Click here to switch to the map view.

The map label for this gene is ribBA [H]

Identifier: 119716675

GI number: 119716675

Start: 2611176

End: 2612456

Strand: Direct

Name: ribBA [H]

Synonym: Noca_2449

Alternate gene names: 119716675

Gene position: 2611176-2612456 (Clockwise)

Preceding gene: 119716674

Following gene: 119716676

Centisome position: 52.37

GC content: 71.27

Gene sequence:

>1281_bases
ATGAGCACCGAGATCAGGCTCGACACCGTCGAGCGGGCGATCGCCGACATCGCCGCCGGCAAGGCCGTGGTCGTCGTCGA
CGACGAGGACCGCGAGAACGAGGGCGACATCATCTTCGCCGCCAGCAAGGCGACCCCCGACCTGATGGCCTTCACGATCC
GCTACAGCAGCGGCGTGATCTGCGTGCCGATGCCGGCCCGGATGCTCGACCGGCTCGAGATCCCGCTGATGACGCCGCAC
AACAAGGACCGGCTGCGTACGGCGTACACGATCTCGGTCGATGCCCGCGACGGGGTGACCACGGGCATCTCCGCCGCCGA
CCGGGCGCACACCGTCCGGGTGCTCGCCGACTCGGCGACCGAGCCGTGGGAGATCACCCGCCCCGGTCACGTCTTCCCAC
TGCGCTACCGCGAGGGCGGCGTGCTGGTGCGCCGCGGACACACCGAGGCCGCGGTCGACCTCGCGAAGCTGGCCGGGTTG
ACCCCCGCGGGCGTGCTGGTCGAGGTCGTCAACGACGACGGGACCATGAAGCGCGGGCCCGAGCTGCGCGCCTTCGCCGA
CGAGCACGGCCTGGCGATGATCTCGATCGACGACCTGGTGCGCTACCGGCGGCGCCACGAGACCCTCGTCGAGCGGGTCG
CCGAGACCCAGCTGCCGACCCGGCACGGTGACTTCACGGCGTACGGCTACCGGATCACCGTCGACGGCTCCGAGCACATC
GCGCTCGTCCACGGCGACATCAGCGGACCGGAGCCCGTGCTCACCCGGGTGCACTCGGAGTGCCTGACCGGCGACGTGTT
CGGCAGCCACCGCTGCGACTGCGGGCCACAACTGGAGGAGGCCCTCGAGCGGATCGTGGCCGAGGGGCGCGGCGTGGTCG
TCTACCTGCGCGGCCACGAGGGCCGCGGGATCGGGCTGGTCGCGAAGCTGCAGGCCTACCAGCTCCAGGACGGCGGCCGG
GACACCGTCGACGCGAACCTCGACCTCGGCCTGCCGGCCGACGCCCGCCACTACGGCACGGCCACCCAGGTGCTGCGCGA
CCTCGGCGTCGGCAGCGTCCGGCTGATGACCAACAACCCGGACAAGGTGCGCAACCTCGAGGACTACGGTGTGTCGGTCG
CCGCCCGGGTGCCGCTGACGCCGCACCCCAACGACCACAACATCGCCTACCTGCTCACCAAGCGCGACCGAATGGGTCAC
GATCTGCCCAACCTTGCCGATGGGGTGCCCGACACCCGTGCCGACGGGGTGCCCGACACCCTTGCCCAGAACGGAGCCTG
A

Upstream 100 bases:

>100_bases
ACCTCGAGGCCGACATCCTCGCCAAGCACGTCGAGCGACTGCTGGCCCACCGTGACCAGGTCGACCGAGTCGGGGCCGAC
CGCACCGAAGGAGCACCCGC

Downstream 100 bases:

>100_bases
CCGATGTCCGGACACGGAGCACCTGCCCCGGCGCCCGTCGACTGCAGTGACCTGCGGGTCGCCGTCGTCGCCGCCAGCTG
GCACACGCAGGTGATGGACG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSTEIRLDTVERAIADIAAGKAVVVVDDEDRENEGDIIFAASKATPDLMAFTIRYSSGVICVPMPARMLDRLEIPLMTPH
NKDRLRTAYTISVDARDGVTTGISAADRAHTVRVLADSATEPWEITRPGHVFPLRYREGGVLVRRGHTEAAVDLAKLAGL
TPAGVLVEVVNDDGTMKRGPELRAFADEHGLAMISIDDLVRYRRRHETLVERVAETQLPTRHGDFTAYGYRITVDGSEHI
ALVHGDISGPEPVLTRVHSECLTGDVFGSHRCDCGPQLEEALERIVAEGRGVVVYLRGHEGRGIGLVAKLQAYQLQDGGR
DTVDANLDLGLPADARHYGTATQVLRDLGVGSVRLMTNNPDKVRNLEDYGVSVAARVPLTPHPNDHNIAYLLTKRDRMGH
DLPNLADGVPDTRADGVPDTLAQNGA

Sequences:

>Translated_426_residues
MSTEIRLDTVERAIADIAAGKAVVVVDDEDRENEGDIIFAASKATPDLMAFTIRYSSGVICVPMPARMLDRLEIPLMTPH
NKDRLRTAYTISVDARDGVTTGISAADRAHTVRVLADSATEPWEITRPGHVFPLRYREGGVLVRRGHTEAAVDLAKLAGL
TPAGVLVEVVNDDGTMKRGPELRAFADEHGLAMISIDDLVRYRRRHETLVERVAETQLPTRHGDFTAYGYRITVDGSEHI
ALVHGDISGPEPVLTRVHSECLTGDVFGSHRCDCGPQLEEALERIVAEGRGVVVYLRGHEGRGIGLVAKLQAYQLQDGGR
DTVDANLDLGLPADARHYGTATQVLRDLGVGSVRLMTNNPDKVRNLEDYGVSVAARVPLTPHPNDHNIAYLLTKRDRMGH
DLPNLADGVPDTRADGVPDTLAQNGA
>Mature_425_residues
STEIRLDTVERAIADIAAGKAVVVVDDEDRENEGDIIFAASKATPDLMAFTIRYSSGVICVPMPARMLDRLEIPLMTPHN
KDRLRTAYTISVDARDGVTTGISAADRAHTVRVLADSATEPWEITRPGHVFPLRYREGGVLVRRGHTEAAVDLAKLAGLT
PAGVLVEVVNDDGTMKRGPELRAFADEHGLAMISIDDLVRYRRRHETLVERVAETQLPTRHGDFTAYGYRITVDGSEHIA
LVHGDISGPEPVLTRVHSECLTGDVFGSHRCDCGPQLEEALERIVAEGRGVVVYLRGHEGRGIGLVAKLQAYQLQDGGRD
TVDANLDLGLPADARHYGTATQVLRDLGVGSVRLMTNNPDKVRNLEDYGVSVAARVPLTPHPNDHNIAYLLTKRDRMGHD
LPNLADGVPDTRADGVPDTLAQNGA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=201, Percent_Identity=50.2487562189055, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=53.3678756476684, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=48.5294117647059, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=45.0292397660819, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 46322; Mature: 46191

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEIRLDTVERAIADIAAGKAVVVVDDEDRENEGDIIFAASKATPDLMAFTIRYSSGVI
CCCEEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCEEEEEEEECCCEE
CVPMPARMLDRLEIPLMTPHNKDRLRTAYTISVDARDGVTTGISAADRAHTVRVLADSAT
EECCCHHHHHHCCCCEECCCCHHHEEEEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCC
EPWEITRPGHVFPLRYREGGVLVRRGHTEAAVDLAKLAGLTPAGVLVEVVNDDGTMKRGP
CCEEECCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
ELRAFADEHGLAMISIDDLVRYRRRHETLVERVAETQLPTRHGDFTAYGYRITVDGSEHI
CCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCEE
ALVHGDISGPEPVLTRVHSECLTGDVFGSHRCDCGPQLEEALERIVAEGRGVVVYLRGHE
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
GRGIGLVAKLQAYQLQDGGRDTVDANLDLGLPADARHYGTATQVLRDLGVGSVRLMTNNP
CCCEEEEEEEEEEEECCCCCCEEECCEECCCCCCCCCCCHHHHHHHHCCCCEEEEEECCC
DKVRNLEDYGVSVAARVPLTPHPNDHNIAYLLTKRDRMGHDLPNLADGVPDTRADGVPDT
HHHCCHHHCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCHH
LAQNGA
HHCCCC
>Mature Secondary Structure 
STEIRLDTVERAIADIAAGKAVVVVDDEDRENEGDIIFAASKATPDLMAFTIRYSSGVI
CCEEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCEEEEEEEECCCEE
CVPMPARMLDRLEIPLMTPHNKDRLRTAYTISVDARDGVTTGISAADRAHTVRVLADSAT
EECCCHHHHHHCCCCEECCCCHHHEEEEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCC
EPWEITRPGHVFPLRYREGGVLVRRGHTEAAVDLAKLAGLTPAGVLVEVVNDDGTMKRGP
CCEEECCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
ELRAFADEHGLAMISIDDLVRYRRRHETLVERVAETQLPTRHGDFTAYGYRITVDGSEHI
CCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCEE
ALVHGDISGPEPVLTRVHSECLTGDVFGSHRCDCGPQLEEALERIVAEGRGVVVYLRGHE
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
GRGIGLVAKLQAYQLQDGGRDTVDANLDLGLPADARHYGTATQVLRDLGVGSVRLMTNNP
CCCEEEEEEEEEEEECCCCCCEEECCEECCCCCCCCCCCHHHHHHHHCCCCEEEEEECCC
DKVRNLEDYGVSVAARVPLTPHPNDHNIAYLLTKRDRMGHDLPNLADGVPDTRADGVPDT
HHHCCHHHCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCHH
LAQNGA
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA