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The map label for this gene is mutM

Identifier: 119717504

GI number: 119717504

Start: 3487632

End: 3488519

Strand: Reverse

Name: mutM

Synonym: Noca_3280

Alternate gene names: 119717504

Gene position: 3488519-3487632 (Counterclockwise)

Preceding gene: 119717505

Following gene: 119717503

Centisome position: 69.97

GC content: 74.66

Gene sequence:

>888_bases
TTGCCGGAGCTGCCCGAGGTCGAAGTGGTGCGCGCCGGCCTCGAGCGGCACGTGCTCGGCGCCACGATCGCCCGCGTCGA
CGTGCTGCACCCGCGGCCGGTGCGCCGCGACCTGCGCGGCCCGGCCGGCTTCGCCGCCGCGCTGACCGGCCGCCGCATCG
AGGCGGCCCGCCGACGCGGCAAGTACCTCTGGCTGCCGCTGGACAACGGCGACGCGCTGCTCGGCCACCTGGGCATGAGC
GGCCAGCTGCTCGTCCAGCCGCCCGATGCCCCCGACGAGCGGCACCTGCGCGTGCGGCTCGCGCTCGAGGGCGCCGACGA
GGGCAGGGAGCTGCGGTTCGTCGACCAGCGGATGTTCGGCGGTCTGTCGGTCTCGGCGGGCGGCGCGGACCTGCCGCCCG
AGATCGCGCACATCGCCCGTGACCCGCTCGATCCCGAGTTCGACGACGACGACTTCGTGCGCCGGGTGCGCCGGCGTACG
TCGGGGGTCAAGCGACAGCTCCTGGACCAGAACCTGATCTCCGGGGTCGGCAACATCTACGCCGACGAGGCGCTGTGGCG
CGCGCGGATCCACGGCGAGCGCCCGGGCGACCGGCTCACCGCGACCCGGGTCCGTGAGCTCCTCGCCCACGCGCGCGAGG
TGATGCTCGCGGCGCTGGGGGAGGGCGGCACCTCCTTCGACGCGCTCTACGTCAACGTCAACGGCGAGTCGGGCTACTTC
GACCGCTCGCTGCACGCGTACGGGCGCGAGGGCGAGGCGTGCGAGCGCTGCGGCACGCCGATCCGGAGGGTCGCGTTCAT
GAATCGGTCGTCGTACTTCTGCCCGGTGTGCCAGCCGGCGCCCAGGAGACGTCGGGCGGCCTCCTCGCGGGTGCGGGTCC
CGGACTGA

Upstream 100 bases:

>100_bases
GAGACGGCGTACGGCGAGATCGCCTCCGACCTCGGCGTCGACGACCCAGCCGTGGACGCGGCCGCCCACTCCGCCCACAA
GAGCTGACCCGAGGCACGAC

Downstream 100 bases:

>100_bases
GCGAATTGACCCGGAGGCTCGCGAGTGGGACTCTTGAAGACGGCCCGCCATCGCGGACCCTCCCCACCACCCGGAAGGCT
TTGTCCATGGCCAAGGCGCT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MPELPEVEVVRAGLERHVLGATIARVDVLHPRPVRRDLRGPAGFAAALTGRRIEAARRRGKYLWLPLDNGDALLGHLGMS
GQLLVQPPDAPDERHLRVRLALEGADEGRELRFVDQRMFGGLSVSAGGADLPPEIAHIARDPLDPEFDDDDFVRRVRRRT
SGVKRQLLDQNLISGVGNIYADEALWRARIHGERPGDRLTATRVRELLAHAREVMLAALGEGGTSFDALYVNVNGESGYF
DRSLHAYGREGEACERCGTPIRRVAFMNRSSYFCPVCQPAPRRRRAASSRVRVPD

Sequences:

>Translated_295_residues
MPELPEVEVVRAGLERHVLGATIARVDVLHPRPVRRDLRGPAGFAAALTGRRIEAARRRGKYLWLPLDNGDALLGHLGMS
GQLLVQPPDAPDERHLRVRLALEGADEGRELRFVDQRMFGGLSVSAGGADLPPEIAHIARDPLDPEFDDDDFVRRVRRRT
SGVKRQLLDQNLISGVGNIYADEALWRARIHGERPGDRLTATRVRELLAHAREVMLAALGEGGTSFDALYVNVNGESGYF
DRSLHAYGREGEACERCGTPIRRVAFMNRSSYFCPVCQPAPRRRRAASSRVRVPD
>Mature_294_residues
PELPEVEVVRAGLERHVLGATIARVDVLHPRPVRRDLRGPAGFAAALTGRRIEAARRRGKYLWLPLDNGDALLGHLGMSG
QLLVQPPDAPDERHLRVRLALEGADEGRELRFVDQRMFGGLSVSAGGADLPPEIAHIARDPLDPEFDDDDFVRRVRRRTS
GVKRQLLDQNLISGVGNIYADEALWRARIHGERPGDRLTATRVRELLAHAREVMLAALGEGGTSFDALYVNVNGESGYFD
RSLHAYGREGEACERCGTPIRRVAFMNRSSYFCPVCQPAPRRRRAASSRVRVPD

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=281, Percent_Identity=35.2313167259786, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1786932, Length=283, Percent_Identity=26.1484098939929, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_NOCSJ (A1SLU7)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924469.1
- ProteinModelPortal:   A1SLU7
- SMR:   A1SLU7
- STRING:   A1SLU7
- GeneID:   4599142
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3280
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RYAKMIG
- PhylomeDB:   A1SLU7
- ProtClustDB:   PRK01103
- BioCyc:   NSP35761:NOCA_3280-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 32775; Mature: 32644

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 269-269 BINDING 95-95 BINDING 117-117 BINDING 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRAGLERHVLGATIARVDVLHPRPVRRDLRGPAGFAAALTGRRIEAARRRG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHCHHHHHHHHCC
KYLWLPLDNGDALLGHLGMSGQLLVQPPDAPDERHLRVRLALEGADEGRELRFVDQRMFG
CEEEEEECCCCEEEEECCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHC
GLSVSAGGADLPPEIAHIARDPLDPEFDDDDFVRRVRRRTSGVKRQLLDQNLISGVGNIY
CEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEALWRARIHGERPGDRLTATRVRELLAHAREVMLAALGEGGTSFDALYVNVNGESGYF
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCC
DRSLHAYGREGEACERCGTPIRRVAFMNRSSYFCPVCQPAPRRRRAASSRVRVPD
CCHHHHCCCCCHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PELPEVEVVRAGLERHVLGATIARVDVLHPRPVRRDLRGPAGFAAALTGRRIEAARRRG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHCHHHHHHHHCC
KYLWLPLDNGDALLGHLGMSGQLLVQPPDAPDERHLRVRLALEGADEGRELRFVDQRMFG
CEEEEEECCCCEEEEECCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHC
GLSVSAGGADLPPEIAHIARDPLDPEFDDDDFVRRVRRRTSGVKRQLLDQNLISGVGNIY
CEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEALWRARIHGERPGDRLTATRVRELLAHAREVMLAALGEGGTSFDALYVNVNGESGYF
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCC
DRSLHAYGREGEACERCGTPIRRVAFMNRSSYFCPVCQPAPRRRRAASSRVRVPD
CCHHHHCCCCCHHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA