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The map label for this gene is ndk

Identifier: 119717688

GI number: 119717688

Start: 3675201

End: 3675608

Strand: Reverse

Name: ndk

Synonym: Noca_3466

Alternate gene names: 119717688

Gene position: 3675608-3675201 (Counterclockwise)

Preceding gene: 119717689

Following gene: 119717687

Centisome position: 73.72

GC content: 70.34

Gene sequence:

>408_bases
ATGAGTCTGCGCACCCTCGTCCTCCTCAAGCCCGACGCCGTCCGCCGCGGGCTGGTCGGAGCCATCCTGTCGCGCTACGA
GGCGAAGGGCCTGACCATCGTCGCGATGGAGCAGCGCACCATCGACGCCGCGGTCGCCGACCAGCACTACGCCGAGCACG
TCGCGAAGGAGTTCTACCCGCCGCTGCGCGACTTCGTGACCGGCGGACCGCTCGTGGCGCTGGTGCTCGAGGGCGACAAC
TCGGTCGACGTGGTGCGCCTGCTGAACGGTGCCACGGACGGCAGCAAGGCCGCCCCCGGGACCATCCGGGGCGACTTCTC
GCTGTCCAACCGCGAGAACCTCGTGCACGGCTCGGACTCCCCGGAGTCGGCCGAGCGCGAGATCGGGATCTGGTTCCCGG
GTCTCTGA

Upstream 100 bases:

>100_bases
GCGGGCGGCCGAGTCCCGCGGATGAGCGGCCCAAAGCCCTGCCGCTGAGCGCCGAAGGGCCCTCGTGGCGGCCCCCTCGC
CGCTCGCTAGGGTGCGGACC

Downstream 100 bases:

>100_bases
CCTGACCTGACCTGACCTGACCTGGGGCCGCTCCGGGCCGGGCGGACGGTCCTCCAGTTTCATCGGCCGGCCGATGAAAC
CCGTGCCTGGACGACGAAGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MSLRTLVLLKPDAVRRGLVGAILSRYEAKGLTIVAMEQRTIDAAVADQHYAEHVAKEFYPPLRDFVTGGPLVALVLEGDN
SVDVVRLLNGATDGSKAAPGTIRGDFSLSNRENLVHGSDSPESAEREIGIWFPGL

Sequences:

>Translated_135_residues
MSLRTLVLLKPDAVRRGLVGAILSRYEAKGLTIVAMEQRTIDAAVADQHYAEHVAKEFYPPLRDFVTGGPLVALVLEGDN
SVDVVRLLNGATDGSKAAPGTIRGDFSLSNRENLVHGSDSPESAEREIGIWFPGL
>Mature_134_residues
SLRTLVLLKPDAVRRGLVGAILSRYEAKGLTIVAMEQRTIDAAVADQHYAEHVAKEFYPPLRDFVTGGPLVALVLEGDNS
VDVVRLLNGATDGSKAAPGTIRGDFSLSNRENLVHGSDSPESAEREIGIWFPGL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4826862, Length=129, Percent_Identity=48.062015503876, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI66392203, Length=129, Percent_Identity=44.9612403100775, Blast_Score=123, Evalue=6e-29,
Organism=Homo sapiens, GI66392227, Length=129, Percent_Identity=44.9612403100775, Blast_Score=122, Evalue=6e-29,
Organism=Homo sapiens, GI66392205, Length=129, Percent_Identity=44.9612403100775, Blast_Score=122, Evalue=6e-29,
Organism=Homo sapiens, GI4505409, Length=129, Percent_Identity=44.9612403100775, Blast_Score=122, Evalue=6e-29,
Organism=Homo sapiens, GI66392192, Length=129, Percent_Identity=44.9612403100775, Blast_Score=122, Evalue=6e-29,
Organism=Homo sapiens, GI38045913, Length=129, Percent_Identity=43.4108527131783, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4557797, Length=129, Percent_Identity=43.4108527131783, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI37693993, Length=129, Percent_Identity=46.5116279069767, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI5031951, Length=133, Percent_Identity=36.8421052631579, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=32.3308270676692, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=32.3308270676692, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788866, Length=129, Percent_Identity=44.9612403100775, Blast_Score=109, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17506807, Length=129, Percent_Identity=44.9612403100775, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=129, Percent_Identity=50.3875968992248, Blast_Score=134, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45549037, Length=129, Percent_Identity=44.9612403100775, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI18860097, Length=132, Percent_Identity=34.8484848484849, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_NOCSJ (A1SMD1)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924653.1
- ProteinModelPortal:   A1SMD1
- SMR:   A1SMD1
- STRING:   A1SMD1
- GeneID:   4596247
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3466
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   A1SMD1
- ProtClustDB:   PRK00668
- BioCyc:   NSP35761:NOCA_3466-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 14527; Mature: 14395

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRTLVLLKPDAVRRGLVGAILSRYEAKGLTIVAMEQRTIDAAVADQHYAEHVAKEFYP
CCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
PLRDFVTGGPLVALVLEGDNSVDVVRLLNGATDGSKAAPGTIRGDFSLSNRENLVHGSDS
CHHHHHCCCCEEEEEEECCCCEEEHEEECCCCCCCCCCCCEEECCEECCCCCCEECCCCC
PESAEREIGIWFPGL
CCCCCCEEEEECCCC
>Mature Secondary Structure 
SLRTLVLLKPDAVRRGLVGAILSRYEAKGLTIVAMEQRTIDAAVADQHYAEHVAKEFYP
CCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
PLRDFVTGGPLVALVLEGDNSVDVVRLLNGATDGSKAAPGTIRGDFSLSNRENLVHGSDS
CHHHHHCCCCEEEEEEECCCCEEEHEEECCCCCCCCCCCCEEECCEECCCCCCEECCCCC
PESAEREIGIWFPGL
CCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA