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The map label for this gene is tesB [H]

Identifier: 119717075

GI number: 119717075

Start: 3021075

End: 3021941

Strand: Reverse

Name: tesB [H]

Synonym: Noca_2851

Alternate gene names: 119717075

Gene position: 3021941-3021075 (Counterclockwise)

Preceding gene: 119717076

Following gene: 119717074

Centisome position: 60.61

GC content: 73.59

Gene sequence:

>867_bases
GTGCCGAGGAACGCCGACGAGCTCGTCGCGCTGCTCGACCTCGAGCGCATCGACGACAACCTCTTCCGGGGGCAGCAGAT
GCCCTCGTCGCTGCCGCGCGTGTTCGGTGGCCAGGCCGCGGCCCAGTCGCTCGTCGCGGCGACCCGCACCGTCGACCCGG
CGTACGTCGTGCACTCGCTGCACTCCTACTTCCTCCAGCCCGGAGACACCCAGGCGCCGACGATCTACGACGTCGAGAAC
CTCCGCGACGGCCGCTCGTTCGCGACCCGGCGGGTGCTCGCACGCCAGCACGGGCGCCCGATCTACGCGCTGACCGCGAA
CTTCCACCAGCCCGAGCCCGGGTTCGAGCACCAGGACCGGATGCCCGCTGTGGTCGCGCCGGAGGAGGCGATCGACGCGC
GGGCGGCGGCCAAGGAGCTCGACCCCGGCCGCGACACCTCGCACGACTCCGAGTGGGACGTGGTCGACTTCCGCTACGTC
GGCTCCGACGGCGACGGGCTGATCGAGCCCGACCCGCGGCACCCGGCGCGGCAGCGGTTCTGGCTGCGGGTCTCCTCGCC
GCTGCCGGACGACCCGGTCCAGCACGTCGCGGCGTTCACCTACCTCTCCGACATGACCTTGATGGGCGCGGCGCTCGCGC
CGCACGGCGTCCGGGTCGGCGGGCCCGAGACGCTCGTGGCGTCCCTCGACCACGCGGTGTGGTTCCACCGGCCGTTCCGC
GCCGACGAGTGGTGGCTCTACGACCAGGTCTCGCCGTCCGCGTCGGGCGGCCGCGGGCTGGTGCTGGCCCGGGTGTTCAC
CCAGGACGGCACCCTGGTCGCGAGCGTGGCCCAGGAGGCGCTGATCCGCCGCAGGACGCGATCGTGA

Upstream 100 bases:

>100_bases
GACCAGCGGCTGCCCACGGGCGAGGAGATCGGCAAGGAGTTCGAGCGGTTCCTCGCCGGCCTCGACCGCCCGGGCGACGA
CGAGCCCCAGGGCTGACTGG

Downstream 100 bases:

>100_bases
GCGGGGGAGCGTCGGGCCCGACCGCGGAGCTGGTCGGGCTGCTCGACCTGGAGCGGATCGACGCCGACCTGTTCCGCGGC
GGGCAGCCGGACTCGGTCCG

Product: palmitoyl-CoA hydrolase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MPRNADELVALLDLERIDDNLFRGQQMPSSLPRVFGGQAAAQSLVAATRTVDPAYVVHSLHSYFLQPGDTQAPTIYDVEN
LRDGRSFATRRVLARQHGRPIYALTANFHQPEPGFEHQDRMPAVVAPEEAIDARAAAKELDPGRDTSHDSEWDVVDFRYV
GSDGDGLIEPDPRHPARQRFWLRVSSPLPDDPVQHVAAFTYLSDMTLMGAALAPHGVRVGGPETLVASLDHAVWFHRPFR
ADEWWLYDQVSPSASGGRGLVLARVFTQDGTLVASVAQEALIRRRTRS

Sequences:

>Translated_288_residues
MPRNADELVALLDLERIDDNLFRGQQMPSSLPRVFGGQAAAQSLVAATRTVDPAYVVHSLHSYFLQPGDTQAPTIYDVEN
LRDGRSFATRRVLARQHGRPIYALTANFHQPEPGFEHQDRMPAVVAPEEAIDARAAAKELDPGRDTSHDSEWDVVDFRYV
GSDGDGLIEPDPRHPARQRFWLRVSSPLPDDPVQHVAAFTYLSDMTLMGAALAPHGVRVGGPETLVASLDHAVWFHRPFR
ADEWWLYDQVSPSASGGRGLVLARVFTQDGTLVASVAQEALIRRRTRS
>Mature_287_residues
PRNADELVALLDLERIDDNLFRGQQMPSSLPRVFGGQAAAQSLVAATRTVDPAYVVHSLHSYFLQPGDTQAPTIYDVENL
RDGRSFATRRVLARQHGRPIYALTANFHQPEPGFEHQDRMPAVVAPEEAIDARAAAKELDPGRDTSHDSEWDVVDFRYVG
SDGDGLIEPDPRHPARQRFWLRVSSPLPDDPVQHVAAFTYLSDMTLMGAALAPHGVRVGGPETLVASLDHAVWFHRPFRA
DEWWLYDQVSPSASGGRGLVLARVFTQDGTLVASVAQEALIRRRTRS

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=288, Percent_Identity=38.5416666666667, Blast_Score=191, Evalue=7e-49,
Organism=Escherichia coli, GI1786657, Length=278, Percent_Identity=42.8057553956835, Blast_Score=218, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI71988741, Length=289, Percent_Identity=35.2941176470588, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17558508, Length=322, Percent_Identity=36.9565217391304, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17531889, Length=273, Percent_Identity=36.2637362637363, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI115532456, Length=273, Percent_Identity=36.2637362637363, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17531885, Length=273, Percent_Identity=36.2637362637363, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71982224, Length=304, Percent_Identity=30.9210526315789, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI212645202, Length=294, Percent_Identity=29.2517006802721, Blast_Score=114, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 31948; Mature: 31817

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRNADELVALLDLERIDDNLFRGQQMPSSLPRVFGGQAAAQSLVAATRTVDPAYVVHSL
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHH
HSYFLQPGDTQAPTIYDVENLRDGRSFATRRVLARQHGRPIYALTANFHQPEPGFEHQDR
HHHHCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCC
MPAVVAPEEAIDARAAAKELDPGRDTSHDSEWDVVDFRYVGSDGDGLIEPDPRHPARQRF
CCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHEE
WLRVSSPLPDDPVQHVAAFTYLSDMTLMGAALAPHGVRVGGPETLVASLDHAVWFHRPFR
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCC
ADEWWLYDQVSPSASGGRGLVLARVFTQDGTLVASVAQEALIRRRTRS
CCCCEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PRNADELVALLDLERIDDNLFRGQQMPSSLPRVFGGQAAAQSLVAATRTVDPAYVVHSL
CCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHH
HSYFLQPGDTQAPTIYDVENLRDGRSFATRRVLARQHGRPIYALTANFHQPEPGFEHQDR
HHHHCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCC
MPAVVAPEEAIDARAAAKELDPGRDTSHDSEWDVVDFRYVGSDGDGLIEPDPRHPARQRF
CCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHEE
WLRVSSPLPDDPVQHVAAFTYLSDMTLMGAALAPHGVRVGGPETLVASLDHAVWFHRPFR
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCC
ADEWWLYDQVSPSASGGRGLVLARVFTQDGTLVASVAQEALIRRRTRS
CCCCEEEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]