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The map label for this gene is groEL

Identifier: 119718201

GI number: 119718201

Start: 4200741

End: 4202366

Strand: Reverse

Name: groEL

Synonym: Noca_3982

Alternate gene names: 119718201

Gene position: 4202366-4200741 (Counterclockwise)

Preceding gene: 119718202

Following gene: 119718199

Centisome position: 84.29

GC content: 68.08

Gene sequence:

>1626_bases
ATGCCGAAGCTGATTGCTTTCAACGAGGAGGCCCGGCGCGGTCTCGAGCGTGGCATGAACACGCTCGCGGACGCTGTCAA
GGTCACGCTCGGGCCCAAGGGTCGCAACGTCGTCCTCGAGAAGAAGTGGGGCGCCCCCACGATCACCAACGATGGTGTGT
CCATCGCCAAGGAGATCGAGCTCGAGGACCCCTACGAGAAGATCGGTGCCGAGCTCGTCAAGGAGGTCGCCAAGAAGACC
GACGACGTCGCCGGCGACGGCACCACCACCGCCACCGTCCTCGCCCAGGCGATGGTCCGCGAGGGCCTGCGCAACGTGGC
CGCCGGTGCGAACCCGATGGGCCTCAAGCGCGGCATCGAGGCGGCCGTCGAGGCCGTGTCCGGCCAGCTGCTGAGCATGG
CCAAGGACGTCGAGACCAAGGAGCAGATCGCGTCCACCGCGAGCATCTCCGCGGCCGACACGACCGTCGGCGAGATCATC
GCCGAGGCGATGGACAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAGGAGTCGAACACCTTCGGGCTCGACCTCGAACT
CACCGAGGGCATGCGCTTCGACAAGGGCTACATCTCGGCGTACTTCGTCACCGACCCCGAGCGGATGGAGACGGTCCTCG
AGGACCCCTACGTCCTGATCGCGAACCAGAAGATCTCCTCGGTCAAGGACCTGCTGCCGCTGCTCGAGAAGGTCATGCAG
TCCGGCAAGCCGCTGCTGATCCTGGCCGAGGACGTCGACGGCGAGGCCCTGTCCACGCTGGTCGTCAACAAGATCCGCGG
CACCTTCAAGTCCGTCGCCGTCAAGGCCCCGGGCTTCGGTGACCGCCGCAAGGCCATGCTGCAGGACATCGCGATCCTCA
CCGGCGGCCAGGTCATCTCCGAGGAGGTCGGCCTCAAGCTCGAGTCGACCGGCATCGAGCTGCTCGGCCAGGCCCGCAAG
GTCGTCATCACCAAGGACGAGACCACGATCGTCGAGGGTGCCGGCGACGCCGACCAGATCGCCGGCCGGGTCAACCAGAT
CCGCGCCGAGATCGAGAAGTCGGACTCCGACTACGACCGCGAGAAGCTCCAGGAGCGCCTCGCCAAGCTGGCCGGCGGCG
TGGCCGTCATCAAGGTCGGCGCGGCCACCGAGGTCGAGCTCAAGGAGCGCAAGCACCGCATCGAGGACGCCGTTCGCAAC
GCGAAGGCGGCCGTCGAGGAGGGCATCGTCGCCGGTGGTGGCGTGGCGCTCGTCCAGGCTGCCAACGCCGCGTTCGACAA
GCTCGACCTCACCGGTGACGAGGCCGTGGGTGCGCAGATCGTGCGCTTCGCGACCGATGCCCCGCTCAAGCAGATCGCGA
TCAACGCCGGCCTCGAGGGCGGCGTCGTGGCGGAGAAGGTGCGCGGCCTCACGGCCGGTCACGGCCTCAATGCGGCCACC
GGCGAGTACGTCGACATGATCGCCTCGGGCATCATCGACCCCGCCAAGGTGACCCGCAGCGCGCTGCAGAACGCCGCCTC
CATCGCGGCGCTCTTCCTCACCACCGAGGCCGTCGTGGCCGACAAGCCGGAGAAGGCCGCCCCGATGGGCGACCCGTCCG
GCGGCATGGGCGGCATGGACTTCTGA

Upstream 100 bases:

>100_bases
GGCGAGAAAGGGTTCGCCGGAGCCAGGGTGGCCGTCCGTCGCGGGCAACCCGTCGACCCGGATCCATGAACTCTCTTCAT
TGCGAAGGATCGCAGGAGTT

Downstream 100 bases:

>100_bases
GCACCCCTTGGTCGGCCTGGCTCCGAGCCAGGCCGATCAAAGCCAGGTGCCGGGTCGAGGAGCGTCGACCGGACCGAGCG
AAGCGAGGAACGGCGACGCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MPKLIAFNEEARRGLERGMNTLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQAMVREGLRNVAAGANPMGLKRGIEAAVEAVSGQLLSMAKDVETKEQIASTASISAADTTVGEII
AEAMDKVGKEGVITVEESNTFGLDLELTEGMRFDKGYISAYFVTDPERMETVLEDPYVLIANQKISSVKDLLPLLEKVMQ
SGKPLLILAEDVDGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDIAILTGGQVISEEVGLKLESTGIELLGQARK
VVITKDETTIVEGAGDADQIAGRVNQIRAEIEKSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRN
AKAAVEEGIVAGGGVALVQAANAAFDKLDLTGDEAVGAQIVRFATDAPLKQIAINAGLEGGVVAEKVRGLTAGHGLNAAT
GEYVDMIASGIIDPAKVTRSALQNAASIAALFLTTEAVVADKPEKAAPMGDPSGGMGGMDF

Sequences:

>Translated_541_residues
MPKLIAFNEEARRGLERGMNTLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQAMVREGLRNVAAGANPMGLKRGIEAAVEAVSGQLLSMAKDVETKEQIASTASISAADTTVGEII
AEAMDKVGKEGVITVEESNTFGLDLELTEGMRFDKGYISAYFVTDPERMETVLEDPYVLIANQKISSVKDLLPLLEKVMQ
SGKPLLILAEDVDGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDIAILTGGQVISEEVGLKLESTGIELLGQARK
VVITKDETTIVEGAGDADQIAGRVNQIRAEIEKSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRN
AKAAVEEGIVAGGGVALVQAANAAFDKLDLTGDEAVGAQIVRFATDAPLKQIAINAGLEGGVVAEKVRGLTAGHGLNAAT
GEYVDMIASGIIDPAKVTRSALQNAASIAALFLTTEAVVADKPEKAAPMGDPSGGMGGMDF
>Mature_540_residues
PKLIAFNEEARRGLERGMNTLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTD
DVAGDGTTTATVLAQAMVREGLRNVAAGANPMGLKRGIEAAVEAVSGQLLSMAKDVETKEQIASTASISAADTTVGEIIA
EAMDKVGKEGVITVEESNTFGLDLELTEGMRFDKGYISAYFVTDPERMETVLEDPYVLIANQKISSVKDLLPLLEKVMQS
GKPLLILAEDVDGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDIAILTGGQVISEEVGLKLESTGIELLGQARKV
VITKDETTIVEGAGDADQIAGRVNQIRAEIEKSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNA
KAAVEEGIVAGGGVALVQAANAAFDKLDLTGDEAVGAQIVRFATDAPLKQIAINAGLEGGVVAEKVRGLTAGHGLNAATG
EYVDMIASGIIDPAKVTRSALQNAASIAALFLTTEAVVADKPEKAAPMGDPSGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=525, Percent_Identity=46.8571428571429, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI31542947, Length=525, Percent_Identity=46.8571428571429, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI5453603, Length=574, Percent_Identity=25.4355400696864, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI24307939, Length=357, Percent_Identity=25.2100840336134, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=60.4562737642585, Blast_Score=610, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=47.5378787878788, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI193210679, Length=216, Percent_Identity=46.7592592592593, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17564182, Length=551, Percent_Identity=21.7785843920145, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=50.9541984732824, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322524, Length=183, Percent_Identity=28.4153005464481, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320058, Length=179, Percent_Identity=26.8156424581006, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=48.2041587901701, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=48.2041587901701, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550936, Length=523, Percent_Identity=45.3154875717017, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45550132, Length=523, Percent_Identity=45.3154875717017, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45550935, Length=523, Percent_Identity=45.3154875717017, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17864606, Length=541, Percent_Identity=40.1109057301294, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=34.4106463878327, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=34.4106463878327, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI28571140, Length=568, Percent_Identity=24.4718309859155, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI18858175, Length=568, Percent_Identity=24.4718309859155, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_NOCSJ (A1SNU4)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_925166.1
- ProteinModelPortal:   A1SNU4
- SMR:   A1SNU4
- STRING:   A1SNU4
- GeneID:   4598117
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3982
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   SANDEEV
- ProtClustDB:   PRK00013
- BioCyc:   NSP35761:NOCA_3982-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56829; Mature: 56697

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLIAFNEEARRGLERGMNTLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIE
CCCEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHCC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQAMVREGLRNVAAGANPMGLKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AAVEAVSGQLLSMAKDVETKEQIASTASISAADTTVGEIIAEAMDKVGKEGVITVEESNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
FGLDLELTEGMRFDKGYISAYFVTDPERMETVLEDPYVLIANQKISSVKDLLPLLEKVMQ
EEEEEEECCCCEECCCCEEEEEECCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
SGKPLLILAEDVDGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDIAILTGGQVIS
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHHH
EEVGLKLESTGIELLGQARKVVITKDETTIVEGAGDADQIAGRVNQIRAEIEKSDSDYDR
HHHCCEEECCCHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
EKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALVQA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ANAAFDKLDLTGDEAVGAQIVRFATDAPLKQIAINAGLEGGVVAEKVRGLTAGHGLNAAT
HHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
GEYVDMIASGIIDPAKVTRSALQNAASIAALFLTTEAVVADKPEKAAPMGDPSGGMGGMD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
F
C
>Mature Secondary Structure 
PKLIAFNEEARRGLERGMNTLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIE
CCEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHCC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQAMVREGLRNVAAGANPMGLKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AAVEAVSGQLLSMAKDVETKEQIASTASISAADTTVGEIIAEAMDKVGKEGVITVEESNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
FGLDLELTEGMRFDKGYISAYFVTDPERMETVLEDPYVLIANQKISSVKDLLPLLEKVMQ
EEEEEEECCCCEECCCCEEEEEECCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
SGKPLLILAEDVDGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDIAILTGGQVIS
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHHH
EEVGLKLESTGIELLGQARKVVITKDETTIVEGAGDADQIAGRVNQIRAEIEKSDSDYDR
HHHCCEEECCCHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
EKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALVQA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ANAAFDKLDLTGDEAVGAQIVRFATDAPLKQIAINAGLEGGVVAEKVRGLTAGHGLNAAT
HHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
GEYVDMIASGIIDPAKVTRSALQNAASIAALFLTTEAVVADKPEKAAPMGDPSGGMGGMD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA