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The map label for this gene is argG

Identifier: 119716700

GI number: 119716700

Start: 2634705

End: 2636138

Strand: Direct

Name: argG

Synonym: Noca_2474

Alternate gene names: 119716700

Gene position: 2634705-2636138 (Clockwise)

Preceding gene: 119716699

Following gene: 119716701

Centisome position: 52.84

GC content: 70.29

Gene sequence:

>1434_bases
GTGAGCAAGGTCCTGACGTCCCTCCCGGTCGGCCAGCGGGTCGGCATCGCGTTCTCGGGAGGCCTGGACACCTCGGTGGC
GGTGGCCTGGATGCGCGACAAGGGCGCGATCCCGTGCACCTACACCGCCGACATCGGCCAGTACGACGAGCCCGACGTCT
CGGGCGTGCCCGCCCGGGCCCGCGAGTACGGCGCCGAGATCGCCCGCGTGGTCGACTGCCGGGCGCAGCTGGTCGAGGAG
GGGCTGGCGGCTCTCGCCTGCGGCGCCTTCCACATCCGCTCGGGCGGCCGGATCTACTTCAACACCACGCCACTCGGCCG
CGCCGTGACCGGCACCATCCTGGTCCGGGCGATGCACGAGGACGGCGTCGACATCTGGGGCGACGGGTCCACCTTCAAGG
GCAACGACATCGAGCGGTTCTACCGCTACGGCCTGCTGGCCAACCCGCAGCTGCGCATCTACAAGCCCTGGCTGGACCCC
GACTTCGTCCACGAGCTCGGTGGCCGCACCGAGATGAGCCAGTGGCTGACCAGCCACGGCCTGCCCTACCGCGACTCCCA
GGAGAAGGCGTACTCCACCGACGCGAACATCTGGGGCGCCACCCACGAGGCGAAGACCCTCGAGCACCTGGACACCTCGC
TGGAGGTGGTCACGCCGATCATGGGGGTCCGCTTCTGGGACCCGGCGGTCGACATCGCCACCGAGGACGTCACCGTCGCG
TTCGAGCAGGGCCGCCCGGTGGCGCTCAACGGCCGTCGGTTCGACGACCCGGTCGAGCTGGTCGAGGAGGCCAACGCGAT
CGGGGGCCGGCACGGCCTCGGGATGTCGGACCAGATCGAGAACCGGATCATCGAGGCGAAGTCGCGCGGCGTCTACGAGG
CGCCCGGCATGGCCCTGCTGTGGCTCACCTACGAGCGGCTGATGAACGCGATCCACAACGAGGACACGCTGGCGAACTAC
CAGATCAGCGGGCGTCGCCTCGGCCGCCTGCTGTACGAAGGACGGTGGCTCGACCCGCAGGCGCTGATGCTGCGCGAGTC
GATCCAGCGCTGGGTCGCGTCGGTGGTGACCGGCGAGGTGACCGTCCGGCTGCGTCGGGGGGAGGACTACACGATCGTGC
GGACCGAGGGCCCGGCGCTGTCCTACCACCCCGAGAAGCTCTCGATGGAGCGCACCTCGAACTCGGCGTTCGGGCCGACC
GACCGGATCGGCCAGCTCACGATGCGCAACCTCGACATCGCCGACTCGCGCGCGATGCTCGAGATGTACGCCGGGCAGCC
ACTCGACCAGGGCCAGGTGCTGGTCGAGAACGGCACGCTGTTCGGTGAGCTGCCGTCCGGCGGGTTCGACCAGATCACCG
AGAACCCGGAGGTGCAGGCCGAGCCGGAGGAGGAGGCCCTCGACGCGGCCGCGATGGAGGCCGGGACCGACTGA

Upstream 100 bases:

>100_bases
TGGTGATCGGCCGCGGCGCGAGCAGCGGCGACGCCCTGGCCCGCCGCTTCCTCGCCCTCGCCGACGCCAACCAGCACCTC
CAGCAGAGAGAAGATCATTC

Downstream 100 bases:

>100_bases
TGGGCACGAACACCGGGAAGCTCTGGGGCGGCCGCTTCGCGGGCGGCCCGTCGCCGGAGCTGGACGCGCTGTCCCGCTCG
ACCCACTTCGACTGGCGGCT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSKVLTSLPVGQRVGIAFSGGLDTSVAVAWMRDKGAIPCTYTADIGQYDEPDVSGVPARAREYGAEIARVVDCRAQLVEE
GLAALACGAFHIRSGGRIYFNTTPLGRAVTGTILVRAMHEDGVDIWGDGSTFKGNDIERFYRYGLLANPQLRIYKPWLDP
DFVHELGGRTEMSQWLTSHGLPYRDSQEKAYSTDANIWGATHEAKTLEHLDTSLEVVTPIMGVRFWDPAVDIATEDVTVA
FEQGRPVALNGRRFDDPVELVEEANAIGGRHGLGMSDQIENRIIEAKSRGVYEAPGMALLWLTYERLMNAIHNEDTLANY
QISGRRLGRLLYEGRWLDPQALMLRESIQRWVASVVTGEVTVRLRRGEDYTIVRTEGPALSYHPEKLSMERTSNSAFGPT
DRIGQLTMRNLDIADSRAMLEMYAGQPLDQGQVLVENGTLFGELPSGGFDQITENPEVQAEPEEEALDAAAMEAGTD

Sequences:

>Translated_477_residues
MSKVLTSLPVGQRVGIAFSGGLDTSVAVAWMRDKGAIPCTYTADIGQYDEPDVSGVPARAREYGAEIARVVDCRAQLVEE
GLAALACGAFHIRSGGRIYFNTTPLGRAVTGTILVRAMHEDGVDIWGDGSTFKGNDIERFYRYGLLANPQLRIYKPWLDP
DFVHELGGRTEMSQWLTSHGLPYRDSQEKAYSTDANIWGATHEAKTLEHLDTSLEVVTPIMGVRFWDPAVDIATEDVTVA
FEQGRPVALNGRRFDDPVELVEEANAIGGRHGLGMSDQIENRIIEAKSRGVYEAPGMALLWLTYERLMNAIHNEDTLANY
QISGRRLGRLLYEGRWLDPQALMLRESIQRWVASVVTGEVTVRLRRGEDYTIVRTEGPALSYHPEKLSMERTSNSAFGPT
DRIGQLTMRNLDIADSRAMLEMYAGQPLDQGQVLVENGTLFGELPSGGFDQITENPEVQAEPEEEALDAAAMEAGTD
>Mature_476_residues
SKVLTSLPVGQRVGIAFSGGLDTSVAVAWMRDKGAIPCTYTADIGQYDEPDVSGVPARAREYGAEIARVVDCRAQLVEEG
LAALACGAFHIRSGGRIYFNTTPLGRAVTGTILVRAMHEDGVDIWGDGSTFKGNDIERFYRYGLLANPQLRIYKPWLDPD
FVHELGGRTEMSQWLTSHGLPYRDSQEKAYSTDANIWGATHEAKTLEHLDTSLEVVTPIMGVRFWDPAVDIATEDVTVAF
EQGRPVALNGRRFDDPVELVEEANAIGGRHGLGMSDQIENRIIEAKSRGVYEAPGMALLWLTYERLMNAIHNEDTLANYQ
ISGRRLGRLLYEGRWLDPQALMLRESIQRWVASVVTGEVTVRLRRGEDYTIVRTEGPALSYHPEKLSMERTSNSAFGPTD
RIGQLTMRNLDIADSRAMLEMYAGQPLDQGQVLVENGTLFGELPSGGFDQITENPEVQAEPEEEALDAAAMEAGTD

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=408, Percent_Identity=28.4313725490196, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI16950633, Length=408, Percent_Identity=28.4313725490196, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1789563, Length=424, Percent_Identity=67.9245283018868, Blast_Score=610, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6324514, Length=423, Percent_Identity=29.3144208037825, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21358151, Length=415, Percent_Identity=28.9156626506024, Blast_Score=162, Evalue=6e-40,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_NOCSJ (A1SJJ3)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923665.1
- ProteinModelPortal:   A1SJJ3
- SMR:   A1SJJ3
- STRING:   A1SJJ3
- GeneID:   4597096
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2474
- eggNOG:   COG0137
- HOGENOM:   HBG289560
- OMA:   HIDIVEN
- PhylomeDB:   A1SJJ3
- ProtClustDB:   PRK05370
- BioCyc:   NSP35761:NOCA_2474-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00581
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 52670; Mature: 52539

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 43-43 BINDING 99-99 BINDING 129-129 BINDING 131-131 BINDING 131-131 BINDING 135-135 BINDING 135-135 BINDING 136-136 BINDING 136-136 BINDING 139-139 BINDING 192-192 BINDING 194-194 BINDING 201-201 BINDING 203-203 BINDING 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVLTSLPVGQRVGIAFSGGLDTSVAVAWMRDKGAIPCTYTADIGQYDEPDVSGVPARA
CCCCHHHCCCCCEECEEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHH
REYGAEIARVVDCRAQLVEEGLAALACGAFHIRSGGRIYFNTTPLGRAVTGTILVRAMHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCCCHHHEEEHEEEECCC
DGVDIWGDGSTFKGNDIERFYRYGLLANPQLRIYKPWLDPDFVHELGGRTEMSQWLTSHG
CCCEEECCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHCC
LPYRDSQEKAYSTDANIWGATHEAKTLEHLDTSLEVVTPIMGVRFWDPAVDIATEDVTVA
CCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCCCHHCCCCCEEEE
FEQGRPVALNGRRFDDPVELVEEANAIGGRHGLGMSDQIENRIIEAKSRGVYEAPGMALL
EECCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEH
WLTYERLMNAIHNEDTLANYQISGRRLGRLLYEGRWLDPQALMLRESIQRWVASVVTGEV
HHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEE
TVRLRRGEDYTIVRTEGPALSYHPEKLSMERTSNSAFGPTDRIGQLTMRNLDIADSRAML
EEEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHH
EMYAGQPLDQGQVLVENGTLFGELPSGGFDQITENPEVQAEPEEEALDAAAMEAGTD
HHHCCCCCCCCCEEEECCEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKVLTSLPVGQRVGIAFSGGLDTSVAVAWMRDKGAIPCTYTADIGQYDEPDVSGVPARA
CCCHHHCCCCCEECEEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCHHH
REYGAEIARVVDCRAQLVEEGLAALACGAFHIRSGGRIYFNTTPLGRAVTGTILVRAMHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCCCHHHEEEHEEEECCC
DGVDIWGDGSTFKGNDIERFYRYGLLANPQLRIYKPWLDPDFVHELGGRTEMSQWLTSHG
CCCEEECCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCCCHHHHHHHHHCC
LPYRDSQEKAYSTDANIWGATHEAKTLEHLDTSLEVVTPIMGVRFWDPAVDIATEDVTVA
CCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCCCHHCCCCCEEEE
FEQGRPVALNGRRFDDPVELVEEANAIGGRHGLGMSDQIENRIIEAKSRGVYEAPGMALL
EECCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEH
WLTYERLMNAIHNEDTLANYQISGRRLGRLLYEGRWLDPQALMLRESIQRWVASVVTGEV
HHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEE
TVRLRRGEDYTIVRTEGPALSYHPEKLSMERTSNSAFGPTDRIGQLTMRNLDIADSRAML
EEEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHH
EMYAGQPLDQGQVLVENGTLFGELPSGGFDQITENPEVQAEPEEEALDAAAMEAGTD
HHHCCCCCCCCCEEEECCEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA