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The map label for this gene is guaB [H]

Identifier: 119717867

GI number: 119717867

Start: 3868895

End: 3870397

Strand: Reverse

Name: guaB [H]

Synonym: Noca_3645

Alternate gene names: 119717867

Gene position: 3870397-3868895 (Counterclockwise)

Preceding gene: 119717868

Following gene: 119717863

Centisome position: 77.63

GC content: 70.19

Gene sequence:

>1503_bases
GTGGAGCTGCCTGAGAAGTTCGCCGCCCTCGGCCTGACCTACGACGACGTCCTGCTGCTGCCGGGTCACTCCGACCTCGC
GCCCGCGGACATCGACATGACCTCGCGGCTGACCCGCGAGATCTCGTTGAAGGTCCCGCTCGTGAGCGCCGCGATGGACA
CCGTGACCGAGTCGCGGATGGCGATCGCGATGGCGCGCCAGGGCGGCCTGGGCGTGCTGCACCGCAACCTGTCGATCGAG
GACCAGGCCTACCAGGTCGACCTGGTCAAGCGGACCCAGACCGGCATCATCTCCAACCCGGTGACGATCGGGCCGGACGC
GACCCTCGAGCAGCTCGACCAGCTCGCCGGGGAGTACCGCATCTCCGGCTTCCCGGTCGTCGACGCCGACAACCGCCTGC
TCGGCATCATCACCAACCGCGACCTGCGGTTCACCCCCGTCGCGGAGTGGGCCACCACCAAGGTCGACGAGGTGATGACG
CCGATGCCGCTGATCACCGCGCCCCCCGACATCTCCCGCGAGGACGCCACCCTGCTGCTGCGCCAGCACAAGCGCGAGCG
GCTGCCGCTGGTCGACGCGCAGGGCCGGCTGGCCGGCCTGATCACCGTCAAGGACTTCGTGAAGTCCGAGCAGTTCCCGC
ATGCCTCCAAGGACGGCGCGGGGCGACTGATGGTGGGGGCCGCGATCGGCTACTTCGGTGACGCCTGGCAGCGCGCGACC
ACGCTCGTGGAGGCCGGTGTGGACGTGCTGGTCGCCGACACCGCCCACGGTCACGTCACGCTGCTGCTCGACATGGTGCG
CCGCCTCAAGGCCGACCCGGCCACCCGCCACGTCCAGGTGATCGGCGGCAACGTCGCCACCCGCGACGGCGCGCAGGCCT
TCGTCGATGCCGGCGCCGACGCCGTGAAGGTCGGGTTCGGGCCCGGCTCGATCTGCACGACCCGGGTCGTCACCGGCTGC
GGCGTACCCCAGATCACTGCCGTGTACGAGGCGTCGCTGGCCTGCCAGCCGGTCGGCGTGCCGGTGATCGCCGACGGCGG
GCTGCAGCAGTCGGGCGACATCGCCAAGGCGATCGTTGCCGGCGCCGAGACCGTGATGATCGGCTCGCTGCTGGCCGGCT
GCGAGGAGTCGCCCGGCGAGCTGATCTTCGTCAACGGCAAGCAGTACAAGTCCTACCGCGGGATGGGCTCGTTGGCGGCG
ATGTCCAGCCGCGGCAAGAAGTCCTACTCCAAGGACCGGTACTTCCAGGCCGAGGTGACCAGCGACGACAAGATCGTGCC
CGAGGGGATCGAGGGCCAGGTCGCCTACCGGGGCCCGCTGGCCGCGGTCGCCCACCAGCTGATCGGCGGCCTGAACCAGT
CGATGTTCTACATCGGCGCGGCGACGATCCCCGAGCTCCAGGCGAAGGGCCGCTTCGTGCGGATCACCTCGGCCTCGCTC
AAGGAGAGCCACCCCCACGACGTCCAGATGACCGTCGAGGCCCCCAACTACTCCGGCCGCTAG

Upstream 100 bases:

>100_bases
GACCCTGCGCCGGTTCCACGGCCCCGGCCGTCCCAGGAACGACCGTCTCTCCCCTGAGCCGTGGTGCCGGGCCCGTTCCG
GGCGCAGGTAGGCTGTCGGA

Downstream 100 bases:

>100_bases
CGACCAAGGATCGCTAGAACGCGTAGCCCACCTGGTTGATCTTCACCCGGGCTCGCTTGGCGAGCTGGACCGTCAATCGG
GTGTGGGCCGCGACCGGCAC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MELPEKFAALGLTYDDVLLLPGHSDLAPADIDMTSRLTREISLKVPLVSAAMDTVTESRMAIAMARQGGLGVLHRNLSIE
DQAYQVDLVKRTQTGIISNPVTIGPDATLEQLDQLAGEYRISGFPVVDADNRLLGIITNRDLRFTPVAEWATTKVDEVMT
PMPLITAPPDISREDATLLLRQHKRERLPLVDAQGRLAGLITVKDFVKSEQFPHASKDGAGRLMVGAAIGYFGDAWQRAT
TLVEAGVDVLVADTAHGHVTLLLDMVRRLKADPATRHVQVIGGNVATRDGAQAFVDAGADAVKVGFGPGSICTTRVVTGC
GVPQITAVYEASLACQPVGVPVIADGGLQQSGDIAKAIVAGAETVMIGSLLAGCEESPGELIFVNGKQYKSYRGMGSLAA
MSSRGKKSYSKDRYFQAEVTSDDKIVPEGIEGQVAYRGPLAAVAHQLIGGLNQSMFYIGAATIPELQAKGRFVRITSASL
KESHPHDVQMTVEAPNYSGR

Sequences:

>Translated_500_residues
MELPEKFAALGLTYDDVLLLPGHSDLAPADIDMTSRLTREISLKVPLVSAAMDTVTESRMAIAMARQGGLGVLHRNLSIE
DQAYQVDLVKRTQTGIISNPVTIGPDATLEQLDQLAGEYRISGFPVVDADNRLLGIITNRDLRFTPVAEWATTKVDEVMT
PMPLITAPPDISREDATLLLRQHKRERLPLVDAQGRLAGLITVKDFVKSEQFPHASKDGAGRLMVGAAIGYFGDAWQRAT
TLVEAGVDVLVADTAHGHVTLLLDMVRRLKADPATRHVQVIGGNVATRDGAQAFVDAGADAVKVGFGPGSICTTRVVTGC
GVPQITAVYEASLACQPVGVPVIADGGLQQSGDIAKAIVAGAETVMIGSLLAGCEESPGELIFVNGKQYKSYRGMGSLAA
MSSRGKKSYSKDRYFQAEVTSDDKIVPEGIEGQVAYRGPLAAVAHQLIGGLNQSMFYIGAATIPELQAKGRFVRITSASL
KESHPHDVQMTVEAPNYSGR
>Mature_500_residues
MELPEKFAALGLTYDDVLLLPGHSDLAPADIDMTSRLTREISLKVPLVSAAMDTVTESRMAIAMARQGGLGVLHRNLSIE
DQAYQVDLVKRTQTGIISNPVTIGPDATLEQLDQLAGEYRISGFPVVDADNRLLGIITNRDLRFTPVAEWATTKVDEVMT
PMPLITAPPDISREDATLLLRQHKRERLPLVDAQGRLAGLITVKDFVKSEQFPHASKDGAGRLMVGAAIGYFGDAWQRAT
TLVEAGVDVLVADTAHGHVTLLLDMVRRLKADPATRHVQVIGGNVATRDGAQAFVDAGADAVKVGFGPGSICTTRVVTGC
GVPQITAVYEASLACQPVGVPVIADGGLQQSGDIAKAIVAGAETVMIGSLLAGCEESPGELIFVNGKQYKSYRGMGSLAA
MSSRGKKSYSKDRYFQAEVTSDDKIVPEGIEGQVAYRGPLAAVAHQLIGGLNQSMFYIGAATIPELQAKGRFVRITSASL
KESHPHDVQMTVEAPNYSGR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=489, Percent_Identity=41.3087934560327, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI217035146, Length=466, Percent_Identity=41.4163090128755, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI156616279, Length=466, Percent_Identity=41.4163090128755, Blast_Score=338, Evalue=1e-92,
Organism=Homo sapiens, GI34328928, Length=466, Percent_Identity=41.4163090128755, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI34328930, Length=466, Percent_Identity=41.4163090128755, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI217035148, Length=466, Percent_Identity=40.7725321888412, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI217035152, Length=458, Percent_Identity=41.0480349344978, Blast_Score=328, Evalue=9e-90,
Organism=Homo sapiens, GI217035150, Length=466, Percent_Identity=39.0557939914163, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI50541956, Length=232, Percent_Identity=37.0689655172414, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI50541954, Length=232, Percent_Identity=37.0689655172414, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI50541952, Length=232, Percent_Identity=37.0689655172414, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI50541948, Length=232, Percent_Identity=37.0689655172414, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI156104880, Length=244, Percent_Identity=33.1967213114754, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1788855, Length=498, Percent_Identity=50.2008032128514, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1786293, Length=229, Percent_Identity=34.9344978165939, Blast_Score=138, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=483, Percent_Identity=37.2670807453416, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=433, Percent_Identity=38.568129330254, Blast_Score=284, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=284, Percent_Identity=33.8028169014084, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322012, Length=490, Percent_Identity=39.3877551020408, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6323585, Length=489, Percent_Identity=37.8323108384458, Blast_Score=326, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=489, Percent_Identity=38.8548057259714, Blast_Score=322, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=344, Percent_Identity=38.6627906976744, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=135, Percent_Identity=40, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=40.0826446280992, Blast_Score=341, Evalue=6e-94,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=40.0826446280992, Blast_Score=341, Evalue=6e-94,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=39.5033860045147, Blast_Score=297, Evalue=1e-80,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53283; Mature: 53283

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPEKFAALGLTYDDVLLLPGHSDLAPADIDMTSRLTREISLKVPLVSAAMDTVTESRM
CCCCHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHEEEEECCHHHHHHHHHHHHHH
AIAMARQGGLGVLHRNLSIEDQAYQVDLVKRTQTGIISNPVTIGPDATLEQLDQLAGEYR
EEEECCCCCCEEEEECCCCCCCEEEEEEEHHHCCCCCCCCEEECCCCHHHHHHHHHCCEE
ISGFPVVDADNRLLGIITNRDLRFTPVAEWATTKVDEVMTPMPLITAPPDISREDATLLL
CCCEEEECCCCCEEEEEECCCEEEEECHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHH
RQHKRERLPLVDAQGRLAGLITVKDFVKSEQFPHASKDGAGRLMVGAAIGYFGDAWQRAT
HHHHHHCCCEECCCCCEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
TLVEAGVDVLVADTAHGHVTLLLDMVRRLKADPATRHVQVIGGNVATRDGAQAFVDAGAD
HHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEECCCCHHHHHHCCCC
AVKVGFGPGSICTTRVVTGCGVPQITAVYEASLACQPVGVPVIADGGLQQSGDIAKAIVA
EEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHH
GAETVMIGSLLAGCEESPGELIFVNGKQYKSYRGMGSLAAMSSRGKKSYSKDRYFQAEVT
CCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEEC
SDDKIVPEGIEGQVAYRGPLAAVAHQLIGGLNQSMFYIGAATIPELQAKGRFVRITSASL
CCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCEEEEEECHH
KESHPHDVQMTVEAPNYSGR
CCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MELPEKFAALGLTYDDVLLLPGHSDLAPADIDMTSRLTREISLKVPLVSAAMDTVTESRM
CCCCHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHEEEEECCHHHHHHHHHHHHHH
AIAMARQGGLGVLHRNLSIEDQAYQVDLVKRTQTGIISNPVTIGPDATLEQLDQLAGEYR
EEEECCCCCCEEEEECCCCCCCEEEEEEEHHHCCCCCCCCEEECCCCHHHHHHHHHCCEE
ISGFPVVDADNRLLGIITNRDLRFTPVAEWATTKVDEVMTPMPLITAPPDISREDATLLL
CCCEEEECCCCCEEEEEECCCEEEEECHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHH
RQHKRERLPLVDAQGRLAGLITVKDFVKSEQFPHASKDGAGRLMVGAAIGYFGDAWQRAT
HHHHHHCCCEECCCCCEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
TLVEAGVDVLVADTAHGHVTLLLDMVRRLKADPATRHVQVIGGNVATRDGAQAFVDAGAD
HHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEECCCCHHHHHHCCCC
AVKVGFGPGSICTTRVVTGCGVPQITAVYEASLACQPVGVPVIADGGLQQSGDIAKAIVA
EEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHH
GAETVMIGSLLAGCEESPGELIFVNGKQYKSYRGMGSLAAMSSRGKKSYSKDRYFQAEVT
CCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEEC
SDDKIVPEGIEGQVAYRGPLAAVAHQLIGGLNQSMFYIGAATIPELQAKGRFVRITSASL
CCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCEEEEEECHH
KESHPHDVQMTVEAPNYSGR
CCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]