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The map label for this gene is fmt

Identifier: 119716669

GI number: 119716669

Start: 2604145

End: 2605095

Strand: Direct

Name: fmt

Synonym: Noca_2442

Alternate gene names: 119716669

Gene position: 2604145-2605095 (Clockwise)

Preceding gene: 119716668

Following gene: 119716670

Centisome position: 52.23

GC content: 75.29

Gene sequence:

>951_bases
ATGCGCGTCGTCTTCGCCGGCACCCCCGAGGTGGCCATCCCCGTCCTGGACGCGGTCGCCGCGTCCTCCCACGAGCTCGT
CGCCGTGGTCACCCGTCCCGACGCACCCGCCGGCCGGGGGCGGCGGCTGCTGGCGAGCCCGGTCGCGCTCCGTGCGGAGG
AGCTGGGGGTCCCGGTGCTCAAGCCCGCCCACCCCAAGGATCCGGAGTTCCAGGAGCAGCTGCGCGCGCTGCGGCCGGAC
TGCTGTCCCGTCGTCGCGTACGGCGCGCTGCTGCCGCAGGCGGCGCTCGACATCCCGGTCCACGGGTGGGTCAACCTGCA
CTTCTCGGCGCTCCCCGCCTGGCGGGGAGCGGCCCCCGTCCAGCACGCGATCTGGGCCGGGGACGAGGTCACCGGGGCCA
CCACCTTCCGGATCGTCAAGGAGCTCGACGCGGGGCCGACGTACGGCGTGATGACCGAACGGATCCGCCCCACCGACACC
GCAGGGGACCTGCTCGCGCGACTCGCCGAGGGCGGCGCGGGGCTGATGGTCGCCACGCTCGACGGCATCGAGGACGGCTC
CCTGGAGGCCCGGCCGCAGCAGGCCGAGGGGGTCTCCTACGCCCCGAAGGTCGAGGTCGAGGACGCACGCGTGGACTGGT
CGCGACCGGCGGTCGTGATCGACCACCAGGTGCGCGCCTGCACCCCCGCCCCGGGCGCCTGGACCACCGTGGCCGGCGAG
CGCCTCAAGCTCGGGCCGGTCACCCACGCCGATGCCCACGGCTCCCAGGGCCTCGGGCCGGGAGAGCTGGGGGTCGGCAA
GCACGACGTGCTGGTCGGCACCGGCACCACGGCCGTCCGGCTCGGTGACGTGCGCCCGCACGGCCGCAAGCAGATGGCCG
CCGCGGACTGGGCCCGCGGAGCCCGGCTGCAGACAGGTGTCCGAATCGGCGTGGCTTTCGGTGAAAGCTGA

Upstream 100 bases:

>100_bases
AGGCCGCGATGAAGGCGATCCGCGAGTCGGAGTGGTTCGGCCTCGACGCCCCCCAGGTGAAGGTCTCTCCGCACGCCACG
CACGGGCTCGGCTTCTGAGC

Downstream 100 bases:

>100_bases
GGCGCGGGTCGATACGGTCGTCTGCATGAGCCGTCCGGCGCATGCAGGCGACCAGGTGCCGTTCACCAAGGGGTCCTACA
GGCCGCGGCCCGCCCGTCTC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MRVVFAGTPEVAIPVLDAVAASSHELVAVVTRPDAPAGRGRRLLASPVALRAEELGVPVLKPAHPKDPEFQEQLRALRPD
CCPVVAYGALLPQAALDIPVHGWVNLHFSALPAWRGAAPVQHAIWAGDEVTGATTFRIVKELDAGPTYGVMTERIRPTDT
AGDLLARLAEGGAGLMVATLDGIEDGSLEARPQQAEGVSYAPKVEVEDARVDWSRPAVVIDHQVRACTPAPGAWTTVAGE
RLKLGPVTHADAHGSQGLGPGELGVGKHDVLVGTGTTAVRLGDVRPHGRKQMAAADWARGARLQTGVRIGVAFGES

Sequences:

