATCCGCGGGCACCGCCGTACCTATGTCGGCGCGCTGCCCGGCCGGATCGTGCGCGCGATC
AAGGAGGCCGGCTCGATGAACCCGGTCGTGCTCCTCGACGAGGTCGACAAGGTCGGCTCCGACTACCGGGGCGACCCCGC
GGCCGCGCTGCTCGAGGTCCTCGACCCGGCGCAGAACCACACCTTCCGCGACCACTACCTGGAGCTGGACCTGGACCTCT
CCGACGTGCTGTTCATCGCGACCGCGAACGTCGTGGAGCAGATCCCGTCGGCGCTGCTGGACCGGATGGAGCTGGTGACG
CTCGACGGGTACACCGAGGACGACAAGGTCGGCATCGCCCGCGACTTCCTGCTGCCCCGCCAGCTCGAGCGCGCGGCGCT
GACCTCCGACGAGGTGCGGGTGACCGACGCCGCGCTGCGCGAGATGGCCGCCAACTACACCCGCGAGGCCGGCGTGCGCC
AGATGGAGCGGCTGCTCGCCAAGGCGCTGCGCAAGGCGGCGACCCGGCTCGCCACGGGCGCGGTCCAGGTCGACATCGAC
GTGGCGGACCTCAAGGACCTGGTCGGCCGGCCGCGGTTCACCCCCGAGGCACCGGAGCGTACGGCGGTCCCGGGCGTGGC
GACCGGCCTGGCGGTGACCGGGCTCGGCGGCGACGTGCTGTTCATCGAGGCGTCGGCTGCGGAGGGGACCGCCGGCCTCA
CGCTGACCGGCCAGCTCGGCGACGTGATGAAGGAGTCGGCGCAGATCGCGCTGTCCTTCGTCCGCGCGCACGCGGCCGAG
CTCGGGGTGGAGCCGTCGTTCTTCGAGAAGGCGATCCACGTGCACGTGCCGGCCGGCGCCACCCCCAAGGACGGCCCGTC
CGCCGGCATCACCATGGTCACCGCGCTCACCTCGCTGGCCACCGGCCGCCCCGTGCGCTCGGAGGTCGGCATGACCGGCG
AGGTCTCGCTGACCGGCCGGGTGCTGCCGATCGGCGGGCTCAAGCAGAAGCTGCTCGCGGCCCAGCGCCACGGCCTCACC
GAGGTGTTCGTGCCGCTGCGCAACGAGCCGGACCTGGACGACGTACCGGCCGACGTCCTCGGGAGCGTCACGGTGCACCC
GGTCAGCGACGTCCTGGACGTGGTCCGCGGCGCGCTGGCCAGCACCGAGGCGGCCACGGTCGCAGCGTGA

Upstream 100 bases:

>100_bases
GGATCGGGGCACCCAGGACCCTCGGGTGTTCCGGTGTTCGTCAACAGCGAACAGGAGGCGCTCTCCGGAACACCGGCCCG
GGCTCGGGAGTTGAGCGGAC

Downstream 100 bases:

>100_bases
CCGGACGCCTCCGGGCGCGAGACGACGGCCGTCCAACATGTGGATGCGATGTGCACATGCTGAGACGGCCGTCGTACTGT
TCTCCACAGCTCATCAAGAG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 769; Mature: 768

Protein sequence:

>769_residues
MALKLPVLFVPDVVLLPGMVVPLELDESSQAAIDAARAGSDSQVLVAPRLDDRYASYGVIATIERVGKFSGGSPAAVLKA
GPRAAIGSGVTGPGAALWVEVEPAEDVVTPRARELAEEYKRLVVAVLQRREAWQIVDQVHQMTDPSAIADTAGYAPYLST
ERKRELLEDPDVESRLLRVIGWTRDYLAEAELTDKIGEEVRDGMEKQQREYLLRQQLAAIRKELGEGEPEGADDYRARVE
AADVPDAVREALLREVGKLERSSDQNPEAAWIRTWLDTVLELPWSTTTEDANDVAGARAVLDADHHGLDEVKERIVEYLA
VRARRAERGLQVVGGRGSGAVILLAGPPGVGKTSLGESVARALGRRFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAI
KEAGSMNPVVLLDEVDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLELDLDLSDVLFIATANVVEQIPSALLDRMELVT
LDGYTEDDKVGIARDFLLPRQLERAALTSDEVRVTDAALREMAANYTREAGVRQMERLLAKALRKAATRLATGAVQVDID
VADLKDLVGRPRFTPEAPERTAVPGVATGLAVTGLGGDVLFIEASAAEGTAGLTLTGQLGDVMKESAQIALSFVRAHAAE
LGVEPSFFEKAIHVHVPAGATPKDGPSAGITMVTALTSLATGRPVRSEVGMTGEVSLTGRVLPIGGLKQKLLAAQRHGLT
EVFVPLRNEPDLDDVPADVLGSVTVHPVSDVLDVVRGALASTEAATVAA

Sequences:

>Translated_769_residues
MALKLPVLFVPDVVLLPGMVVPLELDESSQAAIDAARAGSDSQVLVAPRLDDRYASYGVIATIERVGKFSGGSPAAVLKA
GPRAAIGSGVTGPGAALWVEVEPAEDVVTPRARELAEEYKRLVVAVLQRREAWQIVDQVHQMTDPSAIADTAGYAPYLST
ERKRELLEDPDVESRLLRVIGWTRDYLAEAELTDKIGEEVRDGMEKQQREYLLRQQLAAIRKELGEGEPEGADDYRARVE
AADVPDAVREALLREVGKLERSSDQNPEAAWIRTWLDTVLELPWSTTTEDANDVAGARAVLDADHHGLDEVKERIVEYLA
VRARRAERGLQVVGGRGSGAVILLAGPPGVGKTSLGESVARALGRRFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAI
KEAGSMNPVVLLDEVDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLELDLDLSDVLFIATANVVEQIPSALLDRMELVT
LDGYTEDDKVGIARDFLLPRQLERAALTSDEVRVTDAALREMAANYTREAGVRQMERLLAKALRKAATRLATGAVQVDID
VADLKDLVGRPRFTPEAPERTAVPGVATGLAVTGLGGDVLFIEASAAEGTAGLTLTGQLGDVMKESAQIALSFVRAHAAE
LGVEPSFFEKAIHVHVPAGATPKDGPSAGITMVTALTSLATGRPVRSEVGMTGEVSLTGRVLPIGGLKQKLLAAQRHGLT
EVFVPLRNEPDLDDVPADVLGSVTVHPVSDVLDVVRGALASTEAATVAA
>Mature_768_residues
ALKLPVLFVPDVVLLPGMVVPLELDESSQAAIDAARAGSDSQVLVAPRLDDRYASYGVIATIERVGKFSGGSPAAVLKAG
PRAAIGSGVTGPGAALWVEVEPAEDVVTPRARELAEEYKRLVVAVLQRREAWQIVDQVHQMTDPSAIADTAGYAPYLSTE
RKRELLEDPDVESRLLRVIGWTRDYLAEAELTDKIGEEVRDGMEKQQREYLLRQQLAAIRKELGEGEPEGADDYRARVEA
ADVPDAVREALLREVGKLERSSDQNPEAAWIRTWLDTVLELPWSTTTEDANDVAGARAVLDADHHGLDEVKERIVEYLAV
RARRAERGLQVVGGRGSGAVILLAGPPGVGKTSLGESVARALGRRFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIK
EAGSMNPVVLLDEVDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLELDLDLSDVLFIATANVVEQIPSALLDRMELVTL
DGYTEDDKVGIARDFLLPRQLERAALTSDEVRVTDAALREMAANYTREAGVRQMERLLAKALRKAATRLATGAVQVDIDV
ADLKDLVGRPRFTPEAPERTAVPGVATGLAVTGLGGDVLFIEASAAEGTAGLTLTGQLGDVMKESAQIALSFVRAHAAEL
GVEPSFFEKAIHVHVPAGATPKDGPSAGITMVTALTSLATGRPVRSEVGMTGEVSLTGRVLPIGGLKQKLLAAQRHGLTE
VFVPLRNEPDLDDVPADVLGSVTVHPVSDVLDVVRGALASTEAATVAA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=566, Percent_Identity=44.8763250883392, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI21396489, Length=699, Percent_Identity=39.0557939914163, Blast_Score=494, Evalue=1e-139,
Organism=Escherichia coli, GI1786643, Length=782, Percent_Identity=42.7109974424552, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17505831, Length=638, Percent_Identity=38.0877742946708, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17556486, Length=774, Percent_Identity=34.3669250645995, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=660, Percent_Identity=38.6363636363636, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI221513036, Length=714, Percent_Identity=37.8151260504202, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24666867, Length=714, Percent_Identity=37.5350140056022, Blast_Score=489, Evalue=1e-138,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 82330; Mature: 82199

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKLPVLFVPDVVLLPGMVVPLELDESSQAAIDAARAGSDSQVLVAPRLDDRYASYGVI
CCEECCHHHCCCHHHHCCEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHCHHH
ATIERVGKFSGGSPAAVLKAGPRAAIGSGVTGPGAALWVEVEPAEDVVTPRARELAEEYK
HHHHHHHCCCCCCCCCEEECCCCHHCCCCCCCCCCEEEEEECCHHHHCCCHHHHHHHHHH
RLVVAVLQRREAWQIVDQVHQMTDPSAIADTAGYAPYLSTERKRELLEDPDVESRLLRVI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHH
GWTRDYLAEAELTDKIGEEVRDGMEKQQREYLLRQQLAAIRKELGEGEPEGADDYRARVE
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHC
AADVPDAVREALLREVGKLERSSDQNPEAAWIRTWLDTVLELPWSTTTEDANDVAGARAV
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LDADHHGLDEVKERIVEYLAVRARRAERGLQVVGGRGSGAVILLAGPPGVGKTSLGESVA
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHH
RALGRRFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIKEAGSMNPVVLLDEVDKVGS
HHHHHHHHHHHHCCCCCHHHHCCCCHHEECCCHHHHHHHHHHHCCCCCEEEEECHHHCCC
DYRGDPAAALLEVLDPAQNHTFRDHYLELDLDLSDVLFIATANVVEQIPSALLDRMELVT
CCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LDGYTEDDKVGIARDFLLPRQLERAALTSDEVRVTDAALREMAANYTREAGVRQMERLLA
ECCCCCCCCCCHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALRKAATRLATGAVQVDIDVADLKDLVGRPRFTPEAPERTAVPGVATGLAVTGLGGDVL
HHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCEEECCCCCEE
FIEASAAEGTAGLTLTGQLGDVMKESAQIALSFVRAHAAELGVEPSFFEKAIHVHVPAGA
EEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCEEEEEECCCC
TPKDGPSAGITMVTALTSLATGRPVRSEVGMTGEVSLTGRVLPIGGLKQKLLAAQRHGLT
CCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCEEEECCEEEECCHHHHHHHHHHHCCCC
EVFVPLRNEPDLDDVPADVLGSVTVHPVSDVLDVVRGALASTEAATVAA
EEEEECCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
ALKLPVLFVPDVVLLPGMVVPLELDESSQAAIDAARAGSDSQVLVAPRLDDRYASYGVI
CEECCHHHCCCHHHHCCEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHCHHH
ATIERVGKFSGGSPAAVLKAGPRAAIGSGVTGPGAALWVEVEPAEDVVTPRARELAEEYK
HHHHHHHCCCCCCCCCEEECCCCHHCCCCCCCCCCEEEEEECCHHHHCCCHHHHHHHHHH
RLVVAVLQRREAWQIVDQVHQMTDPSAIADTAGYAPYLSTERKRELLEDPDVESRLLRVI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHH
GWTRDYLAEAELTDKIGEEVRDGMEKQQREYLLRQQLAAIRKELGEGEPEGADDYRARVE
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHC
AADVPDAVREALLREVGKLERSSDQNPEAAWIRTWLDTVLELPWSTTTEDANDVAGARAV
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LDADHHGLDEVKERIVEYLAVRARRAERGLQVVGGRGSGAVILLAGPPGVGKTSLGESVA
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHH
RALGRRFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIKEAGSMNPVVLLDEVDKVGS
HHHHHHHHHHHHCCCCCHHHHCCCCHHEECCCHHHHHHHHHHHCCCCCEEEEECHHHCCC
DYRGDPAAALLEVLDPAQNHTFRDHYLELDLDLSDVLFIATANVVEQIPSALLDRMELVT
CCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LDGYTEDDKVGIARDFLLPRQLERAALTSDEVRVTDAALREMAANYTREAGVRQMERLLA
ECCCCCCCCCCHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALRKAATRLATGAVQVDIDVADLKDLVGRPRFTPEAPERTAVPGVATGLAVTGLGGDVL
HHHHHHHHHHHCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCEEECCCCCEE
FIEASAAEGTAGLTLTGQLGDVMKESAQIALSFVRAHAAELGVEPSFFEKAIHVHVPAGA
EEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCEEEEEECCCC
TPKDGPSAGITMVTALTSLATGRPVRSEVGMTGEVSLTGRVLPIGGLKQKLLAAQRHGLT
CCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCEEEECCEEEECCHHHHHHHHHHHCCCC
EVFVPLRNEPDLDDVPADVLGSVTVHPVSDVLDVVRGALASTEAATVAA
EEEEECCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9425059 [H]