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The map label for this gene is purK [H]

Identifier: 119717712

GI number: 119717712

Start: 3699351

End: 3700550

Strand: Reverse

Name: purK [H]

Synonym: Noca_3490

Alternate gene names: 119717712

Gene position: 3700550-3699351 (Counterclockwise)

Preceding gene: 119717713

Following gene: 119717711

Centisome position: 74.22

GC content: 74.25

Gene sequence:

>1200_bases
GTGCCCAGCCCCGGTGAGTCCAGCCCCGAGCGTCGGCTCGGCCAGCGGATGGCCCCCACCCTCGCCGTGATCGGCGGCGG
CCAGCTGGCCCGGATGATGGCCGCCCCGGCCAACGCACTCGGGCTCCCGCTGCGCCTGCTGGCGGAGGGGGAGGGCGTCT
CGGCGGCCCAGGTGATCCCCGACCACGTGGTCGGGGACTACCGCGACCTCGAGACCCTGCGGAAGGTCACCTCCGGCTGC
CCGGTCGTCACCTTCGACCACGAGCACGTGCCCACCGGGCACCTCCACGCGCTGGAGGAGGACGGCGTCGCGGTGCGGCC
CGGGCCGCACGCCCTGGTGCACGCCCAGGACAAGGCGGTGATGCGAGAGCGCCTCGGCGAGCTCGGCGTGCCCTGCCCCC
GCAACGCCCTGGTCAGGACCGTCGAGGACGTGGCGGCCTTCGGGTTCCCGTGCGTACTGAAGACCTCGCGGGGCGGTTAC
GACGGCAAGGGCGTGTGGTTCGTCCGCTCGGTCGGCGACTGCGAGGAGCCGTTCCGGGCCGCGCTCGAGGCCGACGTCCG
CCTCGTGGCCGAGGAGCTCGTCGACTTCCGGCGGGAGCTCTCGGCGCTCGTGGCGCGCTCGCCCAGCGGGCAGGCCGCGG
CGTACCCCGTCGTCGCCTCCACCCAGGTCGACGGCATCTGCCGCGAGGTGATCGCGCCGGCGCCCGACCTCGACCCCGCG
CTCGCCGGCCGGGCGCAGGAGATCGCGCTGCACATCGCCGGCGCGCTCGACGTGACCGGCATCCTCGCGGTCGAGCTGTT
CGAAACCCGCGACGGCCGGGTCCTGGTCAACGAGCTGGCGATGCGCCCGCACAACACCGGGCACTGGACCCAGGACGGGG
CGGTCACCTCCCAGTTCGAGAACCACCTGCGCGCGGTGCTCGACCTGCCGCTCGGCTCGCCGACGCCCCGGGCCCGGTGG
ACGGTGATGGTGAACATCCTCGGCAGCGACGACACGAGCGTCGGCAGGCTGTACGACGGCTACCCGCACGCGCTCGCCCG
GGACCCGATGCTGCGCGTGCACCTCTACGGCAAGGAGCTGCGGCCGGGCCGCAAGGTCGGGCACGTCAACGCCTACGGCG
AGGACCTCGACGACTGCCTCGAGCGGGCCCGGCACGCCGCGGCCTGGTTCCGCGGTGACCTGGGAGACGAGAGTGAGTAA

Upstream 100 bases:

>100_bases
ACAGCCGGCACCCGCGCCTGATCACCACGATCCGCGGCGAGGGGCTGCGCTTCGAGACCGAGGACCGGACCCGCTGAGCG
ACCCCGTCTAGAGTTCCGGT

Downstream 100 bases:

>100_bases
CCCCTTGGAAGGACGGGCCGTGGAGCCACGAGTCGGCATCGTGATGGGGTCGGACTCCGACTGGCCGGTGATGAAGGCCG
CCGCCGAGGCGCTGGCCGAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MPSPGESSPERRLGQRMAPTLAVIGGGQLARMMAAPANALGLPLRLLAEGEGVSAAQVIPDHVVGDYRDLETLRKVTSGC
PVVTFDHEHVPTGHLHALEEDGVAVRPGPHALVHAQDKAVMRERLGELGVPCPRNALVRTVEDVAAFGFPCVLKTSRGGY
DGKGVWFVRSVGDCEEPFRAALEADVRLVAEELVDFRRELSALVARSPSGQAAAYPVVASTQVDGICREVIAPAPDLDPA
LAGRAQEIALHIAGALDVTGILAVELFETRDGRVLVNELAMRPHNTGHWTQDGAVTSQFENHLRAVLDLPLGSPTPRARW
TVMVNILGSDDTSVGRLYDGYPHALARDPMLRVHLYGKELRPGRKVGHVNAYGEDLDDCLERARHAAAWFRGDLGDESE

Sequences:

>Translated_399_residues
MPSPGESSPERRLGQRMAPTLAVIGGGQLARMMAAPANALGLPLRLLAEGEGVSAAQVIPDHVVGDYRDLETLRKVTSGC
PVVTFDHEHVPTGHLHALEEDGVAVRPGPHALVHAQDKAVMRERLGELGVPCPRNALVRTVEDVAAFGFPCVLKTSRGGY
DGKGVWFVRSVGDCEEPFRAALEADVRLVAEELVDFRRELSALVARSPSGQAAAYPVVASTQVDGICREVIAPAPDLDPA
LAGRAQEIALHIAGALDVTGILAVELFETRDGRVLVNELAMRPHNTGHWTQDGAVTSQFENHLRAVLDLPLGSPTPRARW
TVMVNILGSDDTSVGRLYDGYPHALARDPMLRVHLYGKELRPGRKVGHVNAYGEDLDDCLERARHAAAWFRGDLGDESE
>Mature_398_residues
PSPGESSPERRLGQRMAPTLAVIGGGQLARMMAAPANALGLPLRLLAEGEGVSAAQVIPDHVVGDYRDLETLRKVTSGCP
VVTFDHEHVPTGHLHALEEDGVAVRPGPHALVHAQDKAVMRERLGELGVPCPRNALVRTVEDVAAFGFPCVLKTSRGGYD
GKGVWFVRSVGDCEEPFRAALEADVRLVAEELVDFRRELSALVARSPSGQAAAYPVVASTQVDGICREVIAPAPDLDPAL
AGRAQEIALHIAGALDVTGILAVELFETRDGRVLVNELAMRPHNTGHWTQDGAVTSQFENHLRAVLDLPLGSPTPRARWT
VMVNILGSDDTSVGRLYDGYPHALARDPMLRVHLYGKELRPGRKVGHVNAYGEDLDDCLERARHAAAWFRGDLGDESE

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=374, Percent_Identity=31.5508021390374, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1788155, Length=392, Percent_Identity=29.5918367346939, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=384, Percent_Identity=34.6354166666667, Blast_Score=204, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42971; Mature: 42840

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPGESSPERRLGQRMAPTLAVIGGGQLARMMAAPANALGLPLRLLAEGEGVSAAQVIP
CCCCCCCCHHHHHHHHHCCEEEEECCHHHHHHHHCCCCHHCCCEEEEECCCCCCHHHHCC
DHVVGDYRDLETLRKVTSGCPVVTFDHEHVPTGHLHALEEDGVAVRPGPHALVHAQDKAV
HHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCCCEEECCCCCEEEECHHHHH
MRERLGELGVPCPRNALVRTVEDVAAFGFPCVLKTSRGGYDGKGVWFVRSVGDCEEPFRA
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCHHHHHH
ALEADVRLVAEELVDFRRELSALVARSPSGQAAAYPVVASTQVDGICREVIAPAPDLDPA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEECCHHHHHHHHHHCCCCCCCHH
LAGRAQEIALHIAGALDVTGILAVELFETRDGRVLVNELAMRPHNTGHWTQDGAVTSQFE
HCCCHHHHHEEECCHHHHHHHEEEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCHHHHHH
NHLRAVLDLPLGSPTPRARWTVMVNILGSDDTSVGRLYDGYPHALARDPMLRVHLYGKEL
HHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHCCCEEEEEEECCCC
RPGRKVGHVNAYGEDLDDCLERARHAAAWFRGDLGDESE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PSPGESSPERRLGQRMAPTLAVIGGGQLARMMAAPANALGLPLRLLAEGEGVSAAQVIP
CCCCCCCHHHHHHHHHCCEEEEECCHHHHHHHHCCCCHHCCCEEEEECCCCCCHHHHCC
DHVVGDYRDLETLRKVTSGCPVVTFDHEHVPTGHLHALEEDGVAVRPGPHALVHAQDKAV
HHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCCCEEECCCCCEEEECHHHHH
MRERLGELGVPCPRNALVRTVEDVAAFGFPCVLKTSRGGYDGKGVWFVRSVGDCEEPFRA
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCHHHHHH
ALEADVRLVAEELVDFRRELSALVARSPSGQAAAYPVVASTQVDGICREVIAPAPDLDPA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCEEECCHHHHHHHHHHCCCCCCCHH
LAGRAQEIALHIAGALDVTGILAVELFETRDGRVLVNELAMRPHNTGHWTQDGAVTSQFE
HCCCHHHHHEEECCHHHHHHHEEEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCHHHHHH
NHLRAVLDLPLGSPTPRARWTVMVNILGSDDTSVGRLYDGYPHALARDPMLRVHLYGKEL
HHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHCCCEEEEEEECCCC
RPGRKVGHVNAYGEDLDDCLERARHAAAWFRGDLGDESE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]