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The map label for this gene is groL1

Identifier: 119717868

GI number: 119717868

Start: 3870577

End: 3872202

Strand: Reverse

Name: groL1

Synonym: Noca_3646

Alternate gene names: 119717868

Gene position: 3872202-3870577 (Counterclockwise)

Preceding gene: 119717869

Following gene: 119717867

Centisome position: 77.66

GC content: 70.05

Gene sequence:

>1626_bases
ATGCCCAAGATCCTGGAGTTCGACGAGCACGCCCGGCGCGCCCTGGAGCGCGGCGTCGACGCGCTCGCCAACGCCGTCAA
GGTCACGCTCGGCCCGAAGGGCCGCTACGTCGTCCTGGACAAGAAGTGGGGCGCCCCGACCATCACCAACGACGGCGTGA
CCGTCGCGCGTGAGGTCGAGCTGGACGACCCGTTCGAGAACCTCGGTGCGCAGCTCACCAAGGAGGTCGCCACCAAGACC
AACGACATCGCGGGCGACGGTACGACGACCGCGACGGTGCTGGCCCAGGCGATGGTCCACGAGGGCCTGCGCGCGGTCAC
CGCCGGCGCGAACCCGATGGGACTCAAGCGCGGCATGGACGCCGCTGCCGAGGCCGTGGGCGACGCCCTCAAGGAGGCGG
CCCGCGAGGTCGAGTCGCGCGAGGACATGGCGTCGGTCGCCACGATCTCGAGCCGTGACAGCGTGATCGGCGACCTGCTC
GCCGAGGCCTTCGACAAGGTCGGCAAGGACGGCGTGATCACGGTCGAGGAGTCCAACACCATGGGCACCGAGCTCGAGTT
CACCGAGGGCATGCAGTTCGACAAGGGCTACATCAGCCAGTACTTCGTCACCGACCCGGAGCGGATGGAGGCCGTCCTCG
AGGACCCCTACATCCTGCTGCACCAGGGCAAGATCTCCGCGGTCGCCGAGCTGCTGCCGCTGCTGGAGAAGGTGATCCAG
TCCGGCAAGCCGCTGTTCATCCTGGCCGAGGACGTGGAGGGCGAGGCGCTCTCCACCCTGGTCGTGAACAAGATCCGCGG
CACCTTCAACGCGGTCGCGGTGAAGAGCCCGGCGTTCGGTGACCGTCGCAAGGCGATGATGCAGGACATCGCGACCCTGA
CCGGCGGTCAGGTCGTCGCCCCCGAGGTCGGACTCAAGCTCGACCAGGTCGGCCTCGAGGTGCTCGGCCAGGCCCGCCGC
GTCGTCGTCACCAAGGACGACACCACGATCGTGGACGGCGCCGGCGACCCCAAGGACGTCGAGGGCCGGGTCAACCAGAT
CAAGGCCGAGGTGGAGAACACCGACTCCGACTGGGACCGCGAGAAGCTCCAGGAGCGGCTCGCGAAGCTGGCCGGCGGCG
TGTGCGTGATCAAGGTCGGCGCCGCCACCGAGGTGGAGCTGAAGGAGAAGAAGCACCGCATCGAGGACGCCGTCTCCGCG
ACGCGCGCCGCGATCGAGGAGGGCATCGTCGCCGGCGGCGGCTCCGCCCTCGTCCACGCGGTCTCGGTGCTCTCCGACGA
CCTCGGCCTCACCGGCGACGAGGCGCTCGGCGTCCGCGTGGTCCGCAAGGCCGCCGACGAGCCGCTGCGCTGGATCGCCG
AGAACGGCGGGGTCAACGGCTACGTCGTCACCACCAAGGTCCGCGAGCTCGGCCTCGGCAACGGCTTCAACGCCGCCACC
GAGGAGTACGGCGACCTGGTCGCCCAGGGCGTCCTGGACCCGGTGAAGGTCACCCGCTCCGCGCTGGTCAACGCCACCTC
GATCGCGGGCATGCTGCTCACGACCGAGACCCTGGTCGTCGACAAGCCCGAGGAGGAGGAGCCCGCGGCAGCCGGTCACG
GCCACGGGCACGGCCACGGCCACTGA

Upstream 100 bases:

>100_bases
CTGAAGTCCTTCCGGGTCGTGTGCCTGACGACGCGCCATGGCGCGCTCTCAGGCACACGACCCGGTCTTCGTTAGACCCG
GTCTTCGATAGAGGAGAGAA

Downstream 100 bases:

>100_bases
CCCACCCCGCTTCACGCCGAGTCGGCGCCAGTTCGTGCAACTGGCGCCGACTCGCGCATTTCGGCGGGCAGGACGCGCCG
ACCCTGCGCCGGTTCCACGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MPKILEFDEHARRALERGVDALANAVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAREVELDDPFENLGAQLTKEVATKT
NDIAGDGTTTATVLAQAMVHEGLRAVTAGANPMGLKRGMDAAAEAVGDALKEAAREVESREDMASVATISSRDSVIGDLL
AEAFDKVGKDGVITVEESNTMGTELEFTEGMQFDKGYISQYFVTDPERMEAVLEDPYILLHQGKISAVAELLPLLEKVIQ
SGKPLFILAEDVEGEALSTLVVNKIRGTFNAVAVKSPAFGDRRKAMMQDIATLTGGQVVAPEVGLKLDQVGLEVLGQARR
VVVTKDDTTIVDGAGDPKDVEGRVNQIKAEVENTDSDWDREKLQERLAKLAGGVCVIKVGAATEVELKEKKHRIEDAVSA
TRAAIEEGIVAGGGSALVHAVSVLSDDLGLTGDEALGVRVVRKAADEPLRWIAENGGVNGYVVTTKVRELGLGNGFNAAT
EEYGDLVAQGVLDPVKVTRSALVNATSIAGMLLTTETLVVDKPEEEEPAAAGHGHGHGHGH

Sequences:

>Translated_541_residues
MPKILEFDEHARRALERGVDALANAVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAREVELDDPFENLGAQLTKEVATKT
NDIAGDGTTTATVLAQAMVHEGLRAVTAGANPMGLKRGMDAAAEAVGDALKEAAREVESREDMASVATISSRDSVIGDLL
AEAFDKVGKDGVITVEESNTMGTELEFTEGMQFDKGYISQYFVTDPERMEAVLEDPYILLHQGKISAVAELLPLLEKVIQ
SGKPLFILAEDVEGEALSTLVVNKIRGTFNAVAVKSPAFGDRRKAMMQDIATLTGGQVVAPEVGLKLDQVGLEVLGQARR
VVVTKDDTTIVDGAGDPKDVEGRVNQIKAEVENTDSDWDREKLQERLAKLAGGVCVIKVGAATEVELKEKKHRIEDAVSA
TRAAIEEGIVAGGGSALVHAVSVLSDDLGLTGDEALGVRVVRKAADEPLRWIAENGGVNGYVVTTKVRELGLGNGFNAAT
EEYGDLVAQGVLDPVKVTRSALVNATSIAGMLLTTETLVVDKPEEEEPAAAGHGHGHGHGH
>Mature_540_residues
PKILEFDEHARRALERGVDALANAVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAREVELDDPFENLGAQLTKEVATKTN
DIAGDGTTTATVLAQAMVHEGLRAVTAGANPMGLKRGMDAAAEAVGDALKEAAREVESREDMASVATISSRDSVIGDLLA
EAFDKVGKDGVITVEESNTMGTELEFTEGMQFDKGYISQYFVTDPERMEAVLEDPYILLHQGKISAVAELLPLLEKVIQS
GKPLFILAEDVEGEALSTLVVNKIRGTFNAVAVKSPAFGDRRKAMMQDIATLTGGQVVAPEVGLKLDQVGLEVLGQARRV
VVTKDDTTIVDGAGDPKDVEGRVNQIKAEVENTDSDWDREKLQERLAKLAGGVCVIKVGAATEVELKEKKHRIEDAVSAT
RAAIEEGIVAGGGSALVHAVSVLSDDLGLTGDEALGVRVVRKAADEPLRWIAENGGVNGYVVTTKVRELGLGNGFNAATE
EYGDLVAQGVLDPVKVTRSALVNATSIAGMLLTTETLVVDKPEEEEPAAAGHGHGHGHGH

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=43.8330170777989, Blast_Score=451, Evalue=1e-126,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=43.8330170777989, Blast_Score=451, Evalue=1e-126,
Organism=Homo sapiens, GI38455427, Length=552, Percent_Identity=21.0144927536232, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=58.745247148289, Blast_Score=597, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17555558, Length=527, Percent_Identity=43.2637571157495, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=41.9811320754717, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=49.618320610687, Blast_Score=493, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322524, Length=122, Percent_Identity=34.4262295081967, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=47.7186311787072, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=47.7186311787072, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=44.106463878327, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=44.106463878327, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=44.106463878327, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17864606, Length=522, Percent_Identity=41.5708812260536, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24584129, Length=525, Percent_Identity=35.2380952380952, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI19921262, Length=525, Percent_Identity=35.2380952380952, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI28571140, Length=560, Percent_Identity=23.3928571428571, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18858175, Length=560, Percent_Identity=23.3928571428571, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_NOCSJ (A1SMW1)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924833.1
- ProteinModelPortal:   A1SMW1
- SMR:   A1SMW1
- STRING:   A1SMW1
- GeneID:   4595758
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3646
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   RIISEAV
- ProtClustDB:   CLSK2783730
- BioCyc:   NSP35761:NOCA_3646-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57287; Mature: 57156

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKILEFDEHARRALERGVDALANAVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAREVE
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEEC
LDDPFENLGAQLTKEVATKTNDIAGDGTTTATVLAQAMVHEGLRAVTAGANPMGLKRGMD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHH
AAAEAVGDALKEAAREVESREDMASVATISSRDSVIGDLLAEAFDKVGKDGVITVEESNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
MGTELEFTEGMQFDKGYISQYFVTDPERMEAVLEDPYILLHQGKISAVAELLPLLEKVIQ
CCCEEECCCCCCCCCHHHHHEECCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
SGKPLFILAEDVEGEALSTLVVNKIRGTFNAVAVKSPAFGDRRKAMMQDIATLTGGQVVA
CCCCEEEEEECCCCHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHHHHHHHHHCCCEEEC
PEVGLKLDQVGLEVLGQARRVVVTKDDTTIVDGAGDPKDVEGRVNQIKAEVENTDSDWDR
HHHCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCH
EKLQERLAKLAGGVCVIKVGAATEVELKEKKHRIEDAVSATRAAIEEGIVAGGGSALVHA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
VSVLSDDLGLTGDEALGVRVVRKAADEPLRWIAENGGVNGYVVTTKVRELGLGNGFNAAT
HHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEEHHHHCCCCCCCHHH
EEYGDLVAQGVLDPVKVTRSALVNATSIAGMLLTTETLVVDKPEEEEPAAAGHGHGHGHG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCC
H
C
>Mature Secondary Structure 
PKILEFDEHARRALERGVDALANAVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAREVE
CCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEEC
LDDPFENLGAQLTKEVATKTNDIAGDGTTTATVLAQAMVHEGLRAVTAGANPMGLKRGMD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHH
AAAEAVGDALKEAAREVESREDMASVATISSRDSVIGDLLAEAFDKVGKDGVITVEESNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCC
MGTELEFTEGMQFDKGYISQYFVTDPERMEAVLEDPYILLHQGKISAVAELLPLLEKVIQ
CCCEEECCCCCCCCCHHHHHEECCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
SGKPLFILAEDVEGEALSTLVVNKIRGTFNAVAVKSPAFGDRRKAMMQDIATLTGGQVVA
CCCCEEEEEECCCCHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHHHHHHHHHCCCEEEC
PEVGLKLDQVGLEVLGQARRVVVTKDDTTIVDGAGDPKDVEGRVNQIKAEVENTDSDWDR
HHHCCCHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCH
EKLQERLAKLAGGVCVIKVGAATEVELKEKKHRIEDAVSATRAAIEEGIVAGGGSALVHA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
VSVLSDDLGLTGDEALGVRVVRKAADEPLRWIAENGGVNGYVVTTKVRELGLGNGFNAAT
HHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEEHHHHCCCCCCCHHH
EEYGDLVAQGVLDPVKVTRSALVNATSIAGMLLTTETLVVDKPEEEEPAAAGHGHGHGHG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA