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The map label for this gene is ada [H]

Identifier: 119717525

GI number: 119717525

Start: 3506586

End: 3508070

Strand: Reverse

Name: ada [H]

Synonym: Noca_3301

Alternate gene names: 119717525

Gene position: 3508070-3506586 (Counterclockwise)

Preceding gene: 119717527

Following gene: 119717524

Centisome position: 70.36

GC content: 75.96

Gene sequence:

>1485_bases
ATGACCGGCACCGAGACGCGCGACGATCGGCTGGACCGCGAGTCCTGCTATCGCGCCGTCAAGTCGCGCGACCGCCGGTT
CGACGGCGTCTTCTACACCGCGGTCCGCACCACGGGGATCTACTGCCGGCCCTCGTGCCCGGCCCGGACCCCGGCGTACC
AGAACGTCACGTTCCACCCGAGCGCGGCCTCCGCGCAGGCCGCGGGCTTCCGCGCCTGCAAGCGCTGCCTGCCGGACGCC
ACGCCCGGCAGCCCGGACTGGGACGTCGCGGCCACCGCCGCCGGCCGGGCGATGCGGCTGATCGCCGACGGTGTCGTGGA
CCGGGAGGGCGTCGACGGGCTGGCCCGCCGGGTCGGCTACACCCCCCGCCACCTCACCCGGATCCTCACCGCCGAGCTCG
GCGCCGGCCCACTGGCGTTGGCGCGGGCCAAGCGGGCGCAGACCGCACGCGTGCTCATCGAGACGACCGAGCTGACCTAC
GCAGATGCCGCGTTCGCCTCCGGCTTCTCCAGCGTCCGGCAGTTCAACGACACGATCCGCGAGGTGTACGACGCGTCCCC
GACCGACCTGCGCGGGCGGCGCGGCGGCCGCGCCGCCACCGGCACCGTCACGATGCGGTTGGCCGTGCGGACGCCGTACC
ACGGGTCGGCGCTGCTCGGCTTCCTCGCCACCCGCGCCGTGCCGGGCGTCGAAGCGGCGGGCGCGGACTGGTACGCGCGG
ACGCTCGCCCTGCCGCATGGCACCGGCACCGTCCGGCTGCAGGTGCCCGACGTCGTCCAGTCCGGGCTGACGGCGTTCGC
GACCGCCACGTTCGTGCTCGACGACCTCCGCGACACCGCCGCCGCCACCGAGCGGGTGCGCCGGCTGCTGGACGCCGACT
GCGACCCGGTGGCCGTCGCCGACGCCTTCACGGGCGATCCCGTCATCGGGCCGCTCGTGCGGGCCCGGCCGGGCCTGCGG
GTGCCCGGCCACGTCGACGGCCACGAGATCGCGGTCCGCGCTGTGCTCGGCCAGCAGGTCAGCGTGGCCCGGGCCCGCAC
CCTCGCGGCGCGGCTCGTCGCGCAGCACGGACGCCCGGTGACGCGACCCGACGGCACGCTCACCCACCTGTTCCCGGACC
CCGACGTGTTGGCCGGGCTGGCGCCCGAGGAGCTGCCGATGCCGCGCTCCCGCGGCCGGGCGCTGATCGCACTGTGCCAC
GCCGTCGCCTCCGGGGACATCGCGCTGGACCGCGGTCCCGACCGCGGGGACGTACGCCGGGCGCTGCTGGCCATCCCCGG
GATCGGGCCGTGGACGGCCGACTACATCGCGCTCCGGGCGCTCGGCGATCCGGACGTCTTCCTGCCGACCGACGTCGGCA
TCCGCAACGCGCTCACCGGCCTCGGGCGGGACCCGTCGACGGCGGCGGACCTCGCTCGGCGTTGGTCGCCCTGGCGCTCC
TACGCGCAGGTGTACCTCTGGCAGACCCTCAGCAAGGAGAACTGA

Upstream 100 bases:

>100_bases
GAACGCCAACCGTTCAACAACTTCCGAGACGCGCCACTAGGCTGACGGTCGTGTCCGATTCCCGCCAGATGTGGTCGGTG
GCGTCGGTCAGGATGGTCCC

Downstream 100 bases:

>100_bases
GATGTGGACCGTGATGGACTCACCCGTCGGTGAGCTGCGGCTCGTCGAGCACAACGGCGCGATCACCGCGATCGAGTTCT
CGCCGTTCCGCGACAACGAC

Product: DNA-3-methyladenine glycosylase II / transcriptional regulator Ada / DNA-O6-methylguanine--protein-cysteine S-methyltransferase

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTGTETRDDRLDRESCYRAVKSRDRRFDGVFYTAVRTTGIYCRPSCPARTPAYQNVTFHPSAASAQAAGFRACKRCLPDA
TPGSPDWDVAATAAGRAMRLIADGVVDREGVDGLARRVGYTPRHLTRILTAELGAGPLALARAKRAQTARVLIETTELTY
ADAAFASGFSSVRQFNDTIREVYDASPTDLRGRRGGRAATGTVTMRLAVRTPYHGSALLGFLATRAVPGVEAAGADWYAR
TLALPHGTGTVRLQVPDVVQSGLTAFATATFVLDDLRDTAAATERVRRLLDADCDPVAVADAFTGDPVIGPLVRARPGLR
VPGHVDGHEIAVRAVLGQQVSVARARTLAARLVAQHGRPVTRPDGTLTHLFPDPDVLAGLAPEELPMPRSRGRALIALCH
AVASGDIALDRGPDRGDVRRALLAIPGIGPWTADYIALRALGDPDVFLPTDVGIRNALTGLGRDPSTAADLARRWSPWRS
YAQVYLWQTLSKEN

Sequences:

>Translated_494_residues
MTGTETRDDRLDRESCYRAVKSRDRRFDGVFYTAVRTTGIYCRPSCPARTPAYQNVTFHPSAASAQAAGFRACKRCLPDA
TPGSPDWDVAATAAGRAMRLIADGVVDREGVDGLARRVGYTPRHLTRILTAELGAGPLALARAKRAQTARVLIETTELTY
ADAAFASGFSSVRQFNDTIREVYDASPTDLRGRRGGRAATGTVTMRLAVRTPYHGSALLGFLATRAVPGVEAAGADWYAR
TLALPHGTGTVRLQVPDVVQSGLTAFATATFVLDDLRDTAAATERVRRLLDADCDPVAVADAFTGDPVIGPLVRARPGLR
VPGHVDGHEIAVRAVLGQQVSVARARTLAARLVAQHGRPVTRPDGTLTHLFPDPDVLAGLAPEELPMPRSRGRALIALCH
AVASGDIALDRGPDRGDVRRALLAIPGIGPWTADYIALRALGDPDVFLPTDVGIRNALTGLGRDPSTAADLARRWSPWRS
YAQVYLWQTLSKEN
>Mature_493_residues
TGTETRDDRLDRESCYRAVKSRDRRFDGVFYTAVRTTGIYCRPSCPARTPAYQNVTFHPSAASAQAAGFRACKRCLPDAT
PGSPDWDVAATAAGRAMRLIADGVVDREGVDGLARRVGYTPRHLTRILTAELGAGPLALARAKRAQTARVLIETTELTYA
DAAFASGFSSVRQFNDTIREVYDASPTDLRGRRGGRAATGTVTMRLAVRTPYHGSALLGFLATRAVPGVEAAGADWYART
LALPHGTGTVRLQVPDVVQSGLTAFATATFVLDDLRDTAAATERVRRLLDADCDPVAVADAFTGDPVIGPLVRARPGLRV
PGHVDGHEIAVRAVLGQQVSVARARTLAARLVAQHGRPVTRPDGTLTHLFPDPDVLAGLAPEELPMPRSRGRALIALCHA
VASGDIALDRGPDRGDVRRALLAIPGIGPWTADYIALRALGDPDVFLPTDVGIRNALTGLGRDPSTAADLARRWSPWRSY
AQVYLWQTLSKEN

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=288, Percent_Identity=39.5833333333333, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1788542, Length=169, Percent_Identity=35.5029585798817, Blast_Score=92, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 52965; Mature: 52833

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTETRDDRLDRESCYRAVKSRDRRFDGVFYTAVRTTGIYCRPSCPARTPAYQNVTFHP
CCCCCCCHHHCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCEEECC
SAASAQAAGFRACKRCLPDATPGSPDWDVAATAAGRAMRLIADGVVDREGVDGLARRVGY
CCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
TPRHLTRILTAELGAGPLALARAKRAQTARVLIETTELTYADAAFASGFSSVRQFNDTIR
CHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
EVYDASPTDLRGRRGGRAATGTVTMRLAVRTPYHGSALLGFLATRAVPGVEAAGADWYAR
HHHCCCCCCCCCCCCCCEEECEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
TLALPHGTGTVRLQVPDVVQSGLTAFATATFVLDDLRDTAAATERVRRLLDADCDPVAVA
EEECCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
DAFTGDPVIGPLVRARPGLRVPGHVDGHEIAVRAVLGQQVSVARARTLAARLVAQHGRPV
CCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
TRPDGTLTHLFPDPDVLAGLAPEELPMPRSRGRALIALCHAVASGDIALDRGPDRGDVRR
CCCCCCEEEECCCHHHHHCCCCHHCCCCHHHCHHHHHHHHHHHCCCEEECCCCCHHHHHH
ALLAIPGIGPWTADYIALRALGDPDVFLPTDVGIRNALTGLGRDPSTAADLARRWSPWRS
HHHHCCCCCCCHHHHHEEEECCCCCEEECCCCCHHHHHHHCCCCCCHHHHHHHHCCHHHH
YAQVYLWQTLSKEN
HHHHHHHHHHCCCC
>Mature Secondary Structure 
TGTETRDDRLDRESCYRAVKSRDRRFDGVFYTAVRTTGIYCRPSCPARTPAYQNVTFHP
CCCCCCHHHCCHHHHHHHHHHHCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCEEECC
SAASAQAAGFRACKRCLPDATPGSPDWDVAATAAGRAMRLIADGVVDREGVDGLARRVGY
CCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
TPRHLTRILTAELGAGPLALARAKRAQTARVLIETTELTYADAAFASGFSSVRQFNDTIR
CHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
EVYDASPTDLRGRRGGRAATGTVTMRLAVRTPYHGSALLGFLATRAVPGVEAAGADWYAR
HHHCCCCCCCCCCCCCCEEECEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
TLALPHGTGTVRLQVPDVVQSGLTAFATATFVLDDLRDTAAATERVRRLLDADCDPVAVA
EEECCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
DAFTGDPVIGPLVRARPGLRVPGHVDGHEIAVRAVLGQQVSVARARTLAARLVAQHGRPV
CCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
TRPDGTLTHLFPDPDVLAGLAPEELPMPRSRGRALIALCHAVASGDIALDRGPDRGDVRR
CCCCCCEEEECCCHHHHHCCCCHHCCCCHHHCHHHHHHHHHHHCCCEEECCCCCHHHHHH
ALLAIPGIGPWTADYIALRALGDPDVFLPTDVGIRNALTGLGRDPSTAADLARRWSPWRS
HHHHCCCCCCCHHHHHEEEECCCCCEEECCCCCHHHHHHHCCCCCCHHHHHHHHCCHHHH
YAQVYLWQTLSKEN
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]