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The map label for this gene is ald [H]

Identifier: 119716714

GI number: 119716714

Start: 2656219

End: 2657334

Strand: Direct

Name: ald [H]

Synonym: Noca_2488

Alternate gene names: 119716714

Gene position: 2656219-2657334 (Clockwise)

Preceding gene: 119716713

Following gene: 119716715

Centisome position: 53.27

GC content: 69.62

Gene sequence:

>1116_bases
GTGAAGGTGGGCGTCCCCAAGGAAGTCAAGAACAACGAGTACCGGGTGGCGATCACGCCCATCGGTGTGCACGAGCTGAC
CGCGCACGGTCACCAGGTGTACATCGAACGCGGTGCCGGTGAGGGCTCCTCGATCCACGACGAGGAGTACGCCGCGGCCG
GGGCGCAGATCGTCCCGGACGCGGACAGCACGTGGGGCGACGTCGAGCTGGTCCTCAAGGTCAAGGAGCCGGTCGCCGAG
GAGTACCACCGGCTGCGCGAGGGGCTGACCCTGTTCACCTACCTCCACCTCGCGGCGGACAAGAGGCTGACCGACAAGCT
GCTCGACACCAAGGTCACCGCGATCGCGTACGAGACCGTGCAGCTGCCGTCGGGCGGCCTGCCGCTGCTGTACCCGATGT
CCGAGGTCGCCGGCTGCCTGGCGCCCCAGGTCGGGGGCTACTCCCTCATGCGGGCCCAGGGCGGCCGCGGCGTCCTCATG
GGGGGTGTCGGTGGCGTCGCCAACGCCAAGGTCGTGATCATCGGTGCCGGCGTCTCGGGCCAGAACGCCGCCAACATCGC
CCTCGGCATGGGGGCCGACGTCACCTTGCTCGACAACGACCTGGACAAGCTGCGGATGTCGTTCTGGCGCTACAACAACC
GGGTGCACGGCCTCGCGTCCTCGAAGCTGGCGATCGAGCAGCAGGTCACCGAGGCCGACCTGGTCATCGGAGCGGTGCTG
ATCCCCGGGGCCGCCGCGCCCAAGCTGGTCAGCAACGAGCTGGTCTCCCGGATGAAGCCCGGCTCGGTCCTCGTCGACAT
CGCGGTCGACCAGGGCGGCTGCTTCGAGGACACCCGGCCGACCACGCACGCGGACCCGACGTACCAGGTGCACAACTCGA
CGTTCTACTGCGTGGCGAACATGCCCGGGGCGGTCCCGAACACCTCGACCTACGCGCTGACGAATGCCACGCTGCCCTAT
GTCGTCGCCGTCGCGGACAAGGGCTGGCAGCAGGCCAGCCGCGACGACCACAGCCTGGCCCTCGGCCTGAACACCCACGC
GGGCCGGCTCACGAACGCGGCCGTGGGTGCGGCGGTCGGGGTCGCGGCCGACCCGTTGGACTCCGTCCTGACGTGA

Upstream 100 bases:

>100_bases
TGGGCCGACCTCTTCCGGGAGCTCACCCGGATCTACGCTCGCCGGGAGTAGGCTCGCGCAGCCACAACGGCGTGGCGCTG
AGAACTGAAGGAGCGATGCG

Downstream 100 bases:

>100_bases
ACGACCCAGCGTCGAACGACGTCGCGCGCGCGGTCCGGACCTACCTCGACCACCTGACGGTCGAGCGCGGCCTCGCGACG
AACACGCTGACGTCGTATCG

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKVGVPKEVKNNEYRVAITPIGVHELTAHGHQVYIERGAGEGSSIHDEEYAAAGAQIVPDADSTWGDVELVLKVKEPVAE
EYHRLREGLTLFTYLHLAADKRLTDKLLDTKVTAIAYETVQLPSGGLPLLYPMSEVAGCLAPQVGGYSLMRAQGGRGVLM
GGVGGVANAKVVIIGAGVSGQNAANIALGMGADVTLLDNDLDKLRMSFWRYNNRVHGLASSKLAIEQQVTEADLVIGAVL
IPGAAAPKLVSNELVSRMKPGSVLVDIAVDQGGCFEDTRPTTHADPTYQVHNSTFYCVANMPGAVPNTSTYALTNATLPY
VVAVADKGWQQASRDDHSLALGLNTHAGRLTNAAVGAAVGVAADPLDSVLT

Sequences:

>Translated_371_residues
MKVGVPKEVKNNEYRVAITPIGVHELTAHGHQVYIERGAGEGSSIHDEEYAAAGAQIVPDADSTWGDVELVLKVKEPVAE
EYHRLREGLTLFTYLHLAADKRLTDKLLDTKVTAIAYETVQLPSGGLPLLYPMSEVAGCLAPQVGGYSLMRAQGGRGVLM
GGVGGVANAKVVIIGAGVSGQNAANIALGMGADVTLLDNDLDKLRMSFWRYNNRVHGLASSKLAIEQQVTEADLVIGAVL
IPGAAAPKLVSNELVSRMKPGSVLVDIAVDQGGCFEDTRPTTHADPTYQVHNSTFYCVANMPGAVPNTSTYALTNATLPY
VVAVADKGWQQASRDDHSLALGLNTHAGRLTNAAVGAAVGVAADPLDSVLT
>Mature_371_residues
MKVGVPKEVKNNEYRVAITPIGVHELTAHGHQVYIERGAGEGSSIHDEEYAAAGAQIVPDADSTWGDVELVLKVKEPVAE
EYHRLREGLTLFTYLHLAADKRLTDKLLDTKVTAIAYETVQLPSGGLPLLYPMSEVAGCLAPQVGGYSLMRAQGGRGVLM
GGVGGVANAKVVIIGAGVSGQNAANIALGMGADVTLLDNDLDKLRMSFWRYNNRVHGLASSKLAIEQQVTEADLVIGAVL
IPGAAAPKLVSNELVSRMKPGSVLVDIAVDQGGCFEDTRPTTHADPTYQVHNSTFYCVANMPGAVPNTSTYALTNATLPY
VVAVADKGWQQASRDDHSLALGLNTHAGRLTNAAVGAAVGVAADPLDSVLT

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=310, Percent_Identity=34.5161290322581, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI122939153, Length=310, Percent_Identity=34.5161290322581, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1787887, Length=333, Percent_Identity=32.4324324324324, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17550456, Length=359, Percent_Identity=29.8050139275766, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39014; Mature: 39014

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGVPKEVKNNEYRVAITPIGVHELTAHGHQVYIERGAGEGSSIHDEEYAAAGAQIVPD
CCCCCCCHHCCCCEEEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCEEECC
ADSTWGDVELVLKVKEPVAEEYHRLREGLTLFTYLHLAADKRLTDKLLDTKVTAIAYETV
CCCCCCCEEEEEEEHHHHHHHHHHHHCCCEEEHHHHHHHCCHHHHHHHHHHEEEEEEEEE
QLPSGGLPLLYPMSEVAGCLAPQVGGYSLMRAQGGRGVLMGGVGGVANAKVVIIGAGVSG
ECCCCCCEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCCCC
QNAANIALGMGADVTLLDNDLDKLRMSFWRYNNRVHGLASSKLAIEQQVTEADLVIGAVL
CCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHEEEEEE
IPGAAAPKLVSNELVSRMKPGSVLVDIAVDQGGCFEDTRPTTHADPTYQVHNSTFYCVAN
ECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCEEEEEEC
MPGAVPNTSTYALTNATLPYVVAVADKGWQQASRDDHSLALGLNTHAGRLTNAAVGAAVG
CCCCCCCCCEEEEECCCCCEEEEEECCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHC
VAADPLDSVLT
CCCCCHHHHCC
>Mature Secondary Structure
MKVGVPKEVKNNEYRVAITPIGVHELTAHGHQVYIERGAGEGSSIHDEEYAAAGAQIVPD
CCCCCCCHHCCCCEEEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCEEECC
ADSTWGDVELVLKVKEPVAEEYHRLREGLTLFTYLHLAADKRLTDKLLDTKVTAIAYETV
CCCCCCCEEEEEEEHHHHHHHHHHHHCCCEEEHHHHHHHCCHHHHHHHHHHEEEEEEEEE
QLPSGGLPLLYPMSEVAGCLAPQVGGYSLMRAQGGRGVLMGGVGGVANAKVVIIGAGVSG
ECCCCCCEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEECCCCC
QNAANIALGMGADVTLLDNDLDKLRMSFWRYNNRVHGLASSKLAIEQQVTEADLVIGAVL
CCCCEEEEECCCCEEEECCCHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHEEEEEE
IPGAAAPKLVSNELVSRMKPGSVLVDIAVDQGGCFEDTRPTTHADPTYQVHNSTFYCVAN
ECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCEEEEEEC
MPGAVPNTSTYALTNATLPYVVAVADKGWQQASRDDHSLALGLNTHAGRLTNAAVGAAVG
CCCCCCCCCEEEEECCCCCEEEEEECCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHC
VAADPLDSVLT
CCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]