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The map label for this gene is tesB [H]

Identifier: 119717074

GI number: 119717074

Start: 3020188

End: 3021078

Strand: Reverse

Name: tesB [H]

Synonym: Noca_2850

Alternate gene names: 119717074

Gene position: 3021078-3020188 (Counterclockwise)

Preceding gene: 119717075

Following gene: 119717071

Centisome position: 60.59

GC content: 73.51

Gene sequence:

>891_bases
GTGAGCGGGGGAGCGTCGGGCCCGACCGCGGAGCTGGTCGGGCTGCTCGACCTGGAGCGGATCGACGCCGACCTGTTCCG
CGGCGGGCAGCCGGACTCGGTCCGGGCCCGGGTCTACGGCGGCCAGGTCGCCGCCCAGGCGCTGGTCGCGGCGACCCGCA
CCGTGGAACCGGCGTACGCCGTCCACTCGCTGCACTCCTACTTCCTGCTGCCCGGCGACTACTCGGTGCCGATCGTCTAC
GACGTCGAGCGGATCCGCGACGGGCGGTCCTTCCAGACGCGGCGGGTGATCGCGCGCCAGCACGGGCGGGCGATCTACTT
CCAGGTGCTGGACTTCCAGCGTGCCGAGGAGGGCTTCGAGCACCAGGACGCGATGCCCGAGGTGAAGCCGCCGGAGGAGG
GCCTCGACCTGGTCGACGTCATGCGTCGCGGCGGCAACGCCGAGGCGGACGCCCTCGGCAAGGAGTGGGGCGCGCTCGAC
GTGCGCTGGCTCGGCAACTCGCGGTTCGGTCTCGAGGCCGACCCGGACCGCCCCTCCCAGGCCCGGATGTGGGTGCGGCT
CAAGGAGGGGCTCGGCGACGACCCGGTCGTCCACCTCGCGGCGTTCACCTACGCCAGCGACGTGAGCCTGCTCGGCTCGA
CGCTCGCCGCGCACGGCGTGAACCCCTCGAAGACGCAGATGGCGTCGCTGGACCACACGATCTGGTTCCACCGGCCGTTC
CGCGCGGACGAGTGGTGGCTCTACGACCAGGTCTCGCCCGCGGCGGTGGGTGCCCGCGGGCTGGCCTTCGGCCGGATCTT
CACCCAGGACGGCACCCTGGTCGCCACGGTCGCGCAGGAGGGCCTGATCCGGCCCCGGGGCGAGGGGTACGCCGGACCCG
GCATGGCCTGA

Upstream 100 bases:

>100_bases
CGGGCGGCCGCGGGCTGGTGCTGGCCCGGGTGTTCACCCAGGACGGCACCCTGGTCGCGAGCGTGGCCCAGGAGGCGCTG
ATCCGCCGCAGGACGCGATC

Downstream 100 bases:

>100_bases
GCCCGGCGCACCGAGGCCCGGGTCGTGTGCCTGAGGACGCGCCATGGCGCGTCCTCAGGCACACGACCCGTCAGGTGGGG
TCGCTCGTCCGGCCCGCGAG

Product: palmitoyl-CoA hydrolase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSGGASGPTAELVGLLDLERIDADLFRGGQPDSVRARVYGGQVAAQALVAATRTVEPAYAVHSLHSYFLLPGDYSVPIVY
DVERIRDGRSFQTRRVIARQHGRAIYFQVLDFQRAEEGFEHQDAMPEVKPPEEGLDLVDVMRRGGNAEADALGKEWGALD
VRWLGNSRFGLEADPDRPSQARMWVRLKEGLGDDPVVHLAAFTYASDVSLLGSTLAAHGVNPSKTQMASLDHTIWFHRPF
RADEWWLYDQVSPAAVGARGLAFGRIFTQDGTLVATVAQEGLIRPRGEGYAGPGMA

Sequences:

>Translated_296_residues
MSGGASGPTAELVGLLDLERIDADLFRGGQPDSVRARVYGGQVAAQALVAATRTVEPAYAVHSLHSYFLLPGDYSVPIVY
DVERIRDGRSFQTRRVIARQHGRAIYFQVLDFQRAEEGFEHQDAMPEVKPPEEGLDLVDVMRRGGNAEADALGKEWGALD
VRWLGNSRFGLEADPDRPSQARMWVRLKEGLGDDPVVHLAAFTYASDVSLLGSTLAAHGVNPSKTQMASLDHTIWFHRPF
RADEWWLYDQVSPAAVGARGLAFGRIFTQDGTLVATVAQEGLIRPRGEGYAGPGMA
>Mature_295_residues
SGGASGPTAELVGLLDLERIDADLFRGGQPDSVRARVYGGQVAAQALVAATRTVEPAYAVHSLHSYFLLPGDYSVPIVYD
VERIRDGRSFQTRRVIARQHGRAIYFQVLDFQRAEEGFEHQDAMPEVKPPEEGLDLVDVMRRGGNAEADALGKEWGALDV
RWLGNSRFGLEADPDRPSQARMWVRLKEGLGDDPVVHLAAFTYASDVSLLGSTLAAHGVNPSKTQMASLDHTIWFHRPFR
ADEWWLYDQVSPAAVGARGLAFGRIFTQDGTLVATVAQEGLIRPRGEGYAGPGMA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=288, Percent_Identity=41.3194444444444, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1786657, Length=273, Percent_Identity=41.3919413919414, Blast_Score=197, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71988741, Length=290, Percent_Identity=38.6206896551724, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17558508, Length=299, Percent_Identity=38.7959866220736, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI115532456, Length=274, Percent_Identity=33.2116788321168, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17531889, Length=274, Percent_Identity=33.2116788321168, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17531885, Length=274, Percent_Identity=33.2116788321168, Blast_Score=143, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71982224, Length=301, Percent_Identity=31.8936877076412, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI212645202, Length=281, Percent_Identity=32.0284697508897, Blast_Score=120, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32359; Mature: 32228

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGGASGPTAELVGLLDLERIDADLFRGGQPDSVRARVYGGQVAAQALVAATRTVEPAYA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHH
VHSLHSYFLLPGDYSVPIVYDVERIRDGRSFQTRRVIARQHGRAIYFQVLDFQRAEEGFE
HHHHHHEEEECCCCCCEEEEEHHHHCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHCCC
HQDAMPEVKPPEEGLDLVDVMRRGGNAEADALGKEWGALDVRWLGNSRFGLEADPDRPSQ
HHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHH
ARMWVRLKEGLGDDPVVHLAAFTYASDVSLLGSTLAAHGVNPSKTQMASLDHTIWFHRPF
HHHHHEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCC
RADEWWLYDQVSPAAVGARGLAFGRIFTQDGTLVATVAQEGLIRPRGEGYAGPGMA
CCCCCEEECCCCHHHHCCCCEEEEEEEECCCCEEEEEHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGGASGPTAELVGLLDLERIDADLFRGGQPDSVRARVYGGQVAAQALVAATRTVEPAYA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHH
VHSLHSYFLLPGDYSVPIVYDVERIRDGRSFQTRRVIARQHGRAIYFQVLDFQRAEEGFE
HHHHHHEEEECCCCCCEEEEEHHHHCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHCCC
HQDAMPEVKPPEEGLDLVDVMRRGGNAEADALGKEWGALDVRWLGNSRFGLEADPDRPSQ
HHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHH
ARMWVRLKEGLGDDPVVHLAAFTYASDVSLLGSTLAAHGVNPSKTQMASLDHTIWFHRPF
HHHHHEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCC
RADEWWLYDQVSPAAVGARGLAFGRIFTQDGTLVATVAQEGLIRPRGEGYAGPGMA
CCCCCEEECCCCHHHHCCCCEEEEEEEECCCCEEEEEHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]