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The map label for this gene is bioF [C]

Identifier: 119717635

GI number: 119717635

Start: 3614178

End: 3615320

Strand: Reverse

Name: bioF [C]

Synonym: Noca_3413

Alternate gene names: 119717635

Gene position: 3615320-3614178 (Counterclockwise)

Preceding gene: 119717636

Following gene: 119717634

Centisome position: 72.51

GC content: 72.88

Gene sequence:

>1143_bases
ATGAGCCCTCTGGGCGACTCGATCACATGGGAGGACTGGCTCACGGGCCGGGCCGCCGACCGTGAGGAGGCCGGGTTGGT
CCGGCGCCTTCATCCCCGTCGACCGCACGAGACGGTCCTCGACCTCGCCAGCAACGACTACCTCGGGCTCAGCCACCATC
CCCAGGTCCGTCGCGCCGCGGCCGCCGCGGCCCTGCGCTGGGGCGCCGGAGCGACCGCGTCCCGGCTGGTCACGGGCACC
CTGACCCTGCACACCGACCTCGAGGCCGAGCTCGCCGACTGGCTCGGACAGCCGGCCGCTCTCGTGCTTTCGACCGGTTA
CCACGCCAACCTCGCCGCCGTCACCGCGCTCGCCGACCGCGACGCGCACATCATCTCTGACGCCCACATCCACGCGTCCC
TCATCGACGCCGTCCGGCTCTCGAGCGCCCGACTCACCGTGGTCCCCCACAACGACGTGACCGCGGTCCGGGCCGCGCTC
ACCGCGCACCCCGGCCGGCGGACGCTCGTGCTGGCCGAGTCGGTCTACTCCGTCCTCGGCGACCGCGCCCCTCTGGTCGA
CCTCGCCGACGCCTGCGCGGGCCATGGCGCCTGGCTGCTGGTCGACGAGGCCCACGCGCTCGGAGTGCACGGACCCGGAC
TCGTCAAGGCATGTGGCCTGGCCGACCGACCCGACGTGATCGTGACCGCCACCCTCTCCAAGAGCCTTGGCAGCCAAGGC
GGCGCGATCCTGGGCACCACCGCGCTGATCGAGCACCTGATCAACACCGCCCGCCCCTTCATCTTCGACACCGGCCTCAA
CCCCGCCGCCACCGCCGCTGCCCTGACCGCGACGCGGATCACCCGAATCCACCCCCAACTGGCCGCCACTGTCCACGCCC
GCGTCACCGCCCTGGCCGGCCTCCTCGACGTCCCCGCGCCGGCAGGCGCAGTGCTGTCGGTGCCGATGCCCTCACCTTCG
GATGCCCTCGCCGCCCAGGCCGAGCTGCTCACAGGCGGCGTGCGGGTCGGCTGCTTCCGACCACCCTCAGTACCAGACGG
GATCTCCCGGCTCCGGATCACCGCCAGCGCCGGCATGGCCCCCGAGGACTGGCAACGAGCCACGCAAGCCCTTCACAGCG
TCACCCGCAGGGCCCGGTCATGA

Upstream 100 bases:

>100_bases
CTGGGACGAATGTTCCGCCGGCCGACCCGTTGTCAGCGCCGGCGCCGTGCCGACCGGTGACCTACAGCCCCGAGGACCCC
ACGACCGGGTCCGACCCTCG

Downstream 100 bases:

>100_bases
CCGGCCGGATCGTCATCGTCACCGGCACCAACACCGGCGTCGGGAAGACCATTGCGACCGCGGCCCTCGCCGCTCGCGCG
CTCGGCCACCGAGAACGGGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSPLGDSITWEDWLTGRAADREEAGLVRRLHPRRPHETVLDLASNDYLGLSHHPQVRRAAAAAALRWGAGATASRLVTGT
LTLHTDLEAELADWLGQPAALVLSTGYHANLAAVTALADRDAHIISDAHIHASLIDAVRLSSARLTVVPHNDVTAVRAAL
TAHPGRRTLVLAESVYSVLGDRAPLVDLADACAGHGAWLLVDEAHALGVHGPGLVKACGLADRPDVIVTATLSKSLGSQG
GAILGTTALIEHLINTARPFIFDTGLNPAATAAALTATRITRIHPQLAATVHARVTALAGLLDVPAPAGAVLSVPMPSPS
DALAAQAELLTGGVRVGCFRPPSVPDGISRLRITASAGMAPEDWQRATQALHSVTRRARS

Sequences:

>Translated_380_residues
MSPLGDSITWEDWLTGRAADREEAGLVRRLHPRRPHETVLDLASNDYLGLSHHPQVRRAAAAAALRWGAGATASRLVTGT
LTLHTDLEAELADWLGQPAALVLSTGYHANLAAVTALADRDAHIISDAHIHASLIDAVRLSSARLTVVPHNDVTAVRAAL
TAHPGRRTLVLAESVYSVLGDRAPLVDLADACAGHGAWLLVDEAHALGVHGPGLVKACGLADRPDVIVTATLSKSLGSQG
GAILGTTALIEHLINTARPFIFDTGLNPAATAAALTATRITRIHPQLAATVHARVTALAGLLDVPAPAGAVLSVPMPSPS
DALAAQAELLTGGVRVGCFRPPSVPDGISRLRITASAGMAPEDWQRATQALHSVTRRARS
>Mature_379_residues
SPLGDSITWEDWLTGRAADREEAGLVRRLHPRRPHETVLDLASNDYLGLSHHPQVRRAAAAAALRWGAGATASRLVTGTL
TLHTDLEAELADWLGQPAALVLSTGYHANLAAVTALADRDAHIISDAHIHASLIDAVRLSSARLTVVPHNDVTAVRAALT
AHPGRRTLVLAESVYSVLGDRAPLVDLADACAGHGAWLLVDEAHALGVHGPGLVKACGLADRPDVIVTATLSKSLGSQGG
AILGTTALIEHLINTARPFIFDTGLNPAATAAALTATRITRIHPQLAATVHARVTALAGLLDVPAPAGAVLSVPMPSPSD
ALAAQAELLTGGVRVGCFRPPSVPDGISRLRITASAGMAPEDWQRATQALHSVTRRARS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=31.6091954022989, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=31.6091954022989, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=32.4712643678161, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=32.4712643678161, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=32.4712643678161, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4502025, Length=334, Percent_Identity=33.5329341317365, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI40316939, Length=334, Percent_Identity=33.5329341317365, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=28.099173553719, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI119220554, Length=267, Percent_Identity=27.7153558052434, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI5454084, Length=293, Percent_Identity=24.9146757679181, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1786993, Length=344, Percent_Identity=36.3372093023256, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1790046, Length=351, Percent_Identity=31.6239316239316, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=375, Percent_Identity=29.6, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32566772, Length=229, Percent_Identity=32.3144104803493, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17560912, Length=232, Percent_Identity=31.4655172413793, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560914, Length=232, Percent_Identity=31.4655172413793, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71982617, Length=269, Percent_Identity=23.7918215613383, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=269, Percent_Identity=23.7918215613383, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=365, Percent_Identity=32.3287671232877, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320267, Length=229, Percent_Identity=28.82096069869, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323954, Length=265, Percent_Identity=24.5283018867925, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24662918, Length=352, Percent_Identity=28.4090909090909, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17137420, Length=244, Percent_Identity=36.8852459016393, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24653280, Length=313, Percent_Identity=26.1980830670927, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653276, Length=313, Percent_Identity=26.1980830670927, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653278, Length=313, Percent_Identity=26.1980830670927, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136286, Length=256, Percent_Identity=26.5625, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 39563; Mature: 39432

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLGDSITWEDWLTGRAADREEAGLVRRLHPRRPHETVLDLASNDYLGLSHHPQVRRAA
CCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHH
AAAALRWGAGATASRLVTGTLTLHTDLEAELADWLGQPAALVLSTGYHANLAAVTALADR
HHHHHHCCCCCCHHHEEEEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCC
DAHIISDAHIHASLIDAVRLSSARLTVVPHNDVTAVRAALTAHPGRRTLVLAESVYSVLG
CCEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCEEEEEHHHHHHHHC
DRAPLVDLADACAGHGAWLLVDEAHALGVHGPGLVKACGLADRPDVIVTATLSKSLGSQG
CCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHCCCCCCCCEEEEEEEHHHCCCCC
GAILGTTALIEHLINTARPFIFDTGLNPAATAAALTATRITRIHPQLAATVHARVTALAG
CEEEHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LLDVPAPAGAVLSVPMPSPSDALAAQAELLTGGVRVGCFRPPSVPDGISRLRITASAGMA
HHCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHEEEEECCCCC
PEDWQRATQALHSVTRRARS
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPLGDSITWEDWLTGRAADREEAGLVRRLHPRRPHETVLDLASNDYLGLSHHPQVRRAA
CCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHH
AAAALRWGAGATASRLVTGTLTLHTDLEAELADWLGQPAALVLSTGYHANLAAVTALADR
HHHHHHCCCCCCHHHEEEEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCC
DAHIISDAHIHASLIDAVRLSSARLTVVPHNDVTAVRAALTAHPGRRTLVLAESVYSVLG
CCEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCEEEEEHHHHHHHHC
DRAPLVDLADACAGHGAWLLVDEAHALGVHGPGLVKACGLADRPDVIVTATLSKSLGSQG
CCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHCCCCCCCCEEEEEEEHHHCCCCC
GAILGTTALIEHLINTARPFIFDTGLNPAATAAALTATRITRIHPQLAATVHARVTALAG
CEEEHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LLDVPAPAGAVLSVPMPSPSDALAAQAELLTGGVRVGCFRPPSVPDGISRLRITASAGMA
HHCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCHHHEEEEECCCCC
PEDWQRATQALHSVTRRARS
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA