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The map label for this gene is argH

Identifier: 119716701

GI number: 119716701

Start: 2636138

End: 2637550

Strand: Direct

Name: argH

Synonym: Noca_2475

Alternate gene names: 119716701

Gene position: 2636138-2637550 (Clockwise)

Preceding gene: 119716700

Following gene: 119716702

Centisome position: 52.87

GC content: 73.53

Gene sequence:

>1413_bases
ATGGGCACGAACACCGGGAAGCTCTGGGGCGGCCGCTTCGCGGGCGGCCCGTCGCCGGAGCTGGACGCGCTGTCCCGCTC
GACCCACTTCGACTGGCGGCTGACGCCCTACGACCTCGCCGGGTCGCGGGCGCACGCCAACGCCCTGCACCGCGCCGGTC
TGCTGACCGACGCGGACCTGGCCGAGCTGCGCCGCGGCCTGGACGCACTGGGGGAGCGGTACGCCGCCGGCACGCTGCGG
CCCGACCCCTCCGACGAGGACGTCCACGGCGCCCTCGAACGGCTGCTGGTCGACGAGGTCGGCCCCGAGGTCGGTGGCCG
GCTGCGCGCCGGGCGCAGCCGCAACGACCAGATCGCGACGCTGTTCAAGGTGTTCCTCCGCGACCATGCCGCCGTGGTCG
CGGGCCAGGTGCTCGACCTCGTGGACGCACTGGCCGGCCAGGCCCGCGCGGCCGGTGACGCGGTGATGCCCGGCCGCACC
CATCTCCAGCACGCGCAGCCGGTGCTGCTGGCCCACCACCTGCTCGCACACTGCTGGGCGCTGCTGCGCGACGTCGACCG
GCTCCGCGACTGGGACGCCCGCGTGGCCGCGGACTCGCCGTACGGCTCCGGTGCGCTGGCCGGCTCGAGCCTCGGCCTGG
ACCCGGAGGGCGTGGCGGCCGAGCTCGGCTTCAGCGGCTCCAGTGCCAACTCGATCGACGGGACCGCGTCACGGGACTTC
GTCGCCGAGTTCGCCTACGTCACCGCCCAGATCGGCGTCGACGTCAGCCGGATCGCCGAAGAGGTGATCTTGTGGTCGAC
CCGCGAGTTCGGCTTCGTCACGCTGCACGACTCCTGGTCCACCGGGTCCAGCATCATGCCGCAGAAGAAGAACCCGGACA
TCGCGGAGCTGGCGCGCGGCAAGGCCGGCCGGCTGATCGGCAACCTGTCGGGCCTGCTGGCCACGCTCAAGGCGCTCCCT
CTCGCATACAACCGCGACCTGCAGGAGGACAAGGAGCCGGTGTTCGACTCGGTGGACACGCTCGAGGTGCTGCTGCCGGC
GTTCACGGGCCTGGTGGCGACCCTCGCCTTCGACACCGAACGGATGGCCGACCTCGCGCCCCAGGGATTCTCCCTGGCCA
CCGACGTCGCCGAGTGGCTGGTCCGCGAGGGGGTGCCGTTCCGGATCGCCCACGAGGTCGCGGGCGCCTGCGTGCGTCGT
TGCGAGGAGCTCGGCATCGAGCTCGCGGACCTCACCGACGAGCAGTTCGCCGAGATCTCCCCGGCGCTGACGCCCGGGGT
GCGCGAGGTGCTCAGCGTCGCCGGCTCCGTCTCGGCGCGGGACGGACGCGGCGGCACCGCGCCGATCCGGGTCCGCGAGC
AGCTCGCCGAGCTCACCGGCCTCGTCGACGGACACCGTGACCGGCTCGGCTGA

Upstream 100 bases:

>100_bases
CGTCCGGCGGGTTCGACCAGATCACCGAGAACCCGGAGGTGCAGGCCGAGCCGGAGGAGGAGGCCCTCGACGCGGCCGCG
ATGGAGGCCGGGACCGACTG

Downstream 100 bases:

>100_bases
CCTTCCCGCCCAGCTCGCCGGCCCCGTCCTCGACGTGGCGCCGCGGCTGCTGAACGCGGTGCTCCGGCACGGCGACGTCG
CGGTGCGGCTGACCGAGGTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MGTNTGKLWGGRFAGGPSPELDALSRSTHFDWRLTPYDLAGSRAHANALHRAGLLTDADLAELRRGLDALGERYAAGTLR
PDPSDEDVHGALERLLVDEVGPEVGGRLRAGRSRNDQIATLFKVFLRDHAAVVAGQVLDLVDALAGQARAAGDAVMPGRT
HLQHAQPVLLAHHLLAHCWALLRDVDRLRDWDARVAADSPYGSGALAGSSLGLDPEGVAAELGFSGSSANSIDGTASRDF
VAEFAYVTAQIGVDVSRIAEEVILWSTREFGFVTLHDSWSTGSSIMPQKKNPDIAELARGKAGRLIGNLSGLLATLKALP
LAYNRDLQEDKEPVFDSVDTLEVLLPAFTGLVATLAFDTERMADLAPQGFSLATDVAEWLVREGVPFRIAHEVAGACVRR
CEELGIELADLTDEQFAEISPALTPGVREVLSVAGSVSARDGRGGTAPIRVREQLAELTGLVDGHRDRLG

Sequences:

>Translated_470_residues
MGTNTGKLWGGRFAGGPSPELDALSRSTHFDWRLTPYDLAGSRAHANALHRAGLLTDADLAELRRGLDALGERYAAGTLR
PDPSDEDVHGALERLLVDEVGPEVGGRLRAGRSRNDQIATLFKVFLRDHAAVVAGQVLDLVDALAGQARAAGDAVMPGRT
HLQHAQPVLLAHHLLAHCWALLRDVDRLRDWDARVAADSPYGSGALAGSSLGLDPEGVAAELGFSGSSANSIDGTASRDF
VAEFAYVTAQIGVDVSRIAEEVILWSTREFGFVTLHDSWSTGSSIMPQKKNPDIAELARGKAGRLIGNLSGLLATLKALP
LAYNRDLQEDKEPVFDSVDTLEVLLPAFTGLVATLAFDTERMADLAPQGFSLATDVAEWLVREGVPFRIAHEVAGACVRR
CEELGIELADLTDEQFAEISPALTPGVREVLSVAGSVSARDGRGGTAPIRVREQLAELTGLVDGHRDRLG
>Mature_469_residues
GTNTGKLWGGRFAGGPSPELDALSRSTHFDWRLTPYDLAGSRAHANALHRAGLLTDADLAELRRGLDALGERYAAGTLRP
DPSDEDVHGALERLLVDEVGPEVGGRLRAGRSRNDQIATLFKVFLRDHAAVVAGQVLDLVDALAGQARAAGDAVMPGRTH
LQHAQPVLLAHHLLAHCWALLRDVDRLRDWDARVAADSPYGSGALAGSSLGLDPEGVAAELGFSGSSANSIDGTASRDFV
AEFAYVTAQIGVDVSRIAEEVILWSTREFGFVTLHDSWSTGSSIMPQKKNPDIAELARGKAGRLIGNLSGLLATLKALPL
AYNRDLQEDKEPVFDSVDTLEVLLPAFTGLVATLAFDTERMADLAPQGFSLATDVAEWLVREGVPFRIAHEVAGACVRRC
EELGIELADLTDEQFAEISPALTPGVREVLSVAGSVSARDGRGGTAPIRVREQLAELTGLVDGHRDRLG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=467, Percent_Identity=43.0406852248394, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=467, Percent_Identity=43.0406852248394, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI68303549, Length=467, Percent_Identity=40.8993576017131, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI68303547, Length=467, Percent_Identity=40.2569593147752, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1790398, Length=450, Percent_Identity=41.3333333333333, Blast_Score=311, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6321806, Length=460, Percent_Identity=40.4347826086956, Blast_Score=340, Evalue=3e-94,
Organism=Drosophila melanogaster, GI221473854, Length=449, Percent_Identity=42.7616926503341, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI78706858, Length=449, Percent_Identity=42.7616926503341, Blast_Score=341, Evalue=5e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_NOCSJ (A1SJJ4)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923666.1
- ProteinModelPortal:   A1SJJ4
- SMR:   A1SJJ4
- STRING:   A1SJJ4
- GeneID:   4597097
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2475
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MPGRTHL
- PhylomeDB:   A1SJJ4
- ProtClustDB:   PRK00855
- BioCyc:   NSP35761:NOCA_2475-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50114; Mature: 49983

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTNTGKLWGGRFAGGPSPELDALSRSTHFDWRLTPYDLAGSRAHANALHRAGLLTDADL
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEECCCHHCCCCHHHHHHHHHHCCCCCHHH
AELRRGLDALGERYAAGTLRPDPSDEDVHGALERLLVDEVGPEVGGRLRAGRSRNDQIAT
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCCHHCCCCCCCHHHHH
LFKVFLRDHAAVVAGQVLDLVDALAGQARAAGDAVMPGRTHLQHAQPVLLAHHLLAHCWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHH
LLRDVDRLRDWDARVAADSPYGSGALAGSSLGLDPEGVAAELGFSGSSANSIDGTASRDF
HHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHH
VAEFAYVTAQIGVDVSRIAEEVILWSTREFGFVTLHDSWSTGSSIMPQKKNPDIAELARG
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCC
KAGRLIGNLSGLLATLKALPLAYNRDLQEDKEPVFDSVDTLEVLLPAFTGLVATLAFDTE
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RMADLAPQGFSLATDVAEWLVREGVPFRIAHEVAGACVRRCEELGIELADLTDEQFAEIS
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCC
PALTPGVREVLSVAGSVSARDGRGGTAPIRVREQLAELTGLVDGHRDRLG
CCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
GTNTGKLWGGRFAGGPSPELDALSRSTHFDWRLTPYDLAGSRAHANALHRAGLLTDADL
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEECCCHHCCCCHHHHHHHHHHCCCCCHHH
AELRRGLDALGERYAAGTLRPDPSDEDVHGALERLLVDEVGPEVGGRLRAGRSRNDQIAT
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCCHHCCCCCCCHHHHH
LFKVFLRDHAAVVAGQVLDLVDALAGQARAAGDAVMPGRTHLQHAQPVLLAHHLLAHCWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHH
LLRDVDRLRDWDARVAADSPYGSGALAGSSLGLDPEGVAAELGFSGSSANSIDGTASRDF
HHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHH
VAEFAYVTAQIGVDVSRIAEEVILWSTREFGFVTLHDSWSTGSSIMPQKKNPDIAELARG
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCC
KAGRLIGNLSGLLATLKALPLAYNRDLQEDKEPVFDSVDTLEVLLPAFTGLVATLAFDTE
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RMADLAPQGFSLATDVAEWLVREGVPFRIAHEVAGACVRRCEELGIELADLTDEQFAEIS
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCC
PALTPGVREVLSVAGSVSARDGRGGTAPIRVREQLAELTGLVDGHRDRLG
CCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA