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The map label for this gene is fadI [H]

Identifier: 119717071

GI number: 119717071

Start: 3016539

End: 3017819

Strand: Reverse

Name: fadI [H]

Synonym: Noca_2847

Alternate gene names: 119717071

Gene position: 3017819-3016539 (Counterclockwise)

Preceding gene: 119717074

Following gene: 119717068

Centisome position: 60.53

GC content: 72.05

Gene sequence:

>1281_bases
ATGGCAGCCAACACCCGACGCGTCGCCGTCCTCGGCGGCAACCGGATCCCCTTCGCCCGCTCCAACACCGTGTACGCCGA
GGCGTCCAACCAGGACATGCTCACCGCCGCGATCGACGGCCTGGTCGAGCGGTTCGGGCTCCAGGGCGAGCGGCTCGGCG
AGGTCGTCGCCGGTGCGGTGCTCAAGCACGCGCGCGACTTCAACCTGACCCGCGAGTCGGTGCTCGGCTCCAAGCTCGCG
CCCGAGACACCGGCGACCGACCTCCAGCAGGCGTGCGGGACCGGCCTGCAGGCCGCGATCCAGGTGGCCAACAAGATCGC
CCTCGGGCAGATCGAGGCCGGGATCGCGGGCGGCACCGACACCACCTCCGACGCGCCCGTCGCGATCAGCGACCGGCTCC
GCAAGAAGCTGATGAAGGTCAACGCCGCCCGGGACACCAAGGGCAAGCTGCTCGCGCTCGGCGCGATCCGGCCCGGTGAC
ATCGGCCTGGAGATCCCGCAGAACGGCGAGCCTCGGACCCGGCTGTCGATGGGCGAGCACGCCGCGCTCACCGCCCTGGA
GTGGCAGATCGGCCGGGAGGAGCAGGACGAGCTGGCCGCCGCGTCGCACCAGCACCTGGCGGCGGCGTACGACCGCGGCT
GGCTCGACGACCAGATCACGCCGTTCCGCGGCGTCGAGCGGGACAACAACCTGCGCCCCGACTCGACCGCGGAGAAGCTG
GCCAAGCTCAAGCCGGTCTTCGGCAAGGGCGAGGCGGCGACGATGACCGCCGGCAACTCCACGCCGCTGACCGACGGCGC
CTCCGCGGTGCTGCTCGCGAGCGAGGAGTGGGCCGACGAGCACGGGCTGGCGCCGCTGGCGTACTTCGTGGACTCCGAGA
CCGCGGCGGTCGACTACGTGCACGGGGGCGAGGGCCTGCTGATGGCGCCTGCGTACGCCGTCCCGCGGATGCTGGCGCGC
AACGGGCTGACCCTCCAGGACTTCGACTTCTACGAGATCCACGAGGCGTTCGCCTCGCAGGTGCTCGCCACGCTCAAGGC
GTGGGAGGACCCGATCTTCTGCAAGGAGCGGCTCGGACTCGACGCCCCGCTCGGTTCGATCGACCGCTCGAAGCTGAACG
TCAACGGCTCCTCGCTGGCGGCGGGGCACCCGTTCGCCGCCACCGGCGGCCGGATCCTCAACGTCGCCGCCAAGCTGCTC
GCCGAGAAGGGGTCGGGCCGGGCGCTGATCTCGATCTGCGCCGCGGGCGGCCAGGGCGTCGTCGCGATCCTGGAGCGGTG
A

Upstream 100 bases:

>100_bases
CATGACGGGTATGTAACTCCTTGTGTAACTGAGAGTCCAGATTTCGTGATCTGGCCCTCATGTCCTTCTCTCGTTCCCCT
GCTCGACGGAGGATGAACCC

Downstream 100 bases:

>100_bases
GCGAGGACGCGCGGTGAGTCAGCGCGTAGCGAGCGCGAGCGCGGCCGCGACGAGGTAGTCGCGCACCTGGTCGGGCGAGA
TGCTGCCGACCGTCGGCACG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAANTRRVAVLGGNRIPFARSNTVYAEASNQDMLTAAIDGLVERFGLQGERLGEVVAGAVLKHARDFNLTRESVLGSKLA
PETPATDLQQACGTGLQAAIQVANKIALGQIEAGIAGGTDTTSDAPVAISDRLRKKLMKVNAARDTKGKLLALGAIRPGD
IGLEIPQNGEPRTRLSMGEHAALTALEWQIGREEQDELAAASHQHLAAAYDRGWLDDQITPFRGVERDNNLRPDSTAEKL
AKLKPVFGKGEAATMTAGNSTPLTDGASAVLLASEEWADEHGLAPLAYFVDSETAAVDYVHGGEGLLMAPAYAVPRMLAR
NGLTLQDFDFYEIHEAFASQVLATLKAWEDPIFCKERLGLDAPLGSIDRSKLNVNGSSLAAGHPFAATGGRILNVAAKLL
AEKGSGRALISICAAGGQGVVAILER

Sequences:

>Translated_426_residues
MAANTRRVAVLGGNRIPFARSNTVYAEASNQDMLTAAIDGLVERFGLQGERLGEVVAGAVLKHARDFNLTRESVLGSKLA
PETPATDLQQACGTGLQAAIQVANKIALGQIEAGIAGGTDTTSDAPVAISDRLRKKLMKVNAARDTKGKLLALGAIRPGD
IGLEIPQNGEPRTRLSMGEHAALTALEWQIGREEQDELAAASHQHLAAAYDRGWLDDQITPFRGVERDNNLRPDSTAEKL
AKLKPVFGKGEAATMTAGNSTPLTDGASAVLLASEEWADEHGLAPLAYFVDSETAAVDYVHGGEGLLMAPAYAVPRMLAR
NGLTLQDFDFYEIHEAFASQVLATLKAWEDPIFCKERLGLDAPLGSIDRSKLNVNGSSLAAGHPFAATGGRILNVAAKLL
AEKGSGRALISICAAGGQGVVAILER
>Mature_425_residues
AANTRRVAVLGGNRIPFARSNTVYAEASNQDMLTAAIDGLVERFGLQGERLGEVVAGAVLKHARDFNLTRESVLGSKLAP
ETPATDLQQACGTGLQAAIQVANKIALGQIEAGIAGGTDTTSDAPVAISDRLRKKLMKVNAARDTKGKLLALGAIRPGDI
GLEIPQNGEPRTRLSMGEHAALTALEWQIGREEQDELAAASHQHLAAAYDRGWLDDQITPFRGVERDNNLRPDSTAEKLA
KLKPVFGKGEAATMTAGNSTPLTDGASAVLLASEEWADEHGLAPLAYFVDSETAAVDYVHGGEGLLMAPAYAVPRMLARN
GLTLQDFDFYEIHEAFASQVLATLKAWEDPIFCKERLGLDAPLGSIDRSKLNVNGSSLAAGHPFAATGGRILNVAAKLLA
EKGSGRALISICAAGGQGVVAILER

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=37.4707259953162, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI167614485, Length=432, Percent_Identity=30.787037037037, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI4501853, Length=433, Percent_Identity=29.5612009237875, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI148539872, Length=436, Percent_Identity=28.6697247706422, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI4557237, Length=407, Percent_Identity=28.2555282555283, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=38.3529411764706, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI87082165, Length=431, Percent_Identity=29.2343387470998, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1788554, Length=429, Percent_Identity=31.002331002331, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1787663, Length=438, Percent_Identity=31.5068493150685, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI48994986, Length=432, Percent_Identity=28.0092592592593, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=36.9158878504673, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI133906874, Length=430, Percent_Identity=28.8372093023256, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17535921, Length=432, Percent_Identity=27.3148148148148, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25147385, Length=429, Percent_Identity=25.8741258741259, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=21.8592964824121, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322031, Length=377, Percent_Identity=32.6259946949602, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=384, Percent_Identity=28.6458333333333, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=36.9767441860465, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24655093, Length=430, Percent_Identity=27.4418604651163, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17648125, Length=436, Percent_Identity=29.8165137614679, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24640423, Length=434, Percent_Identity=26.4976958525346, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 44916; Mature: 44785

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANTRRVAVLGGNRIPFARSNTVYAEASNQDMLTAAIDGLVERFGLQGERLGEVVAGAV
CCCCCCEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LKHARDFNLTRESVLGSKLAPETPATDLQQACGTGLQAAIQVANKIALGQIEAGIAGGTD
HHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHECCCCCCCCC
TTSDAPVAISDRLRKKLMKVNAARDTKGKLLALGAIRPGDIGLEIPQNGEPRTRLSMGEH
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCHHCCCCCC
AALTALEWQIGREEQDELAAASHQHLAAAYDRGWLDDQITPFRGVERDNNLRPDSTAEKL
HHEEEEEHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
AKLKPVFGKGEAATMTAGNSTPLTDGASAVLLASEEWADEHGLAPLAYFVDSETAAVDYV
HHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEECHHHCHHCCCCEEEEEECCCCEEEEEE
HGGEGLLMAPAYAVPRMLARNGLTLQDFDFYEIHEAFASQVLATLKAWEDPIFCKERLGL
ECCCCEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
DAPLGSIDRSKLNVNGSSLAAGHPFAATGGRILNVAAKLLAEKGSGRALISICAAGGQGV
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCE
VAILER
EEEECC
>Mature Secondary Structure 
AANTRRVAVLGGNRIPFARSNTVYAEASNQDMLTAAIDGLVERFGLQGERLGEVVAGAV
CCCCCEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LKHARDFNLTRESVLGSKLAPETPATDLQQACGTGLQAAIQVANKIALGQIEAGIAGGTD
HHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHECCCCCCCCC
TTSDAPVAISDRLRKKLMKVNAARDTKGKLLALGAIRPGDIGLEIPQNGEPRTRLSMGEH
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEECCCCCCCCHHCCCCCC
AALTALEWQIGREEQDELAAASHQHLAAAYDRGWLDDQITPFRGVERDNNLRPDSTAEKL
HHEEEEEHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
AKLKPVFGKGEAATMTAGNSTPLTDGASAVLLASEEWADEHGLAPLAYFVDSETAAVDYV
HHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEECHHHCHHCCCCEEEEEECCCCEEEEEE
HGGEGLLMAPAYAVPRMLARNGLTLQDFDFYEIHEAFASQVLATLKAWEDPIFCKERLGL
ECCCCEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
DAPLGSIDRSKLNVNGSSLAAGHPFAATGGRILNVAAKLLAEKGSGRALISICAAGGQGV
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCE
VAILER
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA