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The map label for this gene is phoP [H]

Identifier: 119716281

GI number: 119716281

Start: 2195970

End: 2196722

Strand: Reverse

Name: phoP [H]

Synonym: Noca_2050

Alternate gene names: 119716281

Gene position: 2196722-2195970 (Counterclockwise)

Preceding gene: 119716282

Following gene: 119716273

Centisome position: 44.06

GC content: 73.04

Gene sequence:

>753_bases
GTGGGGCCTGTCTCAGCGGGCGTGCCCGGTTCGCTCGGGCGGGTCGCGCTCGTGGTGGAGGACGACGAGGACATCCGCGC
GCTCATCGTGTACACCCTCGAGACCCAGGGCTTCGAGGTGTTCGCCGTCGGCTCCGGCCTCGAAGGGGTGGCGGCGGTCC
GCGACCGGCAGCCCGACCTGATCACCCTGGACCTGGGGCTGCCGGGGATCGACGGGATCGAGGCCTGCCGGCGGATCCGC
GAGATCAGCGACGCATACGTCGTGATGATCACCGCCCGTGACGACGAGATCGACCGGCTGCTCGGCCTCGAGACCGGTGC
CGACGACTTCATCGCCAAGCCGTTCAGCGCCCGCGAGCTCAAGGCCCGGGTGAACGCGATGTTCCGCCGGCCGCGCACCG
GAGGTGGCGCCCAGCGCCCGGACGCGCCCGCCGAGGACCCGCACGAGCTCCTCGTGCACGGTCCGCTGCGCGTGGACGTG
GAGGGCCGGCGCGCGTTCCGCGACGGCCAGGAGCTGGTGCTGACCCGCACCGAGTTCGACCTGCTGACCGAGCTGATGCG
GGCGCCCTCCCGGGTGTGGTCGCGCGAGGCCCTGCTGCGCAGCGTGTGGGGCACCGACTGGGCCTCGGACACGCACCTCG
TGGAGGTCCACGTCGGCAACCTGCGGCGCAAGCTCGCGGCGGGCACCGACGGCTCGACCCGGTTCATCCGCACCGTGCGC
GGCGTGGGCTACCGGATGGAGCTGCCTGCCTAG

Upstream 100 bases:

>100_bases
ATGACCGGGCTCTACCACCGCCACGACGACGCCTGAGCCGCGGACCGGCGTATCTCAAGAATTCCGCAAGAAGTGGCATC
ATCGGCGCATGGAGACCGAC

Downstream 100 bases:

>100_bases
CCGGCCAGGTGGTCGGCGAGCACCCGCTCGAGCCGGCTCGCGGCCGGCGCCAGGGCCGCGGCCGCGGCGTCCGCCCCCGG
CAGGTCCCGCAGCCGCAGGT

Product: response regulator receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MGPVSAGVPGSLGRVALVVEDDEDIRALIVYTLETQGFEVFAVGSGLEGVAAVRDRQPDLITLDLGLPGIDGIEACRRIR
EISDAYVVMITARDDEIDRLLGLETGADDFIAKPFSARELKARVNAMFRRPRTGGGAQRPDAPAEDPHELLVHGPLRVDV
EGRRAFRDGQELVLTRTEFDLLTELMRAPSRVWSREALLRSVWGTDWASDTHLVEVHVGNLRRKLAAGTDGSTRFIRTVR
GVGYRMELPA

Sequences:

>Translated_250_residues
MGPVSAGVPGSLGRVALVVEDDEDIRALIVYTLETQGFEVFAVGSGLEGVAAVRDRQPDLITLDLGLPGIDGIEACRRIR
EISDAYVVMITARDDEIDRLLGLETGADDFIAKPFSARELKARVNAMFRRPRTGGGAQRPDAPAEDPHELLVHGPLRVDV
EGRRAFRDGQELVLTRTEFDLLTELMRAPSRVWSREALLRSVWGTDWASDTHLVEVHVGNLRRKLAAGTDGSTRFIRTVR
GVGYRMELPA
>Mature_249_residues
GPVSAGVPGSLGRVALVVEDDEDIRALIVYTLETQGFEVFAVGSGLEGVAAVRDRQPDLITLDLGLPGIDGIEACRRIRE
ISDAYVVMITARDDEIDRLLGLETGADDFIAKPFSARELKARVNAMFRRPRTGGGAQRPDAPAEDPHELLVHGPLRVDVE
GRRAFRDGQELVLTRTEFDLLTELMRAPSRVWSREALLRSVWGTDWASDTHLVEVHVGNLRRKLAAGTDGSTRFIRTVRG
VGYRMELPA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=42.6724137931034, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=238, Percent_Identity=39.9159663865546, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1790860, Length=233, Percent_Identity=39.9141630901288, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=35.8078602620087, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1786911, Length=232, Percent_Identity=36.6379310344828, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=39.2241379310345, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=34.1991341991342, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=38.961038961039, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=29.4372294372294, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=33.7606837606838, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=32.4561403508772, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=31.4655172413793, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1787375, Length=234, Percent_Identity=29.9145299145299, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.2576419213974, Blast_Score=91, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27496; Mature: 27364

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPVSAGVPGSLGRVALVVEDDEDIRALIVYTLETQGFEVFAVGSGLEGVAAVRDRQPDL
CCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCEEEEEECCCCCCHHHHHCCCCCE
ITLDLGLPGIDGIEACRRIREISDAYVVMITARDDEIDRLLGLETGADDFIAKPFSAREL
EEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCHHHHHHCCCCCCCHHHCCCCCHHHH
KARVNAMFRRPRTGGGAQRPDAPAEDPHELLVHGPLRVDVEGRRAFRDGQELVLTRTEFD
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEECCEEEEECCCHHHCCCCEEEEEEHHHH
LLTELMRAPSRVWSREALLRSVWGTDWASDTHLVEVHVGNLRRKLAAGTDGSTRFIRTVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHCCCCCCHHHHHHHH
GVGYRMELPA
CCCEEEECCC
>Mature Secondary Structure 
GPVSAGVPGSLGRVALVVEDDEDIRALIVYTLETQGFEVFAVGSGLEGVAAVRDRQPDL
CCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCEEEEEECCCCCCHHHHHCCCCCE
ITLDLGLPGIDGIEACRRIREISDAYVVMITARDDEIDRLLGLETGADDFIAKPFSAREL
EEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCHHHHHHCCCCCCCHHHCCCCCHHHH
KARVNAMFRRPRTGGGAQRPDAPAEDPHELLVHGPLRVDVEGRRAFRDGQELVLTRTEFD
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEECCEEEEECCCHHHCCCCEEEEEEHHHH
LLTELMRAPSRVWSREALLRSVWGTDWASDTHLVEVHVGNLRRKLAAGTDGSTRFIRTVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHCCCCCCHHHHHHHH
GVGYRMELPA
CCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]