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The map label for this gene is pdhR [H]

Identifier: 119716363

GI number: 119716363

Start: 2281734

End: 2282474

Strand: Direct

Name: pdhR [H]

Synonym: Noca_2132

Alternate gene names: 119716363

Gene position: 2281734-2282474 (Clockwise)

Preceding gene: 119716362

Following gene: 119716374

Centisome position: 45.76

GC content: 63.97

Gene sequence:

>741_bases
ATGGACCCAGCTGAGGCTCATTGGACCCCGATTCGAGTACCACGCAGCCACGAACTAGTTCTCGCACAGATAGAAGACCA
GATCGTGCACGGCAGGCTACGGCCCGGGGACCGACTCCCTCCCGAACGTGACCTGGCCAAGAGCCTAAGCGTCAGTCGCG
GCGCGGTCCGCGAAGCGATAAGAGTTCTGGAATCTTTGGGGGTTATTCGTGCATCGCCCGGCTCAGGCGCAAAGGCCGGG
TCCCTTGTCGTTGCCGAAGACACAGCCGCGATGTCGACCGTCTTCCGCCTTCACCTTGCGCTCGCTTCCTTCTCCCAACG
TGAGGTCATGGAGGTGCGGGTGCAGCTCGAACGCTGGAGCGCCCACGAGGCCGCCCAAGCTGCTGGCCGCGGAAACCTTG
AGGACCTCGACCGCTTGCTTGAGGCAATGAAGTCTCCCGAAATCGAAAGCGCGCGCTTCAACGCCATCGACGCCGCGTTC
CACCTGGGCCTGGCCGAGGCTGCTGACAACCGGCTCCTTGCGACCCTCATGAGCGCCATTCGCGACGCCGTGCAACGAGA
GATGGCCGCCGCATTCGCTGACCTGGCCAACGCGCCGGCCGTCATGAGCCAACTCGCTTCGGAGCATGCGGCGATCCTCG
AGGCAGTTCGCGGCGGCAAGGCCGAGGAAGCTGCGGACCTGGTTCAAGCACACATCGAGGGGTTCTACGGATACCTCGAC
GTCGACCGACGCCGCACCTAA

Upstream 100 bases:

>100_bases
GTGTTCGGAACCTACGTCGAGACACCTGTGTACTGAGCAGGCAATCCCAACCTTGCGTGGGAAGGTGGTCTTACGACCAT
GCGTTCAGGAAGGGGATGCG

Downstream 100 bases:

>100_bases
GTCGATCACACGACCCAACGCGTCAGCTGTAGCCGACGGGGTGCCTGTGGGCGCGGGTTCTGCGCTGTTAGCTCCAGGTT
CTCCCACCGAGAGCGGTGGC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MDPAEAHWTPIRVPRSHELVLAQIEDQIVHGRLRPGDRLPPERDLAKSLSVSRGAVREAIRVLESLGVIRASPGSGAKAG
SLVVAEDTAAMSTVFRLHLALASFSQREVMEVRVQLERWSAHEAAQAAGRGNLEDLDRLLEAMKSPEIESARFNAIDAAF
HLGLAEAADNRLLATLMSAIRDAVQREMAAAFADLANAPAVMSQLASEHAAILEAVRGGKAEEAADLVQAHIEGFYGYLD
VDRRRT

Sequences:

>Translated_246_residues
MDPAEAHWTPIRVPRSHELVLAQIEDQIVHGRLRPGDRLPPERDLAKSLSVSRGAVREAIRVLESLGVIRASPGSGAKAG
SLVVAEDTAAMSTVFRLHLALASFSQREVMEVRVQLERWSAHEAAQAAGRGNLEDLDRLLEAMKSPEIESARFNAIDAAF
HLGLAEAADNRLLATLMSAIRDAVQREMAAAFADLANAPAVMSQLASEHAAILEAVRGGKAEEAADLVQAHIEGFYGYLD
VDRRRT
>Mature_246_residues
MDPAEAHWTPIRVPRSHELVLAQIEDQIVHGRLRPGDRLPPERDLAKSLSVSRGAVREAIRVLESLGVIRASPGSGAKAG
SLVVAEDTAAMSTVFRLHLALASFSQREVMEVRVQLERWSAHEAAQAAGRGNLEDLDRLLEAMKSPEIESARFNAIDAAF
HLGLAEAADNRLLATLMSAIRDAVQREMAAAFADLANAPAVMSQLASEHAAILEAVRGGKAEEAADLVQAHIEGFYGYLD
VDRRRT

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=230, Percent_Identity=30, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789353, Length=204, Percent_Identity=28.921568627451, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790032, Length=208, Percent_Identity=32.2115384615385, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790780, Length=168, Percent_Identity=32.1428571428571, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26639; Mature: 26639

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPAEAHWTPIRVPRSHELVLAQIEDQIVHGRLRPGDRLPPERDLAKSLSVSRGAVREAI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RVLESLGVIRASPGSGAKAGSLVVAEDTAAMSTVFRLHLALASFSQREVMEVRVQLERWS
HHHHHCCCEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHEAAQAAGRGNLEDLDRLLEAMKSPEIESARFNAIDAAFHLGLAEAADNRLLATLMSAI
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
RDAVQREMAAAFADLANAPAVMSQLASEHAAILEAVRGGKAEEAADLVQAHIEGFYGYLD
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
VDRRRT
CCCCCC
>Mature Secondary Structure
MDPAEAHWTPIRVPRSHELVLAQIEDQIVHGRLRPGDRLPPERDLAKSLSVSRGAVREAI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RVLESLGVIRASPGSGAKAGSLVVAEDTAAMSTVFRLHLALASFSQREVMEVRVQLERWS
HHHHHCCCEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHEAAQAAGRGNLEDLDRLLEAMKSPEIESARFNAIDAAFHLGLAEAADNRLLATLMSAI
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
RDAVQREMAAAFADLANAPAVMSQLASEHAAILEAVRGGKAEEAADLVQAHIEGFYGYLD
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
VDRRRT
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]