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The map label for this gene is hsaD [H]

Identifier: 119716372

GI number: 119716372

Start: 2289576

End: 2290430

Strand: Reverse

Name: hsaD [H]

Synonym: Noca_2141

Alternate gene names: 119716372

Gene position: 2290430-2289576 (Counterclockwise)

Preceding gene: 119716373

Following gene: 119716371

Centisome position: 45.94

GC content: 63.27

Gene sequence:

>855_bases
ATGACATCAATCGACTTTGATTCGACCAGCCGGTTCGTCACGACACCTGAGGCGCGAGTTCACCTAAACGAGACCGGCGA
TGGGCCTCCGCTGGTCCTGCTACACGGGGGCGGTCCCGGGGGTTCGGGATGGAGCAACTTCAAACAGAACGTCGCGACGC
TCAGCAAATCTTTCCGTGTTCTCGTCATAGACCAGGTTGGGTACGGCCTGACGGACAAGCCGGAGTTCGACGAGCCCTAC
TACGTCCTCTCGGCTCGGGTCATTCGCGATGTCCTGGACATCCTGGGAATCAAGCAGGCTGACTTCGTCGGGAACTCTCT
GGGCGGCGGGACCGCCCTCCGCCTGGCGATCGACTATCCCGACCGTGTGCGGCGGCTCATCCTGATGGGTCCCGGAGGAG
GGGCGAAGAACATCTTCGCCGTCGACCCGGCAGAAGGCCAGAAGGTCCTGATCGACTTCTACGCAGCACCGGGGCCCACT
CGCGAGAAGATGCGCCGCCTCGTCGAGATTATGACCTACGACCACTCGTTCGTGACCGATGACCTGATCGAGGAGCGCTT
CGCGGCCGCGACCGCTCCGGGCGCCGAGGAGGGTGCCCTTCGGGCACTGCGGTCCATTGGGTCGTCAGCGAGCCCGAACG
AGAACCAGCTCTGGCGGCATCTGGCGAACGTGCCTCATCGCACGCTTCTGATGTGGGGGCGCGACGATCGGACTATGCCG
CTCGATGGCGCGTTCTTCGCCCTGAAGGAGATGCCGGATGCGCAACTGCACGTGTTCCCTCGGTGTGGGCACTGGGCCCA
ACTGGAACACCAGGACGCGTTCGATCGCCTCACGACCGACTTCCTACTGCATTGA

Upstream 100 bases:

>100_bases
GTTCAGCTAGCAAACCTCCGGCCGGGCCGCCGAGAACGGCGGCCGGGACCACGTCCCAGGATCTATCCGTCAGTTCGAGC
TTGAAAGCAGATGCAAGTAG

Downstream 100 bases:

>100_bases
GCTAAGGCGTCGAATTCTGATCCGGCCGGAGGCCAGCGGCACATTATGCGCCCTCAGTCGACGTCGGTCCCCCAGGCAAG
TGTGAGCCAGGGCCGAAGCG

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; Meta-cleavage product hydrolase; MCP hydrolase [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MTSIDFDSTSRFVTTPEARVHLNETGDGPPLVLLHGGGPGGSGWSNFKQNVATLSKSFRVLVIDQVGYGLTDKPEFDEPY
YVLSARVIRDVLDILGIKQADFVGNSLGGGTALRLAIDYPDRVRRLILMGPGGGAKNIFAVDPAEGQKVLIDFYAAPGPT
REKMRRLVEIMTYDHSFVTDDLIEERFAAATAPGAEEGALRALRSIGSSASPNENQLWRHLANVPHRTLLMWGRDDRTMP
LDGAFFALKEMPDAQLHVFPRCGHWAQLEHQDAFDRLTTDFLLH

Sequences:

>Translated_284_residues
MTSIDFDSTSRFVTTPEARVHLNETGDGPPLVLLHGGGPGGSGWSNFKQNVATLSKSFRVLVIDQVGYGLTDKPEFDEPY
YVLSARVIRDVLDILGIKQADFVGNSLGGGTALRLAIDYPDRVRRLILMGPGGGAKNIFAVDPAEGQKVLIDFYAAPGPT
REKMRRLVEIMTYDHSFVTDDLIEERFAAATAPGAEEGALRALRSIGSSASPNENQLWRHLANVPHRTLLMWGRDDRTMP
LDGAFFALKEMPDAQLHVFPRCGHWAQLEHQDAFDRLTTDFLLH
>Mature_283_residues
TSIDFDSTSRFVTTPEARVHLNETGDGPPLVLLHGGGPGGSGWSNFKQNVATLSKSFRVLVIDQVGYGLTDKPEFDEPYY
VLSARVIRDVLDILGIKQADFVGNSLGGGTALRLAIDYPDRVRRLILMGPGGGAKNIFAVDPAEGQKVLIDFYAAPGPTR
EKMRRLVEIMTYDHSFVTDDLIEERFAAATAPGAEEGALRALRSIGSSASPNENQLWRHLANVPHRTLLMWGRDDRTMPL
DGAFFALKEMPDAQLHVFPRCGHWAQLEHQDAFDRLTTDFLLH

Specific function: Catalyzes the hydrolysis of a carbon-carbon bond in 4,5- 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19- hexanorandrostan-5-oic acid (DOHNAA) and 2-hydroxy-hexa-2,4- dienoic acid (HHD). Al

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HsaD family [H]

Homologues:

Organism=Homo sapiens, GI27597073, Length=121, Percent_Identity=33.8842975206612, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87081721, Length=284, Percent_Identity=36.2676056338028, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17554012, Length=291, Percent_Identity=24.3986254295533, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.7.1.8 [H]

Molecular weight: Translated: 31359; Mature: 31228

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIDFDSTSRFVTTPEARVHLNETGDGPPLVLLHGGGPGGSGWSNFKQNVATLSKSFRV
CCCCCCCCCCCEEECCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCEE
LVIDQVGYGLTDKPEFDEPYYVLSARVIRDVLDILGIKQADFVGNSLGGGTALRLAIDYP
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEECCC
DRVRRLILMGPGGGAKNIFAVDPAEGQKVLIDFYAAPGPTREKMRRLVEIMTYDHSFVTD
HHEEEEEEECCCCCCCCEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHH
DLIEERFAAATAPGAEEGALRALRSIGSSASPNENQLWRHLANVPHRTLLMWGRDDRTMP
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
LDGAFFALKEMPDAQLHVFPRCGHWAQLEHQDAFDRLTTDFLLH
CCHHHHHHHCCCCCEEEEEECCCCCHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSIDFDSTSRFVTTPEARVHLNETGDGPPLVLLHGGGPGGSGWSNFKQNVATLSKSFRV
CCCCCCCCCCEEECCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCEE
LVIDQVGYGLTDKPEFDEPYYVLSARVIRDVLDILGIKQADFVGNSLGGGTALRLAIDYP
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEECCC
DRVRRLILMGPGGGAKNIFAVDPAEGQKVLIDFYAAPGPTREKMRRLVEIMTYDHSFVTD
HHEEEEEEECCCCCCCCEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHH
DLIEERFAAATAPGAEEGALRALRSIGSSASPNENQLWRHLANVPHRTLLMWGRDDRTMP
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
LDGAFFALKEMPDAQLHVFPRCGHWAQLEHQDAFDRLTTDFLLH
CCHHHHHHHCCCCCEEEEEECCCCCHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA