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The map label for this gene is purE [H]

Identifier: 119717711

GI number: 119717711

Start: 3698819

End: 3699358

Strand: Reverse

Name: purE [H]

Synonym: Noca_3489

Alternate gene names: 119717711

Gene position: 3699358-3698819 (Counterclockwise)

Preceding gene: 119717712

Following gene: 119717706

Centisome position: 74.2

GC content: 72.96

Gene sequence:

>540_bases
GTGAGTAACCCCTTGGAAGGACGGGCCGTGGAGCCACGAGTCGGCATCGTGATGGGGTCGGACTCCGACTGGCCGGTGAT
GAAGGCCGCCGCCGAGGCGCTGGCCGAGTTCGACATCGGCTACGAGGCGGACGTGGTCTCGGCGCACCGGATGCCCGAGG
AGATGCTGGCCTACGGCAGGGAGGCCGCGGACCGCGGCCTGTCCGTGATCGTGGCCGGCGCCGGTGGGGCCGCCCACCTG
CCGGGCATGCTCGCTGCGGTGACGCCGCTGCCCGTGATCGGCGTACCGGTGCCGCTGAAGAACCTGGACGGTCTGGACTC
CCTCCTCTCGATCGTCCAGATGCCCGCGGGCGTCCCGGTCGCCACCGTCGCGGTCGGCGGCGCCCGCAACGCGGGCCTGC
TCGCCGTGCGGATCCTGGCCGCCACCGACCCCGAGCTCCAGGACAAGATGCGCGCCTTCCAGGCGGAGCTGCGAACCACC
GCGCAGCACAAGGGTGAGGCGGTCCGCAACGACCGGCCCGGCCGGCGCCTCGGCTTCTAG

Upstream 100 bases:

>100_bases
AAGGTCGGGCACGTCAACGCCTACGGCGAGGACCTCGACGACTGCCTCGAGCGGGCCCGGCACGCCGCGGCCTGGTTCCG
CGGTGACCTGGGAGACGAGA

Downstream 100 bases:

>100_bases
GACGGCGCCGCTAGGAGCGCTCGCCCACGAGTCCGTGCTCGTAGGCGAAGACCACGATCTGCACCCGGTCACGCAGCCCG
AGCTTGCGCAGGATCGCGCC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MSNPLEGRAVEPRVGIVMGSDSDWPVMKAAAEALAEFDIGYEADVVSAHRMPEEMLAYGREAADRGLSVIVAGAGGAAHL
PGMLAAVTPLPVIGVPVPLKNLDGLDSLLSIVQMPAGVPVATVAVGGARNAGLLAVRILAATDPELQDKMRAFQAELRTT
AQHKGEAVRNDRPGRRLGF

Sequences:

>Translated_179_residues
MSNPLEGRAVEPRVGIVMGSDSDWPVMKAAAEALAEFDIGYEADVVSAHRMPEEMLAYGREAADRGLSVIVAGAGGAAHL
PGMLAAVTPLPVIGVPVPLKNLDGLDSLLSIVQMPAGVPVATVAVGGARNAGLLAVRILAATDPELQDKMRAFQAELRTT
AQHKGEAVRNDRPGRRLGF
>Mature_178_residues
SNPLEGRAVEPRVGIVMGSDSDWPVMKAAAEALAEFDIGYEADVVSAHRMPEEMLAYGREAADRGLSVIVAGAGGAAHLP
GMLAAVTPLPVIGVPVPLKNLDGLDSLLSIVQMPAGVPVATVAVGGARNAGLLAVRILAATDPELQDKMRAFQAELRTTA
QHKGEAVRNDRPGRRLGF

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=54.954954954955, Blast_Score=125, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324702, Length=144, Percent_Identity=61.8055555555556, Blast_Score=177, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18639; Mature: 18508

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLEGRAVEPRVGIVMGSDSDWPVMKAAAEALAEFDIGYEADVVSAHRMPEEMLAYGR
CCCCCCCCEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHCH
EAADRGLSVIVAGAGGAAHLPGMLAAVTPLPVIGVPVPLKNLDGLDSLLSIVQMPAGVPV
HHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCE
ATVAVGGARNAGLLAVRILAATDPELQDKMRAFQAELRTTAQHKGEAVRNDRPGRRLGF
EEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
>Mature Secondary Structure 
SNPLEGRAVEPRVGIVMGSDSDWPVMKAAAEALAEFDIGYEADVVSAHRMPEEMLAYGR
CCCCCCCEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHCH
EAADRGLSVIVAGAGGAAHLPGMLAAVTPLPVIGVPVPLKNLDGLDSLLSIVQMPAGVPV
HHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCE
ATVAVGGARNAGLLAVRILAATDPELQDKMRAFQAELRTTAQHKGEAVRNDRPGRRLGF
EEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002 [H]