>Translated_316_residues
MRVVFAGTPEVAIPVLDAVAASSHELVAVVTRPDAPAGRGRRLLASPVALRAEELGVPVLKPAHPKDPEFQEQLRALRPD
CCPVVAYGALLPQAALDIPVHGWVNLHFSALPAWRGAAPVQHAIWAGDEVTGATTFRIVKELDAGPTYGVMTERIRPTDT
AGDLLARLAEGGAGLMVATLDGIEDGSLEARPQQAEGVSYAPKVEVEDARVDWSRPAVVIDHQVRACTPAPGAWTTVAGE
RLKLGPVTHADAHGSQGLGPGELGVGKHDVLVGTGTTAVRLGDVRPHGRKQMAAADWARGARLQTGVRIGVAFGES
>Mature_316_residues
MRVVFAGTPEVAIPVLDAVAASSHELVAVVTRPDAPAGRGRRLLASPVALRAEELGVPVLKPAHPKDPEFQEQLRALRPD
CCPVVAYGALLPQAALDIPVHGWVNLHFSALPAWRGAAPVQHAIWAGDEVTGATTFRIVKELDAGPTYGVMTERIRPTDT
AGDLLARLAEGGAGLMVATLDGIEDGSLEARPQQAEGVSYAPKVEVEDARVDWSRPAVVIDHQVRACTPAPGAWTTVAGE
RLKLGPVTHADAHGSQGLGPGELGVGKHDVLVGTGTTAVRLGDVRPHGRKQMAAADWARGARLQTGVRIGVAFGES

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=252, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI164663775, Length=220, Percent_Identity=32.7272727272727, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21614513, Length=255, Percent_Identity=28.2352941176471, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1789683, Length=303, Percent_Identity=38.9438943894389, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1788589, Length=244, Percent_Identity=30.327868852459, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI133930964, Length=258, Percent_Identity=26.7441860465116, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45550868, Length=303, Percent_Identity=29.3729372937294, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28571984, Length=233, Percent_Identity=30.4721030042918, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585660, Length=326, Percent_Identity=24.8466257668712, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_NOCSJ (A1SJG2)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923634.1
- ProteinModelPortal:   A1SJG2
- SMR:   A1SJG2
- STRING:   A1SJG2
- GeneID:   4598278
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2442
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   A1SJG2
- ProtClustDB:   PRK00005
- BioCyc:   NSP35761:NOCA_2442-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33086; Mature: 33086

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVFAGTPEVAIPVLDAVAASSHELVAVVTRPDAPAGRGRRLLASPVALRAEELGVPVL
CEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCHHHHHHHHCCCCCC
KPAHPKDPEFQEQLRALRPDCCPVVAYGALLPQAALDIPVHGWVNLHFSALPAWRGAAPV
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCH
QHAIWAGDEVTGATTFRIVKELDAGPTYGVMTERIRPTDTAGDLLARLAEGGAGLMVATL
HHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEE
DGIEDGSLEARPQQAEGVSYAPKVEVEDARVDWSRPAVVIDHQVRACTPAPGAWTTVAGE
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCEEECCCCCCCEEECCCC
RLKLGPVTHADAHGSQGLGPGELGVGKHDVLVGTGTTAVRLGDVRPHGRKQMAAADWARG
EEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHCC
ARLQTGVRIGVAFGES
CEEECCEEEEEEECCC
>Mature Secondary Structure
MRVVFAGTPEVAIPVLDAVAASSHELVAVVTRPDAPAGRGRRLLASPVALRAEELGVPVL
CEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCHHHHHHHHCCCCCC
KPAHPKDPEFQEQLRALRPDCCPVVAYGALLPQAALDIPVHGWVNLHFSALPAWRGAAPV
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCH
QHAIWAGDEVTGATTFRIVKELDAGPTYGVMTERIRPTDTAGDLLARLAEGGAGLMVATL
HHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEE
DGIEDGSLEARPQQAEGVSYAPKVEVEDARVDWSRPAVVIDHQVRACTPAPGAWTTVAGE
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCEEECCCCCCCEEECCCC
RLKLGPVTHADAHGSQGLGPGELGVGKHDVLVGTGTTAVRLGDVRPHGRKQMAAADWARG
EEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCHHHHHHHHHCC
ARLQTGVRIGVAFGES
CEEECCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA