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The map label for this gene is bhbA [H]

Identifier: 119716362

GI number: 119716362

Start: 2279960

End: 2281669

Strand: Direct

Name: bhbA [H]

Synonym: Noca_2131

Alternate gene names: 119716362

Gene position: 2279960-2281669 (Clockwise)

Preceding gene: 119716361

Following gene: 119716363

Centisome position: 45.73

GC content: 60.94

Gene sequence:

>1710_bases
ATGAGCACCCACGAGGCCGACGCCATCAAGATCACCAACGAGGCCGCCGTCAAGGCCATCGAGGAACGACTCGCAGGGTG
GGAGAGCCACGAGCTCGAGGCATTCTTGCAACGGACGCCAGAGTCGAAGGGAGTGTTCCGCACTGGCAGCGGCGCCCCCG
TCAAGAGGGTCTACACGCCGGCTGACCTTCCCGAGGACTGGAACGATATCGGACTTCCGGGTCAATTCCCGTTCACGCGA
GGGCCTTACCCGACCATGTACCGGGGCCGCCACTGGACGATGCGCCAGATCGCCGGATTCGGTCAAGCCGAAGAGACCAA
CAAGCGCTTCCAGTACCTCATCAACCAGGGACAGACGGGCCTCTCCGTCGACTTCGACATGCCCACACTGATGGGTCTCG
ACAGCGACGACCCCATGAGTCTGGGAGAGGTCGGCCGCGAAGGAGTCGCCGTCGACGTGCTCTCCGACATGGAGGCACTC
TTCGACGGAATCGACCTGGAGAACATCTCCGTGTCGATGACCATCAACCCGTCTGCCTGGATCCTGCTGGCCATGTACAT
CGCTGTAGCCGAAGACAAGGGCTACGACCTGAACCGACTGAGCGGAACGATTCAGAACGACATCCTCAAGGAGTACGTCG
CCCAAAAGGAATGGATCTTCCCGGTTCGTCCGAGTATGCGCATTGTCCGAGACTGCATCGCTTATTGCGCTGAGAATATG
GCCCGTTATAACCCGGTCAACATCAGCGGGTACCACATCAGCGAAGCCGGCGCGAACGCCGTGCAGGAGGTCGCCTTCAC
CATGGCGATCACGCGCGCCTACGTGAGTGACGTCATTGCGGCCGGCGTCGACGTCGACACGTTCGCTCCGCGACTGTCGT
TCTTCTTCGTGAGCCAGGCTGACTTCTTCGAGGAAGCCGCAAAGTTCAGGGCTGTCCGGCGCTTCTACGCCAAGATGATG
CGCGACGAGTTCGGAGCCGAGAACGAACAGTCCATGCGGCTCCGGTTCCACGCTCAGACTGCAGCGGCAACGCTGACCAA
GCCACAACCCATGAACAACATCATCCGCACGACGCTCCAAGCCCTCTCAGCAATCCTGGGCGGGGCACAGTCGCTCCACA
CCAACGGTCTCGACGAGGCGTACACGATCCCGAGCGAAACCGCCATGAAGATCGCGCTTCGCACCCAGCAGGTCATCGCA
CATGAGACTGGCGTTCCTAGCATTGTCGACCCCCTCGGCGGCTCGTACTACGTCGAGGCACTTACCGATGAGATCGAAAC
GGGAATTCACGACTATCTAGCCAAGATCGAAAGCCTTGGTGGAGTCGTAGCAGCGATCGAGAACGGCTTTATGCAGCGCG
AGATCTCAGACACGGCCTACCAGTACGCGCTCCGCAAGGAGAGCGGCGACCGCCCTGTGCTTGGGGTCAATATGTACATC
GATGAGAACTCGACGGAAGAGATCGAGACACACCAGCTCGACCCCGAGTCCGAGCAGCGCCAGATCCGCCGCGTGCAGCA
GGTACGTGCGGAGCGCAACGCCGAGACCGCACAGGCAGCTCTCGCAACCCTGGTCGAAACAGCTCGCGACAACGACGCCA
ATCTCATGCCGGCAACCATCGCCGCTGTCCGAGCCGGTCTGTCGATGGGCGAGATCACCGGTGCACTACGCGACGTGTTC
GGAACCTACGTCGAGACACCTGTGTACTGA

Upstream 100 bases:

>100_bases
CGAACTTGTCGAAGGCGTACGCATCGGGCGGCTCAGTCCGCACGAAGCCGCACATGCACTGGTAAGCGGCAAAACACAAC
TTGACTGAGGAAGGACGAGC

Downstream 100 bases:

>100_bases
GCAGGCAATCCCAACCTTGCGTGGGAAGGTGGTCTTACGACCATGCGTTCAGGAAGGGGATGCGATGGACCCAGCTGAGG
CTCATTGGACCCCGATTCGA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MSTHEADAIKITNEAAVKAIEERLAGWESHELEAFLQRTPESKGVFRTGSGAPVKRVYTPADLPEDWNDIGLPGQFPFTR
GPYPTMYRGRHWTMRQIAGFGQAEETNKRFQYLINQGQTGLSVDFDMPTLMGLDSDDPMSLGEVGREGVAVDVLSDMEAL
FDGIDLENISVSMTINPSAWILLAMYIAVAEDKGYDLNRLSGTIQNDILKEYVAQKEWIFPVRPSMRIVRDCIAYCAENM
ARYNPVNISGYHISEAGANAVQEVAFTMAITRAYVSDVIAAGVDVDTFAPRLSFFFVSQADFFEEAAKFRAVRRFYAKMM
RDEFGAENEQSMRLRFHAQTAAATLTKPQPMNNIIRTTLQALSAILGGAQSLHTNGLDEAYTIPSETAMKIALRTQQVIA
HETGVPSIVDPLGGSYYVEALTDEIETGIHDYLAKIESLGGVVAAIENGFMQREISDTAYQYALRKESGDRPVLGVNMYI
DENSTEEIETHQLDPESEQRQIRRVQQVRAERNAETAQAALATLVETARDNDANLMPATIAAVRAGLSMGEITGALRDVF
GTYVETPVY

Sequences:

>Translated_569_residues
MSTHEADAIKITNEAAVKAIEERLAGWESHELEAFLQRTPESKGVFRTGSGAPVKRVYTPADLPEDWNDIGLPGQFPFTR
GPYPTMYRGRHWTMRQIAGFGQAEETNKRFQYLINQGQTGLSVDFDMPTLMGLDSDDPMSLGEVGREGVAVDVLSDMEAL
FDGIDLENISVSMTINPSAWILLAMYIAVAEDKGYDLNRLSGTIQNDILKEYVAQKEWIFPVRPSMRIVRDCIAYCAENM
ARYNPVNISGYHISEAGANAVQEVAFTMAITRAYVSDVIAAGVDVDTFAPRLSFFFVSQADFFEEAAKFRAVRRFYAKMM
RDEFGAENEQSMRLRFHAQTAAATLTKPQPMNNIIRTTLQALSAILGGAQSLHTNGLDEAYTIPSETAMKIALRTQQVIA
HETGVPSIVDPLGGSYYVEALTDEIETGIHDYLAKIESLGGVVAAIENGFMQREISDTAYQYALRKESGDRPVLGVNMYI
DENSTEEIETHQLDPESEQRQIRRVQQVRAERNAETAQAALATLVETARDNDANLMPATIAAVRAGLSMGEITGALRDVF
GTYVETPVY
>Mature_568_residues
STHEADAIKITNEAAVKAIEERLAGWESHELEAFLQRTPESKGVFRTGSGAPVKRVYTPADLPEDWNDIGLPGQFPFTRG
PYPTMYRGRHWTMRQIAGFGQAEETNKRFQYLINQGQTGLSVDFDMPTLMGLDSDDPMSLGEVGREGVAVDVLSDMEALF
DGIDLENISVSMTINPSAWILLAMYIAVAEDKGYDLNRLSGTIQNDILKEYVAQKEWIFPVRPSMRIVRDCIAYCAENMA
RYNPVNISGYHISEAGANAVQEVAFTMAITRAYVSDVIAAGVDVDTFAPRLSFFFVSQADFFEEAAKFRAVRRFYAKMMR
DEFGAENEQSMRLRFHAQTAAATLTKPQPMNNIIRTTLQALSAILGGAQSLHTNGLDEAYTIPSETAMKIALRTQQVIAH
ETGVPSIVDPLGGSYYVEALTDEIETGIHDYLAKIESLGGVVAAIENGFMQREISDTAYQYALRKESGDRPVLGVNMYID
ENSTEEIETHQLDPESEQRQIRRVQQVRAERNAETAQAALATLVETARDNDANLMPATIAAVRAGLSMGEITGALRDVFG
TYVETPVY

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=541, Percent_Identity=41.7744916820702, Blast_Score=437, Evalue=1e-123,
Organism=Escherichia coli, GI1789284, Length=522, Percent_Identity=43.8697318007663, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI25144500, Length=520, Percent_Identity=44.8076923076923, Blast_Score=456, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 63004; Mature: 62873

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHEADAIKITNEAAVKAIEERLAGWESHELEAFLQRTPESKGVFRTGSGAPVKRVYTP
CCCCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCEEECC
ADLPEDWNDIGLPGQFPFTRGPYPTMYRGRHWTMRQIAGFGQAEETNKRFQYLINQGQTG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCC
LSVDFDMPTLMGLDSDDPMSLGEVGREGVAVDVLSDMEALFDGIDLENISVSMTINPSAW
CEEECCCHHHCCCCCCCCCCHHHCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEECCHHH
ILLAMYIAVAEDKGYDLNRLSGTIQNDILKEYVAQKEWIFPVRPSMRIVRDCIAYCAENM
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
ARYNPVNISGYHISEAGANAVQEVAFTMAITRAYVSDVIAAGVDVDTFAPRLSFFFVSQA
HHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECHH
DFFEEAAKFRAVRRFYAKMMRDEFGAENEQSMRLRFHAQTAAATLTKPQPMNNIIRTTLQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHCCCCCCHHHHHHHHHH
ALSAILGGAQSLHTNGLDEAYTIPSETAMKIALRTQQVIAHETGVPSIVDPLGGSYYVEA
HHHHHHCCHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHH
LTDEIETGIHDYLAKIESLGGVVAAIENGFMQREISDTAYQYALRKESGDRPVLGVNMYI
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
DENSTEEIETHQLDPESEQRQIRRVQQVRAERNAETAQAALATLVETARDNDANLMPATI
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHH
AAVRAGLSMGEITGALRDVFGTYVETPVY
HHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STHEADAIKITNEAAVKAIEERLAGWESHELEAFLQRTPESKGVFRTGSGAPVKRVYTP
CCCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECCCCCCCCEEECC
ADLPEDWNDIGLPGQFPFTRGPYPTMYRGRHWTMRQIAGFGQAEETNKRFQYLINQGQTG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCC
LSVDFDMPTLMGLDSDDPMSLGEVGREGVAVDVLSDMEALFDGIDLENISVSMTINPSAW
CEEECCCHHHCCCCCCCCCCHHHCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEECCHHH
ILLAMYIAVAEDKGYDLNRLSGTIQNDILKEYVAQKEWIFPVRPSMRIVRDCIAYCAENM
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
ARYNPVNISGYHISEAGANAVQEVAFTMAITRAYVSDVIAAGVDVDTFAPRLSFFFVSQA
HHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECHH
DFFEEAAKFRAVRRFYAKMMRDEFGAENEQSMRLRFHAQTAAATLTKPQPMNNIIRTTLQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHCCCCCCHHHHHHHHHH
ALSAILGGAQSLHTNGLDEAYTIPSETAMKIALRTQQVIAHETGVPSIVDPLGGSYYVEA
HHHHHHCCHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHH
LTDEIETGIHDYLAKIESLGGVVAAIENGFMQREISDTAYQYALRKESGDRPVLGVNMYI
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
DENSTEEIETHQLDPESEQRQIRRVQQVRAERNAETAQAALATLVETARDNDANLMPATI
CCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHH
AAVRAGLSMGEITGALRDVFGTYVETPVY
HHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]