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The map label for this gene is yogA [H]

Identifier: 119716649

GI number: 119716649

Start: 2581358

End: 2582389

Strand: Direct

Name: yogA [H]

Synonym: Noca_2422

Alternate gene names: 119716649

Gene position: 2581358-2582389 (Clockwise)

Preceding gene: 119716648

Following gene: 119716650

Centisome position: 51.77

GC content: 74.52

Gene sequence:

>1032_bases
ATGCGTGCAGTCGTCTACCAGCAGACCGGCCCGTCCTCGGTGCTGGAGGTCGTGGAGCGCGACCTCCCCGTGCCCGGACC
CGGCGAGGTCCGGGTCCGGGTCGTCCGGGCCGGCGTGAACCCGACGGACTGGAAGTTCCGGGCCGGCATGATGACCGAGT
ATGACGAGGTCGTGCCCGGCCAGGACGGAGCGGGCGTCGTCGACGCGGTCGGTGAGGGGGTCGACGGCCTGGCGGTCGGC
GATCGGGTCTGGCTGGTGCTCGCCCAGGCGGGGCGCGCGTACGGGACCGCCGCCGAGCTGACCGTCCAGCCCGCCGCTCG
GGTGGTACCCCTCCCGGCCGACGCGTCGTTCGACCTCGGCGCGAGCCTCGGCGTGCCCGCGGTCACGGCGCACCGCGCCC
TGACCGCAGCCGAGGGTGGGCCCAGCCGGCTGTGGCCGGGTGCACTGGAGGGCCGGGTCGTTCTCGTGGCAGGGGGAGCG
GGCGCCGTCGGCAATGCCGCGATCCAGCTGGCCCGCTGGGCCGGGGCGACCGTGGTCACCACGGTCAGCAGTGCCGAGAA
GGCCGCGCTCGCCCGCGCCGCCGGCGCCGACCACGTCGTGAACTACCGGGAGCCGGGCGCGGCGCAGGCGATCCTCGAGA
CCGCCCCCGACGGCGTCGACCTCGCCGTCGAGGTCGCACCCGCGCAGAACATCGAGCTCGACCTCGACGTGGTGCGGGTG
CACGGCACCGTCTCGATCTACGCCAACAACGGCGGGGACACCCTGACCATGCCGCTGCGGGCGGCGTTCGGGAAGAACCT
GCGCTTCCAGTTCCTGATCCTCTACACGCTGCGCGAGGACCTGCTCCGGGCGGCGGTCGAGGACATCTCTGTCGCCCTCG
CCGCCGGTGCGCTCCGGGTCGGTGAGGAGGCCGGCCTGCCGCTCCACCACTACCCGCTGGCTCAGGCCGCCGAGGCCCAC
GACGCGGTGGAGGGCGGCGTCGTCGGGAAGGTGCTGCTCGACGTGGGGTCTGCCGCGGACCGGGACCTTTGA

Upstream 100 bases:

>100_bases
CCGGCTCGGTGGTGCCCTACTCCCAGCTCTCGCGCGGCACCAAGCGGGAGTGGTTGAAGGCCTGTGCGGGGATGGCCGCG
GCGCTCTGAGAGACTGCGCC

Downstream 100 bases:

>100_bases
CTGCAAGGTCATTCACGGCGGTGCACGGTCATTCGCGCCACCCCGCGCAGCCACCGGCCCGGTGTCGCGAGACTCCTCAT
GCGGGCCCCGTCGGGGCTCC

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRAVVYQQTGPSSVLEVVERDLPVPGPGEVRVRVVRAGVNPTDWKFRAGMMTEYDEVVPGQDGAGVVDAVGEGVDGLAVG
DRVWLVLAQAGRAYGTAAELTVQPAARVVPLPADASFDLGASLGVPAVTAHRALTAAEGGPSRLWPGALEGRVVLVAGGA
GAVGNAAIQLARWAGATVVTTVSSAEKAALARAAGADHVVNYREPGAAQAILETAPDGVDLAVEVAPAQNIELDLDVVRV
HGTVSIYANNGGDTLTMPLRAAFGKNLRFQFLILYTLREDLLRAAVEDISVALAAGALRVGEEAGLPLHHYPLAQAAEAH
DAVEGGVVGKVLLDVGSAADRDL

Sequences:

>Translated_343_residues
MRAVVYQQTGPSSVLEVVERDLPVPGPGEVRVRVVRAGVNPTDWKFRAGMMTEYDEVVPGQDGAGVVDAVGEGVDGLAVG
DRVWLVLAQAGRAYGTAAELTVQPAARVVPLPADASFDLGASLGVPAVTAHRALTAAEGGPSRLWPGALEGRVVLVAGGA
GAVGNAAIQLARWAGATVVTTVSSAEKAALARAAGADHVVNYREPGAAQAILETAPDGVDLAVEVAPAQNIELDLDVVRV
HGTVSIYANNGGDTLTMPLRAAFGKNLRFQFLILYTLREDLLRAAVEDISVALAAGALRVGEEAGLPLHHYPLAQAAEAH
DAVEGGVVGKVLLDVGSAADRDL
>Mature_343_residues
MRAVVYQQTGPSSVLEVVERDLPVPGPGEVRVRVVRAGVNPTDWKFRAGMMTEYDEVVPGQDGAGVVDAVGEGVDGLAVG
DRVWLVLAQAGRAYGTAAELTVQPAARVVPLPADASFDLGASLGVPAVTAHRALTAAEGGPSRLWPGALEGRVVLVAGGA
GAVGNAAIQLARWAGATVVTTVSSAEKAALARAAGADHVVNYREPGAAQAILETAPDGVDLAVEVAPAQNIELDLDVVRV
HGTVSIYANNGGDTLTMPLRAAFGKNLRFQFLILYTLREDLLRAAVEDISVALAAGALRVGEEAGLPLHHYPLAQAAEAH
DAVEGGVVGKVLLDVGSAADRDL

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=341, Percent_Identity=28.1524926686217, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI13236495, Length=341, Percent_Identity=28.1524926686217, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI194239676, Length=338, Percent_Identity=27.2189349112426, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI28557745, Length=230, Percent_Identity=34.3478260869565, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI24308257, Length=254, Percent_Identity=28.740157480315, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI22538446, Length=353, Percent_Identity=26.9121813031161, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI22538444, Length=353, Percent_Identity=26.9121813031161, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI18379349, Length=237, Percent_Identity=31.6455696202532, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI47519420, Length=234, Percent_Identity=28.6324786324786, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=333, Percent_Identity=29.1291291291291, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=260, Percent_Identity=37.3076923076923, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71987554, Length=235, Percent_Identity=30.2127659574468, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35210; Mature: 35210

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVYQQTGPSSVLEVVERDLPVPGPGEVRVRVVRAGVNPTDWKFRAGMMTEYDEVVPG
CCEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEECCCCCCHHHHCCC
QDGAGVVDAVGEGVDGLAVGDRVWLVLAQAGRAYGTAAELTVQPAARVVPLPADASFDLG
CCCCCHHHHHCCCCCCEEECCEEEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCC
ASLGVPAVTAHRALTAAEGGPSRLWPGALEGRVVLVAGGAGAVGNAAIQLARWAGATVVT
CCCCCCCHHHHHEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEE
TVSSAEKAALARAAGADHVVNYREPGAAQAILETAPDGVDLAVEVAPAQNIELDLDVVRV
EECCHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEE
HGTVSIYANNGGDTLTMPLRAAFGKNLRFQFLILYTLREDLLRAAVEDISVALAAGALRV
EEEEEEEEECCCCEEEEEEHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEE
GEEAGLPLHHYPLAQAAEAHDAVEGGVVGKVLLDVGSAADRDL
CHHCCCCEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRAVVYQQTGPSSVLEVVERDLPVPGPGEVRVRVVRAGVNPTDWKFRAGMMTEYDEVVPG
CCEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEECCCCCCHHHHCCC
QDGAGVVDAVGEGVDGLAVGDRVWLVLAQAGRAYGTAAELTVQPAARVVPLPADASFDLG
CCCCCHHHHHCCCCCCEEECCEEEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCC
ASLGVPAVTAHRALTAAEGGPSRLWPGALEGRVVLVAGGAGAVGNAAIQLARWAGATVVT
CCCCCCCHHHHHEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEE
TVSSAEKAALARAAGADHVVNYREPGAAQAILETAPDGVDLAVEVAPAQNIELDLDVVRV
EECCHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEE
HGTVSIYANNGGDTLTMPLRAAFGKNLRFQFLILYTLREDLLRAAVEDISVALAAGALRV
EEEEEEEEECCCCEEEEEEHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEE
GEEAGLPLHHYPLAQAAEAHDAVEGGVVGKVLLDVGSAADRDL
CHHCCCCEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]