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The map label for this gene is guaA [H]

Identifier: 119717853

GI number: 119717853

Start: 3849134

End: 3850717

Strand: Reverse

Name: guaA [H]

Synonym: Noca_3631

Alternate gene names: 119717853

Gene position: 3850717-3849134 (Counterclockwise)

Preceding gene: 119717854

Following gene: 119717850

Centisome position: 77.23

GC content: 71.46

Gene sequence:

>1584_bases
ATGACGCAGCCCGCGGAGCACGATCTGGTCCTGGTGGTCGACTTCGGGGCGCAGTACGCCCAGCTGATCGCCCGGCGGGT
CCGCGAGGCGCGGGTCTACTCCGAGATCGTGCCGCACACGACCCCGGTGGCCGAGATCCTGGCCCGCGAGCCGAAGGCGA
TCATCCTCTCCGGCGGCCCGTCCTCGGTCTACGAGCCCGACGCCCCGAGCATCGACCCCGCGATCTTCACCTCCGGCACC
CCGGTGTTCGGGATGTGCTACGGCTTCCAGCTGATGGCCCAGGGCCTCGGGGGCGAGGTGGCCCACACCGGCGCCCGGGA
GTACGGGCGTACGGCGGTCGCCGTGGCCCGACCCGGGACGCTGCTGGCGGACATCCCCGCGCACCACACCGTGTGGATGT
CGCACGGCGACTCGGTGGCGGCCGCCCCGTCCGGCTTCGACGTGCTGGCCTCGACGGCCACGACGCCGGTGGCGGCGTTC
GAGGACGTCGACCGCGGCCTGGCCGGCGTCCAGTGGCACCCCGAGGTGCTGCACACCGAGCACGGCCAGAAGGTGCTCGA
GCACTTCCTGGTCCAGATCGCCCACTGCCGCCAGACCTGGACCATGGTCAACATCGTCGAGGAGCAGATCGAGGCCATCC
GCGCGCAGATCGGCGATCGCGGCCAGGCGATCTGCGGGCTGTCCGGCGGCGTCGACTCCGCGGTCGCGGCCGCGATCGTG
CAGCGGGCGATCGGCGACCGGCTCACCTGTGTGTACGTCGACCACGGGCTGATGCGCCAGGGCGAGACCGAGCAGGTCGA
GCGCGACTTCGTGGCCGCGACCGGCGTCGACCTCAAGGTCGTCGACGCCGAGAAGCAGTTCCTCGACGCACTCGCGGGCG
TCACCGACCCCGAGGAGAAGCGCAAGATCATCGGCCGCGAGTTCATCCGGGTCTTCGAGGCCGCGGAGGCGGACATCCTC
GGCGGGAGTCTGCCGGACGATGGGGGGAGCAAGGTCGCGTTCCTCGTCCAGGGCACGCTCTACCCCGACGTGGTCGAGTC
CGGCGGGGGAGCGGGGACCTCCAACATCAAGTCACACCACAACGTCGGCGGCCTGCCCGACGACCTCGAGTTCGAGCTGG
TCGAGCCGCTGCGCACCCTGTTCAAGGACGAGGTCCGGCTGGTCGGCGAGCAGCTCGGCCTGCCGGCCGAGATCGTGTGG
CGCCAGCCGTTCCCGGGCCCCGGGCTCGGCATCCGGATCATCGGCGAGGTCACCCGCGAGCGGCTCGACATCCTCCGCGA
GGCCGACGCCATCGCCCGGGAGGAGCTCACCCGCGCCGGCCTGGACCGCGACATCTGGCAGTTCCCCGTCGTGCTCCTCG
CCGACGTCCGCTCGGTCGGCGTCCAGGGTGACCACCGCACCTACGGACACCCCGTCGTGCTCCGTCCGGTCACCTCCGAG
GACGCGATGACCGCCGACTGGGCGCGGCTGCCGTACGACGTGCTCGAGCGGATCTCGACCCGGATCACCAACGAGGTGCG
GGAGATCAACCGGGTGACGGTCGACATCACCTCCAAGCCCCCGGGCACCATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GTTCCCGGATTGCCTGAGAAGACAGCCGTGCACCGAGCCTGGATCTCTCCCACCGAAGCGAGGCGGTGGGTCGGCTGCTC
GCCTCGATAGGCTGTGCCGC

Downstream 100 bases:

>100_bases
CCGCCCGGTCGAGGTCAGCCGAGGAACTCGGCGATCCGCTCGTGGTACCCCGGAGGCTGCAGGAGGAACGAGTCGTGGCC
GAACGGTGAGGCCAGCTCGG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTQPAEHDLVLVVDFGAQYAQLIARRVREARVYSEIVPHTTPVAEILAREPKAIILSGGPSSVYEPDAPSIDPAIFTSGT
PVFGMCYGFQLMAQGLGGEVAHTGAREYGRTAVAVARPGTLLADIPAHHTVWMSHGDSVAAAPSGFDVLASTATTPVAAF
EDVDRGLAGVQWHPEVLHTEHGQKVLEHFLVQIAHCRQTWTMVNIVEEQIEAIRAQIGDRGQAICGLSGGVDSAVAAAIV
QRAIGDRLTCVYVDHGLMRQGETEQVERDFVAATGVDLKVVDAEKQFLDALAGVTDPEEKRKIIGREFIRVFEAAEADIL
GGSLPDDGGSKVAFLVQGTLYPDVVESGGGAGTSNIKSHHNVGGLPDDLEFELVEPLRTLFKDEVRLVGEQLGLPAEIVW
RQPFPGPGLGIRIIGEVTRERLDILREADAIAREELTRAGLDRDIWQFPVVLLADVRSVGVQGDHRTYGHPVVLRPVTSE
DAMTADWARLPYDVLERISTRITNEVREINRVTVDITSKPPGTIEWE

Sequences:

>Translated_527_residues
MTQPAEHDLVLVVDFGAQYAQLIARRVREARVYSEIVPHTTPVAEILAREPKAIILSGGPSSVYEPDAPSIDPAIFTSGT
PVFGMCYGFQLMAQGLGGEVAHTGAREYGRTAVAVARPGTLLADIPAHHTVWMSHGDSVAAAPSGFDVLASTATTPVAAF
EDVDRGLAGVQWHPEVLHTEHGQKVLEHFLVQIAHCRQTWTMVNIVEEQIEAIRAQIGDRGQAICGLSGGVDSAVAAAIV
QRAIGDRLTCVYVDHGLMRQGETEQVERDFVAATGVDLKVVDAEKQFLDALAGVTDPEEKRKIIGREFIRVFEAAEADIL
GGSLPDDGGSKVAFLVQGTLYPDVVESGGGAGTSNIKSHHNVGGLPDDLEFELVEPLRTLFKDEVRLVGEQLGLPAEIVW
RQPFPGPGLGIRIIGEVTRERLDILREADAIAREELTRAGLDRDIWQFPVVLLADVRSVGVQGDHRTYGHPVVLRPVTSE
DAMTADWARLPYDVLERISTRITNEVREINRVTVDITSKPPGTIEWE
>Mature_526_residues
TQPAEHDLVLVVDFGAQYAQLIARRVREARVYSEIVPHTTPVAEILAREPKAIILSGGPSSVYEPDAPSIDPAIFTSGTP
VFGMCYGFQLMAQGLGGEVAHTGAREYGRTAVAVARPGTLLADIPAHHTVWMSHGDSVAAAPSGFDVLASTATTPVAAFE
DVDRGLAGVQWHPEVLHTEHGQKVLEHFLVQIAHCRQTWTMVNIVEEQIEAIRAQIGDRGQAICGLSGGVDSAVAAAIVQ
RAIGDRLTCVYVDHGLMRQGETEQVERDFVAATGVDLKVVDAEKQFLDALAGVTDPEEKRKIIGREFIRVFEAAEADILG
GSLPDDGGSKVAFLVQGTLYPDVVESGGGAGTSNIKSHHNVGGLPDDLEFELVEPLRTLFKDEVRLVGEQLGLPAEIVWR
QPFPGPGLGIRIIGEVTRERLDILREADAIAREELTRAGLDRDIWQFPVVLLADVRSVGVQGDHRTYGHPVVLRPVTSED
AMTADWARLPYDVLERISTRITNEVREINRVTVDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=562, Percent_Identity=34.8754448398576, Blast_Score=298, Evalue=8e-81,
Organism=Escherichia coli, GI1788854, Length=537, Percent_Identity=48.975791433892, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1789760, Length=153, Percent_Identity=30.0653594771242, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=35.8260869565217, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71992717, Length=577, Percent_Identity=35.8752166377816, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=35.8260869565217, Blast_Score=295, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=47.0249520153551, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322638, Length=198, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281365319, Length=552, Percent_Identity=35.5072463768116, Blast_Score=279, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57152; Mature: 57021

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPAEHDLVLVVDFGAQYAQLIARRVREARVYSEIVPHTTPVAEILAREPKAIILSGGP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCC
SSVYEPDAPSIDPAIFTSGTPVFGMCYGFQLMAQGLGGEVAHTGAREYGRTAVAVARPGT
CCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHCCHHHHCCEEEEEECCCC
LLADIPAHHTVWMSHGDSVAAAPSGFDVLASTATTPVAAFEDVDRGLAGVQWHPEVLHTE
EEEECCCCCEEEEECCCCCEECCCCHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCH
HGQKVLEHFLVQIAHCRQTWTMVNIVEEQIEAIRAQIGDRGQAICGLSGGVDSAVAAAIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
QRAIGDRLTCVYVDHGLMRQGETEQVERDFVAATGVDLKVVDAEKQFLDALAGVTDPEEK
HHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCHHHH
RKIIGREFIRVFEAAEADILGGSLPDDGGSKVAFLVQGTLYPDVVESGGGAGTSNIKSHH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCC
NVGGLPDDLEFELVEPLRTLFKDEVRLVGEQLGLPAEIVWRQPFPGPGLGIRIIGEVTRE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEHHHHHHHH
RLDILREADAIAREELTRAGLDRDIWQFPVVLLADVRSVGVQGDHRTYGHPVVLRPVTSE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
DAMTADWARLPYDVLERISTRITNEVREINRVTVDITSKPPGTIEWE
CCCCCHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TQPAEHDLVLVVDFGAQYAQLIARRVREARVYSEIVPHTTPVAEILAREPKAIILSGGP
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCC
SSVYEPDAPSIDPAIFTSGTPVFGMCYGFQLMAQGLGGEVAHTGAREYGRTAVAVARPGT
CCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHCCHHHHCCEEEEEECCCC
LLADIPAHHTVWMSHGDSVAAAPSGFDVLASTATTPVAAFEDVDRGLAGVQWHPEVLHTE
EEEECCCCCEEEEECCCCCEECCCCHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHCH
HGQKVLEHFLVQIAHCRQTWTMVNIVEEQIEAIRAQIGDRGQAICGLSGGVDSAVAAAIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
QRAIGDRLTCVYVDHGLMRQGETEQVERDFVAATGVDLKVVDAEKQFLDALAGVTDPEEK
HHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCHHHH
RKIIGREFIRVFEAAEADILGGSLPDDGGSKVAFLVQGTLYPDVVESGGGAGTSNIKSHH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCC
NVGGLPDDLEFELVEPLRTLFKDEVRLVGEQLGLPAEIVWRQPFPGPGLGIRIIGEVTRE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEHHHHHHHH
RLDILREADAIAREELTRAGLDRDIWQFPVVLLADVRSVGVQGDHRTYGHPVVLRPVTSE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
DAMTADWARLPYDVLERISTRITNEVREINRVTVDITSKPPGTIEWE
CCCCCHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]