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The map label for this gene is aes [H]

Identifier: 119717706

GI number: 119717706

Start: 3693752

End: 3694621

Strand: Reverse

Name: aes [H]

Synonym: Noca_3484

Alternate gene names: 119717706

Gene position: 3694621-3693752 (Counterclockwise)

Preceding gene: 119717711

Following gene: 119717705

Centisome position: 74.1

GC content: 76.32

Gene sequence:

>870_bases
ATGCTCTACCCCGAGGCGCAGCGCGCCGTGGCGGCCGCGGCCGACGAGACGCCCGTGTGGGCCGAGGGCTACGACGTCGA
GGACGCGCGCGCCCGGGCCCGGGAGGCGGCTGCGACCGAGCCGCGCGAGGAGGTCGCGGAGGTGCGCGACGTCGACGCGG
ACGGGGTGCCGTGCCGGCTCTACCGGCCGGCGGGCGCCGCGCCGGGCGTGGTCCTCCACGTCCACGGCGGCGGGTTCGTG
TTCAACGACATCGACGTGCACGACCCGGGCGCACGGCGGCTGGCGAACCGCAGCGGCCTGAGCGTGCTCAGCGTGGACTA
CCGCCGACCGCCGGAGCACCGGTTCCCGGCCGCGCCCGACGACGTCTCGACCGCGTCCGCCTGGGCCGAGCGCGAGCTCG
ACGGACCGCTGTTCGCGCACGGAGACAGCGCGGGTGGCAACCTGGCGCTCGTCGCCGCCCTGCGCCACCCCGACCGGTTC
GCGGCGCTCGTCCTGATCTACCCGTTCCTCGACCCGACGGCGGCGTTCGAGTCCTACCGGACCGCGGCGGACGGCTTCGA
CCGGCGGGAGGCGGAGTGGTACTGGCAGCAGTACGCCGCAACGCCGGCCGACCTCGCCGACCCCAGCCTCGCGCCCCTGC
TCTCCGAGCGGCTCGGGACGCTTCCTCCCACCCTGGTCGTGACCGCGGAGCACGACCCGCTGCGCGACGAGGGCGAGGAG
CTGGCCCGCCGGCTGGCCGAGGCCGGCGTCGAGGTGACCGCCACCCGCTACCTCGGCCAGGTGCACGGCTTCTGGCGCCA
CCCGAGCGTCTTCACCGCGTCCGAGCCGTTGATCCGGCAGGCGGCGGGCTTCCTGCGCCAGCACGGCTGA

Upstream 100 bases:

>100_bases
CTCCATCTGAGGTGCCGATCGGCTGGCCCGGAGTACCGCCGTGGTCAGCCCTCGGCCAGGAGCGCCGTCTCGGGCCGCAG
GGCTCAGTAGGGTGCGGGCC

Downstream 100 bases:

>100_bases
CAGGATGGGCGCCATGCGCGTGCACCTCGGCTGCGACCATGCCGGACTCGACCTCAAGGACCACCTCAGTCGCTGGCTCA
CCGACCACGGCTACGAGCCC

Product: alpha/beta hydrolase domain-containing protein

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MLYPEAQRAVAAAADETPVWAEGYDVEDARARAREAAATEPREEVAEVRDVDADGVPCRLYRPAGAAPGVVLHVHGGGFV
FNDIDVHDPGARRLANRSGLSVLSVDYRRPPEHRFPAAPDDVSTASAWAERELDGPLFAHGDSAGGNLALVAALRHPDRF
AALVLIYPFLDPTAAFESYRTAADGFDRREAEWYWQQYAATPADLADPSLAPLLSERLGTLPPTLVVTAEHDPLRDEGEE
LARRLAEAGVEVTATRYLGQVHGFWRHPSVFTASEPLIRQAAGFLRQHG

Sequences:

>Translated_289_residues
MLYPEAQRAVAAAADETPVWAEGYDVEDARARAREAAATEPREEVAEVRDVDADGVPCRLYRPAGAAPGVVLHVHGGGFV
FNDIDVHDPGARRLANRSGLSVLSVDYRRPPEHRFPAAPDDVSTASAWAERELDGPLFAHGDSAGGNLALVAALRHPDRF
AALVLIYPFLDPTAAFESYRTAADGFDRREAEWYWQQYAATPADLADPSLAPLLSERLGTLPPTLVVTAEHDPLRDEGEE
LARRLAEAGVEVTATRYLGQVHGFWRHPSVFTASEPLIRQAAGFLRQHG
>Mature_289_residues
MLYPEAQRAVAAAADETPVWAEGYDVEDARARAREAAATEPREEVAEVRDVDADGVPCRLYRPAGAAPGVVLHVHGGGFV
FNDIDVHDPGARRLANRSGLSVLSVDYRRPPEHRFPAAPDDVSTASAWAERELDGPLFAHGDSAGGNLALVAALRHPDRF
AALVLIYPFLDPTAAFESYRTAADGFDRREAEWYWQQYAATPADLADPSLAPLLSERLGTLPPTLVVTAEHDPLRDEGEE
LARRLAEAGVEVTATRYLGQVHGFWRHPSVFTASEPLIRQAAGFLRQHG

Specific function: Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1786682, Length=244, Percent_Identity=27.4590163934426, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17567059, Length=292, Percent_Identity=26.027397260274, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=173, Percent_Identity=29.4797687861272, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001146, Length=192, Percent_Identity=31.25, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540028, Length=170, Percent_Identity=31.7647058823529, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 31460; Mature: 31460

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYPEAQRAVAAAADETPVWAEGYDVEDARARAREAAATEPREEVAEVRDVDADGVPCRL
CCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEE
YRPAGAAPGVVLHVHGGGFVFNDIDVHDPGARRLANRSGLSVLSVDYRRPPEHRFPAAPD
ECCCCCCCCEEEEEECCEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCC
DVSTASAWAERELDGPLFAHGDSAGGNLALVAALRHPDRFAALVLIYPFLDPTAAFESYR
CCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEEECCCCHHEEEEHHHHCCCHHHHHHHHH
TAADGFDRREAEWYWQQYAATPADLADPSLAPLLSERLGTLPPTLVVTAEHDPLRDEGEE
HHHCCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
LARRLAEAGVEVTATRYLGQVHGFWRHPSVFTASEPLIRQAAGFLRQHG
HHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYPEAQRAVAAAADETPVWAEGYDVEDARARAREAAATEPREEVAEVRDVDADGVPCRL
CCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEE
YRPAGAAPGVVLHVHGGGFVFNDIDVHDPGARRLANRSGLSVLSVDYRRPPEHRFPAAPD
ECCCCCCCCEEEEEECCEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCC
DVSTASAWAERELDGPLFAHGDSAGGNLALVAALRHPDRFAALVLIYPFLDPTAAFESYR
CCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEEECCCCHHEEEEHHHHCCCHHHHHHHHH
TAADGFDRREAEWYWQQYAATPADLADPSLAPLLSERLGTLPPTLVVTAEHDPLRDEGEE
HHHCCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHH
LARRLAEAGVEVTATRYLGQVHGFWRHPSVFTASEPLIRQAAGFLRQHG
HHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA